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Results 701 - 750 of 2834
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Verreault Jonathan - - 2012
The northern fulmar (Fulmarus glacialis) has previously been shown to accumulate a wide range, and occasionally high concentrations of organochlorines (OCs) (e.g., PCBs, chlorobenzenes, DDT- and chlordane-related compounds, dioxins and furans). The present study aimed to investigate, using a meta-analysis approach, the variations in cytochrome P450 (CYP) 1A-like enzyme induction ...
Lasa Aide - - 2012
Four motile facultative anaerobic marine isolates (Vb 10.8(T) [CECT 7225(T), CAIM 1869(T)], CMJ 9.4 [CECT 8091, CAIM 1870], CMJ 9.11 and Cmf 13.9), were obtained from cultured clams (Venerupis philippinarum and Venerupis decussata) in Galicia (NW Spain). These isolates were studied by a polyphasic approach, including a phylogenetic analysis based ...
Hatzinger Paul B - - 2012
Stable isotope ratio analysis is increasingly being applied as a tool to detect, understand, and quantify biodegradation of organic and inorganic contaminants in groundwater. An important feature of this approach is that it allows degradative losses of contaminants to be distinguished from those caused by non-destructive processes such as dilution, ...
Kiem Sara A - - 2012
Homeostasis of the human stress response system is critically maintained by a hierarchical system of neural and endocrine elements for which intact negative feedback is important to prevent maladaptation towards stress. Such feedback is efficiently probed by the established combined dexamethasone-suppression/corticotropin-releasing hormone stimulation (dex/CRH) test. Here we investigate which suprahypothalamic ...
Ozdemir Süleyman - - 2012
OBJECTIVES: The aim of this study was to analyze the incidence and etiologic factors of non-use and limited use of cochlear implants. The patients' age, gender, duration of implantation and additional disabilities were investigated. PATIENTS AND METHODS: Of the 413 (200 males, 213 females) pediatric patients (age under 16) implanted ...
Shin Min Sun MS Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, - - 2013
We investigated whether healthy young (age ≤ 40) and elderly (age ≥ 65) people infected with cytomegalovirus (CMV) had similar levels of CD8(+) T cell cytokine production and proliferation in response to an immunodominant CMV pp65 peptide pool given the role of CD8(+) T cells in controlling viral infection and ...
Goel Shakti A SA Department of Surgery, University of Wisconsin, 1111 Highland Ave, Madison, WI 53705, - - 2013
Restenosis, or arterial lumen re-narrowing, occurs in 30-50% of the patients undergoing angioplasty. Adaptive remodeling is the compensatory enlargement of the vessel size, and has been reported to prevent the deleterious effects of restenosis. Our previous studies have shown that elevated transforming growth factor (TGF-β) and its signaling protein Smad3 ...
O'Brien Fearghal - - 2012
A recent theory of adolescent risk taking that may be applicable to young drivers proposed that young people engage in more risks because they are more impulsive. While past research has found that problematic drivers do tend to score higher on measures of impulsivity, most of this research has relied ...
Esposito Gabriella - - 2012
Fragile X syndrome (FXS) is the main cause of heritable mental retardation. In most patients, it is associated with an increased number of CGG repeats (>200) within the 5'-untranslated region of the FMR1 gene, and with methylation of the expanded repeats and of the promoter. FXS female carriers and transmitting ...
Wang Yu - - 2012
Coupling with triolein-embedded cellulose acetate membrane (TECAM) technique, hydroxypropyl β-cyclodextrins (HPCD) extraction method, and the greenhouse pot experiments, the influences of biochars on polychlorinated biphenyls (PCBs) bioavailability in soil to plant (Brassica chinensis L. and Daucus carota) were investigated. Addition of 2% biochars to soils significantly reduced the uptake of ...
Amaral Guilherme Pires - - 2012
The pathology of a gastric ulcer is complex and multifactorial. Gastric ulcers affect many people around the world and its development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. In this study, we evaluated the ethanolic extract of Rosmarinus officinalis L. (eeRo); this ...
Ishihara Yasuhiro - - 2012
Increasing evidence shows that progesterone, a neuroactive steroid, has protective actions in central nervous system, but there is little evidence to show the protective mechanism of progesterone on neurotoxicity induced by environmental chemicals. In this study, we examined the effects of progesterone on neuronal injury induced by tributyltin (TBT) in ...
Choi C W - - 2012
BACKGROUND: The relationship between the subjective skin type and the casual sebum level was not fully clarified. OBJECTIVES: To investigate the characteristics of subjective skin type and to find the relationship between the subjective skin types and the skin type-related symptoms, casual sebum level, along with the objective skin type. ...
Lees Mackenzie - - 2012
OBJECTIVES: The primary purpose of this study was to establish the ability of pediatric anesthesiologists to learn to use two video laryngoscopes - the GlideScope(®) system (GS) and the Karl Storz Direct Coupled Interface, DCI(®) , (KS). BACKGROUND: The number of intubation attempts required to attain proficiency with a video ...
Liu Bin - - 2012
Ischemic neuron death is presumably caused by excitotoxicity. Here, we studied whether ischemia impaired astrocytes and GABAergic neurons to exacerbate glutamate-dependent neural excitotoxicity by electrophysiologically recording these nerve cells in cortical slices. Our results showed that ischemia impaired the activity of glutamate-transporters (Glu-T) on the astrocytes, as well as the ...
Tenk Christine M - - 2012
Neonatal administration of the bacterial cell wall component, lipopolysaccharide (LPS) has been shown to alter a variety of behavioural and physiological processes in the adult rat, including altering adult anxiety-like behaviour. Research conducted to date, however, has produced conflicting findings with some results demonstrating increases in adult anxiety-like behaviour while ...
Larrouy-Maestri Pauline - - 2012
OBJECTIVE: Vocal accuracy of a sung performance can be evaluated by two methods: acoustic analyses and subjective judgments. Acoustic analyses have been presented as a more reliable solution but both methods are still used for the evaluation of singing voice accuracy. This article presents a first time direct comparison of ...
Carrasco Anna - - 2012
An ideal method of immune cell isolation should provide maximum cell yield without disturbing functional properties. Intestinal endoscopic biopsies, in contrast to surgical samples, allow the study of all disease stages but have the drawback of a minimum amount of tissue available, making protocol optimization mandatory. We compared for the ...
Ahmad Muhammad Nauman - - 2012
Although ozone is well-documented to reduce crop yields in the densely populated Indo-Gangetic Plain, there is little knowledge of its effects in other parts of south Asia. We surveyed crops close to the city of Peshawar, in north-west Pakistan, for visible injury, linking this to passive measurements of ozone concentrations. ...
Caccia Silvio - - 2012
Unexpected drug interactions have led to the withdrawal of many drugs, raising concern about the gap between what is known at the time of approval and the risk of serious effects in the longer term, particularly in high-risk populations generally excluded from drug development. This is because the majority of ...
Khademian Hossein - - 2012
GNE myopathy or hereditary inclusion body myopathy (HIBM) is an ultra-rare severely disabling autosomal recessive adult onset muscle disease which affects roughly 1-3 individuals per million worldwide. Genetically, HIBM is caused by mutations in the glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase gene (GNE), resulting in diminished enzyme function and reduced sialic acid biosynthesis. ...
Shevyrin Vadim - - 2012
By means of gas chromatography with mass spectrometry detector (GC-MS), liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance spectroscopy (NMR), structure of a series from a novel class of synthetic cannabimimetics bearing 2,2,3,3-tetramethylcyclopropanecarbonyl moiety was established. It was found that this fragment could undergo thermal ring-opening into isomeric structures. The ...
Greco Barbara B Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, - - 2013
Several synaptic genes predisposing to autism-spectrum disorder (ASD) have been identified. Nonsense and missense mutations in the SYN1 gene encoding for Synapsin I have been identified in families segregating for idiopathic epilepsy and ASD and genetic mapping analyses have identified variations in the SYN2 gene as significantly contributing to epilepsy ...
Baker Hannah M - - 2012
BACKGROUND: There is no valid and reliable instrument to evaluate genetic education and counseling received by parents who have an infant with a positive newborn screen for cystic fibrosis (CF). METHODS: This study assessed the validity and reliability of a new instrument designed to evaluate the effectiveness of genetic education ...
Le Borgne Gwenael - - 2012
OBJECTIVES: To assess long-term quality of life (QOL) in cervical cancer survivors (CCSs), 5, 10, and 15 years after diagnosis. METHODS: In a cross-sectional population-based study, CCSs diagnosed in 1990, 1995, or 2000 were randomly selected from 3 tumor registries in France. Healthy controls were randomly selected from electoral rolls, ...
Paduch Marcin M Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, - - 2013
A set of phage display sorting strategies and validation methodologies are presented that are capable of producing high performance synthetic antibodies (sABs) with customized properties. Exquisite control of antigen and conditions during the phage display selection process can yield sABs that: (1) recognize conformational states, (2) target specific regions of ...
Batista Pedro J PJ Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford, CA 94305, - - 2013
Cells are highly organized structures. In addition to membrane delimited organelles, proteins and RNAs can organize themselves into specific domains. Some examples include stress granules and subnuclear bodies. This level of organization is essential for the correct execution of multiple processes in the cell, ranging from cell signaling to assembly ...
Morgan Philip B - - 2012
PURPOSE: To evaluate the performance of a silicone hydrogel daily disposable lens in neophyte subjects over 12 months. METHODS: Seventy four subjects with no previous contact lens experience were randomised to wear narafilcon A (1 DAY ACUVUE(®) TruEye™) lenses (LW group) or to wear no contact lenses (NLW group) for ...
Smith Ezra - - 2012
Emotional faces are motivationally salient stimuli that automatically capture attention and rapidly potentiate neural processing. Because of their superior temporal resolution, scalp-recorded event-related potentials (ERPs) are ideal for examining rapid changes in neural activity. Some reports have found larger ERPs for fearful and angry faces compared to both neutral and ...
Wang Jiye - - 2012
High-altitude hypoxia impedes cognitive performance. It is not well known whether the prophylactic use of acetazolamide for altitude sickness can influence cognitive performance at high altitude. When ascending to high altitude locations, one may face medical risks, including cognitive impairment, which may significantly hinder climbing abilities or exploratory behavior. Effective ...
Malmborg Jonas J DMPK Department, AstraZeneca CNS and Pain R&D, S-151 85 Sodertalje, Sweden. - - 2013
Predicting the pharmacokinetics (PK) of prodrugs and their corresponding active drugs is challenging, as there are many variables to consider. Prodrug conversion characteristics in different tissues are generally measured, but integrating these variables to a PK profile is not a common practice. In this paper, a joined in vitro/in silico-in ...
Hermanns Norbert - - 2012
Family physicians are responsible for diagnosing and treating the majority of people with type 2 diabetes mellitus and co-morbid depression. As a result of the impact of co-morbid depression on patient self-care and treatment outcomes, screening for depression in the context of a structured approach to case management and patient ...
Hanai Hiroyuki - - 2012
Leukocytapheresis (LCAP) appears to remove or inactivate inflammatory cells and to reset immunological responses, resulting to cure responders of ulcerative colitis (UC). The changes of T cell subsets were investigated in UC patients treated with LCAP. Levels of T cell subsets in peripheral blood before and after LCAP were analysed ...
Gu Langyu - - 2012
The geological complexity generated by the uplift of the Qinghai-Tibetan Plateau and the resulting habitat heterogeneity have functioned together with climatic oscillations in the Quaternary to have a profound impact on the patterns of genetic diversity and demography of the fauna in this region. To understand the effect of the ...
Collins Gary S GS Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Linton Road, Oxford OX2 6UD, UK. - - 2013
To evaluate the performance of QCancer® (Renal) for predicting the absolute risk of renal tract cancer in a large independent UK cohort of patients from general practice records. Open cohort study to validate QCancer® (Renal) prediction model. Record from 365 practices from United Kingdom contributing to The Health Improvement Network ...
Duguid Ian C - - 2012
The N-methyl-D-aspartate (NMDA) receptor plays an essential role in excitatory transmission, synaptic integration, and learning and memory. In the classical view, postsynaptic NMDA receptors act as canonical coincidence detectors providing a 'molecular switch' for the induction of various forms of short- and long-term synaptic plasticity. Over the past twenty years ...
Lee Si-Hyung - - 2012
BACKGROUND: A phototrichogram scalp measurement method using a headband and a tapeline was introduced as a non-invasive and economical measuring technique. OBJECTIVE: To evaluate the reliability and reproducibility of the two-point scoring method by phototrichogram using a headband and a tapeline. METHODS: The scalp hair of seven volunteers were measured ...
George Paltoglou - - 2012
OBJECTIVE: To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non-PCOS women, and their genotypes association with hyperandrogenemia and insulin resistance. DESIGN: Case-control genetic association study. SETTING: University Hospital Endocrine Unit. PATIENTS: 142 PCOS cases (NIH criteria) and 112 controls. MAIN OUTCOME MEASURE: ...
Hoffman Matthew R MR Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, - - 2013
Clinical application of mechanical interruption methods for measuring aerodynamic parameters has been hindered by relatively high intrasubject variability. To improve the intrasubject reliability, we evaluated the effect of auditory and visual feedback on subject performance when measuring aerodynamic parameters with the airflow interrupter. Eleven subjects performed four sets of 10 ...
Shechter Ravid - - 2012
The poor recovery of the central nervous system (CNS) after injury, coupled with its complex and immunologically-privileged nature, led to the belief that CNS repair is different from the repair of other tissues. Here, we consider CNS repair from a novel perspective, suggesting that CNS responses to injury resemble wound ...
Jones Hendrée E HE RTI International, Research Triangle Park, NC 27709, USA. - - 2013
The relationship between cigarette smoking and neonatal and maternal clinical outcomes among opioid-agonist-treated pregnant patients is sparse. (1) Is smoking measured at study entry related to neonatal and maternal outcomes in pregnant women receiving opioid-agonist medication? (2) Is it more informative to use a multi-item measure of smoking dependence or ...
Bouzat Pierre - - 2012
The time course of asymptomatic pulmonary oedema during high-altitude exposure and its potential relationship with changes in cardiac function remain to clarify. Eleven volunteers were rapidly exposed to 4,350m during a 4-day period. Each subject received clinical examination and thoracic ultrasonography to assess ultrasound lung comets (USLC) on day 1, ...
Trasande Leonardo L Department of Pediatrics, New York University School of Medicine, New York, NY, United States. - - 2013
Prior research on the physical health of children exposed to the World Trade Center (WTC) attacks has largely relied on parental report via questionnaire. We examined the impact of clinically-reported exposures on the physical health of children who lived and/or attended school in downtown Manhattan on September 11, 2001. We ...
Komazawa Hiroki - - 2012
Chronic renal failure (CRF) leads to decreased drug renal clearance and glomerular filtration rate. However, little is known about renal tubular excretion and reabsorption in CRF. We examined transport activity of renal transporters using rats with adenine-induced CRF. We examined the effect of adenine-induced CRF on mRNA level, protein expression ...
Lembo David - - 2012
Cyclodextrin-based nanosponges (NS) are solid nanoparticles, obtained from the cross-linking of cyclodextrins, that have been proposed as delivery systems for many types of drugs. Various NS derivatives are currently under investigation in order that their properties might be tuned for different applications. In this work, new carboxylated cyclodextrin-based nanosponges (Carb-NS) ...
Zucali P A PA Humanitas Cancer Center, Via Manzoni 56, Rozzano, Milan, - - 2013
The WHO-classification was shown to be an independent prognostic marker in some but not all retrospective studies possibly due to lack of reproducibility. We investigated the reproducibility of the WHO-classification and its prognostic implication using a large series of resected thymomas. Four independent pathologists histologically classified a surgical series of ...
Beets Karen - - 2012
Vascular patterning involves sprouting of blood vessels, which is governed by orchestrated communication between cells in the surrounding tissue and endothelial cells (ECs) lining the blood vessels. Single ECs are selected for sprouting by hypoxia-induced stimuli and become the 'tip' or leader cell that guides new sprouts. The 'stalk' or ...
Kolb Andreas F - - 2012
B-vitamin deficiency is a risk factor for vascular disease. The mechanism by which the deficiency impacts on disease risk is unclear. We have analysed whether the inflammatory response of mononuclear cells can be modified by cellular folate status in vitro. We show that the mouse monocyte cell line RAW264.7 grown ...
de Assis Moura Ghirardi Ana Carolina - - 2012
PURPOSE: To develop and validate a score that can serve as a screening index for voice disorders in teachers. METHODS: The subjects of this study were 252 female teachers, with and without voice disorders (WVD and WOVD) from the public school system of São Paulo, Brazil. All subjects underwent medical ...
Nawrocki Annalise M - - 2012
The model organism Hydra belongs to the hydrozoan clade Aplanulata. Despite being a popular model system for development, little is known about the phylogenetic placement of this taxon or the relationships of its closest relatives. Previous studies have been conflicting regarding sister group relationships and have been unable to resolve ...
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