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de Carvalho Luís Filipe Abreu - - 2013
Several studies have reported faster recoveries, lower pain scores, and superior cosmetic results after mini-laparoscopic cholecystectomy (MLC). The purpose of this study was to perform a randomized controlled trial, comparing MLC with conventional laparoscopic cholecystectomy (LC). Forty-one patients with symptomatic cholecystolithiasis were randomized between the two groups: 23 having undergone ...
Freund L B - - 2013
The phenomenon of thermal fluctuation of a biomembrane within a stack of like membranes was introduced in a pioneering paper [Helfrich W (1978) Z Naturforsch A 33(3):305-315]. Internal energy arises in a representative membrane through elastic resistance to bending deformation, and membrane motion is further restrained through steric interaction with ...
Tzelepis Fanny - - 2013
CD8(+) T cells undergo rapid expansion during infection with intracellular pathogens, which is followed by swift and massive culling of primed CD8(+) T cells. The mechanisms that govern the massive contraction and maintenance of primed CD8(+) T cells are not clear. We show in this study that the transcription factor, ...
Hirsch Heather A HA Department Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, - - 2013
Metformin, the first-line drug for treating diabetes, inhibits cellular transformation and selectively kills cancer stem cells in breast cancer cell lines. In a Src-inducible model of cellular transformation, metformin inhibits the earliest known step in the process, activation of the inflammatory transcription factor NF-κB. Metformin strongly delays cellular transformation in ...
Weeks Margaret R MR Institute for Community Research, Hartford, Connecticut, USA. - - 2013
The female condom (FC), an effective barrier method for HIV/sexually transmitted infection (STI) prevention, continues to be absent from most community settings, including reproductive health and treatment clinics. Reducing or eliminating basic barriers, including lack of awareness, knowledge of proper use, and access to free samples, may significantly increase use ...
Hayden Joshua A JA Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
Calprotectin (CP) is a transition metal-chelating antimicrobial protein of the calcium-binding S100 family that is produced and released by neutrophils. It inhibits the growth of various pathogenic microorganisms by sequestering the transition metal ions manganese and zinc. In this work, we investigate the manganese-binding properties of CP. We demonstrate that ...
Watson Kyle D KD Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556, - - 2013
Herein two new and concise synthetic approaches for making an unsaturated bicyclic oxamazin core are reported. The first involves the use of an intramolecular Diels-Alder reaction to form both of the fused rings in one step. The second approach incorporates ring-closing olefin metathesis in the final step to form the ...
Nakano Kazuhisa K Division of Rheumatology, Allergy and Immunology, University of California San Diego School of Medicine, La Jolla, CA 92093, - - 2013
Rheumatoid arthritis (RA) is a chronic inflammatory disease in which fibroblast-like synoviocytes (FLS) exhibit an aggressive phenotype. Although the mechanisms responsible are not well defined, epigenetic determinants such as DNA methylation might contribute. DNA methyltransferases (DNMTs) are critical enzymes that establish and maintain DNA methylation. We evaluated whether proinflammatory cytokines ...
Chen Xin X Basic Science Program, Science Applications International Corporation-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA. - - 2013
Several lines of evidence indicate the instability of CD4(+)Foxp3(+) regulatory T cells (Tregs). We have therefore investigated means of promoting the stability of Tregs. In this study, we found that the proportion of Tregs in mouse strains deficient in TNFR2 or its ligands was reduced in the thymus and peripheral ...
Wie Seong-Heon SH Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South - - 2013
HIV is able to outpace the innate immune response, including that mediated by interferon (IFN), to establish a productive infection. Primary macrophages, however, may be protected from HIV infection by treatment with type I IFN before virus exposure. The ability of HIV to modulate the type I IFN-mediated innate immune ...
Schrimshaw Eric W EW Center for the Psychosocial Study of Health & Illness, Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, NY, USA. - - 2013
Although bisexual men report lower levels of mental health relative to gay men, few studies have examined the factors that contribute to bisexual men's mental health. Bisexual men are less likely to disclose, and more likely to conceal (i.e., a desire to hide), their sexual orientation than gay men. Theory ...
Okazaki Shintaro S Department of Finance and Marketing Research, College of Economics and Business Administration, Universidad Autónoma de Madrid, Madrid, Spain. - - 2013
Online gossip has been recognized as small talk on social networking sites (SNSs) that influences consumer behavior, but little attention has been paid to its role. This study makes three theoretical predictions: (a) propensity to gossip online leads to greater information value, entertainment value, and friendship value; (b) upon exposure ...
Cristante Enrico E William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United - - 2013
The blood-brain barrier (BBB), a critical guardian of communication between the periphery and the brain, is frequently compromised in neurological diseases such as multiple sclerosis (MS), resulting in the inappropriate passage of molecules and leukocytes into the brain. Here we show that the glucocorticoid anti-inflammatory messenger annexin A1 (ANXA1) is ...
Cohen Philip P MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, United Kingdom. - - 2013
Over the past 15 years protein kinases have become the pharmaceutical industry's most important class of drug target in the field of cancer. Some 20 drugs that target kinases have been approved for clinical use over the past decade, and hundreds more are undergoing clinical trials. However, the recent approval ...
Kuster Diederik W D DW Cell and Molecular Physiology, Health Science Division, Loyola University of Chicago, 2160 First Ave, Bldg 102, Room 4637, Maywood, IL 60153, USA. - - 2013
Cardiac myosin-binding protein C (cMyBP-C) regulates cross-bridge cycling kinetics and, thereby, fine-tunes the rate of cardiac muscle contraction and relaxation. Its effects on cardiac kinetics are modified by phosphorylation. Three phosphorylation sites (Ser275, Ser284, and Ser304) have been identified in vivo, all located in the cardiac-specific M-domain of cMyBP-C. However, ...
Magnuson Elizabeth A EA Saint Luke's Mid America Heart Institute, Kansas City, MO 64111, - - 2013
Studies from the balloon angioplasty and bare metal stent eras have demonstrated that coronary artery bypass grafting (CABG) is cost-effective compared with percutaneous coronary intervention (PCI) for patients undergoing multivessel coronary revascularization-particularly among patients with complex coronary artery disease or diabetes mellitus. Whether these results apply in the drug-eluting stent ...
Osada Hiroaki H Department of Cardiovascular Surgery, Mitsubishi Kyoto Hospital, Kyoto, Japan. - - 2013
Extensive clinicopathological analyses of aortic dissection have implicated hypertension and genetic abnormalities as the major pathogenic mechanisms. However, previous findings from pathological examinations have often been inconsistent with these mechanisms. In this paper, we suggest a significant role for the vasa vasorum in the aetiology and pathogenesis of aortic dissection. ...
Brackenbury William J WJ Department of Pharmacology and Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, - - 2013
Voltage-gated Na(+) channel (VGSC) β1 subunits, encoded by SCN1B, are multifunctional channel modulators and cell adhesion molecules (CAMs). Mutations in SCN1B are associated with the genetic epilepsy with febrile seizures plus (GEFS+) spectrum disorders in humans, and Scn1b-null mice display severe spontaneous seizures and ataxia from postnatal day (P)10. The ...
Limesand Sean W SW Dept. of Animal Sciences, Univ. of Arizona, 1650 E. Limberlost Dr., Tucson, AZ 85719, USA. - - 2013
In pregnancy complicated by placental insufficiency (PI) and intrauterine growth restriction (IUGR), the fetus near term has reduced basal and glucose-stimulated insulin concentrations and reduced β-cell mass. To determine whether suppression of insulin concentrations and β-cell mass precedes reductions in fetal weight, which would implicate insulin deficiency as a cause ...
Foster Shannon M SM Department of Psychology, University of Colorado at Colorado Springs, Colorado Springs, CO 80918, - - 2013
Older adults have been shown to exhibit a positivity effect in processing of emotional stimuli, seemingly focusing more on positive than negative information. Whether this reflects purposeful changes or an unintended side effect of declining cognitive abilities is unclear. For the present study, older adults displaying a wide range of ...
Gordon Leamarie T LT Department of Psychology, Tufts University, Medford, MA 02155, USA. - - 2013
Across three experiments, we examined the effect of repetition lag on priming of unfamiliar visual objects in healthy young and older adults. Multiple levels of lag were examined, ranging from short (one to four intervening stimuli) to long (50 + intervening stimuli). In each experiment, subjects viewed a series of ...
Northey Jason J JJ Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A3, - - 2013
The ErbB2 and TGFβ signaling pathways cooperate to promote the migratory, invasive, and metastatic behavior of breast cancer cells. We previously demonstrated that ShcA is necessary for these synergistic interactions. Through a structure/function approach, we now show that the phosphotyrosine-binding, but not the Src homology 2, domain of ShcA is ...
Swarup Shilpa S Department of Genetics, WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695-7614, - - 2013
Understanding the relationship between genetic variation and phenotypic variation for quantitative traits is necessary for predicting responses to natural and artificial selection and disease risk in human populations, but is challenging because of large sample sizes required to detect and validate loci with small effects. Here, we used the inbred, ...
Rodriguez Pamela C PC Department of Chemistry, Columbia University, New York, NY 10027, - - 2013
We recently introduced fluorescent false neurotransmitters (FFNs) as optical tracers that enable the visualization of neurotransmitter release at individual presynaptic terminals. Here, we describe a pH-responsive FFN probe, FFN102, which as a polar dopamine transporter substrate selectively labels dopamine cell bodies and dendrites in ventral midbrain and dopaminergic synaptic terminals ...
Kantomaa Marko T MT LIKES-Research Center for Sport and Health Sciences, FI-40720 Jyväskylä, Finland. - - 2013
The global epidemic of obesity and physical inactivity may have detrimental implications for young people's cognitive function and academic achievement. This prospective study investigated whether childhood motor function predicts later academic achievement via physical activity, fitness, and obesity. The study sample included 8,061 children from the Northern Finland Birth Cohort ...
Ward Katherine E KE Department of Chemistry and Biochemistry and the Mike and Josie Harper Center for Cancer Research, University of Notre Dame, Notre Dame, IN, - - 2013
Group IVA cytosolic phospholipase A₂ (cPLA₂α), which harbors an N-terminal lipid binding C2 domain and a C-terminal lipase domain, produces arachidonic acid from the sn-2 position of zwitterionic lipids such as phosphatidylcholine. The C2 domain has been shown to bind zwitterionic lipids, but more recently, the anionic phosphomonoester sphingolipid metabolite ...
Tran Hoanh H Department of Cancer Targets, Genentech Inc., South San Francisco, California 94080, USA. - - 2013
The adenomatous polyposis coli (APC) protein functions as a negative regulator of the Wnt signaling pathway. In this capacity, APC forms a "destruction complex" with Axin, CK1α, and GSK3β to foster phosphorylation of the Wnt effector β-catenin earmarking it for Lys-48-linked polyubiquitylation and proteasomal degradation. APC is conjugated with Lys-63-linked ...
Bao Rui R Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, - - 2013
The pH 6 antigen (Psa) of Yersinia pestis consists of fimbriae that bind to two receptors: β1-linked galactosyl residues in glycosphingolipids and the phosphocholine group in phospholipids. Despite the ubiquitous presence of either moiety on the surface of many mammalian cells, Y. pestis appears to prefer interacting with certain types ...
Zhang Qibin Q Biological Sciences Division and the 2 Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA. - - 2013
Using global liquid chromatography-mass spectrometry (LC-MS)-based proteomics analyses, we identified 24 serum proteins that were significantly variant between those with type 1 diabetes (T1D) and healthy controls. Functionally, these proteins represent innate immune responses, the activation cascade of complement, inflammatory responses, and blood coagulation. Targeted verification analyses were performed on ...
Zebrowitz Leslie A LA Department of Psychology, Brandeis University, Waltham, MA 02454, USA. - - 2013
People readily form first impressions from faces, with consensual judgments that have significant social consequences. Similar impressions are shown by children, young adults (YA), and people from diverse cultures. However, this is the first study to systematically investigate older adults' (OA) impressions. OA and YA showed similar levels of within-age ...
Peng Jing J Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, - - 2013
Although estrogen and the enzymes responsible for its metabolism have been detected within the lung, the ability of this tissue to metabolize estrogen has not been demonstrated previously. The goal of this study was to characterize the profile of estrogen metabolites within the murine lung and to determine the effect ...
Tanwar Pradeep S PS Vincent Center for Reproductive Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, - - 2013
Epithelial ovarian cancer is a heterogeneous disease that is subdivided into five major histotypes but the mechanisms driving their differentiation are not clear. Mutations in adenomatous polyposis coli (APC) and β-catenin are commonly observed in the human ovarian endometrioid adenocarcinoma (OEA) patients. However, the mechanisms subsequent to APC deletion in ...
Shallcross Amanda J AJ Department of Psychology, University of Denver, - - 2013
Although aging involves cognitive and physical declines, it is also associated with improved emotional well-being, particularly lower negative affect. However, the relationship between age and global negative affect, versus discrete negative emotions, and the pathways that link age to lower negative affect are not well understood. We hypothesize that 1 ...
Zhuang Tiandi T Department of Biochemistry, Center for Structural Biology, Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, - - 2013
Solution NMR spectroscopy of labeled arrestin-1 was used to explore its interactions with dark-state phosphorylated rhodopsin (P-Rh), phosphorylated opsin (P-opsin), unphosphorylated light-activated rhodopsin (Rh*), and phosphorylated light-activated rhodopsin (P-Rh*). Distinct sets of arrestin-1 elements were seen to be engaged by Rh* and inactive P-Rh, which induced conformational changes that differed ...
Bullwinkle Tammy J TJ Department of Microbiology, Ohio State University, Columbus, Ohio 43210, - - 2013
Post-translational modification of bacterial elongation factor P (EF-P) with (R)-β-lysine at a conserved lysine residue activates the protein in vivo and increases puromycin reactivity of the ribosome in vitro. The additional hydroxylation of EF-P at the same lysine residue by the YfcM protein has also recently been described. The roles ...
Stendell-Hollis Nicole R NR Nutritional Sciences Department, University of Arizona, Tucson, Arizona, USA. - - 2013
Of postpartum women, 15%-20% retain ≥ 5 kg of their gestational weight gain, increasing risk for adult weight gain. Postpartum women are also in a persistent elevated inflammatory state. Both factors could increase the risk of obesity-related chronic disease. We hypothesized that breastfeeding women randomized to a Mediterranean-style (MED) diet ...
Heidel Florian H FH Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, - - 2013
A unique characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSCs and potentially also in leukemia stem cells. Recently, studies have shed light on developmental molecules and evolutionarily conserved signals as regulators of ...
Toffol Elena - - 2012
OBJECTIVE: A proportion of women experience depressive and anxiety symptoms and/or disorders in connection with the menopausal transition. Estrogen-only therapy has been reported to have beneficial effects on mental health, but the effects of combined hormone therapy (HT) on mental health are less clear. We studied the associations between HT ...
Xu Huiqin - - 2012
OBJECTIVE: We studied the radiosensitizing effect of irisquinone on a VX2 lung transplant tumor model during three-dimensional radiotherapy using fluorine-18-deoxyglucose (F-FDG) PET/computed tomography (PET/CT). MATERIALS AND METHODS: Thirty VX2 tumor-bearing rabbits were randomized into three groups: the radiotherapy group, the irisquinone+radiotherapy group, and the control group, each comprising 10 rabbits. ...
Toh Soo Ting - - 2012
Chronic Hepatitis B Virus (HBV) infection is epidemiologically associated with hepatocellular-carcinoma (HCC) but its role in HCC remains poorly understood due to technological limitations. Here, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC patients using an oligo-bead-based strategy, pooled together and sequenced using the ...
Toma Claudio - - 2012
Impairment of language abilities is a common feature in autistic individuals. Heterozygous mutations in the Forkhead Box P2 (FOXP2) gene lead to a severe spoken language disorder. Recently, several studies have pinpointed the involvement of common variants of the Contactin-Associated Protein-Like 2 (CNTNAP2) gene, whose transcription is regulated by the ...
Sarafraz-Yazdi Ali - - 2012
An in situ derivatization and solid-phase microextraction (SPME) method based on sol-gel technology coupled with gas chromatography-flame ionization detection was proposed for the determination of mercury [Hg(ΙΙ)] at ultra-trace levels in water samples.The analytical procedure involves aqueous-phase derivatization of Hg(ΙΙ) with phenylboronic acid in a sample vial and subsequent extraction ...
Méndez Juan Pablo - - 2012
OBJECTIVE: Obesity and osteoporosis are two important public health problems that greatly impact mortality and morbidity. Several similarities between these complex diseases have been identified. The aim of this study was to analyze if different body mass indexes (BMIs) are associated with variations in bone mineral density (BMD) among postmenopausal ...
O'Mahoney Eoin - - 2012
AIM: The aim of our study was to assess improvements in spatial resolution and noise control from the application of the Astonish resolution recovery algorithm for single photon emission computed tomography imaging. Secondary aims were to compare acquisitions made with low-energy general purpose collimators with those obtained using low-energy high-resolution ...
Salmane-Kulikovska Ieva - - 2012
Recent studies suggest that a number of common cold medicines, including nasal decongestants are not suitable for small children. In Latvia nasal decongestants are primarily over-the-counter (OTC) medicines, and patient information leaflets generally permit use of these medicines for small children. The previous studies in Latvia investigating the use of ...
Tamaki Kentaro - - 2012
BACKGROUND: We retrospectively examined the clinical outcome of irradiated versus non-irradiated groups of Japanese breast cancer patients according to their clinical and histopathological characteristics following breast-conserving therapy. METHODS: We retrospectively evaluated a total of 1197 Japanese female breast cancer patients (598 irradiated and 599 non-irradiated) who received breast-conserving therapy. The ...
Graffam Joseph - - 2012
Recidivism outcomes were examined over a 2-year postrelease period for participants of an Australian employment assistance program. The voluntary 12-month program operated from 17 Victorian correctional locations, 7 prisons, and 10 community corrections locations, targeting participants at moderate to high risk of reoffending. Recidivism outcomes included simple rates of reoffending ...
Yoshioka H - - 2012
BackgroundA phase III study (Lung Cancer Evaluation of TS-1) previously demonstrated noninferiority in terms of overall survival (OS) at interim analysis for carboplatin-S-1 compared with carboplatin-paclitaxel for first-line treatment of advanced non-small-cell lung cancer (NSCLC).Patients and methodsA total of 564 patients were randomly assigned to receive either carboplatin on day ...
Sorte Hanne S - - 2012
OBJECTIVES: Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopment disorders with a complex genetic aetiology. The aim of this study was to identify copy number variations (CNVs) with a clinical significance for ASD. MATERIALS AND METHODS: Array-based comparative genomic hybridization was applied to detect CNVs in a clinically ...
Suchankova Petra - - 2012
OBJECTIVES: Numerous studies have shown associations between an on-going depression and elevated serum levels of the acute-phase reactant C-reactive protein (CRP). Also, in suicidal behaviour, a proinflammatory state has been suggested to be of importance for the pathophysiology. There is a genetic susceptibility to suicidal behaviour, but studies with respect ...
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