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Magnuson Elizabeth A EA Saint Luke's Mid America Heart Institute, Kansas City, MO 64111, - - 2013
Studies from the balloon angioplasty and bare metal stent eras have demonstrated that coronary artery bypass grafting (CABG) is cost-effective compared with percutaneous coronary intervention (PCI) for patients undergoing multivessel coronary revascularization-particularly among patients with complex coronary artery disease or diabetes mellitus. Whether these results apply in the drug-eluting stent ...
Osada Hiroaki H Department of Cardiovascular Surgery, Mitsubishi Kyoto Hospital, Kyoto, Japan. - - 2013
Extensive clinicopathological analyses of aortic dissection have implicated hypertension and genetic abnormalities as the major pathogenic mechanisms. However, previous findings from pathological examinations have often been inconsistent with these mechanisms. In this paper, we suggest a significant role for the vasa vasorum in the aetiology and pathogenesis of aortic dissection. ...
Brackenbury William J WJ Department of Pharmacology and Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, - - 2013
Voltage-gated Na(+) channel (VGSC) β1 subunits, encoded by SCN1B, are multifunctional channel modulators and cell adhesion molecules (CAMs). Mutations in SCN1B are associated with the genetic epilepsy with febrile seizures plus (GEFS+) spectrum disorders in humans, and Scn1b-null mice display severe spontaneous seizures and ataxia from postnatal day (P)10. The ...
Limesand Sean W SW Dept. of Animal Sciences, Univ. of Arizona, 1650 E. Limberlost Dr., Tucson, AZ 85719, USA. - - 2013
In pregnancy complicated by placental insufficiency (PI) and intrauterine growth restriction (IUGR), the fetus near term has reduced basal and glucose-stimulated insulin concentrations and reduced β-cell mass. To determine whether suppression of insulin concentrations and β-cell mass precedes reductions in fetal weight, which would implicate insulin deficiency as a cause ...
Foster Shannon M SM Department of Psychology, University of Colorado at Colorado Springs, Colorado Springs, CO 80918, - - 2013
Older adults have been shown to exhibit a positivity effect in processing of emotional stimuli, seemingly focusing more on positive than negative information. Whether this reflects purposeful changes or an unintended side effect of declining cognitive abilities is unclear. For the present study, older adults displaying a wide range of ...
Gordon Leamarie T LT Department of Psychology, Tufts University, Medford, MA 02155, USA. - - 2013
Across three experiments, we examined the effect of repetition lag on priming of unfamiliar visual objects in healthy young and older adults. Multiple levels of lag were examined, ranging from short (one to four intervening stimuli) to long (50 + intervening stimuli). In each experiment, subjects viewed a series of ...
Swarup Shilpa S Department of Genetics, WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695-7614, - - 2013
Understanding the relationship between genetic variation and phenotypic variation for quantitative traits is necessary for predicting responses to natural and artificial selection and disease risk in human populations, but is challenging because of large sample sizes required to detect and validate loci with small effects. Here, we used the inbred, ...
Kantomaa Marko T MT LIKES-Research Center for Sport and Health Sciences, FI-40720 Jyväskylä, Finland. - - 2013
The global epidemic of obesity and physical inactivity may have detrimental implications for young people's cognitive function and academic achievement. This prospective study investigated whether childhood motor function predicts later academic achievement via physical activity, fitness, and obesity. The study sample included 8,061 children from the Northern Finland Birth Cohort ...
Ward Katherine E KE Department of Chemistry and Biochemistry and the Mike and Josie Harper Center for Cancer Research, University of Notre Dame, Notre Dame, IN, - - 2013
Group IVA cytosolic phospholipase A₂ (cPLA₂α), which harbors an N-terminal lipid binding C2 domain and a C-terminal lipase domain, produces arachidonic acid from the sn-2 position of zwitterionic lipids such as phosphatidylcholine. The C2 domain has been shown to bind zwitterionic lipids, but more recently, the anionic phosphomonoester sphingolipid metabolite ...
Bao Rui R Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, - - 2013
The pH 6 antigen (Psa) of Yersinia pestis consists of fimbriae that bind to two receptors: β1-linked galactosyl residues in glycosphingolipids and the phosphocholine group in phospholipids. Despite the ubiquitous presence of either moiety on the surface of many mammalian cells, Y. pestis appears to prefer interacting with certain types ...
Zhang Qibin Q Biological Sciences Division and the 2 Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA. - - 2013
Using global liquid chromatography-mass spectrometry (LC-MS)-based proteomics analyses, we identified 24 serum proteins that were significantly variant between those with type 1 diabetes (T1D) and healthy controls. Functionally, these proteins represent innate immune responses, the activation cascade of complement, inflammatory responses, and blood coagulation. Targeted verification analyses were performed on ...
Zebrowitz Leslie A LA Department of Psychology, Brandeis University, Waltham, MA 02454, USA. - - 2013
People readily form first impressions from faces, with consensual judgments that have significant social consequences. Similar impressions are shown by children, young adults (YA), and people from diverse cultures. However, this is the first study to systematically investigate older adults' (OA) impressions. OA and YA showed similar levels of within-age ...
Tanwar Pradeep S PS Vincent Center for Reproductive Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, - - 2013
Epithelial ovarian cancer is a heterogeneous disease that is subdivided into five major histotypes but the mechanisms driving their differentiation are not clear. Mutations in adenomatous polyposis coli (APC) and β-catenin are commonly observed in the human ovarian endometrioid adenocarcinoma (OEA) patients. However, the mechanisms subsequent to APC deletion in ...
Bullwinkle Tammy J TJ Department of Microbiology, Ohio State University, Columbus, Ohio 43210, - - 2013
Post-translational modification of bacterial elongation factor P (EF-P) with (R)-β-lysine at a conserved lysine residue activates the protein in vivo and increases puromycin reactivity of the ribosome in vitro. The additional hydroxylation of EF-P at the same lysine residue by the YfcM protein has also recently been described. The roles ...
Stendell-Hollis Nicole R NR Nutritional Sciences Department, University of Arizona, Tucson, Arizona, USA. - - 2013
Of postpartum women, 15%-20% retain ≥ 5 kg of their gestational weight gain, increasing risk for adult weight gain. Postpartum women are also in a persistent elevated inflammatory state. Both factors could increase the risk of obesity-related chronic disease. We hypothesized that breastfeeding women randomized to a Mediterranean-style (MED) diet ...
Heidel Florian H FH Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, - - 2013
A unique characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSCs and potentially also in leukemia stem cells. Recently, studies have shed light on developmental molecules and evolutionarily conserved signals as regulators of ...
Mertz Aaron F AF Department of Physics, Yale University, New Haven, CT 06520, - - 2013
Cell-cell and cell-matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of cross talk between these two adhesion types, yet little is known about the impact of these interactions on the mechanical coupling of cells to the extracellular matrix (ECM). Here, we ...
Zhuang Tiandi T Department of Biochemistry, Center for Structural Biology, Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, - - 2013
Solution NMR spectroscopy of labeled arrestin-1 was used to explore its interactions with dark-state phosphorylated rhodopsin (P-Rh), phosphorylated opsin (P-opsin), unphosphorylated light-activated rhodopsin (Rh*), and phosphorylated light-activated rhodopsin (P-Rh*). Distinct sets of arrestin-1 elements were seen to be engaged by Rh* and inactive P-Rh, which induced conformational changes that differed ...
Weeks Margaret R MR Institute for Community Research, Hartford, Connecticut, USA. - - 2013
The female condom (FC), an effective barrier method for HIV/sexually transmitted infection (STI) prevention, continues to be absent from most community settings, including reproductive health and treatment clinics. Reducing or eliminating basic barriers, including lack of awareness, knowledge of proper use, and access to free samples, may significantly increase use ...
Legant Wesley R WR Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, - - 2013
Recent methods have revealed that cells on planar substrates exert both shear (in-plane) and normal (out-of-plane) tractions against the extracellular matrix (ECM). However, the location and origin of the normal tractions with respect to the adhesive and cytoskeletal elements of cells have not been elucidated. We developed a high-spatiotemporal-resolution, multidimensional ...
Zhang Qin Q Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-2175, - - 2013
The oncogenic transcription factor c-Myc causes transformation and tumorigenesis, but it can also induce apoptotic cell death. Although tumor suppressors are necessary for c-Myc to induce apoptosis, the pathways and mechanisms are unclear. To further understand how c-Myc switches from an oncogenic protein to an apoptotic protein, we examined the ...
Kushner Matt G MG Department of Psychiary, University of Minnesota, MN 55454, USA. - - 2013
Treatment for alcohol use disorder (AUD) is far less effective for those with a co-occurring anxiety disorder. Surprisingly, adding an independent anxiety treatment to AUD treatment does not substantially improve the poor alcohol outcomes of these patients. This may reflect the lack of attention from independent treatments to the dynamic ...
Northey Jason J JJ Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A3, - - 2013
The ErbB2 and TGFβ signaling pathways cooperate to promote the migratory, invasive, and metastatic behavior of breast cancer cells. We previously demonstrated that ShcA is necessary for these synergistic interactions. Through a structure/function approach, we now show that the phosphotyrosine-binding, but not the Src homology 2, domain of ShcA is ...
Peng Jing J Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, - - 2013
Although estrogen and the enzymes responsible for its metabolism have been detected within the lung, the ability of this tissue to metabolize estrogen has not been demonstrated previously. The goal of this study was to characterize the profile of estrogen metabolites within the murine lung and to determine the effect ...
Tran Hoanh H Department of Cancer Targets, Genentech Inc., South San Francisco, California 94080, USA. - - 2013
The adenomatous polyposis coli (APC) protein functions as a negative regulator of the Wnt signaling pathway. In this capacity, APC forms a "destruction complex" with Axin, CK1α, and GSK3β to foster phosphorylation of the Wnt effector β-catenin earmarking it for Lys-48-linked polyubiquitylation and proteasomal degradation. APC is conjugated with Lys-63-linked ...
Rodriguez Pamela C PC Department of Chemistry, Columbia University, New York, NY 10027, - - 2013
We recently introduced fluorescent false neurotransmitters (FFNs) as optical tracers that enable the visualization of neurotransmitter release at individual presynaptic terminals. Here, we describe a pH-responsive FFN probe, FFN102, which as a polar dopamine transporter substrate selectively labels dopamine cell bodies and dendrites in ventral midbrain and dopaminergic synaptic terminals ...
Shallcross Amanda J AJ Department of Psychology, University of Denver, - - 2013
Although aging involves cognitive and physical declines, it is also associated with improved emotional well-being, particularly lower negative affect. However, the relationship between age and global negative affect, versus discrete negative emotions, and the pathways that link age to lower negative affect are not well understood. We hypothesize that 1 ...
Wakamatsu Ei E Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, - - 2013
Costimulatory molecules of the CD28 family on T lymphocytes integrate cues from innate immune system sensors and modulate activation responses in conventional CD4(+) T cells (Tconv) and their FoxP3(+) regulatory counterparts (Treg). To better understand how costimulatory and coinhibitory signals might be integrated, we profiled the changes in gene expression ...
Desmarais Sarah L SL Department of Psychology, North Carolina State - - 2013
Identifying substance use disorders among adults with schizophrenia presents unique challenges but is critical to research and practice. This study examined: (a) the accuracy of assessments completed using various approaches in identifying substance use disorders, (b) their ability to discriminate between disorders of abuse and dependence, and (c) the benefits ...
Fang Lin L University of Toronto, Factor-Inwentash Faculty of Social - - 2013
Asian Americans have been largely ignored in the prevention outcome literature. In this study, we tested a parent-child program with a sample of Asian American adolescent girls and their mothers, and evaluated the program's efficacy on decreasing girls' substance use and modifying risk and protective factors at individual, family, and ...
Mrug Sylvie S Department of - - 2013
This study examined age, gender, and racial differences in parental and peer disapproval of alcohol use and in the relationship of these injunctive norms with drinking during adolescence. Participants included 20,239 students ages 11-19 years (average age 14.34; 47% boys; 46% White and 54% Black) from 2 large urban and ...
Pearson Matthew R MR Department of Psychology, Old Dominion - - 2013
Much research links impulsivity with alcohol use and problems. In 2 studies, unplanned (or impulsive) drinking is assessed directly to determine whether it has direct effects on alcohol use and alcohol-related problems. In Study 1, we examined whether unplanned drinking serves as a proximal mediator of the effects of impulsivity-like ...
Arterberry Brooke J BJ Department of Educational, School, and Counseling Psychology, University of - - 2013
The purpose of the present study was to examine cognitive risk factors for driving after use of marijuana. We tested whether marijuana outcome expectancies and specific cognitions about driving after marijuana use were uniquely associated with the likelihood and frequency of driving while high (DWH) and riding with a high ...
Horton Karissa D KD Department of Kinesiology and Health - - 2013
Depressive symptoms are associated with increased levels of cigarette smoking, yet not every individual experiencing depressive symptoms smokes. This study examined whether religious coping moderated the impact of depressive symptoms on past 30-day cigarette use among a racially/ethnically diverse sample of 963 postsecondary vocational students (46.8% women; mean age = ...
Tzelepis Fanny F National Research Council of Canada, Institute for Biological Sciences, Ottawa, Ontario K1A 0R6, - - 2013
CD8(+) T cells undergo rapid expansion during infection with intracellular pathogens, which is followed by swift and massive culling of primed CD8(+) T cells. The mechanisms that govern the massive contraction and maintenance of primed CD8(+) T cells are not clear. We show in this study that the transcription factor, ...
Stathopoulos Vassilios V Department of Statistical Science, Centre for Computational Statistics and Machine Learning, University College London, Gower Street, London WC1E 6BT, - - 2013
Bayesian analysis for Markov jump processes (MJPs) is a non-trivial and challenging problem. Although exact inference is theoretically possible, it is computationally demanding, thus its applicability is limited to a small class of problems. In this paper, we describe the application of Riemann manifold Markov chain Monte Carlo (MCMC) methods ...
Selvakumar Balakrishnan B Solomon H Snyder Department of Neuroscience and Departments of Psychiatry and Behavioral Sciences, Pharmacology and Molecular Sciences, and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, - - 2013
NMDA receptor activation can elicit synaptic plasticity by augmenting conductance of the AMPA receptor GluA1 subsequent to phosphorylation at S831 by Ca(2+)-dependent kinases. NMDA receptor activation also regulates synaptic plasticity by causing endocytosis of AMPA receptor GluA1. We demonstrate a unique signaling cascade for these processes mediated by NMDA receptor-dependent ...
Cohen Philip P MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, United Kingdom. - - 2013
Over the past 15 years protein kinases have become the pharmaceutical industry's most important class of drug target in the field of cancer. Some 20 drugs that target kinases have been approved for clinical use over the past decade, and hundreds more are undergoing clinical trials. However, the recent approval ...
Kuerbis Alexis A Department of Mental Health Policy and Services Research, Research Foundation for Mental Hygiene, - - 2013
Despite ample research demonstrating the role of motivation and self-efficacy in predicting drinking in the context of abstinence, little research explicitly explores their role in the context of moderation, and none have utilized daily diary methods. The purpose of this study was to (a) explore the concordance between global self-report ...
Levitt Ash A Research Institute on Addictions, University at Buffalo, - - 2013
Previous research has suggested that individuals in romantic relationships hold beliefs about the effects of relationship-drinking contexts (e.g., drinking with one's partner) on later relationship functioning, as well as the effects of relationship functioning on later relationship-drinking contexts, and that these reciprocal effects may be stronger among women compared with ...
Toffol Elena - - 2012
OBJECTIVE: A proportion of women experience depressive and anxiety symptoms and/or disorders in connection with the menopausal transition. Estrogen-only therapy has been reported to have beneficial effects on mental health, but the effects of combined hormone therapy (HT) on mental health are less clear. We studied the associations between HT ...
Xu Huiqin - - 2012
OBJECTIVE: We studied the radiosensitizing effect of irisquinone on a VX2 lung transplant tumor model during three-dimensional radiotherapy using fluorine-18-deoxyglucose (F-FDG) PET/computed tomography (PET/CT). MATERIALS AND METHODS: Thirty VX2 tumor-bearing rabbits were randomized into three groups: the radiotherapy group, the irisquinone+radiotherapy group, and the control group, each comprising 10 rabbits. ...
Toh Soo Ting - - 2012
Chronic Hepatitis B Virus (HBV) infection is epidemiologically associated with hepatocellular-carcinoma (HCC) but its role in HCC remains poorly understood due to technological limitations. Here, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC patients using an oligo-bead-based strategy, pooled together and sequenced using the ...
Toma Claudio - - 2012
Impairment of language abilities is a common feature in autistic individuals. Heterozygous mutations in the Forkhead Box P2 (FOXP2) gene lead to a severe spoken language disorder. Recently, several studies have pinpointed the involvement of common variants of the Contactin-Associated Protein-Like 2 (CNTNAP2) gene, whose transcription is regulated by the ...
Sarafraz-Yazdi Ali - - 2012
An in situ derivatization and solid-phase microextraction (SPME) method based on sol-gel technology coupled with gas chromatography-flame ionization detection was proposed for the determination of mercury [Hg(ΙΙ)] at ultra-trace levels in water samples.The analytical procedure involves aqueous-phase derivatization of Hg(ΙΙ) with phenylboronic acid in a sample vial and subsequent extraction ...
Méndez Juan Pablo - - 2012
OBJECTIVE: Obesity and osteoporosis are two important public health problems that greatly impact mortality and morbidity. Several similarities between these complex diseases have been identified. The aim of this study was to analyze if different body mass indexes (BMIs) are associated with variations in bone mineral density (BMD) among postmenopausal ...
O'Mahoney Eoin - - 2012
AIM: The aim of our study was to assess improvements in spatial resolution and noise control from the application of the Astonish resolution recovery algorithm for single photon emission computed tomography imaging. Secondary aims were to compare acquisitions made with low-energy general purpose collimators with those obtained using low-energy high-resolution ...
Salmane-Kulikovska Ieva - - 2012
Recent studies suggest that a number of common cold medicines, including nasal decongestants are not suitable for small children. In Latvia nasal decongestants are primarily over-the-counter (OTC) medicines, and patient information leaflets generally permit use of these medicines for small children. The previous studies in Latvia investigating the use of ...
Tamaki Kentaro - - 2012
BACKGROUND: We retrospectively examined the clinical outcome of irradiated versus non-irradiated groups of Japanese breast cancer patients according to their clinical and histopathological characteristics following breast-conserving therapy. METHODS: We retrospectively evaluated a total of 1197 Japanese female breast cancer patients (598 irradiated and 599 non-irradiated) who received breast-conserving therapy. The ...
Graffam Joseph - - 2012
Recidivism outcomes were examined over a 2-year postrelease period for participants of an Australian employment assistance program. The voluntary 12-month program operated from 17 Victorian correctional locations, 7 prisons, and 10 community corrections locations, targeting participants at moderate to high risk of reoffending. Recidivism outcomes included simple rates of reoffending ...
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