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Park Misun M Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA. - - 2013
Myocyte apoptosis is considered a major mechanism in the pathogenesis of heart failure. Accordingly, manipulations that inhibit apoptosis are assumed to preserve cardiac function by maintaining myocyte numbers. We tested this assumption by examining the effects of caspase inhibition (CI) on cardiac structure and function in C57BL/6 mouse with pressure ...
Deppong Christine M CM Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, - - 2013
Asthma is largely an inflammatory disease, with the development of T cell mediated inflammation in the lung following exposure to allergen or other precipitating factors. Currently, the major therapies for this disease are directed either at relief of bronchoconstriction (ie beta-agonists) or are non-specific immunomodulators (ie, corticosteroids). While much attention ...
Tsai Jack J Yale School of Medicine, New Haven, CT 06516, USA. - - 2013
We examined rates of obesity and associated characteristics in the chronically homeless population to explore how a range of factors, including sociodemographics, housing, food source, physical and mental health, and health service use, were related to being overweight or obese. We conducted multivariate regression analyses on a community sample of ...
Skinner Asheley Cockrell AC The University of North Carolina at Chapel Hill, Department of Pediatrics, Chapel Hill, NC 27599, USA. - - 2013
We compared parental reports of children's height and weight when the values were estimated vs. parent-measured to determine how these reports influence the estimated prevalence of childhood obesity. In the 2007 and 2008 North Carolina Child Health Assessment and Monitoring Program surveys, parents reported height and weight for children aged ...
Morris Samantha A SA Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA, - - 2013
Human diseases such as heart failure, diabetes, neurodegenerative disorders, and many others result from the deficiency or dysfunction of critical cell types. Strategies for therapeutic tissue repair or regeneration require the in vitro manufacture of clinically relevant quantities of defined cell types. In addition to transplantation therapy, the generation of ...
McKenna Cristin C Department of Physical Medicine and Rehabilitation of the University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, USA. - - 2013
People with traumatic brain injury (TBI) may demonstrate action planning disorders and limb apraxia. Many patients, who sustain a spinal cord injury (SCI), sustain a co-occurring TBI (11-29 percent of people with SCI) and therefore are at risk for limb apraxia. People with SCI and TBI (SCI/TBI) rely on powered ...
Baile Matthew G MG Dept. of Physiology, Johns Hopkins School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205-2185, - - 2013
Mitochondria participate in a variety of cellular functions. As such, mitochondrial diseases exhibit numerous clinical phenotypes. Because mitochondrial functions are highly conserved between humans and Saccharomyces cerevisiae, yeast are an excellent model to study mitochondrial disease, providing insight into both physiological and pathophysiological processes.
Hoffman Lucas R LR Seattle Children's Hospital, Seattle, WA 98105, USA. - - 2013
A great deal of excitement and hope has followed the successful trials and US Food and Drug Administration approval of the drug ivacaftor (Kalydeco), the first therapy available that targets the underlying defect that causes cystic fibrosis (CF). Although this drug has currently demonstrated a clinical benefit for a small ...
Herr Natalie Rios NR The University of North Carolina at Chapel Hill, Department of Chemistry, CB 3290, Chapel Hill, NC 27599-3290, - - 2013
Dopamine is a neurotransmitter that is utilized in brain circuits associated with reward processing and motor activity. Advances in microelectrode techniques and cyclic voltammetry have enabled its extracellular concentration fluctuations to be examined on a subsecond time scale in the brain of anesthetized and freely moving animals. The microelectrodes can ...
Espana Rodrigo A RA Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, - - 2013
The mesolimbic dopamine system is an essential participant in the initiation and modulation of various forms of goal-directed behavior, including drug reinforcement and addiction processes. Dopamine neurotransmission is increased by acute administration of all drugs of abuse, including the stimulants cocaine and amphetamine. Chronic exposure to these drugs via voluntary ...
Simpson Jennifer E JE Scientific Technologies Corporation, Tucson, AZ, USA. - - 2013
Meningitis and bacteremia due to Neisseria meningitidis are rare but potentially deadly diseases that can be prevented with immunization. Beginning in 2008, Arizona school immunization requirements were amended to include immunization of children aged 11 years or older with meningococcal vaccine before entering the sixth grade. We describe patterns in ...
Anforth Rachael R Department of Dermatology, Westmead Hospital, Sydney, NSW, - - 2013
The RAF inhibitors vemurafenib and dabrafenib are emerging as the standard of care for Val600 BRAF-mutant metastatic melanoma. These drugs have shown clinical benefit over the standard care (dacarbazine); however, they are associated with frequent cutaneous adverse events, which can be concerning to the patient and their physician. Herein, we ...
Lompre Anne-Marie AM Inserm UMRS 956, Faculte de Médecine Pitie-salpetriere, Paris, France. - - 2013
Cardiac hypertrophy and vascular proliferative diseases are associated with major alterations in calcium homeostasis and calcium signaling. The recent discovery of STIM and Orai has generated great enthusiasm concerning the role of these proteins in the cardiovascular system. We will review the major results concerning the existence and the role ...
McKittrick Noah N University of Pennsylvania, Philadelphia, PA 19104, - - 2013
HIV-infected persons have less robust antibody responses to influenza vaccines. To compare the immunogenicity of high-dose influenza vaccine with that of standard dosing in HIV-positive participants. Randomized, double-blind, controlled trial. (ClinicalTrials.gov: NCT01262846) The MacGregor Clinic of the Hospital of the University of Pennsylvania, Philadelphia, from 27 October 2010 to 27 ...
Fu Hongmei H William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, - - 2013
Coordinated migratory events are required for the development of effective and regulated immunity. Naïve T lymphocytes are programmed to recirculate predominantly in secondary lymphoid tissue by non-specific stimuli. In contrast, primed T cells must identify specific sites of antigen location in non-lymphoid tissue to exert targeted effector responses. Following priming, ...
Westra Bonnie L BL Center for Nursing Informatics, School of Nursing, University of Minnesota, Minneapolis, MN 55434, USA. - - 2013
The purpose of this study was to describe the prevalence, incidence, and effectiveness of home health care (HHC) agencies' services with and without a WOC nurse related to wounds, incontinence, and urinary tract infection (UTI) patient outcomes. There were 449,243 episodes of care from a national convenience sample of 785 ...
Bruckman David D Cleveland Department of Public Health, Cleveland, OH 44106-7069, USA. - - 2013
Little is known about whether public health (PH) enforcement of Ohio's 2007 Smoke Free Workplace Law (SFWPL) is associated with department (agency) characteristics, practice, or state reimbursement to local PH agencies for enforcement. We used mixed methods to determine practice patterns, perceptions, and opinions among the PH workforce involved in ...
Saddoris Michael P MP Department of Psychology, University of North Carolina, Chapel Hill, NC 27599-3270, USA. - - 2013
The catecholamine dopamine (DA) has been implicated in a host of neural processes as diverse as schizophrenia, parkinsonism and reward encoding. Importantly, these distinct features of DA function are due in large part to separate neural circuits involving connections arising from different DA-releasing nuclei and projections to separate afferent targets. ...
Wang Jun J Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, - - 2013
Endotoxin, a component of the outer membrane of gram-negative bacteria, elicits a strong innate and inflammatory immune response associated with the secretion of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α). Because TNF-α polymorphisms that increase TNF-α production are associated with an increased risk of non-Hodgkin lymphoma (NHL), we hypothesized that ...
Tajbakhsh Shahragim S Stem Cells and Development, Department of Developmental & Stem Cell Biology, CNRS URA 2578, Pasteur Institute, 25 rue du Dr. Roux, 75015, Paris, France. - - 2013
Why stem cell numbers decline with age is a major question in regenerative biology and medicine. Skeletal muscle has emerged as a powerful paradigm to address this issue. Recently, genetic and cell marking strategies were used to uncover a new and causal relationship between muscle stem cells and differentiated fibers ...
Jin Byung-Ju BJ Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, - - 2013
Potassium (K(+)) ions released into brain extracellular space (ECS) during neuroexcitation are efficiently taken up by astrocytes. Deletion of astrocyte water channel aquaporin-4 (AQP4) in mice alters neuroexcitation by reducing ECS [K(+)] accumulation and slowing K(+) reuptake. These effects could involve AQP4-dependent: (a) K(+) permeability, (b) resting ECS volume, (c) ...
Yin Ying Y Department of Pharmacology and Cardiovascular Research Center, Temple University School of Medicine, 3500 North Broad Street, MERB 1059, Philadelphia, PA 19140, - - 2013
Metabolic syndrome is a major health issue in the western world. An elevated pro-inflammatory state is often found in patients with metabolic diseases such as type 2 diabetes and obesity. Atherosclerosis is one such clinical manifestation of pro-inflammatory state associated with the vasculature. The exact mechanism by which metabolic stress ...
Meng Shu S Department of Pharmacology, Temple University School of Medicine, 3500 North Broad Street, 10th floor, Philadelphia, PA 19140, - - 2013
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease. Here, we studied transcriptional regulation in homocysteine (Hcy)-induced gene expression in monocytes (MC). We identified 11 Hcy-induced genes, 17 anti-inflammatory cytokine interleukin 10-induced, 8 pro-inflammatory cytokine interferon gamma (IFN gamma)-induced and 8 pro-inflammatory cytokine tumor necrosis factor alpha (TNF alpha)-induced ...
Creeke Paul I - - 2013
Biopharmaceuticals are drugs which are based on naturally occurring proteins (antibodies, receptors, cytokines, enzymes, toxins), nucleic acids (DNA, RNA) or attenuated microorganisms. Immunogenicity of these agents has been commonly described and refers to a specific antidrug antibody response. Such immunogenicity represents a major factor impairing the efficacy of biopharmaceuticals due ...
Iizuka Haku H Department of Orthopedic Surgery, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma, 371-8511, Japan. - - 2013
We retrospectively investigated the radiographic findings in patients with atlanto-axial subluxation (AAS) due to rheumatoid arthritis, and clarified the effect of reduction of the atlanto-axial angle (AAA) on the cranio-cervical and subaxial angles. Forty-one patients, consisting of 29 females and 12 males, with AAS treated by surgery were reviewed. The ...
Fengbin Yu Y Department of Orthopaedic Surgery, No. 98 Hospital of PLA, Huzhou, - - 2013
The Smith-Robinson approach is commonly used to expose the vertebrae in anterior cervical discectomy and fusion (ACDF). Postoperative dysphagia has been frequently reported following this procedure. In this approach, surgical dissection can be carried out either lateral (LEO) or medial (MEO) to the omohyoid muscle. The purpose of this study ...
Hodder Sally L SL Department of Medicine, Division of Infectious Diseases, New Jersey Medical School, Newark, NJ 07101-1709, USA. - - 2013
Women account for 23% of newly diagnosed HIV infections in the United States, but there are few recent, well-characterized cohorts of U.S. women in whom behavior characteristics and HIV acquisition have been well-described. To evaluate HIV incidence and describe behaviors among U.S. women residing in areas of high HIV prevalence. ...
Gangula Pandu R PR Departments of Physiology, Meharry Medical College, Nashville, TN 37208, USA. - - 2013
Both basic science and clinical studies support the concept that vitamin D deficiency is involved in the pathogenesis of cardiovascular and renal diseases through its association with diabetes, obesity, and hypertension. Understanding the underlying mechanisms may provide a rationale for advocating adequate intake of vitamin D and calcium in all ...
Gao Haijun H Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1062, - - 2013
Whether and how gestational protein restriction (PR) affects placental development and function remain unknown. To test the hypothesis that PR can affect trophoblast differentiation in mid-and late pregnancy, rats were fed a 20% or an isocaloric 6% protein diet from Day 1 to 14 or 18 of pregnancy and effects ...
Johnson Matthew E ME Washington State University, School of Molecular Biosciences and Center for Reproductive Biology, Biotechnology-Life Science Building, 1715 NE Fairway Road, Pullman, WA 99164, USA. - - 2013
Errors during meiosis that affect synapsis and recombination between homologous chromosomes contribute to aneuploidy and infertility in humans. Despite the clinical relevance of these defects, we know very little about the mechanisms by which homologous chromosomes interact with one another during mammalian meiotic prophase. Further, we remain ignorant of ...
Van den Akker Alithe L - - 2012
This study investigated relations among children's personality types, trajectories of internalizing and externalizing problems, and overreactive parenting across 6 years. Latent Class Analysis of the Big 5 personality dimensions (modeled as latent factors, based on mother, father and teacher reports) for 429 children (mean age 8 years at Time 1) ...
Chou Hui-Tzu Grace - - 2012
Abstract With the spread of Facebook among people in many countries, some companies have started using applicants' Facebook profiles as a criterion of personnel selection, in an effort to identify good workers among job applicants. However, how using Facebook is connected to individuals' relationships with coworkers and work attitudes is ...
Caprariello Peter A - - 2012
Recent evidence indicates that spending discretionary money with the intention of acquiring life experiences-events that one lives through-makes people happier than spending money with the intention of acquiring material possessions-tangible objects that one obtains and possesses. We propose and show that experiences are more likely to be shared with others, ...
Li Wenzhe - - 2012
Through a novel method, we successfully synthesized electromagnetic (EM) functional polystyrene@polypyrrole@nickel (PS@PPy@Ni) composite microspheres. The PS@PPy spheres with well-defined core/shell structure have been synthesized via an in situ chemical oxidative co-polymerization of pyrrole (Py) and N-2-carboxyethylpyrrole (PyCOOH) templated by PS microspheres. The reaction was carried out under heterophase conditions using ...
Gosselin Eric - - 2012
In the past it was assumed that work attendance equated to performance. It now appears that health-related loss of productivity can be traced equally to workers showing up at work as well as to workers choosing not to. Presenteeism in the workplace, showing up for work while sick, seems now ...
Dai Jiezhi - - 2012
Background Soft-tissue defects in the lower leg, ankle, and heel often require reconstruction with local or free flaps. We try to compare the clinical outcome and complications following transfer of a perforator pedicle-based sural neurocutaneous flap (P-NCF) or a fascia pedicle-based sural neurocutaneous flap (F-NCF).Methods Between March 2007 and December 2010, 92 ...
Mangiapia Gaetano - - 2012
Mutual diffusion coefficients have been measured for several average compositions of the system sodium cholate - sodium deoxycholate - water at 25 °C. The experiments have been grouped in different sets having constant concentration of one component and variable concentration of the other one. Following this approach, it has been ...
Vaughan Simon - - 2013
Progress in astronomy comes from interpreting the signals encoded in the light received from distant objects: the distribution of light over the sky (images), over photon wavelength (spectrum), over polarization angle and over time (usually called light curves by astronomers). In the time domain, we see transient events such as ...
Shrestha Lok Kumar - - 2012
A new class of fullerene (C(60)) crystals with bimodal pore architectures consisting of macropores and mesopores was synthesized by using a liquid-liquid interfacial precipitation (LLIP) method involving an interface between isopropyl alcohol (IPA) and a saturated solution of C(60) in a mixture of benzene and carbon tetrachloride (CCl(4)). By varying ...
Liu Cong - - 2012
The present study examined the associations among procedural injustice, conflict with a supervisor (supervisor conflict), and job strains for employees with different power distance orientations. Using data from 301 university employees, along with corroborative reports from a coworker of each employee, we tested a moderated mediation model in which the ...
Liu Chao - - 2012
We have successfully synthesized and separated a series of tert-butyl 4-C61-benzoate (t-BCB) organofullerene, including monoadduct, bisadduct and triadduct compounds, and investigated their photophysical, electrochemistry, thermal and HPLC analysis. The photovoltaic devices were fabricated based on monoadduct, bisadduct and triadduct products, and the devices based on them exhibited power conversion efficiency ...
Pearson Matthew R - - 2012
Much research links impulsivity with alcohol use and problems. In 2 studies, unplanned (or impulsive) drinking is assessed directly to determine whether it has direct effects on alcohol use and alcohol-related problems. In Study 1, we examined whether unplanned drinking serves as a proximal mediator of the effects of impulsivity-like ...
Maestre Lourdes - - 2012
The olefin aziridination reaction catalyzed by copper and silver complexes bearing hydrotrispyrazolylborate (Tpx) ligands has been investigated from a mechanistic point of view. Several mechanistic probe reactions were carried out, specifically competition experiments with p-substituted styrenes, stereospecificity of olefins, and the effects of the radical inhibitors. Data from these experi-ments ...
Luo Lin - - 2012
Younger and older adults who were either monolingual or bilingual were tested with verbal and spatial working memory (WM) span tasks. Aging was associated with a greater decline in spatial WM than in verbal WM, but the age-related declines were equivalent in both language groups. The bilingual participants outperformed the ...
Kirsch Wladimir - - 2012
In the present study, we show that energetic costs of planned hand movements affect the perception of distances in reaching space. In three experiments, participants prepared hand movements that varied regarding movement amplitude or necessary movement force in either a blockwise or trial-by-trial manner. Before actual execution of the action, ...
Arterberry Brooke J - - 2012
The purpose of the present study was to examine cognitive risk factors for driving after use of marijuana. We tested whether marijuana outcome expectancies and specific cognitions about driving after marijuana use were uniquely associated with the likelihood and frequency of driving while high (DWH) and riding with a high ...
Gong Yun - - 2012
Two octamolybdate-based MOFs with unsaturated coordinated metal centers formulated as Cu(3)(Mo(8)O(26))(H(2)O)(2)(OH)(2)(L1)(4) (L1 = 4H-4-amino-1,2,4-triazole) (1) and Ag(4)(Mo(8)O(26))(L2)(2.5)(H(2)O) (L2 = 3,5-dimethyl-4-amino-4H-1,2,4-triazole) (2) were synthesized and structurally characterized by single-crystal X-ray diffractions. Complex 1 exhibits a 1D chain-like structure. In complex 2, 1D Ag-octamolybdate chains in the ac plane are covalently embedded ...
Chattopadhyay Ishanu - - 2013
We present an unsupervised learning algorithm (GenESeSS) to infer the causal structure of quantized stochastic processes, defined as stochastic dynamical systems evolving over discrete time, and producing quantized observations. Assuming ergodicity and stationarity, GenESeSS infers probabilistic finite state automata models from a sufficiently long observed trace. Our approach is abductive; ...
Du Zhongyu - - 2012
The kinetics of alkaline fading of crystal violet (CV) has been studied by UV-spectrophotometry and microcalorimetry in the critical binary solution of (2-butoxyethanol + water) at the initial reaction stage and various temperatures. It was found that the first-order rate constants obtained from these two methods are well accorded with ...
Huynh Jasmine Y - - 2012
This two-wave study of volunteers examined the effect of family and friend support on the relationship between volunteer demands (emotional demands and work-home conflict) on the one hand, and burnout (exhaustion and cynicism) and organizational connectedness on the other hand. It was hypothesized that family and friend support would moderate ...
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