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Results 101 - 150 of 1606
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Riddle Daniel L - - 2013
Most orthopedic surgeons do not routinely use radiographic classification systems to grade the extent of joint space narrowing in patients considered for total knee arthroplasty. The authors compared the validity and reliability of radiographic measures of tibiofemoral osteoarthritis by 2 experienced and 2 inexperienced orthopedic surgeons on individuals who subsequently ...
Shibayama Yuki - - 2013
Prorenin-induced intracellular signaling pathway is not fully elucidated. We investigated whether the (pro)renin receptor mediates epidermal growth factor (EGF) receptor transactivation through angiotensin (Ang) II-dependent and -independent pathways in human embryo kidney 293 cells. Prorenin (2 nmol/L) caused biphasic phosphorylation of EGF receptor (Tyr992) and extracellular signal-regulated kinase (ERK) 1/2, ...
Patlewicz Grace Yvonne - - 2013
Chemical Regulation and the means by which data is generated for the purposes of risk assessment is undergoing a tremendous shift. There is a strong impetus in Europe, in particular, to move towards non-animal approaches to address data gaps for specific endpoints either in lieu of testing or as part ...
Leinan Paul R - - 2013
The veins distributing oxygenated blood from the placenta to the fetal body have been given much attention in clinical Doppler velocimetry studies, in particular the ductus venosus. The ductus venosus is embedded in the left liver lobe and connects the intra-abdominal portion of the umbilical vein (IUV) directly to the ...
Zhang Fengzu - - 2013
Uniconazole residue dynamics and final residues in supervised field trials at GAP conditions were studied. The residue levels and dissipation rate of uniconazole was detected by LC-MS. At fortification levels of 0.04, 0.2 and 2 mg kg(-1), recoveries ranged from 78.7 % to 100.9 % with RSDs of 0.1 %-4.6 % (n = 5). The dissipation experiments showed ...
Dvir-Ginzberg Mona - - 2013
Osteoarthritis (OA) is a degenerative joint disease particularly affecting the elderly population. Although several genetic features have been characterized as risk factors for OA susceptibility, a growing body of evidence indicates that epigenetic effectors may also modulate gene expression and thus contribute to OA pathology. One such epigenetic regulator of ...
van Dam Leonie L Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre, Rotterdam, Netherlands. - - 2013
A difference between colorectal cancer screening and screening for most other types of cancer is that various screening methods are available. A choice between screening methods is common in the USA. Most European programmes currently offer a single screening method, since it is recommended that only screening strategies with sufficient ...
Coffin Phillip O - - 2013
Chinese translation Opioid overdose is a leading cause of accidental death in the United States. To estimate the cost-effectiveness of distributing naloxone, an opioid antagonist, to heroin users for use at witnessed overdoses. Integrated Markov and decision analytic model using deterministic and probabilistic analyses and incorporating recurrent overdoses and a ...
Paredes-Gamero Edgar J - - 2013
Leukemias are the most common malignancy of childhood and have the highest mortality among aging people. Leukemias are a group of blood disorders characterized by an accumulation of leukemic cells in the peripheral blood of patients as a result of disturbances in proliferation and differentiation. Refractory leukemia remains the most ...
Wang Jun J Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, - - 2013
Endotoxin, a component of the outer membrane of gram-negative bacteria, elicits a strong innate and inflammatory immune response associated with the secretion of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α). Because TNF-α polymorphisms that increase TNF-α production are associated with an increased risk of non-Hodgkin lymphoma (NHL), we hypothesized that ...
Singh Inderpal - - 2013
Acute drug resistance, intolerable side effects and non-specific target activation are the crucial barriers for efficient translational outcome of target directed cancer drug discovery. In the last five years, many of the bull's eye drugs failed to obtain FDA approval because of highly complicated mechanisms of the targeting receptors. These ...
Rahr-Wagner Lene - - 2013
The goal was to study revision rates and clinical outcome after anterior cruciate ligament (ACL) reconstruction using the anteromedial (AM) technique versus the transtibial (TT) technique for femoral drill hole placement. A total of 9,239 primary ACL reconstruction procedures were registered in the Danish Knee Ligament Reconstruction Register between January ...
Bartolucci Simonetta - - 2013
Archaea occupy a considerable diversity of niches ranging from extreme of pH, salinity to temperature that cannot be tolerated by other forms of life. There is an increasing consciousness that they have a key role both on the biogeochemical cycling of elements and in the bioremediation of polluted habitat. A ...
Yuan Falei - - 2013
Detection of microvascular changes in experimental stroke models is limited by current technologies. Using state-of-the-art synchrotron radiation (SR), we explored the feasibility of detecting the normal morphological variations of lenticulostriate arteries (LSAs) and the changes to LSAs following middle cerebral artery occlusion (MCAO). Cerebral microvessels of ICR mice were imaged ...
Wu Mengyan - - 2013
Eukaryotic translation initiation factor 4E (eIF4E) is involved in integration and amplification of many carcinogenesis signals in tumors. However, it remains unclear whether eIF4E over-expresses in NPC and whether it is associated with the development of NPC. Here, we analyzed the expression state of eIF4E, c-Myc, and MMP9 in 24 ...
Krell Jonathan - - 2013
Over recent years there have been major advances in our understanding of tumour biology which have led to improved diagnostic and prognostic techniques and the development of novel targeted therapies. However the reliability of such biomarkers is questionable and the efficacy of new treatments remains predominantly limited by a combination ...
Westra Bonnie L BL Center for Nursing Informatics, School of Nursing, University of Minnesota, Minneapolis, MN 55434, USA. - - 2013
The purpose of this study was to describe the prevalence, incidence, and effectiveness of home health care (HHC) agencies' services with and without a WOC nurse related to wounds, incontinence, and urinary tract infection (UTI) patient outcomes. There were 449,243 episodes of care from a national convenience sample of 785 ...
Pilo-de-la-Fuente Belen - - 2013
Spontaneous intracranial hypotension (SIH) is a rare syndrome characterized by postural headache associated with a low cerebrospinal fluid pressure in the absence of dural puncture or penetrating trauma. Cranial magnetic resonance imaging (MRI) typically shows diffuse pachymeningeal gadolinium enhancement, subdural fluid collections, prominence of cerebral venous sinuses and brain descent. ...
Andress Miranda - - 2013
Military working dogs are often trained and/or worked in locations where the environment is rigorous and austere. Knowledge of training conditions, environmental risks, and appropriate treatment of environmental injuries is essential for the Veterinary Corps officer (VCO). As military practitioners, VCOs are potentially placed in situations where quickly recognizing environmental ...
Stewart Derek - - 2013
Objective To determine UK non-medical prescribers' (NMPs) (supplementary or independent) current participation and self-reported competence in pharmacovigilance, and their perceptions of training and future needs. Setting Non-medical prescribers in health care in the United Kingdom. Awareness of and participation in the Yellow Card Scheme (YCS); attitudes towards ADR reporting; strategies ...
Khelwatty Said Abdullah - - 2013
Colorectal cancer is one of the leading causes of cancer deaths. At present, anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) cetuximab and panitumumab and anti-vascular endothelial growth factor (VEGF) mAb bevacizumab have been incorporated into treatment paradigms for patients with refractory metastatic colorectal cancer. However, many patients simply do ...
Mont Michael A - - 2013
Cruciate-retaining total knee arthroplasty has had high success rates but does not always have optimal functional outcomes. The purpose of this study was to compare 2 polyethylene inserts of varying constraint that were used in a new cruciate-retaining total knee arthroplasty design to determine whether differences were found in clinical ...
Khatri Prateek J - - 2013
Transcatheter aortic valve implantation (TAVI) has emerged as an important treatment for patients with severe symptomatic aortic stenosis who are at high operative risk, but accurate estimates of serious adverse effects in contemporary practice are not available. To quantify the adverse effects associated with TAVI, and to evaluate whether the ...
Liu Danhui - - 2013
Aging is a multifactorial process during which physiological alterations occur in all tissues. A decline in mitochondrial function plays an important role in the process of aging and in aging-associated diseases. The mitochondrial genome encodes 13 essential subunits of protein complexes belonging to the oxidative phosphorylation system, while most of ...
Li Chunyi - - 2013
Deer antlers are the only mammalian organs that, once lost, can fully grow back; therefore, they offer a unique opportunity for investigating the mechanism underlying mammalian organ regeneration. This review summarizes the current knowledge of antler histogenesis. The axis of a pedicle (antecedent of antler) and a first antler consists ...
Peters Jorg - - 2013
Renin is known as a secretory glycoprotein produced, stored and released by the kidney. Renin cleaves angiotensin (ANG) I from angiotensinogen, which is further cleaved to ANG II by ANG-converting enzyme. ANG II acts via specific receptors located at the cell membrane. Recently renin transcripts have been discovered which encode ...
Kaplan Daniel L - - 2013
Motor proteins are enzymes that accomplish mechanical work in a wide variety of biological processes. In this review we focus on bulk and single molecule methods to study how motor proteins function. We discuss in detail the analysis of the motor protein DnaB, a hexameric helicase that unwinds DNA at ...
O'Connor Owen Joseph - - 2013
Ovarian cancer is responsible for the largest proportion of deaths among patients with gynecologic cancer. This paper discusses fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in the imaging of ovarian cancer. We discuss and demonstrate how FDG PET/CT can be used to appropriately guide clinical management decisions in patients with ovarian cancer. ...
Fujita Shuichi - - 2013
We aimed to investigate whether atrial natriuretic peptide (ANP) attenuates angiotensin II (Ang II)-induced myocardial remodeling and to clarify the possible molecular mechanisms involved. Thirty-five 8-week-old male Wistar-Kyoto rats were divided into control, Ang II, Ang II + ANP, and ANP groups. The Ang II and Ang II + ANP ...
Cline Curtis R - - 2013
Military working dogs are often trained and/or work in locations where the potential for snake bites is increased. Knowledge of the local venomous snakes, the effects of their venom, and appropriate initial stabilization is essential for the US Army Veterinary Corps officer (VCO). As military practitioners, VCOs are uniquely situated ...
Wang Siyuan - - 2013
Bacteria derive and maintain a variety of shapes that carry selective benefits. The shapes are usually defined by a mechanically stiff exoskeletal cell wall -- a macro-molecular network of peptidoglycan. The growth of such a network is catalyzed by transglycosylases and transpeptidases, and various cell-wall remodeling enzymes further digest and ...
Zhu Yonggang - - 2013
Microdroplets are widely used for industrial applications such as food, drug, biotechnology and new materials. This review will summarise the key development in microdrop technologies, especially double-emulsion droplet technologies, with a focus on microchip-based techniques. For completeness, the key topics in single emulsion droplets such as generation, control and application ...
Gryskiewicz Joe J University of Minnesota Academic Health Center, School of Dentistry Cleft Palate/Craniofacial Clinics, Minneapolis, Minnesota, USA. - - 2013
Dual-plane breast augmentation (DPBA) can be an effective technique for treating patients with ptotic breasts who fall somewhere in between the traditional requirements for breast augmentation versus a more extensive augmentation-mastopexy. The author outlines indications for DPBA, describes the technique, and presents outcomes data from patients receiving gel or saline ...
van der Meijden Olivier A - - 2013
The purpose of this study was to compare single-row (SR), extended double-row (DR), and augmented, extended double-row (aDR) rotator cuff repairs in a two-tendon, posterosuperior rotator cuff tear (RCT) model with intact rotator cuff tendons. RCTs were created and randomly assigned to SR, DR, or aDR repair (5 each) in ...
Palande Karishma - - 2013
Following activation by their cognate ligands, cytokine receptors undergo intracellular routing towards lysosomes where they are degraded. Cytokine receptor signaling does not terminate at the plasma membrane, but continues throughout the endocytotic pathway. The modes of internalization and intracellular trafficking of specific receptors, the level of recycling towards the plasma ...
Xin Lin - - 2013
In the last decade, phage-display technology for the generation of monoclonal antibodies (mAbs) has improved significantly. Several novel human mAbs directed to a wide range of targets have been generated for the treatment of common malignancies. These targets include antigens associated with apoptosis, angiogenesis and solid tumors, as well as ...
Jadey Snehal - - 2013
A primary target for nicotine is the acetylcholine receptor channel (AChR). Some of the ability of nicotine to activate differentially AChR subtypes has been traced to a transmitter-binding site amino acid that is glycine in lower affinity and lysine in higher affinity AChRs. We studied the effects of mutations of ...
Qin Zhaohui S - - 2013
Assembling a comprehensive catalog of all transcription factors (TFs) and the genes that they regulate (regulon) is important for understanding gene regulation. The sequence-specific conserved binding profiles of TFs can be characterized from whole genome sequences with phylogenetic approaches, and a large number of such profiles have been released. Effective ...
Gazzinelli-Guimarães Pedro Henrique - - 2013
While several mechanisms of immunoregulation have been demonstrated for hookworm and other neglected tropical infections, the influence of apoptosis in the immunomodulation of hookworm infection is still poorly understood. In this study, we demonstrate the cytotoxic and pro-apoptotic activity of hookworm antigens in Jurkat T cells, mesenteric lymph nodes lymphocytes of healthy ...
Hardy Lindsay B - - 2013
Context.-The immunohistochemistry (IHC) laboratory represents a dynamic area of surgical pathology with limited practice guidelines. Studies have shown significant interlaboratory variability in results. Objective.-To establish baseline parameters for IHC validation procedures and practice, and to assess their feasibility of implementation. Design.-In September 2010, a questionnaire was distributed by the College ...
Vitulano Nicola - - 2013
Obstructive sleep apnea syndrome (OSAS) is a highly prevalent disorder. Important risk factors for this disease are represented by obesity, male gender, smoking, some endocrinological disturbances, alcohol intake, use of benzodiazepines, and craniofacial alterations. It is well known that OSAS is a frequent comorbidity as well as a relevant risk ...
Rego-Perez Ignacio - - 2013
The genetic contribution is one of the most notable factors that play a main role in the risk of OA. Despite the genetics of this disease is complex and the finding of risk-related genes has been very challenging, evidence for genetic predisposition has been reported. Besides, in the last years ...
MacLean James A JA - - 2013
Homeobox genes encode transcription factors that have well-established roles in embryonic development. We recently discovered the Rhox genes, a new family of homeobox genes, which are selectively expressed in the developing embryo, postnatal and adult gonads, and accessory tissues associated with mammalian reproduction. The largest and best-characterized Rhox cluster is found in mouse. However, ...
French Keisha L - - 2013
EDUCATIONAL OBJECTIVESAs a result of reading this article, physicians should be able to:1.Diagnose spinal epidural hematoma and spinal epidural abscess.2.Outline the most common neurological deficits that occur from a spinal epidural hematoma or spinal epidural abscess.3.Identify indications for a good or poor prognosis.4.Minimize adverse outcomes for the provider. Spinal epidural ...
Zimmerman Gregory M - - 2013
Secondary exposure to community violence is particularly detrimental for male youths, who disproportionately report witnessing community violence and suffering associated trauma-related symptoms. Yet, few studies have investigated whether parents perceive and report similar gender disparities among youths. In addition, few studies have examined the potentially negative effects of parent-child discord ...
Batchelder Abigail W - - 2013
Increased antiretroviral availability has decreased mortality and increased rates of comorbid chronic illnesses, including type 2 diabetes, among people living with HIV. Little work has compared within-person adherence rates for HIV and comorbid conditions. Sixty-two adults with HIV and type 2 diabetes reported adherence rates, illness representations, beliefs about medications, ...
Gunson Darryl - - 2013
The literature concerning the possibility and desirability of using new pharmacological and possible future genetic techniques to enhance human characteristics is well-established and the debates follow some well-known argumentative patterns. However, one argument in particular stands out and demands attention. This is the attempt to tie the moral necessity of ...
Zhang Lei - - 2013
Abnormal migration of retinal pigment epithelium (RPE) contributes to a variety of disorders such as proliferative vitreoretinopathy. Here, the effect of epidermal growth factor (EGF), and signaling by its receptor (ERGR)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) on RPE cell migration was studied. The in vitro wound healing and migration of the human ...
Faust James J - - 2013
Molecular scaffolds in the mammalian egg are capable of tethering specific proteins involved in regulation of early development. Scaffolds can take the form of cytoskeletal elements, or involve proteins such as MARCKs or RACKSs during important cellular transitions in the egg. Moreover, with each cellular transition (i.e. germinal vesicle breakdown, ...
Wildgoose Petra - - 2013
With the increasing popularity of cosmetic surgery procedures, preoperative psychological assessment of cosmetic surgery patients may improve outcomes by highlighting patient expectations and motivations, as well as by identifying those who may require psychological referral. In this article, the authors describe a systematic literature review to identify and evaluate current ...
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