Search Results
Results 701 - 750 of 1606
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May Joshua S - - 2012
Research has consistently revealed that measures of psychopathy and psychopathic personality traits represent some of the most consistent predictors of violent criminal involvement. As a result, there has been a considerable amount of interest in trying to identify the various etiological factors related to psychopathy. The current study builds on ...
Kuykendal A R AR Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Physicians Office Bldg, 170 Manning Drive, CB 7305, Chapel Hill, NC 27599-7305, USA. - - 2013
Background Androgen deprivation therapy (ADT) in localized prostate cancer improves overall survival and is recommended by National Comprehensive Cancer Network guidelines in certain situations. However, ADT is without benefit in other situations and can actually cause harm. This study examines recent trends in the ADT use and quantifies the cost ...
Schulz Joerg - - 2012
Background:An inverse relationship between risk of schizophrenia and premorbid IQ is a robust empirical finding. Cognitive impairment may be a core feature of schizophrenia in addition to the clinical symptoms that have historically defined the disorder. Aims:To evaluate whether risk of schizophrenia increases linearly or nonlinearly with the lowering of ...
Balakumar Balasubramanian - - 2012
Paediatric femur fractures are managed with the titanium elastic nail system (TENS) in the 5-16-year age group. TENS is costly and not easily available in public hospitals. This study compares TENS nailing with stainless-steel Ender's nail fixation of paediatric femur fractures. A retrospective analysis of patient records from 2006 to ...
Méndez Juan Pablo - - 2012
OBJECTIVE: Obesity and osteoporosis are two important public health problems that greatly impact mortality and morbidity. Several similarities between these complex diseases have been identified. The aim of this study was to analyze if different body mass indexes (BMIs) are associated with variations in bone mineral density (BMD) among postmenopausal ...
Fladvad Torill - - 2012
OBJECTIVE: The objective of the present study was to determine whether genetic variability in UDP-glucuronosyltransferase (UGT) genes, together with clinical factors, contribute to variability in morphine glucuronide (M6G and M3G) to morphine serum concentration ratios in patients with advanced cancer receiving chronic morphine therapy. MATERIALS AND METHODS: A total of ...
Aksoy Cemalettin - - 2012
The Dega acetabuloplasty is considered to be safe and effective in the treatment of hip pathologies, but the number of clinical follow-up series in the literature is not sufficient. The aim of our study was to identify the alterations in acetabular development in 35 patients (43 hips) with developmental dysplasia ...
Drakulich Kevin M - - 2012
While substantial research attention has been paid to the disproportionately high levels of fear of crime among women relative to men, less attention has been paid to the apparent mirror of this: that men have disproportionately more concern for female partners than women do for male partners. The work that ...
Barry Janie - - 2012
High-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS) can be used to measure metal ion levels in whole blood, although the accuracy and repeatability of this method is not yet known in the clinical setting. In this study, chromium, cobalt and titanium ion levels were measured in three whole blood samples, ...
Scott Katreena - - 2012
In batterer intervention programs, there are conflicting recommendations about best practices for responding to client dropout. Risk management philosophies emphasize the importance of swift and sure sanctions for failure to comply with program attendance requirements. In contrast, change theory emphasizes the importance of providing clients with multiple opportunities to engage ...
Biasiotto Giorgio - - 2012
The aim of this paper was to describe the optimized labeling protocol and quality control measures used in the production of [Y]DOTATOC, starting from three different radioactivity levels to treat one, two, or three patients per therapeutic session. We investigated three different starting radioactivity levels. For the low radioactivity preparation ...
Salgado Teresa M - - 2012
BackgroundImplementation of pharmacy services in dialysis centers seems to be limited and requires acceptance from nephrologists. The aim of this study was to explore the opinions of Australian and Portuguese nephrologists toward a potential future provision of clinical pharmacy services in outpatient dialysis centers.MethodsA qualitative study using semistructured interviews was ...
Buerki Sven S Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3DS, UK. - - 2013
Tecophilaeaceae (27 species distributed in eight genera) have a disjunct distribution in California, Chile and southern and tropical mainland Africa. Moreover, although the family mainly occurs in arid ecosystems, it has colonized three Mediterranean-type ecosystems. In this study, the spatio-temporal history of the family is examined using DNA sequence data ...
Falluji Nezar - - 2012
Some patients with peripheral arterial disease may present with critical limb ischemia, a condition associated with high rates of morbidity and mortality. Early diagnosis and effective medical therapy and revascularization are indicated to avoid amputation and reduce mortality. Ideally, a multidisciplinary approach with collaboration between endovascular interventionist, vascular surgeons, podiatrist, ...
Wang Shengjun - - 2012
PURPOSE: The aim of this study was to determine whether recurrence of meningiomas could be reduced by combining somatostatin receptor scintigraphy (SRS) of Tc-HYNIC-octreotide SPECT/CT and radio guidance with a hand-held γ-probe during surgery. MATERIALS AND METHODS: Thirty patients with meningiomas diagnosed by MRI and considered as the study group ...
O'Mahoney Eoin - - 2012
AIM: The aim of our study was to assess improvements in spatial resolution and noise control from the application of the Astonish resolution recovery algorithm for single photon emission computed tomography imaging. Secondary aims were to compare acquisitions made with low-energy general purpose collimators with those obtained using low-energy high-resolution ...
Neubauer Hans - - 2012
OBJECTIVE: Clinical trials have demonstrated an increased risk of breast cancer during estrogen/norethisterone (NET) therapy. With this in mind, the effects of estrogen/NET combination on the proliferation of breast cancer cells overexpressing the progesterone receptor membrane component 1 (PGRMC1) were examined. The same combination was used for the first time ...
Shi Jian J Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, - - 2013
Small heat shock proteins (sHSPs) are ubiquitous chaperones that bind and sequester non-native proteins preventing their aggregation. Despite extensive studies of sHSPs chaperone activity, the location of the bound substrate within the sHSP oligomer has not been determined. In this paper, we used cryoelectron microscopy (cryoEM) to visualize destabilized mutants ...
Toh Soo Ting - - 2012
Chronic Hepatitis B Virus (HBV) infection is epidemiologically associated with hepatocellular-carcinoma (HCC) but its role in HCC remains poorly understood due to technological limitations. Here, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC patients using an oligo-bead-based strategy, pooled together and sequenced using the ...
Urban Marian M Department of Cardiac Surgery, Institute for Clinical and Experimental Medicine, Videnska, Prague, Czech Republic. - - 2013
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: is extracorporeal membrane oxygenation (ECMO) superior to dedicated ventricular assist device (VAD) in patients with acutely failing allograft following transplantation. Altogether, 162 papers were found using the reported search, of which 8 ...
Sehrawat Anuradha A Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, - - 2013
We showed previously that breast cancer chemoprevention with benzyl isothiocyanate (BITC) in MMTV-neu mice was associated with induction of E-cadherin protein in vivo. Loss of E-cadherin expression and induction of mesenchymal markers (e.g. vimentin) are biochemical hallmarks of epithelial-mesenchymal transition (EMT), a developmental process implicated in progression of cancer to ...
Bracke Frank A - - 2012
AIMS: The femoral approach for lead extraction is typically used as a bailout procedure. We describe the results of a femoral approach with a Needle's Eye Snare and Femoral Workstation as a primary tool for extracting pacing leads.PATIENTS AND METHODS AND RESULTS: Four hundred and seventy-six pacing leads implanted for ...
Suchankova Petra - - 2012
OBJECTIVES: Numerous studies have shown associations between an on-going depression and elevated serum levels of the acute-phase reactant C-reactive protein (CRP). Also, in suicidal behaviour, a proinflammatory state has been suggested to be of importance for the pathophysiology. There is a genetic susceptibility to suicidal behaviour, but studies with respect ...
Zhang Luoping L Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, - - 2013
Trichloroethylene (TCE) has been associated with a variety of immunotoxic effects and may be associated with an increased risk of non-Hodgkin lymphoma (NHL). Altered serum immunoglobulin (Ig) levels have been reported in NHL patients and in animals exposed to TCE. Recently, we reported that occupational exposure to TCE is associated ...
Ståhlberg Marcus - - 2012
AIMS: The impact of different basic paced heart rates (pHRs) in patients receiving cardiac resynchronization therapy (CRT) remains largely unknown. The aim of the present study was to investigate the haemodynamic effects of different pHRs (60 or 80 b.p.m.), using an implanted haemodynamic monitor (IHM), during a 2-week period in ...
Graffam Joseph - - 2012
Recidivism outcomes were examined over a 2-year postrelease period for participants of an Australian employment assistance program. The voluntary 12-month program operated from 17 Victorian correctional locations, 7 prisons, and 10 community corrections locations, targeting participants at moderate to high risk of reoffending. Recidivism outcomes included simple rates of reoffending ...
Yoshioka H - - 2012
BackgroundA phase III study (Lung Cancer Evaluation of TS-1) previously demonstrated noninferiority in terms of overall survival (OS) at interim analysis for carboplatin-S-1 compared with carboplatin-paclitaxel for first-line treatment of advanced non-small-cell lung cancer (NSCLC).Patients and methodsA total of 564 patients were randomly assigned to receive either carboplatin on day ...
Sorte Hanne S - - 2012
OBJECTIVES: Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopment disorders with a complex genetic aetiology. The aim of this study was to identify copy number variations (CNVs) with a clinical significance for ASD. MATERIALS AND METHODS: Array-based comparative genomic hybridization was applied to detect CNVs in a clinically ...
Toma Claudio - - 2012
Impairment of language abilities is a common feature in autistic individuals. Heterozygous mutations in the Forkhead Box P2 (FOXP2) gene lead to a severe spoken language disorder. Recently, several studies have pinpointed the involvement of common variants of the Contactin-Associated Protein-Like 2 (CNTNAP2) gene, whose transcription is regulated by the ...
Haig David D Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA. - - 2013
A moss sporophyte inherits a haploid set of genes from the maternal gametophyte to which it is attached and another haploid set of genes from a paternal gametophyte. Evolutionary conflict is expected between genes of maternal and paternal origin that will be expressed as adaptations of sporophytes to extract additional ...
Xu Huiqin - - 2012
OBJECTIVE: We studied the radiosensitizing effect of irisquinone on a VX2 lung transplant tumor model during three-dimensional radiotherapy using fluorine-18-deoxyglucose (F-FDG) PET/computed tomography (PET/CT). MATERIALS AND METHODS: Thirty VX2 tumor-bearing rabbits were randomized into three groups: the radiotherapy group, the irisquinone+radiotherapy group, and the control group, each comprising 10 rabbits. ...
Wang Qi - - 2012
The GTPase-activating protein RLIP76 is overexpressed in many malignant tumor cells, but it is unclear if RLIP76 overexpression contributes to the high proliferative potential of glioma cells. We demonstrate that RLIP76 mRNA and protein expression are positively correlated with glioma grade and that higher RLIP76 expression correlates with shorter patient ...
Zhou Yiming Y Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, - - 2013
We report the case of a 35-year old woman with a giant thymic carcinoid of the left hemithorax. Enhanced computed tomography showed marked vascularization of the tumour, with an enlarged drainage vein. Endovascular embolization of the major feeding arteries of the tumour was performed preoperatively with good angiographic results. A ...
Salmane-Kulikovska Ieva - - 2012
Recent studies suggest that a number of common cold medicines, including nasal decongestants are not suitable for small children. In Latvia nasal decongestants are primarily over-the-counter (OTC) medicines, and patient information leaflets generally permit use of these medicines for small children. The previous studies in Latvia investigating the use of ...
Tamaki Kentaro - - 2012
BACKGROUND: We retrospectively examined the clinical outcome of irradiated versus non-irradiated groups of Japanese breast cancer patients according to their clinical and histopathological characteristics following breast-conserving therapy. METHODS: We retrospectively evaluated a total of 1197 Japanese female breast cancer patients (598 irradiated and 599 non-irradiated) who received breast-conserving therapy. The ...
Wagner Thomas - - 2012
Sentinel node lymphoscintigraphy and biopsy has become standard practice for lymphatic staging in early-stage breast cancer and melanoma. More recently, sentinel node lymphoscintigraphy has also been used in head and neck squamous cell cancers and other solid tumours. Single photon emission computed tomography/computed tomography (SPECT/CT) is a new tool and ...
Xu Chun - - 2012
Altered intracellular calcium homeostasis and oxidative stress are involved in the pathophysiology of bipolar disorder (BD)-I. To explore the genes contributing to these abnormalities, we examined the association with BD of the iPLA2β (PLA2G6), a signaling enzyme that mobilizes the arachidonic acid signaling cascade and activates oxidative stress, and assessed ...
Shafin Nazlahshaniza - - 2012
OBJECTIVE: The aim of this study was to examine the association between changes in blood oxidative stress level/activity and changes in memory performance among postmenopausal women. METHODS: This study involved 39 postmenopausal women who received estrogen-progestin therapy (EPT) for 16 weeks. Verbal learning and memory performance were assessed using the ...
Fernández-Montero José Vicente - - 2012
BACKGROUND:: Liver disease is currently one of the leading causes of death in HIV individuals. Hepatic fibrosis largely mediates this effect and infection with hepatitis C virus (HCV) is the most common aetiology. Few studies have examined so far the predictive value of liver fibrosis staging on mortality and liver ...
Amankwah Ernest K EK Department of Cancer Epidemiology & Genetics, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA. - - 2013
The human SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex plays essential roles in a variety of cellular processes and has been implicated in human cancer. However, the role of germline genetic variants in this complex in relation to cancer risk is not well studied. We assessed the association of 16 variants ...
Gitterman Benjamin - - 2012
PURPOSE OF REVIEW: Sinus disease impacts millions of Americans every year, with significant associated costs on the healthcare system. Primary care physicians (PCPs) are at the frontline of treatment for patients with sinus disease. Patients would be well served by improved collaboration between PCPs and consulting otolaryngologists. RECENT FINDINGS: Recent ...
Feng Li-Li - - 2013
In the present study, we aimed to investigate the immunosuppressive activity of vaticaffinol, a resveratrol tetramer isolated from Vatica mangachapoi, on T lymphocytes both in vitro and in vivo, and further explored its potential molecular mechanism. Resveratrol had a wide spectrum of healthy beneficial effects with multiple targets. Interestingly, its ...
Jansson James - - 2012
OBJECTIVE:: Combination antiretroviral therapy (cART) has greatly improved the life expectancy of people living with HIV (PLHIV). Our study aims to project the life expectancy of PLHIV in a resource-rich setting in the context of the currently available antiretroviral treatments. METHODS:: Patient antiretroviral treatment data were sourced from an observational ...
Barrett Angela A Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London WC1E 6JJ, United Kingdom. - - 2013
p130Cas/breast cancer anti-oestrogen resistance 1 (BCAR1) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which have emerged as key signalling nodes capable of interactions with multiple proteins, with important regulatory roles in normal and pathological cell function. The Cas family of proteins is characterised by the ...
Rice Brian - - 2012
OBJECTIVES:: To calculate annual tuberculosis incidence rates, and investigate risk factors for tuberculosis, among heterosexual adults living with diagnosed HIV in England and Wales. DESIGN:: Analyses of comprehensive national records of persons seen for HIV care between 2002 and 2010 linked to the national tuberculosis database (1999 to 2010) for ...
Gupta Mihir M Stanford University School of Medicine, Stanford, CA, - - 2013
We assessed the relation of inflammatory and coagulation biomarkers with electrocardiographic (ECG) evidence of myocardial ischemia. High-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and D-dimer levels were measured at study entry for 3,085 human immunodeficiency virus-infected participants (mean age 44 years; 26.4% women; 24.6% black) in the Strategies for Management of ...
Perez-Patrigeon Santiago - - 2012
Th1-polarization is promoted by T-bet that has been shown to be increased in the CD8+ T cells of HIV Controller patients. Here we demonstrate that the CD4+ T cells of Controllers also show very significantly increased T-bet expression compared to those of healthy donors and HAART patients. A strong negative ...
McIntyre Lynn L Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, AB, Canada T2N 4Z6. - - 2013
Child hunger represents an adverse experience that could contribute to mental health problems in later life. The objectives of this study were to: (1) examine the long-term effects of the reported experience of child hunger on late adolescence and young adult mental health outcomes; and (2) model the independent contribution ...
Blashill Aaron J AJ Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA. - - 2013
The aim of the current study was to assess psychosocial correlates (i.e., perceived weight, weight control strategies, substance use, and victimization) of frequent indoor tanning in adolescent boys-a group at high risk for developing skin cancer. Participants (N=7,907) were drawn from a nationally representative sample of adolescent boys attending high ...
Sirera Guillem - - 2012
AIMS:: To assess the effectiveness and safety of infrared coagulation (IRC) for the ablation of anal intraepithelial neoplasia (AIN) and to provide data on the prevalence of AIN in HIV-infected patients. PATIENTS AND METHODS:: We performed a single-center, retrospective cohort study based on data collected from a prospectively compiled database ...
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