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la Marca Giancarlo - - 2012
BACKGROUND: Adenosine deaminase (ADA)-severe combined immunodeficiency (SCID) is caused by genetic variants that disrupt the function of ADA. In its early-onset form, it is rapidly fatal to infants. Delayed or late-onset ADA-SCID is characterized by insidious progressive immunodeficiency that leads to permanent organ damage or death. Quantification of T-cell receptor ...
Wegener Jakob - - 2012
The honey bee (Apis mellifera) is characterized by a high degree of phenotypic plasticity of senescence-related processes, and has therefore become a model organism of gerontological research. Sperm of honey bee drones can remain fertile for several years within the storage organ of queens. The reason for this longevity is ...
von Allmen R S - - 2012
OBJECTIVES: To investigate population trends in thoracic aortic disease (dissections and aneurysms) in England and Wales, with focus on the impact of thoracic endovascular aortic repair on procedure numbers and age at repair. MATERIALS AND METHODS: Routine hospital statistics of England and Wales provided admission, procedure and mortality data from ...
Cheng Victoria E - - 2012
A 40 year-old woman presented to hospital with 12h of progressive shortness of breath. She was 11days postpartum, having delivered a full-term male infant. She was discharged on antibiotics for presumed pneumonia, but represented two days later with NYHA class IV symptoms and in acute decompensated heart failure confirmed on ...
van Schoor Albert-Neels - - 2012
BACKGROUND: The ilio-inguinal/iliohypogastric nerve block (INB) is one of the most common peripheral nerve block techniques in pediatric anesthesia, which is largely due to the introduction of ultrasound (US) guidance. Despite the benefits of US guidance, the absence of an US machine should not deter the provider from performing INB, ...
Happyana Nizar - - 2012
Trichomes, especially the capitate-stalked glandular hairs, are well known as the main sites of cannabinoid and essential oil production of Cannabis sativa. In this study the distribution and density of various types of Cannabis sativa L. trichomes, have been investigated by scanning electron microscopy (SEM). Furthermore, glandular trichomes were isolated ...
Wang Ya-Yu - - 2012
Hyperglycemia is common after acute stroke. In the acute phase of stroke (within 24 h), rats with permanent cerebral ischemia developed higher fasting blood glucose and insulin levels in association with up-regulation of hepatic gluconeogenic gene expression, including phosphoenolpyruvate carboxykinase, glucose-6-phosphatase, and fructose-1,6-bisphosphatase. In addition, hepatic gluconeogenesis-associated positive regulators, such ...
Jimenez Nathalia - - 2012
Trans-esophageal echocardiography (TEE) and/or central venous pressure (CVP) monitoring are important in the anesthetic management of spine fusion of pediatric patients with severe muscular weakness. This case highlights an unusual situation of apparent acute right ventricular mechanical obstruction after prone positioning and its prompt recognition with CVP monitoring. The anesthetic ...
Belzil Veronique V - - 2012
Cellular viability depends upon the well-orchestrated functions carried out by numerous protein-coding and non-coding RNAs, as well as RNA-binding proteins. During the last decade, it has become increasingly evident that abnormalities in RNA processing represent a common feature among many neurodegenerative diseases. In "RNAopathies", which include diseases caused by non-coding ...
Brøndum-Jacobsen P - - 2012
BACKGROUND: Vitamin D has potential antithrombotic effects suggesting that vitamin D analogs could be used as adjunctive antithrombotic agents. However, epidemiological evidence of an association between reduced 25-hydroxyvitamin D concentrations and risk of venous thromboembolism is lacking. OBJECTIVES: We tested the hypothesis that reduced plasma 25-hydroxyvitamin D concentrations associate with ...
Willems Elise - - 2012
The purpose of this manuscript was to review recent literature and guidelines regarding phenotypic detection of emerging β-lactamases [extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases and carbapenemases] in Gram-negative bacilli (GNB) in order to formulate recommendations on best practice to screen for them. We conclude that chromogenic ESBL screening agar plates are ...
Ramos Maria - - 2012
OBJECTIVE: To describe the cultural, social and gender features that determine attitudes to colorectal cancer screening in a target group of patients aged 50 to 69 years old in the primary health care setting. METHODS: We performed a qualitative ethnographic study from a gender perspective. Participants consisted of men and ...
Boudry-Labis Elise - - 2012
The increased use of array-CGH and SNP-arrays for genetic diagnosis has led to the identification of new microdeletion/microduplication syndromes and enabled genotype-phenotype correlations to be made. In this study, nine patients with 9q21 deletions were investigated and compared with four previously Decipher reported patients. Genotype-phenotype comparisons of 13 patients revealed ...
André Florian - - 2012
INTRODUCTION: Invasive coronary angiography is the reference method for identification of in-stent restenosis (ISR) bearing the disadvantages of high costs and invasiveness. New approaches like dual-source CT (DSCT) and 256-multi-slice CT (256-MSCT) may potentially be the future methods of choice to reliably exclude ISR in patients with low or intermediate ...
Liu N - - 2012
The novel allele differs from HLA-B*07:02:01 by a single nucleotide substitution at position 538 in exon 3.
Sasaki Eriko - - 2012
Cytokinin (CK) is a plant hormone that plays important regulatory roles in many aspects of plant growth and development. Although functions of CK and its biosynthesis pathway have been studied extensively, there is still no efficient biosynthesis inhibitor, which would be useful for studying CK from a chemical genetic approach. ...
Tenk Christine M - - 2012
Neonatal administration of the bacterial cell wall component, lipopolysaccharide (LPS) has been shown to alter a variety of behavioural and physiological processes in the adult rat, including altering adult anxiety-like behaviour. Research conducted to date, however, has produced conflicting findings with some results demonstrating increases in adult anxiety-like behaviour while ...
Larrouy-Maestri Pauline - - 2012
OBJECTIVE: Vocal accuracy of a sung performance can be evaluated by two methods: acoustic analyses and subjective judgments. Acoustic analyses have been presented as a more reliable solution but both methods are still used for the evaluation of singing voice accuracy. This article presents a first time direct comparison of ...
Carrasco Anna - - 2012
An ideal method of immune cell isolation should provide maximum cell yield without disturbing functional properties. Intestinal endoscopic biopsies, in contrast to surgical samples, allow the study of all disease stages but have the drawback of a minimum amount of tissue available, making protocol optimization mandatory. We compared for the ...
Lim Seung Joo - - 2012
The potential fates in indirect potable reuse systems of 2179 pharmaceutical compounds that currently have been used or may be introduced within the next five years were estimated using a modified quantitative structure activity relationship model. Over 90% of the pharmaceutical compounds analyzed were estimated in this study as non-persistent ...
Zhao Qing - - 2012
This work was initiated to study the concentration effects on phenanthrene and pyrene extraction during process of aging in phaeozem and burozem with or without freeze-thawing cycles. 1, 10, and 100μgg(-1) phenanthrene and pyrene contaminated soils were extracted by 10,000mgL(-1) surfactant SDBS at various times. The extraction amount decreased with ...
Mangiavillano Benedetto - - 2012
BACKGROUND: Fully covered self-expanding metal stents are now being used to treat benign biliary diseases. AIMS: To assess the outcomes of these stents as first-step therapy in patients with biliary leaks secondary to hepato-biliary surgery. METHODS: Thirty patients (56.7% males; mean age: 60.2±13 years) were retrospectively evaluated. The data collected ...
Leath Charles A CA - - 2012
OBJECTIVE: To review the clinical trial experience with chemotherapy for patients with primary Stage IVB, persistent and recurrent cervical cancer. METHODS: Pubmed and cooperative group website search was performed and included clinical trials until September 2012. Emphasis was placed on the phase II and III clinical trial experience of the ...
Klingler Michael J - - 2012
The anuran brainstem is segmentally organized into rhombomeres (r) and this segmental organization is uniquely preserved throughout development. We hypothesized that rhombomeres associated with cranial nerves (CN) also contain oscillators that are capable of producing rhythmic motor output (bursts) in isolation. We used in vitro brainstem preparations from pre- and ...
Zhang Shuai - - 2012
Protective effect of the total flavonoids (TFs) from Rosa laevigata Michx fruit against carbon tetrachloride (CCl(4))-induced hepatotoxicity in mice was investigated. Pretreatment with TFs significantly decreased CCl(4)-induced elevation of serum aspartate transaminase (AST) and alanine transaminase (ALT) activities as well as the relative liver weight. Histopathological observation also revealed that ...
Rahman Mohammad Mazibur - - 2012
Insect neuropeptides are the most diverse and important group of messenger molecules that regulate almost all physiological processes, incl. behavior. In this study, we performed a combination of matrix assisted laser desorption ionization time of flight (MALDI-TOF) and electrospray ionisation quadrupole time of flight (ESI-Q-TOF) mass spectrometry to analyse the ...
Lu Shaoping - - 2012
The activation of phospholipase Dα1 (PLDα1) produces lipid messenger phosphatidic acid and promotes stomatal closure in Arabidopsis. To explore the use of the PLDα1-mediated signalling towards decreasing water loss in crop plants, we introduced Arabidopsis PLDα1 under the control of a guard cell-specific promoter AtKatI(pro) into two canola (Brassica napus) ...
Sánchez-Pérez J - - 2012
BACKGROUND AND OBJECTIVES: Atopic dermatitis (AD) affects both children and adults. The main symptom of this disease is pruritus, which impacts health-related quality of life (HRQOL). The aim of this study was to evaluate the impact of AD on the lives of children and adults with this disease. PATIENTS AND ...
Ahmad Muhammad Nauman - - 2012
Although ozone is well-documented to reduce crop yields in the densely populated Indo-Gangetic Plain, there is little knowledge of its effects in other parts of south Asia. We surveyed crops close to the city of Peshawar, in north-west Pakistan, for visible injury, linking this to passive measurements of ozone concentrations. ...
Caccia Silvio - - 2012
Unexpected drug interactions have led to the withdrawal of many drugs, raising concern about the gap between what is known at the time of approval and the risk of serious effects in the longer term, particularly in high-risk populations generally excluded from drug development. This is because the majority of ...
Khademian Hossein - - 2012
GNE myopathy or hereditary inclusion body myopathy (HIBM) is an ultra-rare severely disabling autosomal recessive adult onset muscle disease which affects roughly 1-3 individuals per million worldwide. Genetically, HIBM is caused by mutations in the glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase gene (GNE), resulting in diminished enzyme function and reduced sialic acid biosynthesis. ...
Shevyrin Vadim - - 2012
By means of gas chromatography with mass spectrometry detector (GC-MS), liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance spectroscopy (NMR), structure of a series from a novel class of synthetic cannabimimetics bearing 2,2,3,3-tetramethylcyclopropanecarbonyl moiety was established. It was found that this fragment could undergo thermal ring-opening into isomeric structures. The ...
Baker Hannah M - - 2012
BACKGROUND: There is no valid and reliable instrument to evaluate genetic education and counseling received by parents who have an infant with a positive newborn screen for cystic fibrosis (CF). METHODS: This study assessed the validity and reliability of a new instrument designed to evaluate the effectiveness of genetic education ...
Le Borgne Gwenael - - 2012
OBJECTIVES: To assess long-term quality of life (QOL) in cervical cancer survivors (CCSs), 5, 10, and 15 years after diagnosis. METHODS: In a cross-sectional population-based study, CCSs diagnosed in 1990, 1995, or 2000 were randomly selected from 3 tumor registries in France. Healthy controls were randomly selected from electoral rolls, ...
Qin Ai-Ying - - 2012
MicroRNAs (MiRNAs) are small non-coding RNAs that regulate their target genes expression at the post-transcriptional level. As accumulating properties of miR-205 have been identified, complex roles of miR-205 in tumor initiation and progression are emerging. MiR-205 acts either as a tumor suppressor through inhibiting proliferation and invasion, or as an ...
Jorquera Héctor - - 2012
Estimating contributions of anthropogenic sources to ambient particulate matter (PM) in desert regions is a challenging issue because wind erosion contributions are ubiquitous, significant and difficult to quantify by using source-oriented, dispersion models. A receptor modeling analysis has been applied to ambient PM(10) and PM(2.5) measured in an industrial zone ...
Jia Lee - - 2012
The complexity of proteomics challenges current methods to provide all peptide mass fingerprints in an ensemble measurement of various proteins at differing concentrations. To detect those low-abundance proteins, nanotechnology provides a technical platform to improve biocompatibility, specificity, reproducibility, and robustness of the current proteomic methods. Here, we comprehensively analyze the ...
Aaby Camilla - - 2012
OBJECTIVES: The main purpose of this study was to evaluate the psychometric abilities of the Norwegian version of the Voice-Related Quality of Life (V-RQOL) measure. A subsidiary goal was to examine whether the formulation of two additional questions would contribute to strengthen the test. METHODS: A total of 104 patients ...
Hattori Yoshiyuki - - 2012
Previously, we reported that cationic nanoparticles (NP) composed of cholesteryl diamine (OH-Chol, (3S)-N-(2-(2-hydroxyethylamino)ethyl)cholesteryl-3-carboxamide) and Tween 80 could deliver plasmid DNA (pDNA) and small interfering RNA (siRNA) with high transfection efficiency into various tumor cells. In this study, to facilitate the endosomal escape of siRNA transfected by lipid-based nanoparticles, we synthesized ...
Armand Philippe - - 2012
In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT). Moreover, little is known about prognostic factors in patients transplanted for transformed indolent lymphoma (TIL). We conducted a retrospective study ...
Ochi Nobuaki - - 2012
Brain metastasis is a major complication in patients with advanced non-small cell lung cancer (NSCLC), which is the malignancy that metastasizes most frequently to the central nervous system (CNS). Although the CNS is protected from cytotoxic agents by the blood-brain barrier under normal conditions, the blood-brain barrier is thought to ...
Gupta Subash C - - 2012
The major goal of cancer drug discovery is to find an agent that is safe and affordable, yet effective against cancer. Here we show that morin (3,5,7,2',4'-pentahydroxyflavone) has potential against cancer cells through suppression of the signal transducer and activator of transcription 3 (STAT3) pathway, which is closely linked to ...
Pearson David G - - 2012
To what extent are visual fantasies constrained by our perceptual experience of the real world? Our study exploits the fact that people's knowledge of the appearance of individuals from the early 20th Century (e.g., Albert Einstein, Winston Churchill) derives predominantly from viewing black-and-white media images. An initial experiment shows that ...
Kowall Bernd - - 2012
AIM: Random glucose is widely used in routine clinical practice. We investigated whether this non-standardized glycemic measure is useful for individual diabetes prediction. METHODS: The Study of Health in Pomerania (SHIP), a population-based cohort study in north-east Germany, included 3107 diabetes-free persons aged 31-81 years at baseline in 1997-2001. 2475 ...
Pietraszewski David - - 2012
Surprisingly little is known about how relationship information is used predict others' behavior. We examine a key element of this ability-how relationship information is used to anticipate how others will react to events in which they are not directly involved. This requires both using relationship information to modify expected reactions ...
Lefèvre J H - - 2012
PURPOSE: To analyze the results of the bibliometric system (SIGAPS score) of scientific publications in the Assistance publique-Hôpitaux de Paris (AP-HP) and to compare the scientific production among the various medical and surgical specialties of the academic hospitals of Paris. METHODS: All the publications imported from Pubmed between 2006 and ...
Jones Hendrée E - - 2012
BACKGROUND: The relationship between cigarette smoking and neonatal and maternal clinical outcomes among opioid-agonist-treated pregnant patients is sparse. OBJECTIVES: (1) Is smoking measured at study entry related to neonatal and maternal outcomes in pregnant women receiving opioid-agonist medication? (2) Is it more informative to use a multi-item measure of smoking ...
Bouzat Pierre - - 2012
The time course of asymptomatic pulmonary oedema during high-altitude exposure and its potential relationship with changes in cardiac function remain to clarify. Eleven volunteers were rapidly exposed to 4,350m during a 4-day period. Each subject received clinical examination and thoracic ultrasonography to assess ultrasound lung comets (USLC) on day 1, ...
Komazawa Hiroki - - 2012
Chronic renal failure (CRF) leads to decreased drug renal clearance and glomerular filtration rate. However, little is known about renal tubular excretion and reabsorption in CRF. We examined transport activity of renal transporters using rats with adenine-induced CRF. We examined the effect of adenine-induced CRF on mRNA level, protein expression ...
Lembo David - - 2012
Cyclodextrin-based nanosponges (NS) are solid nanoparticles, obtained from the cross-linking of cyclodextrins, that have been proposed as delivery systems for many types of drugs. Various NS derivatives are currently under investigation in order that their properties might be tuned for different applications. In this work, new carboxylated cyclodextrin-based nanosponges (Carb-NS) ...
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