Search Results
Results 601 - 650 of 2817
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Ertugrul A S - - 2012
BACKGROUND AND OBJECTIVE: Human β-defensins (hBDs) have a strong antibacterial action against various microorganisms, especially periodontal pathogens. The aim of this study was to compare the total levels of hBD-1 and hBD-3 in the gingival crevicular fluid of healthy patients with gingivitis (HG), healthy patients with chronic periodontitis (HP), patients ...
Ammann T W - - 2012
BACKGROUND AND OBJECTIVE: Subgingival biofilms are the prime etiological factor of periodontal disease. Owing to their complex polymicrobial nature, quantification of individual bacterial species within the biofilm for research and diagnostic purposes can be methodologically challenging. The aims of this study were to establish a quantitative real-time PCR (qPCR) assay ...
Manios Y - - 2012
BACKGROUND: Some small cohort studies have noted that obesity co-exists with lower serum iron levels. The present study aimed to examine the association between being overweight and iron deficiency (ID) in a large cohort of Greek children and adolescents. METHODS: A representative sample of 2492 primary schoolchildren aged 9-13 years old ...
Kim Tae-Seok - - 2012
BACKGROUND: The prognosis of fulminant hepatic failure (FHF) depends on the etiology and reversibility. In this study, we identified the etiological difference of FHF in Korea and analyzed the prognostic factors after liver transplantation (LT) for FHF. METHODS: We retrospectively reviewed 42 patients with FHF who underwent LT from April ...
Skelding Kimberly A - - 2012
Objectives: To determine sex bias in the selection of strategies to evaluate patients with acute myocardial infarction (AMI), and determine if the choice of strategy influences survival. Background: Controversy exists regarding the role of female sex in the use of invasive evaluation for AMI and its possible effect on adverse ...
Price U - - 2012
BACKGROUND AND OBJECTIVE: Local host-modulation therapy is an emerging approach to prevent disease progression in sites with moderate periodontitis. The combination of simvastatin and alendronate would be an intriguing host-modulatory strategy because of the bone-anabolic properties of simvastatin and the antiresorptive/bone-targeting characteristics of alendronate. The objective of this study was ...
Benjamin Mina M - - 2012
Background: Dual anti-platelet therapy including clopidogrel or prasugrel is standard of care for patients receiving stents. Prasugrel has quicker onset so it can be loaded later than clopidogrel with greater efficacy. However, prasugrel is much more expensive than clopidogrel. Objectives: To describe the incidence of 30-day death from cardiovascular causes, ...
Wong Linda L - - 2013
Liver transplantation (LT) provides optimal long-term disease-free survival for hepatocellular carcinoma (HCC). High pre-LT alpha-fetoprotein (AFP) has been associated with HCC recurrence, but it is unclear whether a drop in AFP or locoregional therapy impacts survival/recurrence after LT. LT-recipients transplanted for HCC in three centers (UNOS Region 6) were reviewed ...
Sayah David M DM Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. - - 2013
Community acquired respiratory virus (CARV) infections in lung transplant recipients (LTR) have been associated with adverse outcomes, including acute rejection (AR) and decline in allograft function, in some but not in all studies. Spirometry and transbronchial biopsy results of LTR diagnosed with CARV infection over a two-yr period were extracted ...
Lempe Janne J Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, - - 2013
Robustness, the ability of organisms to buffer phenotypes against perturbations, has drawn renewed interest among developmental biologists and geneticists. A growing body of research supports an important role of robustness in the genotype to phenotype translation, with far-reaching implications for evolutionary processes and disease susceptibility. Similar to animals and fungi, ...
White M C MC Laboratory of Neuropharmacology, Medicinal Chemistry Department, Drug Discovery Division, Southern Research Institute, Birmingham, Alabama 35205, - - 2013
Malignant gliomas have low survival expectations regardless of current treatments. Nonsteroidal anti-inflammatory drugs (NSAIDs) prevent cell transformation and slow cancer cell growth by mechanisms independent of cyclooxygenase (COX) inhibition. Certain NSAIDs trigger the endoplasmic reticulum stress response (ERSR), as revealed by upregulation of molecular chaperones such as GRP78 and C/EBP ...
White-Williams Connie C University of Alabama Medical Center, Birmingham, AL, USA. - - 2013
Despite the fact that social support has been found to be important to cardiovascular health, there is a paucity of information regarding the relationship between social support and outcomes long term after heart transplantation (HT). The purposes of this study were to examine demographic and psychosocial characteristics and their relationship ...
Haines Dru D Hematology/Oncology Department, Children's Hospital & Research Center Oakland, Oakland, CA 94609, USA. - - 2013
Pain is not a symptom generally associated with thalassaemia. However, providers have noted increasing patient reports of pain, creating an impetus for this prospective, observational assessment of pain in thalassaemia patients. The primary study goals were to assess pain prevalence, severity, location, and potential risk factors. This was a multicentre, ...
Casselbrant Margaretha L ML Department of Otolaryngology, Division of Pediatric Otolaryngology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, - - 2013
The Cephalic Index, an anthropometric measure of head shape, was reported to be different between individuals with and without signs of past or concurrent otitis media (OM). In this study, we compared the Cephalic Index and other measures of head shape among groups of children aged 36-48 months with a ...
Webhofer Christian - - 2012
Many quantitative proteomics methods rely on protein and peptide labeling with stable isotopes. We have recently found that the introduction of (15)N into organisms via in vivo metabolic labeling affects protein expression levels as well as metabolic pathways and behavioral phenotypes. Here, we present further evidence for a stable isotope ...
Gao Yanhua - - 2012
Alpine ecosystems are highly sensitive to global climate changes. The Tibetan Plateau is one of the areas that are most sensitive to global climate change. Increases in temperature and changes in precipitation can impact the plateau's ecosystem productivity. Net primary productivity (NPP) is one of the most important factors in ...
Requena C - - 2012
Merkel cell carcinoma is a malignant skin tumor with a poor prognosis that primarily affects photoexposed areas of elderly patients. Tumor size is a very strong prognostic factor, with much better outcomes associated with small lesions, measuring less than 1cm. However, such lesions are rarely seen in the clinic in ...
Hsu Hsiao-Hsien - - 2012
BACKGROUND: While commercial aircraft are known sources of ultrafine particulate matter (UFP), the relationship between airport activity and local real-time UFP concentrations has not been quantified. Understanding these associations will facilitate interpretation of the exposure and health risk implications of UFP related to aviation emissions. OBJECTIVES: We used time-resolved UFP ...
Yu Yiyi - - 2012
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in detail, including organic and aqueous phase composition, organic/aqueous phase ratio, ...
Tsitsanou Katerina E - - 2012
Flavonoids have been discovered as novel inhibitors of glycogen phosphorylase (GP), a target to control hyperglycaemia in type 2 diabetes. To elucidate the mechanism of inhibition, we have determined the crystal structure of the GPb-chrysin complex at 1.9 Å resolution. Chrysin is accommodated at the inhibitor site intercalating between the ...
Fung Carina - - 2012
Activated oncogenes restrict cell proliferation and transformation by triggering a DNA damage-dependent senescence checkpoint in response to DNA hyper-replication. Here we show that loss of the p16(INK) (4a) cyclin dependent kinase inhibitor and melanoma tumour suppressor facilitates a DNA damage response after a hyper-replicative phase in human melanocytes. Unlike cells ...
Bi Y - - 2012
OBJECTIVES: To modify the method for creating an abdominal aortic aneurysm in rabbits, and to study its performance. MATERIALS AND METHODS: A total of 24 New Zealand white rabbits were induced topically with 10 μl of porcine elastase (0, 0.1, 5 and 10 units μl(-1)) to define the optimal concentration (groups A-D). Twelve ...
Deyati Avisek - - 2012
Recent success of companion diagnostics along with the increasing regulatory pressure for better identification of the target population has created an unprecedented incentive for drug discovery companies to invest in novel strategies for biomarker discovery. In parallel with the rapid advancement and clinical adoption of high-throughput technologies, a number of ...
Majak PaweĊ‚ - - 2012
BACKGROUND: The remission of asthma, which is induced during specific immunotherapy (SIT) or appears spontaneously in children is not completely understood and predictors of this phenomenon are still undefined. OBJECTIVE: To assess CD4(+)CD25(+)Foxp3(+) Treg cells and cytokine/proliferation response to allergen-specific stimulation of PBMC as predictors of steroid sparing effect of ...
Schneider Patricia Graciela - - 2012
The cholinergic system has been implicated in several experimental epilepsy models. In a previous study bicuculline (BIC), known to antagonize GABA-A postsynaptic receptor subtype, was administered to rats at subconvulsant (1 mg / kg) and convulsant (7.5 mg / kg) doses and quinuclidinyl benzilate ([(3)H]-QNB) binding to CNS membranes was ...
Ozdemir Ozgur - - 2012
The aim of this study was the investigation of effects of the metenolone enanthate (ME) that is used among athletes as doping and muscle amplifier, on hearts of male and female rats that are in puberty using morphometrical methods. A total of 36 rats which were divided into three separate ...
Fortes Cristina - - 2012
OBJECTIVES: This study investigated the role of walking outdoors on longevity, controlling for individual and other life-style factors as possible confounders. METHODS: A 10-year cohort study was conducted with 152 self-caring and mobile, mean age 80 years, were enrolled in the study. Information on socio-demographic characteristics, clinical and biochemical data, ...
Lavigne Jean-Philippe - - 2012
Imipenem (IPM) is a carbapenem antibiotic frequently used in severe hospital infections. Several reports have mentioned the emergence of resistant isolates exhibiting membrane modifications. A study was conducted between September 2005 and August 2007 to survey infections due to Enterobacter aerogenes in patients hospitalised in a French university hospital. Resistant ...
Lopes A - - 2012
Studies have demonstrated that nutrient deficiency during pregnancy or in early postnatal life results in structural abnormalities in the offspring hippocampus and in cognitive impairment. In an attempt to analyze whether gestational protein restriction might induce learning and memory impairments associated with structural changes in the hippocampus, we carried out ...
Isaka Masahiko - - 2012
Seven lanostane triterpenoids, ganorbiformins A-G, together with twelve known compounds, were isolated from cultures of the mushroom fungus Ganoderma orbiforme BCC 22324. Ganorbiformin A is an unusual rearranged analog, whereas the other compounds share the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T also ...
Siotto Michela - - 2012
The increasing use of new generation plastics has been accompanied by the development of standard methods for studying their biodegradability. Generally, test methods are based on the measurement of CO(2) production, i.e. the mineralization degree of the tested materials. However, in order to describe the biodegradation process, the determination of ...
Cao Zhiguo - - 2012
The annual releases of polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans (PCDD/PCDF) from 68 countries/regions were investigated by correlating quantitative emissions with economic status of the nations. The national dioxin/furan inventories were developed using the PCDD/PCDF Standardized Toolkit, which presents the quantitative releases from ten major source groups to five release vectors. ...
Kobayashi Satoru - - 2012
We describe a boy, 3 years and 6 months old, who experienced a rolandic seizure accompanied by a cluster of atypical absence seizures, the EEGs for which corresponded to those of atypical benign partial epilepsy (ABPE). Of note, this patient suffered from developmental delay beginning in infancy and exhibited giant ...
Pastötter Bernhard - - 2012
People's moods can influence moral judgment. Such influences may arise because moods affect moral emotion, or because moods affect moral thought. The present study provides evidence that, at least in the footbridge dilemma, moods affect moral thought. The results of two experiments are reported in which, after induction of positive, ...
Sierra Roberto - - 2012
Rhizaria is one of the six supergroups of eukaryotes, which comprise the majority of amoeboid and skeleton-building protists living in freshwater and marine ecosystems. There is an overall lack of molecular data for the group and therefore the deep phylogeny of rhizarians is unresolved. Molecular data are particularly scarce for ...
Wibberg Daniel - - 2012
Anastomosis group AG1-IB isolates of the anamorphic basidiomycetous fungus Rhizoctonia solani Kühn affect various agricultural and horticultural important crops including bean, rice, soybean, figs, hortensia, cabbage and lettuce. To gain insights into the genome structure and content, the first draft genome sequence of R. solani AG1-IB isolate 7/3/14 was established. ...
López-López Aline - - 2012
Los Tuxtlas is the northernmost rain forest in North America and is rich in Bradyrhizobium with an unprecedented number of novel lineages. ITS sequence analysis of legumes in polycultures from Los Tuxtlas led to the identification of Phaseolus lunatus and Vigna unguiculata in addition to Phaseolus vulgaris as legumes associated ...
Beets Karen - - 2012
Vascular patterning involves sprouting of blood vessels, which is governed by orchestrated communication between cells in the surrounding tissue and endothelial cells (ECs) lining the blood vessels. Single ECs are selected for sprouting by hypoxia-induced stimuli and become the 'tip' or leader cell that guides new sprouts. The 'stalk' or ...
Kolb Andreas F - - 2012
B-vitamin deficiency is a risk factor for vascular disease. The mechanism by which the deficiency impacts on disease risk is unclear. We have analysed whether the inflammatory response of mononuclear cells can be modified by cellular folate status in vitro. We show that the mouse monocyte cell line RAW264.7 grown ...
de Assis Moura Ghirardi Ana Carolina - - 2012
PURPOSE: To develop and validate a score that can serve as a screening index for voice disorders in teachers. METHODS: The subjects of this study were 252 female teachers, with and without voice disorders (WVD and WOVD) from the public school system of São Paulo, Brazil. All subjects underwent medical ...
Nawrocki Annalise M - - 2012
The model organism Hydra belongs to the hydrozoan clade Aplanulata. Despite being a popular model system for development, little is known about the phylogenetic placement of this taxon or the relationships of its closest relatives. Previous studies have been conflicting regarding sister group relationships and have been unable to resolve ...
Liberelle Benoît - - 2012
We here report the development of a new generation of enzyme-linked immunosorbent assay (ELISA) that takes advantage of a low-fouling carboxymethylated dextran (CMD) layer chemically grafted on ELISA wells. In our approach, the overnight capture antibody adsorption step found in classical ELISA was replaced by a covalent attachment step to ...
Sahlberg Bo - - 2012
There are few studies on associations between airborne microbial exposure, formaldehyde, plasticizers in dwellings and the symptoms compatible with the sick building syndrome (SBS). As a follow-up of the European Community Respiratory Health Survey (ECRHS II), indoor measurements were performed in homes in three North European cities. The aim was ...
Yingyan Wang - - 2012
The neuroprotective effects of ethyl pyruvate (EP) have been proved in several brain injury models, yet very little is known about its action on neonatal white matter injury. To investigate the effect of EP on white matte damage, a stereotactic intracerebral injection of lipopolysaccharide (LPS, 1mg/kg) was performed on postnatal ...
Li Zhongjun - - 2012
A number of monoclonal antibodies against tumor-associated antigens have been developed for the treatment of cancer. The anti-tumor effects of such antibodies can be enhanced by conjugation to immune stimulatory ligands, such as the toll-like receptor 9 agonist CpG oligodeoxynucleotides (CpG). The present study describes methods for the conjugation of ...
López-Otero Diego - - 2012
BACKGROUND: To determine the prognostic value of pro B-type natriuretic peptide (pro-BNP) to predict mortality after transcatheter aortic valve implantation (TAVI). Logistic EuroSCORE (LES) overestimates observed mortality after TAVI. A new risk score specific to TAVI is needed to accurately assess mortality and outcome. METHODS: Eighty-five patients were included. Indications ...
Tsai Yao-Te - - 2012
OBJECTIVE: To share our experience in treating a large cohort of infants with congenital vallecular cysts using endoscopic laser marsupialization. We describe the clinical characteristics of infants with pediatric vallecular cysts and compare these characteristics between infants with and without concurrent laryngomalacia and those who did or did not require ...
Basu Pinaki - - 2012
Understanding and mitigating particle formation in prefilled syringes are critical for ensuring stability of therapeutic proteins. In the current study, siliconized beads were used as a model for the silicone-water interface to evaluate subvisible particle formation and aggregation of a monoclonal antibody (IgG(1) ). Agitation with siliconized beads greatly accelerated ...
Collart Martine - - 2012
The Ccr4-Not complex is a conserved multi-subunit complex in eukaryotes that carries 2 enzymatic activities: ubiquitination mediated by the Not4 RING E3 ligase and deadenylation mediated by the Ccr4 and Caf1 orthologs. This complex has been implicated in all aspects of the mRNA life cycle, from synthesis of mRNAs in ...
Li Xin-Cang - - 2012
Myeloid differentiation factor 88 (MyD88) is an essential regulator in the Toll or Toll-like receptor (TLR) signaling pathway. In the current study, we characterized a novel crustacean MyD88 homolog, SpMyD88, and analyzed its binding activity with SpToll. The full-length cDNA sequence of SpMyD88 is 2933 bp, with a 1419 bp ...
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