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Mansouri Sakineh S Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran. - - 2013
The molecular dynamics simulation method was used to investigate the structural details for human prion protein (PrPN) and its D178N mutant (PrPM). Root-mean-square fluctuations (RMSFs) and the root-mean-square deviations (RMSDs) showed an increase in the flexibility and high dynamic plasticity of PrPM. Average Total energy for PrPM and PrPN sequentially ...
Dützmann Stephan S Department of Neurological Surgery, Johann Wolfgang von Goethe University, Frankfurt/Main, - - 2013
Both open ulnar nerve decompression and retractor-endoscopic ulnar nerve decompression have been shown to yield good results. However, a comparative evaluation of the techniques is lacking. To compare the results of open and endoscopic surgery in cubital tunnel syndrome. One hundred fourteen patients undergoing open (n = 59) or endoscopic ...
Deo Anthony J AJ Department of Psychiatry, Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, New York, NY 10032, - - 2013
Despite proven heritability, little is known about the genetic architecture of mood disorders. Although a number of family and case-control studies have examined the genetics of mood disorders, none have carried out joint linkage-association studies and sought to validate the results with gene expression analyses in an independent cohort. We ...
Dalyai Richard R Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA, - - 2013
Subarachnoid hemorrhage (SAH) is found to have no vascular origin by initial catheter angiography in approximately 15% of cases. The most appropriate course for the type and frequency of additional diagnostic workup remains controversial. To retrospectively assess the diagnostic yield of short-term and long-term repeat catheter angiography in the era ...
Molina Jean-Michel JM University of Paris Diderot, Paris 7 and Department of Infectious Diseases, Saint-Louis Hospital, Paris, France. - - 2013
To compare efficacy, resistance development, and safety between rilpivirine and efavirenz in treatment-naive, HIV-1-infected adults with baseline viral load 100,000 copies/ml or less in the pooled 48-week dataset of the ECHO (Efficacy Comparison in treatment-naive HIV-infected subjects Of TMC278 and EFV) and THRIVE (TMC278 against HIV, in a once-daily RegImen ...
Bronke Corine C Institute for Immunology and Infectious Diseases, Murdoch University, Perth, - - 2013
To define the relative frequencies of different mechanisms of viral escape. A population-based approach to examine the distribution of HIV polymorphism associated with diverse population human leucocyte antigens (HLAs) at sites within and flanking CD8 T-cell epitopes as a correlate of likely mechanisms of viral escape. Sequence windows surrounding 874 ...
Li Li L Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, - - 2013
The catalytic events in members of the nucleotidylyl transferase superfamily are initiated by a millisecond binding of ATP in the active site. Through metadynamics simulations on a class I aminoacyl-tRNA synthetase (aaRSs), the largest group in the superfamily, we calculate the free energy landscape of ATP selection and binding. Mutagenesis ...
Ratanawongsa Neda - - 2013
Poor medication refill adherence contributes to poor cardiometabolic control and diabetes outcomes. Studies linking communication between patients and health care providers to adherence often use self-reported adherence and have not explored differences across communication domains or therapeutic indications. To investigate associations between patient communication ratings and cardiometabolic medication refill adherence, ...
Kesselheim Aaron S - - 2013
Generic prescription drugs are bioequivalent to brand-name versions but may not have consistent color or shape, which can cause confusion and lead to interruptions in medication use. We sought to determine whether switching among different-appearing antiepileptic drugs (AEDs) is associated with increased rates of medication nonpersistence, which can have serious ...
Michaels Allyson M - - 2013
With the increased use of fertility treatments, more women are having multiple births. The purpose of this case study is to describe the efforts of a woman who had undergone a single mastectomy to provide all the breast milk her twins would need with her 1 functioning breast. A review ...
Bettington Mark - - 2013
: To compare the histological features of a consecutive biopsy series of autoimmune gastritis (AIG) with other forms of chronic gastritis to identify morphological clues to the diagnosis. : Morphological features in gastric biopsies were examined in 42 prospectively identified patients with AIG without concomitant neoplasia (n = 184 biopsies), 50 normal ...
Andreson Jennifer - - 2013
Background: Prior to 2010, the World Health Organization recommended that HIV-positive mothers exclusively breastfeed for the first 6 months of life unless replacement feeding was acceptable, feasible, affordable, sustainable, and safe. Community pressure to practice mixed feeding, lack of knowledge on safe feeding, and shame regarding HIV status discourage mothers ...
Tay Clifton Ming - - 2013
SUMMARY: Gain-of-function mutations involving c-kit protein, a cell-surface transmembrane receptor for stem cell factor, have been identified as a key oncogenic driver in a variety of solid tumours. Coupled with the development of tyrosine kinase inhibitors such as imatinib, c-kit has emerged as a viable drug target in what seems ...
Levidou Georgia - - 2013
: To investigate the expression of tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and osteoprotegerin (OPG) in bladder urothelial carcinomas (UCs) and assess possible interrelations with other regulators of TRAIL induced apoptosis (p65/NF-κB, p-ERK1/2, p-AKT) and FGFR3, as well as to elucidate their potential involvement in bladder tumourigenesis and determine ...
Gardiner B J - - 2013
: Inducible resistance to clindamycin in Staphylococcus aureus is common but not easily identified by routine testing, and can result in treatment failure if not detected. The gold standard method is the D-test described by the Clinical and Laboratory Standards Institute (CLSI). The Vitek-2 AST-P612 card contains an 'inducible clindamycin ...
Betts Natasha A - - 2013
: To investigate the effects of affinity-purified rabbit anti-β2GP1, and anti-β2GP1 purified from patients with systemic lupus erythematosus (SLE), on adenosine diphosphate (ADP)-induced aggregation. : Whole blood was collected and processed to obtain platelet poor plasma (PPP) from normal controls (n = 15) and SLE patients (n = 15). Using PPP, anti-β2GP1 titres were ...
Sim James Heng Chiak - - 2013
: Gram positive bacilli (GPB) isolated from soft tissue infections are often neglected or ignored due to their fastidious nature and the lack of reliable phenotypic identification methods. This study was done to characterise clinically significant aero-tolerant GPB isolated from surgically obtained samples in patients with soft tissue infections. : ...
Murali Rajmohan - - 2013
SUMMARY: BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds to BRCA1. BAP1 is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway. Germline mutations of BAP1 confer increased ...
Vitali Mario - - 2013
Anxiety symptoms in depression result often in treatment resistance, residual symptoms, and persistent functional impairment. To assess the effectiveness and safety of adjunctive pregabalin to antidepressants for residual anxiety in patients with major depressive disorder (MDD). A retrospective chart review was conducted to identify partial responders among patients with MDD ...
Mahmood Shamail - - 2013
Clinical antipsychotic trials of intervention effectiveness showed that atypical antipsychotics (AAPs) were associated with significant weight gain and glucose intolerance. A few trials have shown topiramate to reduce weight gain in patients receiving AAPs, although this benefit has not been present in all trials. This study aimed to determine topiramate ...
Kim Jong-Hoon - - 2013
Previous studies have suggested the utility of nonlinear complexity measures of heart rate variability (HRV) in evaluating the regulatory capacity of the neuroautonomic system. The purpose of the present study was to investigate the effects of clozapine on the nonlinear complexity measures of HRV in patients with treatment-resistant schizophrenia to ...
Ramanathan Seethalakshmi S Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA. - - 2013
CONTEXT Economic difficulties at the individual level can lead to a number of behavioral problems, including substance abuse and delinquent behaviors. OBJECTIVE To examine the influence of a nationwide adverse economic environment during infancy, specifically, the high unemployment rates during and after the 1980 and 1981-1982 recessions, on rates of ...
Lerond Jérôme J Department Consultation-Liaison Psychiatry, Hospices Civils deLyon, - - 2013
To investigate the impact of various antipsychotic drugs on the 5-HT1A serotoninergic system, we performed a [F]4-(2-methoxyphenyl)-1-[2-(N-2-pirydynyl)-p-luorobenzamido]-ethyl-piperazine PET study in 19 schizophrenic patients treated with either aripiprazole, which has a partial agonist activity at 5-HT1A receptors, or second-generation antipsychotics (SGA) (olanzapine or risperidone), which do not demonstrate such property. We ...
Levy Rona L RL School of Social Work, University of Washington, Seattle, WA 98105, USA. - - 2013
To determine whether a brief intervention for children with functional abdominal pain and their parents' responses to their child's pain resulted in improved coping 12 months later. Prospective, randomized, longitudinal study. Families were recruited during a 4-year period in Seattle, Washington, and Morristown, New Jersey. Two hundred children with persistent ...
Mustafa Feras Ali FA Northamptonshire Healthcare NHS Foundation Trust and Northampton University, Northampton, United Kingdom. - - 2013
Clozapine is superior to other antipsychotic drugs for treatment of refractory schizophrenia. However, its use has been limited by its potentially serious adverse effects. There is little guidance on the management of patients who discontinue clozapine for reasons such as lack of response, intolerance, or noncompliance. The literature was searched ...
Marcuzzi Annalisa A Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy. - - 2013
Human colostrum and breast milk are known to contain high levels of cytokines, cytokine receptors, and chemokines. To investigate the presence and compare levels of soluble cytokines in paired samples of human colostrum and milk. Levels of 27 cytokines were measured in 9 paired samples of human colostrum (day 2 ...
Durell Todd M TM Eli Lilly and Company and/or one of its subsidiaries, Indianapolis, IN 46285, USA. - - 2013
Attention-deficit/hyperactivity disorder (ADHD) is associated with significant impairment in multiple functional domains. This trial evaluated efficacy in ADHD symptoms and functional outcomes in young adults treated with atomoxetine. Young adults (18-30 years old) with ADHD were randomized to 12 weeks of double-blind treatment with atomoxetine (n = 220) or placebo ...
Wang Yujing - - 2013
This work focuses on constructing a high catalytic activity cathode of an electro-Fenton system, to overcome the defects of low activity, poor stability, and intricate fabrication of supported catalysts. A series of ferrite-carbon aerogel (FCA) monoliths with different iron/carbon ratios was synthesized directly from metal-resin precursors accompanied by phase transformation. ...
Wei DengGuo D UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United - - 2013
High-resolution crystal structures of the DNA duplex sequence d(CGCGAATTCGCG)(2) complexed with three minor-groove ligands are reported. A highly conserved cluster of 11 linked water molecules has been found in the native and all 3 ligand-bound structures, positioned at the boundary of the A/T and G/C regions where the minor groove ...
Lester Sally - - 2013
Quality assurance is an implied concept inherent in every consumer's purchase of a product or service. In laboratory testing, quality assurance encompasses preanalytic (sampling, transport, and handling prior to testing), analytic (measurement), and postanalytic (reporting and interpretation) factors. Quality-assurance programs require that procedures are in place to detect errors in ...
Anderson Tara C - - 2013
Objective-To estimate the seroprevalence of antibodies against H3N8 canine influenza virus (CIV) in a population of US dogs with influenza-like illness (ILI) and to identify factors associated with seropositivity. Design-Cross-sectional study. Animals-1,268 pet and shelter dogs with ILI in 42 states. Procedures-Serum samples collected from dogs from 2005 through June ...
Henke Diana - - 2013
Objective-To determine the prevalence of spinal cord compression subsequent to traumatic intervertebral disk (IVD) extrusion in dogs, characterize factors associated with spinal cord compression in dogs with traumatic IVD extrusion, and evaluate the outcomes of dogs with traumatic IVD extrusion with or without spinal cord compression. Design-Retrospective case series. Animals-31 ...
Ragle Claude A - - 2013
Case Description-A 4-year-old castrated Arabian horse was evaluated for a history of a right-sided nonstrangulating inguinal hernia that was manually reducable. Clinical Findings-Physical examination revealed a right-sided hydrocele and bilateral enlargement of the inguinal rings detectable by both external digital and rectal palpation. Treatment and Outcome-Biportal laparoscopic internal inguinal ring ...
Snyder Christopher J - - 2013
Objective-To evaluate the effects of a routinely used infraorbital nerve block, performed for dental procedures, on the anesthetic requirement for isoflurane in dogs. Design-Prospective controlled study. Animals-8 healthy adult Beagles. Procedures-Dogs were anesthetized with isoflurane, and the minimum alveolar concentration (MAC) of isoflurane was established. A modification of a well-established ...
Fisher Stephen C - - 2013
Objective-To report thoracolumbar caudal articular process malformations with secondary constrictive fibrosis of the spinal cord in Pugs. Design-Retrospective case series. Animals-11 Pugs with neurologic dysfunction resulting from constriction of fibrous tissue secondary to thoracolumbar caudal articular process malformation and 5 Pugs with no neurologic dysfunction. Procedures-Medical records of dogs with ...
Stieger-Vanegas Susanne M - - 2013
Objective-To assess the feasibility and usefulness of CT enterography to evaluate the gastrointestinal tract in clinically normal llamas and alpacas. Design-Prospective observational study. Animals-7 clinically normal alpacas and 8 clinically normal llamas. Procedures-The imaging protocol included orogastric administration of iodinated contrast material mixed with water. Three hours later, helical CT ...
Korosue Kenji - - 2013
Objective-To test the usefulness of measuring pH and refractometry index, compared with measuring calcium carbonate concentration, of preparturient mammary gland secretions for predicting parturition in mares. Design-Evaluation study. Animals-27 pregnant Thoroughbred mares. Procedures-Preparturient mammary gland secretion samples were obtained once or twice daily 10 days prior to foaling until parturition. ...
Ployart Stéphane - - 2013
Objective-To determine the feasibility of thoracoscopic resection of masses located on the right auricle in dogs. Design-Retrospective case series. Animals-Dogs (n = 9) with a mass on the right auricle. Procedures-Hospital records from 2003 to 2011 were reviewed. Only dogs that underwent thoracoscopic resection of a mass on the right ...
Genovese David W - - 2013
Objective-To compare procedure times and major and minor complication rates associated with single-chamber versus dual-chamber pacemaker implantation and with 1-lead, 2-lead, and 3-lead pacemaker implantation in dogs with clinical signs of bradyarrhythmia. Design-Retrospective case series. Animals-54 dogs that underwent pacemaker implantation because of clinical signs of bradyarrhythmia. Procedures-Medical records of ...
Musser Jeffrey M B - - 2013
Objective-To investigate the disposition kinetics of flunixin meglumine when administered IV to budgerigars (Melopsittacus undulatus) and Patagonian conures (Cyanoliseus patagonus). Design-Prospective cohort study. Animals-8 adult Patagonian conures and 24 adult budgerigars. Procedures-Injectable flunixin meglumine (50 mg/mL) was diluted to 10 and 1. 0 mg/mL and administered IV at a dose ...
Rossmeisl John H JH - - 2013
Objective-To analyze survival time and identify prognostic factors associated with outcome following discharge in dogs with primary brain tumors treated palliatively. Design-Prospective case series. Animals-51 dogs with 5 histopathologic types of brain tumors. Procedures-Owners with dogs examined from 2004 to 2008 were invited to participate if dogs had CT or ...
Cai Minying M Department of Chemistry and Biochemistry, 1306 East University Boulevard, University of Arizona, Tucson, AZ 85721, - - 2013
γ-MSH (γ-melanocyte-stimulating hormone, H-Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-Gly-OH), with its exquisite specificity and potency, has recently created much excitement as a drug lead. However, this peptide is like most peptides susceptible to proteolysis in vivo, which potentially decreases its beneficial activities. In our continued effort to design a proteolytically stable ligand with specific receptor ...
Goryanova Bogdana B Department of Chemistry, University at Buffalo, SUNY, Buffalo, NY 14260-3000, - - 2013
The syntheses of two novel truncated analogs of the natural substrate orotidine 5'-monophosphate (OMP) for orotidine 5'-monophosphate decarboxylase (OMPDC) with enhanced reactivity toward decarboxylation are reported: 1-(β-d-erythrofuranosyl)-5-fluoroorotic acid (FEO) and 5'-deoxy-5-fluoroorotidine (5'-dFO). A comparison of the second-order rate constants for the OMPDC-catalyzed decarboxylations of FEO (10 M⁻¹ s⁻¹) and 1-(β-d-erythrofuranosyl)orotic ...
Lancaster Kyle M KM Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, - - 2013
The iron-molybdenum cofactor (FeMoco) of nitrogenase contains a biologically unprecedented μ(6)-coordinated C(4-) ion. Although the role of this interstitial atom in nitrogenase catalysis is unknown, progress in understanding its biosynthetic origins has been made. Here we report valence-to-core Fe Kβ X-ray emission spectroscopy data to show that this C(4-) ion ...
Zhang Haoming H Department of Pharmacology, The University of Michigan Medical School , Ann Arbor, Michigan 48109, - - 2013
The mechanism-based inactivation of cytochrome P450 2B4 (CYP2B4) by 9-ethynylphenanthrene (9EP) has been investigated. The partition ratio and k(inact) are 0.2 and 0.25 min(-1), respectively. Intriguingly, the inactivation exhibits sigmoidal kinetics with a Hill coefficient of 2.5 and an S(50) of 4.5 μM indicative of homotropic cooperativity. Enzyme inactivation led ...
Sanders Mary Ann - - 2013
Context.-Paget disease is an uncommon skin manifestation of breast cancer, associated with either invasive carcinoma or ductal carcinoma in situ in the underlying breast. In very rare cases, tumor cells within the epidermis invade through the basement membrane of the skin into the dermis. Objectives.-To identify a series of cases ...
Stather David R - - 2013
Pulmonary aspergilloma is a chronic fungal infection that has a high mortality when hemoptysis occurs. Surgery is the treatment of choice, but patients often have severe physiologic impairment putting them at risk for significant surgical morbidity and mortality. We present the case of a 63-year-old woman with a large aspergilloma, ...
Garcia Grant H - - 2013
The optimum management for recurrent glenohumeral instability with significant humeral head defects remains controversial. The purpose of this study was to compare outcomes and recurrence rates between patients who underwent osteochondral substitute grafting and patients who underwent remplissage to treat recurrent shoulder instability from an engaging Hill-Sachs defect with a ...
Sai Sarathi Vasan Arvind - - 2013
Point-of-care biosensor systems can potentially improve patient care through real-time and remote health monitoring. Over the past few decades, research has been conducted in the field of biosensors to detect patterns of biomarkers and provide information on their concentration in biological samples for robust diagnosis. In future point-of-care applications, requirements ...
Speranza Lorenza - - 2013
The aim of this study was to investigate the effects of acute pharmacological treatment on the plasma levels of l-arginine, asymmetrical dimethylarginine (ADMA), and symmetrical dimethylarginine (SDMA). We also investigated the related effects on endothelial nitric oxide synthase (eNOS) expression and activity and cytochrome c oxidase activity in the primary ...
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