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Kolle Susanne N - - 2012
To encourage the development and validation of alternative toxicity test methods, the effort required for validation of test methods proposed for regulatory purposes should be minimised. Performance standards (PS) facilitate efficient validation by requiring limited testing. Based on the validated method, PS define accuracy and reliability values that must be ...
Weaver Tyler B - - 2012
The current study examined whether compensatory arm reactions are influenced by the participant's knowledge of the handrail location prior to losing their balance. Thirteen young adults stood on a motor driven platform that could translate in the forward or backward directions. A handrail was positioned in a location that was ...
Shah Navnit - - 2012
The present work deals with improving the solubility of vemurafenib, a practically insoluble drug, by converting it into an amorphous-solid dispersion using a solvent-controlled precipitation process. The dispersion containing vemurafenib and hypromellose acetate succinate (HPMCAS), an enteric polymer, is termed microprecipitated bulk powder (MBP), in which the drug is uniformly ...
Cheng Victoria E - - 2012
A 40 year-old woman presented to hospital with 12h of progressive shortness of breath. She was 11days postpartum, having delivered a full-term male infant. She was discharged on antibiotics for presumed pneumonia, but represented two days later with NYHA class IV symptoms and in acute decompensated heart failure confirmed on ...
van Schoor Albert-Neels - - 2012
BACKGROUND: The ilio-inguinal/iliohypogastric nerve block (INB) is one of the most common peripheral nerve block techniques in pediatric anesthesia, which is largely due to the introduction of ultrasound (US) guidance. Despite the benefits of US guidance, the absence of an US machine should not deter the provider from performing INB, ...
Wiech Katja K Nuffield Department of Clinical Neurosciences, Nuffield Division Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. - - 2013
Recent research on moral decision-making has suggested that many common moral judgments are based on immediate intuitions. However, some individuals arrive at highly counterintuitive utilitarian conclusions about when it is permissible to harm other individuals. Such utilitarian judgments have been attributed to effortful reasoning that has overcome our natural emotional ...
Happyana Nizar - - 2012
Trichomes, especially the capitate-stalked glandular hairs, are well known as the main sites of cannabinoid and essential oil production of Cannabis sativa. In this study the distribution and density of various types of Cannabis sativa L. trichomes, have been investigated by scanning electron microscopy (SEM). Furthermore, glandular trichomes were isolated ...
Bartelli Thais F - - 2012
The opportunistic fungal pathogen Candida albicans causes serious hematogenic hospital acquired candidiasis with worldwide impact on public health. Because of its importance as a nosocomial etiologic agent, C. albicans genome has been largely studied to identify intraspecific variation and several typing methods have been developed to distinguish closely related strains. ...
Wu Yinglin - - 2012
Organochlorine compounds, including polychlorinated biphenyls (PCBs), dichlorodiphenyl trichloroethane (DDTs), hexachlorocyclohexane (HCHs), chlordanes (CHLs) and hexachlorobenzene (HCB) were analyzed in blubber samples collected from fifteen Indo-Pacific humpback dolphins (Sousa chinensis) stranded in the Pearl River Delta during the period from 2004 to 2009. In general, the magnitude of the mean concentrations ...
Webhofer Christian - - 2012
Many quantitative proteomics methods rely on protein and peptide labeling with stable isotopes. We have recently found that the introduction of (15)N into organisms via in vivo metabolic labeling affects protein expression levels as well as metabolic pathways and behavioral phenotypes. Here, we present further evidence for a stable isotope ...
Gao Yanhua - - 2012
Alpine ecosystems are highly sensitive to global climate changes. The Tibetan Plateau is one of the areas that are most sensitive to global climate change. Increases in temperature and changes in precipitation can impact the plateau's ecosystem productivity. Net primary productivity (NPP) is one of the most important factors in ...
Sanchez Daniel J DJ Department of Psychology, Northwestern University, Evanston, IL 60208, United - - 2013
Memory systems theory argues for separate neural systems supporting implicit and explicit memory in the human brain. Neuropsychological studies support this dissociation, but empirical studies of cognitively healthy participants generally observe that both kinds of memory are acquired to at least some extent, even in implicit learning tasks. A key ...
Requena C - - 2012
Merkel cell carcinoma is a malignant skin tumor with a poor prognosis that primarily affects photoexposed areas of elderly patients. Tumor size is a very strong prognostic factor, with much better outcomes associated with small lesions, measuring less than 1cm. However, such lesions are rarely seen in the clinic in ...
Cordioli Michele - - 2012
The construction of waste incinerators in populated areas always causes substantial public concern. Since the heat from waste combustion can be recovered to power district heating networks and allows for the switch-off of domestic boilers in urbanized areas, predictive models for health assessment should also take into account the potential ...
Boudry-Labis Elise - - 2012
The increased use of array-CGH and SNP-arrays for genetic diagnosis has led to the identification of new microdeletion/microduplication syndromes and enabled genotype-phenotype correlations to be made. In this study, nine patients with 9q21 deletions were investigated and compared with four previously Decipher reported patients. Genotype-phenotype comparisons of 13 patients revealed ...
André Florian - - 2012
INTRODUCTION: Invasive coronary angiography is the reference method for identification of in-stent restenosis (ISR) bearing the disadvantages of high costs and invasiveness. New approaches like dual-source CT (DSCT) and 256-multi-slice CT (256-MSCT) may potentially be the future methods of choice to reliably exclude ISR in patients with low or intermediate ...
Liu N - - 2012
The novel allele differs from HLA-B*07:02:01 by a single nucleotide substitution at position 538 in exon 3.
Saluja Bhawana B Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, 410 N. 12th Street, P.O. Box 980533, Richmond, VA 23298-0533, USA. - - 2013
No molecule has been found to be effective against emphysema to date primarily because of its complex pathogenesis that involves elastolysis, oxidation and inflammation. We here describe novel unsulfated or sulfated low molecular weight lignins (LMWLs) chemo-enzymatically prepared from 4-hydroxycinnamic acids monomers, as the first potent triple-action inhibitors of neutrophil ...
Sasaki Eriko - - 2012
Cytokinin (CK) is a plant hormone that plays important regulatory roles in many aspects of plant growth and development. Although functions of CK and its biosynthesis pathway have been studied extensively, there is still no efficient biosynthesis inhibitor, which would be useful for studying CK from a chemical genetic approach. ...
Yuan Lu-Feng - - 2012
Conotoxins are small disulfide-rich peptide toxins, which have the exceptional diversity of sequences. Because conotoxins are able to specifically bind to ion channels and interfere with neurotransmission, they are considered as the excellent pharmacological candidates in drug design. Appropriate type assignment of newly sequenced mature ion channel-targeted conotoxins with computational ...
Miralha Alexandre Lopes - - 2012
OBJECTIVES: Describing rates of seroconversion and its associated factors in a series of Brazilian infants following the final dose of the vaccine at 6 months of age. METHODS: Peripheral blood samples were collected after the third dose of the vaccine for the detection of anti-hepatitis B surface antibodies among infants ...
Neimeijer Renate - - 2012
Although restrained eaters try to limit their food intake, they often fail and indulge in exactly those foods that they want to avoid. A possible explanation is a temporal attentional bias for food cues. It could be that for these people food stimuli are processed relatively efficiently and require less ...
Ahmed Nadeem N Institute of Cardiovascular and Medical Sciences, University of Glasgow, G12 8QQ, Scotland, - - 2013
Acute myocardial infarction (AMI) is a leading cause of mortality and morbidity in the world, despite the rate having significantly declined over the past decade. The aim of this review is to consider the emerging diagnostic and clinical utility of cardiac MRI in patients with recent AMI. Cardiac MRI has ...
Meimaridou Eirini E Queen Mary University of London, Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, - - 2013
Familial Glucocorticoid deficiency (FGD), in which the adrenal cortex fails to produce glucocorticoids, was first shown to be caused by defects in the receptor for ACTH (MC2R) or its accessory protein (MRAP). Certain mutations in the steroidogenic acute regulatory protein (STAR) can also masquerade as FGD. Recently mutations in mini ...
Chakrabarty Amit - - 2012
OBJECTIVES: Implantable devices treated with phosphorylcholine (PC) have been successfully used in cardiac, ophthalmic, and other applications. This surface modification has resulted in a reduction in the host inflammatory responses. This pilot study tested the safety and efficacy of PC treated polypropylene mesh grafts implanted for the treatment of pelvic ...
Peel D - - 2012
Theoretical models are often applied to population genetic data sets without fully considering the effect of missing data. Researchers can deal with missing data by removing individuals that have failed to yield genotypes and/or by removing loci that have failed to yield allelic determinations, but despite their best efforts, most ...
Arginelli Federica - - 2012
BACKGROUND: Multiphoton Laser Tomography (MPT) has developed as a non-invasive tool that allows real-time observation of the skin with subcellular resolution. MPT is readily combined with time resolved detectors to achieve fluorescence lifetime imaging (FLIM). The aim of our study was to identify morphologic MPT/FLIM descriptors of melanocytic nevi, referring ...
Savona-Ventura Charles - - 2013
To determine whether clinical risk assessment for gestational diabetes mellitus (GDM) may preclude the need for universal screening with an oral glucose tolerance test (OGTT) in situations of economic restraint. Women with either GDM (n=119) or normal glucose tolerance (n=1249) were recruited from centers among 11 Mediterranean countries between August ...
Sanchez Zila M ZM Department of Preventive Medicine, Universidade Federal de Sao Paulo, Rua Borges Lagoa 1341, Sao Paulo, Brazil. - - 2013
Lanca perfume (chloroform/ether) is an inhalant used mainly by higher social class students in Brazil. In light of the social and epidemiological features of lanca use, supply, and distribution, this investigation tests hypotheses about the degree to which use of inhalant lanca might be occurring in clusters, consistent with social ...
Schönemann Barbara - - 2012
The contractile vacuole complex (CVC) of freshwater protists serves the extrusion of water and ions, including Ca(2+). No vesicle trafficking based on SNAREs has been detected so far in any CVC. SNAREs (soluble NSF [N-ethylmaleimide sensitive factor] attachment protein receptors) are required for membrane-to-membrane interaction, i.e. docking and fusion also ...
Gao Yanrui - - 2012
PURPOSE: To establish a model of standardized acute barrier disruption, investigate the response of normal human to repeated tape stripping, and analyze the change of damaged skin with non-invasive examination techniques for skin, such as TEWL and squamometry. METHODS: Repeated tape stripping with corneofix was applied on three different anatomical ...
Triolo Michela - - 2012
OBJECTIVE: Low normal thyroid function may promote the development of atherosclerotic cardiovascular disease by thus far poorly defined mechanisms. We tested the impact of thyroid function on HDL anti-oxidative capacity, a metric of its anti-atherogenic functionality, in euthyroid subjects with varying degrees of glucose tolerance. DESIGN AND SUBJECTS: Seventy subjects ...
Zhang Cheng - - 2012
Despite improvements in transplant immunology and clinical and supportive care, acute graft-versus-host disease (aGVHD) remains a clinical challenge and a major cause of morbidity and mortality for patients after allogeneic hematopoietic stem cell transplantation (HSCT). Many ways have been used to prevent and treat aGVHD, however, long-term survival remains poor. ...
Chang Hyo Won - - 2012
The Wnt/β-catenin pathway regulates the viability and radiosensitivity of head and neck squamous cancer cells (HNSCC). Increased β-catenin predisposes HNSCC patients to poor prognosis and survival. This study was conducted to determine the mechanism by which β-catenin regulates the viability of HNSCC. AMC-HN-3, -HN-8, UM-SCC-38, and -SCC-47 cells, which were ...
Gontier Karine - - 2012
In waterfowl, the response to overfeeding differs from one genotype to the other. Pekin ducks generally store lipids in the peripheral tissues while Muscovy and mule ducks promote hepatic lipid storage. A possible reason for these various susceptibilities to hepatic steatosis could be a difference in insulin sensitivity. We suggest ...
Montenegro Jose-Maria - - 2012
Arguably targeting is one of the biggest problems for controlled drug delivery. In the case that drugs can be directed with high efficiency to the target tissue, side-effects of medication are drastically reduced. Colloidal inorganic nanoparticles (NPs) have been proposed and described in the last 10 years as new platforms ...
Chao Tze-Fan - - 2012
BACKGROUND: The components of CHADS(2) score were reported to be important risk factors for the development of atrial fibrillation (AF). The goal of the current study was to investigate whether the CHADS(2) score was a useful scheme in predicting new-onset AF. Furthermore, we aimed to use the CHADS(2) scoring system ...
Selbig William R - - 2012
Urban sediment can act as a transport mechanism for a variety of pollutants to move towards a receiving water body. The concentrations of these pollutants oftentimes exceed levels that are toxic to aquatic organisms. Many treatment structures are designed to capture coarse sediment but do not work well to similarly ...
Ahlsson Fredrik - - 2012
OBJECTIVE: The role of adipokines in the regulation of energy substrate production in non-diabetic pregnant women has not been elucidated. We hypothesize that serum concentrations of adiponectin are related to fetal growth via maternal fat mass, insulin resistance and glucose production, and further, that serum levels of leptin are associated ...
Rosario Roseanne - - 2012
OBJECTIVES: Despite their distinct biology, granulosa cell tumours (GCTs) are treated similarly to other ovarian tumours. Predominantly expressed in granulosa cells, the transcription factor Forkhead Box L2 (FOXL2) is near absent in juvenile-type GCTs. This research aimed to investigate miRNAs as a mechanism of suppression of FOXL2 expression in juvenile-type ...
Mauch Jacqueline - - 2012
BACKGROUND AND OBJECTIVES: Impairment of blood coagulation is one of the main side effects of volume replacement, particularly if artificial colloids such as hydroxyethyl starch (HES) and gelatine preparations are used. This animal study aimed to evaluate the effect of a single fast intravenous crystalloid or colloid fluid bolus on ...
Cavari Yuval - - 2012
We report the case of a 2-year-old Bedouin boy in whom developed severe and unusual complications after being stung, most probably, by the yellow scorpion Leiurus quinquestriatus hebraeus. Five hours after arrival to the emergency department, the boy had multisystem organ failure involving the central nervous system (seizure activity followed ...
Chambers R Andrew RA Laboratory for Translational Neuroscience of Dual Diagnosis & Development, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202, United States. - - 2013
As knowledge deepens about how new neurons are born, differentiate, and wire into the adult mammalian brain, growing evidence depicts hippocampal neurogenesis as a special form of neuroplasticity that may be impaired across psychiatric disorders. This review provides an integrated-evidence based framework describing a neurogenic basis for addictions and addiction ...
Varamenti Evdokia I - - 2012
Elite athletes undergo heavy training programs throughout the year. The aim of the present study was to evaluate blood biomarkers of redox status, oxidative stress, inflammation and angiogenesis over the course of a competitive season in elite female water polo players. The biomarkers were evaluated in four distinct phases of ...
Breuel Wiebke - - 2012
Up to 30% of patients relapse after orthognathic operations, and one reason might be incomplete neuromuscular adaptation of the masticatory muscles. Displacement of the mandible in sagittal or vertical directions, or both, leads to stretching or compression of these muscles. The aim of this study was to analyse stretching factors ...
Yamashita Fumiyoshi - - 2012
Drug delivery systems involve technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile. In order to optimize a function of the delivery systems, their biodistribution characteristics should be systematically understood. Pharmacokinetic analysis based on the clearance concepts provides quantitative information of the biodistribution, which can be ...
He Jia - - 2012
Prediction of the biodegradability of organic pollutants is an ecologically desirable and economically feasible tool for estimating the environmental fate of chemicals. In this paper, linear and nonlinear relationships between biological oxygen demand (BOD) and molecular descriptors/fragments have been investigated for 1130 organic chemicals. Significant relationships have been observed between ...
Bertelsen Michael L - - 2012
INTRODUCTION: It has been suggested that striking on the midfoot or forefoot, rather than the rearfoot, may lessen injury risk in the feet and lower limb. In previous studies, a disparity in distribution in footstrike patterns was found among elite-, sub-elite, and recreational runners. PURPOSE: The purpose of this study ...
Uter W - - 2012
BACKGROUND/PURPOSE: Different devices are used for the non-invasive measurement of (constitutive) skin pigmentation in (epidemiological) studies. Reproducibility of measurements with the Chromameter (CM, model CR 300, Minolta, Osaka) and the Reflectometer (RM, Courage & Khazaka, Cologne) has not yet been examined in detail and was addressed in a set of ...
Leong Karen - - 2012
OBJECTIVE: To determine the reliability of objective voice measures used commonly in clinical practice. SUBJECTS: Eighteen healthy volunteers (nine males and nine females). METHODS: Objective voice measures were performed on 18 healthy volunteers on 10 occasions under similar conditions over a 30-day period. Consistency of measures was analyzed to determine ...
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