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Zhang Shuai - - 2012
Protective effect of the total flavonoids (TFs) from Rosa laevigata Michx fruit against carbon tetrachloride (CCl(4))-induced hepatotoxicity in mice was investigated. Pretreatment with TFs significantly decreased CCl(4)-induced elevation of serum aspartate transaminase (AST) and alanine transaminase (ALT) activities as well as the relative liver weight. Histopathological observation also revealed that ...
Rahman Mohammad Mazibur - - 2012
Insect neuropeptides are the most diverse and important group of messenger molecules that regulate almost all physiological processes, incl. behavior. In this study, we performed a combination of matrix assisted laser desorption ionization time of flight (MALDI-TOF) and electrospray ionisation quadrupole time of flight (ESI-Q-TOF) mass spectrometry to analyse the ...
Lu Shaoping - - 2012
The activation of phospholipase Dα1 (PLDα1) produces lipid messenger phosphatidic acid and promotes stomatal closure in Arabidopsis. To explore the use of the PLDα1-mediated signalling towards decreasing water loss in crop plants, we introduced Arabidopsis PLDα1 under the control of a guard cell-specific promoter AtKatI(pro) into two canola (Brassica napus) ...
Sánchez-Pérez J - - 2012
BACKGROUND AND OBJECTIVES: Atopic dermatitis (AD) affects both children and adults. The main symptom of this disease is pruritus, which impacts health-related quality of life (HRQOL). The aim of this study was to evaluate the impact of AD on the lives of children and adults with this disease. PATIENTS AND ...
Ahmad Muhammad Nauman - - 2012
Although ozone is well-documented to reduce crop yields in the densely populated Indo-Gangetic Plain, there is little knowledge of its effects in other parts of south Asia. We surveyed crops close to the city of Peshawar, in north-west Pakistan, for visible injury, linking this to passive measurements of ozone concentrations. ...
Caccia Silvio - - 2012
Unexpected drug interactions have led to the withdrawal of many drugs, raising concern about the gap between what is known at the time of approval and the risk of serious effects in the longer term, particularly in high-risk populations generally excluded from drug development. This is because the majority of ...
Khademian Hossein - - 2012
GNE myopathy or hereditary inclusion body myopathy (HIBM) is an ultra-rare severely disabling autosomal recessive adult onset muscle disease which affects roughly 1-3 individuals per million worldwide. Genetically, HIBM is caused by mutations in the glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase gene (GNE), resulting in diminished enzyme function and reduced sialic acid biosynthesis. ...
Shevyrin Vadim - - 2012
By means of gas chromatography with mass spectrometry detector (GC-MS), liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance spectroscopy (NMR), structure of a series from a novel class of synthetic cannabimimetics bearing 2,2,3,3-tetramethylcyclopropanecarbonyl moiety was established. It was found that this fragment could undergo thermal ring-opening into isomeric structures. The ...
Baker Hannah M - - 2012
BACKGROUND: There is no valid and reliable instrument to evaluate genetic education and counseling received by parents who have an infant with a positive newborn screen for cystic fibrosis (CF). METHODS: This study assessed the validity and reliability of a new instrument designed to evaluate the effectiveness of genetic education ...
Le Borgne Gwenael - - 2012
OBJECTIVES: To assess long-term quality of life (QOL) in cervical cancer survivors (CCSs), 5, 10, and 15 years after diagnosis. METHODS: In a cross-sectional population-based study, CCSs diagnosed in 1990, 1995, or 2000 were randomly selected from 3 tumor registries in France. Healthy controls were randomly selected from electoral rolls, ...
Qin Ai-Ying - - 2012
MicroRNAs (MiRNAs) are small non-coding RNAs that regulate their target genes expression at the post-transcriptional level. As accumulating properties of miR-205 have been identified, complex roles of miR-205 in tumor initiation and progression are emerging. MiR-205 acts either as a tumor suppressor through inhibiting proliferation and invasion, or as an ...
Jorquera Héctor - - 2012
Estimating contributions of anthropogenic sources to ambient particulate matter (PM) in desert regions is a challenging issue because wind erosion contributions are ubiquitous, significant and difficult to quantify by using source-oriented, dispersion models. A receptor modeling analysis has been applied to ambient PM(10) and PM(2.5) measured in an industrial zone ...
Jia Lee - - 2012
The complexity of proteomics challenges current methods to provide all peptide mass fingerprints in an ensemble measurement of various proteins at differing concentrations. To detect those low-abundance proteins, nanotechnology provides a technical platform to improve biocompatibility, specificity, reproducibility, and robustness of the current proteomic methods. Here, we comprehensively analyze the ...
Aaby Camilla - - 2012
OBJECTIVES: The main purpose of this study was to evaluate the psychometric abilities of the Norwegian version of the Voice-Related Quality of Life (V-RQOL) measure. A subsidiary goal was to examine whether the formulation of two additional questions would contribute to strengthen the test. METHODS: A total of 104 patients ...
Hattori Yoshiyuki - - 2012
Previously, we reported that cationic nanoparticles (NP) composed of cholesteryl diamine (OH-Chol, (3S)-N-(2-(2-hydroxyethylamino)ethyl)cholesteryl-3-carboxamide) and Tween 80 could deliver plasmid DNA (pDNA) and small interfering RNA (siRNA) with high transfection efficiency into various tumor cells. In this study, to facilitate the endosomal escape of siRNA transfected by lipid-based nanoparticles, we synthesized ...
Armand Philippe - - 2012
In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT). Moreover, little is known about prognostic factors in patients transplanted for transformed indolent lymphoma (TIL). We conducted a retrospective study ...
Ochi Nobuaki - - 2012
Brain metastasis is a major complication in patients with advanced non-small cell lung cancer (NSCLC), which is the malignancy that metastasizes most frequently to the central nervous system (CNS). Although the CNS is protected from cytotoxic agents by the blood-brain barrier under normal conditions, the blood-brain barrier is thought to ...
Gupta Subash C - - 2012
The major goal of cancer drug discovery is to find an agent that is safe and affordable, yet effective against cancer. Here we show that morin (3,5,7,2',4'-pentahydroxyflavone) has potential against cancer cells through suppression of the signal transducer and activator of transcription 3 (STAT3) pathway, which is closely linked to ...
Pearson David G - - 2012
To what extent are visual fantasies constrained by our perceptual experience of the real world? Our study exploits the fact that people's knowledge of the appearance of individuals from the early 20th Century (e.g., Albert Einstein, Winston Churchill) derives predominantly from viewing black-and-white media images. An initial experiment shows that ...
Kowall Bernd - - 2012
AIM: Random glucose is widely used in routine clinical practice. We investigated whether this non-standardized glycemic measure is useful for individual diabetes prediction. METHODS: The Study of Health in Pomerania (SHIP), a population-based cohort study in north-east Germany, included 3107 diabetes-free persons aged 31-81 years at baseline in 1997-2001. 2475 ...
Pietraszewski David - - 2012
Surprisingly little is known about how relationship information is used predict others' behavior. We examine a key element of this ability-how relationship information is used to anticipate how others will react to events in which they are not directly involved. This requires both using relationship information to modify expected reactions ...
Lefèvre J H - - 2012
PURPOSE: To analyze the results of the bibliometric system (SIGAPS score) of scientific publications in the Assistance publique-Hôpitaux de Paris (AP-HP) and to compare the scientific production among the various medical and surgical specialties of the academic hospitals of Paris. METHODS: All the publications imported from Pubmed between 2006 and ...
Jones Hendrée E - - 2012
BACKGROUND: The relationship between cigarette smoking and neonatal and maternal clinical outcomes among opioid-agonist-treated pregnant patients is sparse. OBJECTIVES: (1) Is smoking measured at study entry related to neonatal and maternal outcomes in pregnant women receiving opioid-agonist medication? (2) Is it more informative to use a multi-item measure of smoking ...
Bouzat Pierre - - 2012
The time course of asymptomatic pulmonary oedema during high-altitude exposure and its potential relationship with changes in cardiac function remain to clarify. Eleven volunteers were rapidly exposed to 4,350m during a 4-day period. Each subject received clinical examination and thoracic ultrasonography to assess ultrasound lung comets (USLC) on day 1, ...
Trasande Leonardo - - 2012
OBJECTIVE: Prior research on the physical health of children exposed to the World Trade Center (WTC) attacks has largely relied on parental report via questionnaire. We examined the impact of clinically-reported exposures on the physical health of children who lived and/or attended school in downtown Manhattan on September 11, 2001. ...
Komazawa Hiroki - - 2012
Chronic renal failure (CRF) leads to decreased drug renal clearance and glomerular filtration rate. However, little is known about renal tubular excretion and reabsorption in CRF. We examined transport activity of renal transporters using rats with adenine-induced CRF. We examined the effect of adenine-induced CRF on mRNA level, protein expression ...
Lembo David - - 2012
Cyclodextrin-based nanosponges (NS) are solid nanoparticles, obtained from the cross-linking of cyclodextrins, that have been proposed as delivery systems for many types of drugs. Various NS derivatives are currently under investigation in order that their properties might be tuned for different applications. In this work, new carboxylated cyclodextrin-based nanosponges (Carb-NS) ...
Tang Rex W K - - 2012
Much of the mercury (Hg) in freshwater fish of the boreal shield ecoregion is believed to originate from atmospheric deposition. As such, declines in fish Hg concentrations would be expected in response to recent declines in atmospheric Hg deposition in this ecoregion. We compared recent (2005-2010) and historic (1974-1981) muscle ...
Moradi Negin - - 2012
Quality of life is one of the important aspects in the assessment of health and treatment data output. The purpose of this study was to adapt and determine reliability and validity of Voice Handicap Index (VHI) in Persian. The subjects were 80 patients with voice disorders and 80 volunteers without ...
Pettitt Michala E - - 2012
Appropriate characterisation of manufactured nanomaterials (NMs) is vital for many aspects of their synthesis, product formulation, toxicological testing and regulation. As the range and quantity of NMs in production has expanded, the interest in their potential environmental and toxicological consequences has grown. With this growth, there is increased need for ...
Chakrabarty Amit - - 2012
OBJECTIVES: Implantable devices treated with phosphorylcholine (PC) have been successfully used in cardiac, ophthalmic, and other applications. This surface modification has resulted in a reduction in the host inflammatory responses. This pilot study tested the safety and efficacy of PC treated polypropylene mesh grafts implanted for the treatment of pelvic ...
Peel D - - 2012
Theoretical models are often applied to population genetic data sets without fully considering the effect of missing data. Researchers can deal with missing data by removing individuals that have failed to yield genotypes and/or by removing loci that have failed to yield allelic determinations, but despite their best efforts, most ...
Arginelli Federica - - 2012
BACKGROUND: Multiphoton Laser Tomography (MPT) has developed as a non-invasive tool that allows real-time observation of the skin with subcellular resolution. MPT is readily combined with time resolved detectors to achieve fluorescence lifetime imaging (FLIM). The aim of our study was to identify morphologic MPT/FLIM descriptors of melanocytic nevi, referring ...
Wang Xiaobing - - 2012
Sonodynamic therapy (SDT) has shown great potential in target cancer therapy, but it induced cell death modes hasn't been fully investigated. This study was to examine autophagic and apoptotic responses to protoporphyrin IX (PpIX) mediated SDT in murine leukemia L1210 cells. After SDT, the occurrence of autophagy was identified by ...
Kottner Jan - - 2012
BACKGROUND/PURPOSE: Non-contact methods for quantifying skin surface topography in vivo are common in skin research. The surface evaluation of living skin (SELS) and the phaseshift rapid in vivo measurement of skin (PRIMOS) are two approaches to measure skin surface roughness and wrinkling via optical methods. The aim of this study ...
Schönemann Barbara - - 2012
The contractile vacuole complex (CVC) of freshwater protists serves the extrusion of water and ions, including Ca(2+). No vesicle trafficking based on SNAREs has been detected so far in any CVC. SNAREs (soluble NSF [N-ethylmaleimide sensitive factor] attachment protein receptors) are required for membrane-to-membrane interaction, i.e. docking and fusion also ...
Gao Yanrui - - 2012
PURPOSE: To establish a model of standardized acute barrier disruption, investigate the response of normal human to repeated tape stripping, and analyze the change of damaged skin with non-invasive examination techniques for skin, such as TEWL and squamometry. METHODS: Repeated tape stripping with corneofix was applied on three different anatomical ...
Triolo Michela - - 2012
OBJECTIVE: Low normal thyroid function may promote the development of atherosclerotic cardiovascular disease by thus far poorly defined mechanisms. We tested the impact of thyroid function on HDL anti-oxidative capacity, a metric of its anti-atherogenic functionality, in euthyroid subjects with varying degrees of glucose tolerance. DESIGN AND SUBJECTS: Seventy subjects ...
Zhang Cheng - - 2012
Despite improvements in transplant immunology and clinical and supportive care, acute graft-versus-host disease (aGVHD) remains a clinical challenge and a major cause of morbidity and mortality for patients after allogeneic hematopoietic stem cell transplantation (HSCT). Many ways have been used to prevent and treat aGVHD, however, long-term survival remains poor. ...
Steele James - - 2012
It has been known since the 1960s that lactic acid bacteria are essential for the development of cheese flavor. In the ensuing 50 years significant research has been directed at understanding the microbiology, genetics and biochemistry of this process. This review briefly covers the current status of cheese flavor development ...
Shah Dilip - - 2012
Systemic lupus erythematosus (SLE) is characterized by imbalance redox state and increased apoptosis. The activation, proliferation and cell death of lymphocytes are dependent on intracellular levels of glutathione and controlled production of reactive oxygen species (ROS). Changes in the intracellular redox environment of cells, through oxygen-derived free radical production known ...
Chen Wei-Hsin - - 2012
Sprays are an important tool for removing air pollutants through absorption. To recognize the mass transport characteristics of air pollutants in sprays, four different air pollutants of sulfur dioxide (SO(2)), hydrogen chloride (HCl), ammonia (NH(3)), and nitric acid (HNO(3)) absorbed by droplets in sprays are analyzed theoretically in association with ...
Lautenschlager Matthew - - 2012
We describe the adaptation of a sample recovery method for botulinum neurotoxins from stainless steel. Botulinum toxin was recovered from surfaces left to dry for up to 16 hrs and detected by either ELISA or EndoPep mass spectrometry methods. In addition, we demonstrate that this method can be used to ...
Toyoshima Yoshiyuki - - 2012
Aspergillus oryzae is a fungus that is used widely in traditional Japanese fermentation industries. In this study, the lethal and mutagenic effects of different linear energy transfer (LET) radiation in freeze-dried conidia of A. oryzae were investigated. The lethal effect, which was evaluated by a 90% lethal dose, was dependent ...
Liu Shao-Cheng - - 2012
OBJECTIVES: The treatment of ventricular dysphonia (VD) should be based on confirming the true folds pathology. In some patients, the ability of the true folds vibration remains unclear and decision making for performing aggressive surgical interventions can be difficult. STUDY DESIGN: A retrospective study of surgery by chart review. METHODS: ...
Dorgo Sandor - - 2012
OBJECTIVES: To investigate the effectiveness of different applications of mentoring in an older adult exercise program, this study compared the physical fitness scores, the retention and participation rates of older adults trained by student mentors, peer mentors, peer mentors working independently of the researchers, and a non-exercising control group. METHODS: ...
Stojan Jure - - 2012
Cholinesterases do not follow the Michaelis-Menten kinetics. In the past, many reaction schemes were suggested to explain their complex interactions during the substrate turnover. Covalent catalysis was recognized very early and therefore, double intermediate traditional reaction scheme for the hydrolysis of good substrates at low concentrations was postulated. However, at ...
Song Xinzhang - - 2012
Chinese Fir and Moso bamboo are the two most important forest plantation species in subtropical China. However, information on greenhouse gas emissions from these forests is still scarce. A field study was carried out to compare soil CO(2) flux dynamics in Chinese Fir and Moso bamboo forests over a 12-month ...
Rosa Maria I - - 2012
OBJECTIVE: To investigate the efficacy, compared to placebo, of fluconazole 150mg weekly, given for six months as prophylaxis against recurrent vulvovaginal candidiasis (RVVC). STUDY DESIGN: A quantitative systematic review was performed, and randomized controlled trials were included. We conducted searches at Medline, EMBASE, Lilacs, Cochrane Library and ICI Web of ...
Schulman S - - 2012
The comment of Tripodi and Moia regarding the inaccuracy of the international normalized ratio (INR) above 4.5 is correct, since calibration of thromboplastin is performed with plasmas from patients with mostly adequate anticoagulation (INR 1.5 to 4.5) [1]. They are concerned that our suggestion in the latest edition of the ...
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