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Results 701 - 750 of 2817
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Bouzat Pierre - - 2012
The time course of asymptomatic pulmonary oedema during high-altitude exposure and its potential relationship with changes in cardiac function remain to clarify. Eleven volunteers were rapidly exposed to 4,350m during a 4-day period. Each subject received clinical examination and thoracic ultrasonography to assess ultrasound lung comets (USLC) on day 1, ...
Komazawa Hiroki - - 2012
Chronic renal failure (CRF) leads to decreased drug renal clearance and glomerular filtration rate. However, little is known about renal tubular excretion and reabsorption in CRF. We examined transport activity of renal transporters using rats with adenine-induced CRF. We examined the effect of adenine-induced CRF on mRNA level, protein expression ...
Lembo David - - 2012
Cyclodextrin-based nanosponges (NS) are solid nanoparticles, obtained from the cross-linking of cyclodextrins, that have been proposed as delivery systems for many types of drugs. Various NS derivatives are currently under investigation in order that their properties might be tuned for different applications. In this work, new carboxylated cyclodextrin-based nanosponges (Carb-NS) ...
Tang Rex W K - - 2012
Much of the mercury (Hg) in freshwater fish of the boreal shield ecoregion is believed to originate from atmospheric deposition. As such, declines in fish Hg concentrations would be expected in response to recent declines in atmospheric Hg deposition in this ecoregion. We compared recent (2005-2010) and historic (1974-1981) muscle ...
Moradi Negin - - 2012
Quality of life is one of the important aspects in the assessment of health and treatment data output. The purpose of this study was to adapt and determine reliability and validity of Voice Handicap Index (VHI) in Persian. The subjects were 80 patients with voice disorders and 80 volunteers without ...
Pettitt Michala E - - 2012
Appropriate characterisation of manufactured nanomaterials (NMs) is vital for many aspects of their synthesis, product formulation, toxicological testing and regulation. As the range and quantity of NMs in production has expanded, the interest in their potential environmental and toxicological consequences has grown. With this growth, there is increased need for ...
Chakrabarty Amit - - 2012
OBJECTIVES: Implantable devices treated with phosphorylcholine (PC) have been successfully used in cardiac, ophthalmic, and other applications. This surface modification has resulted in a reduction in the host inflammatory responses. This pilot study tested the safety and efficacy of PC treated polypropylene mesh grafts implanted for the treatment of pelvic ...
Peel D - - 2012
Theoretical models are often applied to population genetic data sets without fully considering the effect of missing data. Researchers can deal with missing data by removing individuals that have failed to yield genotypes and/or by removing loci that have failed to yield allelic determinations, but despite their best efforts, most ...
Arginelli Federica - - 2012
BACKGROUND: Multiphoton Laser Tomography (MPT) has developed as a non-invasive tool that allows real-time observation of the skin with subcellular resolution. MPT is readily combined with time resolved detectors to achieve fluorescence lifetime imaging (FLIM). The aim of our study was to identify morphologic MPT/FLIM descriptors of melanocytic nevi, referring ...
Wang Xiaobing - - 2012
Sonodynamic therapy (SDT) has shown great potential in target cancer therapy, but it induced cell death modes hasn't been fully investigated. This study was to examine autophagic and apoptotic responses to protoporphyrin IX (PpIX) mediated SDT in murine leukemia L1210 cells. After SDT, the occurrence of autophagy was identified by ...
Kottner Jan - - 2012
BACKGROUND/PURPOSE: Non-contact methods for quantifying skin surface topography in vivo are common in skin research. The surface evaluation of living skin (SELS) and the phaseshift rapid in vivo measurement of skin (PRIMOS) are two approaches to measure skin surface roughness and wrinkling via optical methods. The aim of this study ...
Schönemann Barbara - - 2012
The contractile vacuole complex (CVC) of freshwater protists serves the extrusion of water and ions, including Ca(2+). No vesicle trafficking based on SNAREs has been detected so far in any CVC. SNAREs (soluble NSF [N-ethylmaleimide sensitive factor] attachment protein receptors) are required for membrane-to-membrane interaction, i.e. docking and fusion also ...
Gao Yanrui - - 2012
PURPOSE: To establish a model of standardized acute barrier disruption, investigate the response of normal human to repeated tape stripping, and analyze the change of damaged skin with non-invasive examination techniques for skin, such as TEWL and squamometry. METHODS: Repeated tape stripping with corneofix was applied on three different anatomical ...
Triolo Michela - - 2012
OBJECTIVE: Low normal thyroid function may promote the development of atherosclerotic cardiovascular disease by thus far poorly defined mechanisms. We tested the impact of thyroid function on HDL anti-oxidative capacity, a metric of its anti-atherogenic functionality, in euthyroid subjects with varying degrees of glucose tolerance. DESIGN AND SUBJECTS: Seventy subjects ...
Zhang Cheng - - 2012
Despite improvements in transplant immunology and clinical and supportive care, acute graft-versus-host disease (aGVHD) remains a clinical challenge and a major cause of morbidity and mortality for patients after allogeneic hematopoietic stem cell transplantation (HSCT). Many ways have been used to prevent and treat aGVHD, however, long-term survival remains poor. ...
Steele James - - 2012
It has been known since the 1960s that lactic acid bacteria are essential for the development of cheese flavor. In the ensuing 50 years significant research has been directed at understanding the microbiology, genetics and biochemistry of this process. This review briefly covers the current status of cheese flavor development ...
Chen Wei-Hsin - - 2012
Sprays are an important tool for removing air pollutants through absorption. To recognize the mass transport characteristics of air pollutants in sprays, four different air pollutants of sulfur dioxide (SO(2)), hydrogen chloride (HCl), ammonia (NH(3)), and nitric acid (HNO(3)) absorbed by droplets in sprays are analyzed theoretically in association with ...
Lautenschlager Matthew - - 2012
We describe the adaptation of a sample recovery method for botulinum neurotoxins from stainless steel. Botulinum toxin was recovered from surfaces left to dry for up to 16 hrs and detected by either ELISA or EndoPep mass spectrometry methods. In addition, we demonstrate that this method can be used to ...
Toyoshima Yoshiyuki - - 2012
Aspergillus oryzae is a fungus that is used widely in traditional Japanese fermentation industries. In this study, the lethal and mutagenic effects of different linear energy transfer (LET) radiation in freeze-dried conidia of A. oryzae were investigated. The lethal effect, which was evaluated by a 90% lethal dose, was dependent ...
Liu Shao-Cheng - - 2012
OBJECTIVES: The treatment of ventricular dysphonia (VD) should be based on confirming the true folds pathology. In some patients, the ability of the true folds vibration remains unclear and decision making for performing aggressive surgical interventions can be difficult. STUDY DESIGN: A retrospective study of surgery by chart review. METHODS: ...
Dorgo Sandor - - 2012
OBJECTIVES: To investigate the effectiveness of different applications of mentoring in an older adult exercise program, this study compared the physical fitness scores, the retention and participation rates of older adults trained by student mentors, peer mentors, peer mentors working independently of the researchers, and a non-exercising control group. METHODS: ...
Stojan Jure - - 2012
Cholinesterases do not follow the Michaelis-Menten kinetics. In the past, many reaction schemes were suggested to explain their complex interactions during the substrate turnover. Covalent catalysis was recognized very early and therefore, double intermediate traditional reaction scheme for the hydrolysis of good substrates at low concentrations was postulated. However, at ...
Song Xinzhang - - 2012
Chinese Fir and Moso bamboo are the two most important forest plantation species in subtropical China. However, information on greenhouse gas emissions from these forests is still scarce. A field study was carried out to compare soil CO(2) flux dynamics in Chinese Fir and Moso bamboo forests over a 12-month ...
Rosa Maria I - - 2012
OBJECTIVE: To investigate the efficacy, compared to placebo, of fluconazole 150mg weekly, given for six months as prophylaxis against recurrent vulvovaginal candidiasis (RVVC). STUDY DESIGN: A quantitative systematic review was performed, and randomized controlled trials were included. We conducted searches at Medline, EMBASE, Lilacs, Cochrane Library and ICI Web of ...
Schulman S - - 2012
The comment of Tripodi and Moia regarding the inaccuracy of the international normalized ratio (INR) above 4.5 is correct, since calibration of thromboplastin is performed with plasmas from patients with mostly adequate anticoagulation (INR 1.5 to 4.5) [1]. They are concerned that our suggestion in the latest edition of the ...
Cuddy L C - - 2012
OBJECTIVES: The aim of this prospective case series was to evaluate the suitability of a pre-tied ligating loop for liver biopsy or partial or complete liver lobectomy via midline coeliotomy for diagnosis or treatment of hepatic disease. METHODS: Nine client-owned animals (six dogs and three cats) in which liver biopsy ...
Frasinariu Otilia E - - 2012
Non-alcoholic fatty liver disease is a multifactorial condition, ranging from simple steatosis to non-alcoholic steatohepatitis with or without fibrosis. In non-alcoholic fatty liver disease, alteration of gut microbiota and increased intestinal permeability increase exposure of the liver to gut-derived bacterial products: lipopolysaccharides and unmethylated CpG DNA. These products stimulate innate ...
Woo Seung Hoon - - 2012
OBJECTIVES: Temporary or permanent vocal paralysis can occur after head and neck surgery for thyroid cancer, esophageal resection, a chest operation that includes lung parenchymal resection due to a vagus or recurrent laryngeal nerve injury, and so forth. These days, the main treatment for vocal fold paralysis is the injection ...
Varamenti Evdokia I - - 2012
Elite athletes undergo heavy training programs throughout the year. The aim of the present study was to evaluate blood biomarkers of redox status, oxidative stress, inflammation and angiogenesis over the course of a competitive season in elite female water polo players. The biomarkers were evaluated in four distinct phases of ...
Breuel Wiebke - - 2012
Up to 30% of patients relapse after orthognathic operations, and one reason might be incomplete neuromuscular adaptation of the masticatory muscles. Displacement of the mandible in sagittal or vertical directions, or both, leads to stretching or compression of these muscles. The aim of this study was to analyse stretching factors ...
Yamashita Fumiyoshi - - 2012
Drug delivery systems involve technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile. In order to optimize a function of the delivery systems, their biodistribution characteristics should be systematically understood. Pharmacokinetic analysis based on the clearance concepts provides quantitative information of the biodistribution, which can be ...
Allen Kelli D - - 2012
Physical therapy (PT) is a key component of treatment for knee osteoarthritis (OA) and can decrease pain and improve function. Given the expected rise in prevalence of knee OA and the associated demand for treatment, there is a need for models of care that cost-effectively extend PT services for patients ...
Chen Hai-Yang - - 2012
Considering the advantages and limitations of a single receptor model, in this study, a combined technique of nonnegative matrix factorization analysis with effective weighted variance solution (NMF-EWV) was proposed for source apportionment. Utilizing NMF, major linear independent factor loadings with nonnegative elements were extracted to identify potential pollution sources. Then, ...
Liu N - - 2012
The A*24:02:17 allele differs from the most close matching allele A*24:02:01:01 by one nucleotide substitution in exon 2, at position 264.
Bailey Lucy - - 2012
In 2006 the anti-CD28 superagonistic IgG4 TGN1412, having passed pre-clinical safety screens, caused a severe 'cytokine storm' in 6 healthy volunteers. Others have shown that for TGN1412 to induce an inflammatory signal in human peripheral blood mononuclear cells (PBMCs) or in human diluted blood, endothelial cells or bound monoclonal antibody ...
Selbig William R - - 2012
Urban sediment can act as a transport mechanism for a variety of pollutants to move towards a receiving water body. The concentrations of these pollutants oftentimes exceed levels that are toxic to aquatic organisms. Many treatment structures are designed to capture coarse sediment but do not work well to similarly ...
Ahlsson Fredrik - - 2012
OBJECTIVE: The role of adipokines in the regulation of energy substrate production in non-diabetic pregnant women has not been elucidated. We hypothesize that serum concentrations of adiponectin are related to fetal growth via maternal fat mass, insulin resistance and glucose production, and further, that serum levels of leptin are associated ...
Rosario Roseanne - - 2012
OBJECTIVES: Despite their distinct biology, granulosa cell tumours (GCTs) are treated similarly to other ovarian tumours. Predominantly expressed in granulosa cells, the transcription factor Forkhead Box L2 (FOXL2) is near absent in juvenile-type GCTs. This research aimed to investigate miRNAs as a mechanism of suppression of FOXL2 expression in juvenile-type ...
Mauch Jacqueline - - 2012
BACKGROUND AND OBJECTIVES: Impairment of blood coagulation is one of the main side effects of volume replacement, particularly if artificial colloids such as hydroxyethyl starch (HES) and gelatine preparations are used. This animal study aimed to evaluate the effect of a single fast intravenous crystalloid or colloid fluid bolus on ...
Cavari Yuval - - 2012
We report the case of a 2-year-old Bedouin boy in whom developed severe and unusual complications after being stung, most probably, by the yellow scorpion Leiurus quinquestriatus hebraeus. Five hours after arrival to the emergency department, the boy had multisystem organ failure involving the central nervous system (seizure activity followed ...
Morgan Philip B - - 2012
PURPOSE: To evaluate the performance of a silicone hydrogel daily disposable lens in neophyte subjects over 12 months. METHODS: Seventy four subjects with no previous contact lens experience were randomised to wear narafilcon A (1 DAY ACUVUE(®) TruEye™) lenses (LW group) or to wear no contact lenses (NLW group) for ...
Smith Ezra - - 2012
Emotional faces are motivationally salient stimuli that automatically capture attention and rapidly potentiate neural processing. Because of their superior temporal resolution, scalp-recorded event-related potentials (ERPs) are ideal for examining rapid changes in neural activity. Some reports have found larger ERPs for fearful and angry faces compared to both neutral and ...
Wang Jiye - - 2012
High-altitude hypoxia impedes cognitive performance. It is not well known whether the prophylactic use of acetazolamide for altitude sickness can influence cognitive performance at high altitude. When ascending to high altitude locations, one may face medical risks, including cognitive impairment, which may significantly hinder climbing abilities or exploratory behavior. Effective ...
Hatzinger Paul B - - 2012
Stable isotope ratio analysis is increasingly being applied as a tool to detect, understand, and quantify biodegradation of organic and inorganic contaminants in groundwater. An important feature of this approach is that it allows degradative losses of contaminants to be distinguished from those caused by non-destructive processes such as dilution, ...
Kiem Sara A - - 2012
Homeostasis of the human stress response system is critically maintained by a hierarchical system of neural and endocrine elements for which intact negative feedback is important to prevent maladaptation towards stress. Such feedback is efficiently probed by the established combined dexamethasone-suppression/corticotropin-releasing hormone stimulation (dex/CRH) test. Here we investigate which suprahypothalamic ...
Ozdemir Süleyman - - 2012
OBJECTIVES: The aim of this study was to analyze the incidence and etiologic factors of non-use and limited use of cochlear implants. The patients' age, gender, duration of implantation and additional disabilities were investigated. PATIENTS AND METHODS: Of the 413 (200 males, 213 females) pediatric patients (age under 16) implanted ...
O'Brien Fearghal - - 2012
A recent theory of adolescent risk taking that may be applicable to young drivers proposed that young people engage in more risks because they are more impulsive. While past research has found that problematic drivers do tend to score higher on measures of impulsivity, most of this research has relied ...
Arruda Martha M - - 2012
Erythrocytes from sickle cell anaemia (SCA) patients continuously produce larger amounts of pro-oxidants than normal cells. Oxidative stress seems to primarily affect the membrane and results in haemolysis. The use of antioxidants in vitro reduces the generation of pro-oxidants. To evaluate the impact of vitamins C (VitC) and E (VitE) ...
Zoldák Gabriel - - 2012
Force spectroscopy has developed into an indispensable tool for studying folding and binding of proteins on a single molecule level in real time. Design of the pulling geometry allows tuning the reaction coordinate in a very precise manner. Many recent experiments have taken advantage of this possibility and have provided ...
Wang Li-Zhong - - 2012
BACKGROUND: There is a risk of inadvertent dural or vascular puncture for the traditional single-shot caudal block performed by inserting the needle into the sacral canal through the sacral hiatus. This prospective, randomized study was to evaluate the clinical feasibility of the hiatus injection under ultrasound guidance for caudal block ...
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