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Muniz-Terrera Graciela - - 2012
The terminal decline hypothesis states that in the proximity of death, an individual's decline in cognitive abilities accelerates. We aimed at estimating the onset of faster rate of decline in global cognition using Mini Mental State Examination (MMSE) scores from participants of the Cambridge City over 75 Cohort Study (CC75C), ...
Stefani Christian - - 2012
Thiosemicarbazone chelators, including the 2'-benzoylpyridine thiosemicarbazones (BpT) class, show marked potential as anticancer agents. Importantly, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) has been investigated in >20 phase I and II clinical trials. However, side effects associated with 3-AP administration include methemoglobinemia. Considering this problem, novel BpT analogues were designed bearing hydrophobic, electron-donating substituents ...
Condon Robert H - - 2013
A perceived recent increase in global jellyfish abundance has been portrayed as a symptom of degraded oceans. This perception is based primarily on a few case studies and anecdotal evidence, but a formal analysis of global temporal trends in jellyfish populations has been missing. Here, we analyze all available long-term ...
Wensveen Felix M - - 2012
Memory T cells form a highly specific defense layer against reinfection with previously encountered pathogens. In addition, memory T cells provide protection against pathogens that are similar, but not identical to the original infectious agent. This is because each T cell response harbors multiple clones with slightly different affinities, thereby ...
Kuster Diederik W D DW Cell and Molecular Physiology, Health Science Division, Loyola University of Chicago, 2160 First Ave, Bldg 102, Room 4637, Maywood, IL 60153, USA. - - 2013
Cardiac myosin-binding protein C (cMyBP-C) regulates cross-bridge cycling kinetics and, thereby, fine-tunes the rate of cardiac muscle contraction and relaxation. Its effects on cardiac kinetics are modified by phosphorylation. Three phosphorylation sites (Ser275, Ser284, and Ser304) have been identified in vivo, all located in the cardiac-specific M-domain of cMyBP-C. However, ...
Cardini Flavia - - 2012
Understanding other people's feelings in social interactions depends on the ability to map onto our body the sensory experiences we observed on other people's bodies. It has been shown that the perception of tactile stimuli on the face is improved when concurrently viewing a face being touched. This Visual Remapping ...
Levitt Ash A Research Institute on Addictions, University at Buffalo, - - 2013
Previous research has suggested that individuals in romantic relationships hold beliefs about the effects of relationship-drinking contexts (e.g., drinking with one's partner) on later relationship functioning, as well as the effects of relationship functioning on later relationship-drinking contexts, and that these reciprocal effects may be stronger among women compared with ...
Tanwar Pradeep S PS Vincent Center for Reproductive Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, - - 2013
Epithelial ovarian cancer is a heterogeneous disease that is subdivided into five major histotypes but the mechanisms driving their differentiation are not clear. Mutations in adenomatous polyposis coli (APC) and β-catenin are commonly observed in the human ovarian endometrioid adenocarcinoma (OEA) patients. However, the mechanisms subsequent to APC deletion in ...
Cornish Neil J - - 2013
A worldwide array of highly sensitive ground-based interferometers stands poised to usher in a new era in astronomy with the first direct detection of gravitational waves. The data from these instruments will provide a unique perspective on extreme astrophysical objects, such as neutron stars and black holes, and will allow ...
Grenha Rosa - - 2013
The quorum-sensing regulator PlcR is the master regulator of most known virulence factors in Bacillus cereus. It is a helix-turn-helix (HTH)-type transcription factor activated upon binding of its cognate signaling peptide PapR on a tetratricopeptide repeat-type regulatory domain. The structural and functional properties of PlcR have defined a new family ...
Peng Jinghua - - 2012
Puerarin is an isoflavone component extracted from Kudzu (Pueraria lobata) and has been demonstrated to alleviate alcohol-related disorder. The purpose of this study was to examine whether puerarin ameliorates chronic alcoholic liver injury through inhibition of endotxin gut-leakage, the subsequent Kupffer cells (KCs) activation and lipopolysaccharide (LPS) receptors expression. Rats ...
Dell'osso Bernardo - - 2012
Peg-interferon (Peg-IFN) and ribavirin (RBV) therapy is reported to induce psychiatric symptoms and syndromes in 20% of patients treated for Hepatitis C Virus (HCV) infection. Present study was aimed to quantify the phenomenon and assess the influence of psychiatric counseling over antiviral completion rate and the use of psychometric tools, ...
Osada Hiroaki H Department of Cardiovascular Surgery, Mitsubishi Kyoto Hospital, Kyoto, Japan. - - 2013
Extensive clinicopathological analyses of aortic dissection have implicated hypertension and genetic abnormalities as the major pathogenic mechanisms. However, previous findings from pathological examinations have often been inconsistent with these mechanisms. In this paper, we suggest a significant role for the vasa vasorum in the aetiology and pathogenesis of aortic dissection. ...
Shaikh Irshad - - 2012
Abstract Background: Uncertainty exists surrounding the laparoscopic approach to the repair of giant paraesophageal hiatus hernias (GPHHs), in regard to both long-term outcomes and its role in the emergency presentation. The aim of this study was to assess the outcome of laparoscopic GPHH repair, compared with traditional open surgery, in ...
Foster Shannon M SM Department of Psychology, University of Colorado at Colorado Springs, Colorado Springs, CO 80918, - - 2013
Older adults have been shown to exhibit a positivity effect in processing of emotional stimuli, seemingly focusing more on positive than negative information. Whether this reflects purposeful changes or an unintended side effect of declining cognitive abilities is unclear. For the present study, older adults displaying a wide range of ...
Weeks Margaret R MR Institute for Community Research, Hartford, Connecticut, USA. - - 2013
The female condom (FC), an effective barrier method for HIV/sexually transmitted infection (STI) prevention, continues to be absent from most community settings, including reproductive health and treatment clinics. Reducing or eliminating basic barriers, including lack of awareness, knowledge of proper use, and access to free samples, may significantly increase use ...
Mavica Lauren W - - 2012
Previous research has suggested that people are unable to correctly choose which unfamiliar voice and static image of a face belong to the same person. Here, we present evidence that people can perform this task with greater than chance accuracy. In Experiment 1, participants saw photographs of two, same-gender models, ...
Winfree Walter R - - 2012
The U.S. Spanish-speaking population has rapidly increased in recent decades and there is a need for psychometrically supported assessment measures for researchers and clinicians who work with this population. A Spanish version of a self-report measure of gamblers' cognitive distortions [Gamblers' Beliefs Questionnaire (GBQ); Steenbergh, Meyers, Whelan, & May, 2002] ...
Bulf Hermann - - 2012
Visual attention is one of the infant's primary tools for gathering relevant information from the environment for further processing and learning. The space-based component of visual attention in infants has been widely investigated; however, the object-based component of visual attention has received scarce interest. This scarcity is surprising, given the ...
Gonkowski Sławomir - - 2012
Cocaine-and amphetamine-regulated transcript peptide (CART) is a neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract, but knowledge about its distribution, functions and co-localisation with other neuronal factors, especially in humans, is very scarce. During the present investigation the distribution and immunohistochemical reaction (IR) of CART - like immunoreactive ...
Magnuson Elizabeth A EA Saint Luke's Mid America Heart Institute, Kansas City, MO 64111, - - 2013
Studies from the balloon angioplasty and bare metal stent eras have demonstrated that coronary artery bypass grafting (CABG) is cost-effective compared with percutaneous coronary intervention (PCI) for patients undergoing multivessel coronary revascularization-particularly among patients with complex coronary artery disease or diabetes mellitus. Whether these results apply in the drug-eluting stent ...
Cristante Enrico E William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United - - 2013
The blood-brain barrier (BBB), a critical guardian of communication between the periphery and the brain, is frequently compromised in neurological diseases such as multiple sclerosis (MS), resulting in the inappropriate passage of molecules and leukocytes into the brain. Here we show that the glucocorticoid anti-inflammatory messenger annexin A1 (ANXA1) is ...
Horton Karissa D KD Department of Kinesiology and Health - - 2013
Depressive symptoms are associated with increased levels of cigarette smoking, yet not every individual experiencing depressive symptoms smokes. This study examined whether religious coping moderated the impact of depressive symptoms on past 30-day cigarette use among a racially/ethnically diverse sample of 963 postsecondary vocational students (46.8% women; mean age = ...
Walsh Ali Morton - - 2013
In higher organisms such as vertebrates, it is generally believed that lateral transfer of genetic information does not readily occur, with the exception of retroviral infection. However, horizontal transfer (HT) of protein coding repetitive elements is the simplest way to explain the patchy distribution of BovB, a long interspersed element ...
Kim Jihyo - - 2012
Analysis of protein dynamics using single-molecule fluorescence resonance energy transfer (smFRET) is widely used to understand the structure and function of proteins. Nonetheless, site-specific labeling of proteins with a pair of donor and acceptor dyes still remains a challenge. Here we present a general and facile method for site-specific dual ...
Richard Edo - - 2012
OBJECTIVE To evaluate the association of late-life depression with mild cognitive impairment (MCI) and dementia in a multiethnic community cohort. DESIGN AND SETTING A cohort study was conducted in Northern Manhattan, New York, New York. PARTICIPANTS A total of 2160 community-dwelling Medicare recipients aged 65 years or older were included ...
Choi Jin-Ho - - 2012
BACKGROUND: Despite complete interruption of antegrade coronary artery flow in the setting of a chronic total occlusion (CTO), clinical recognition of myocardial infarction (MI) is often challenging. Using cardiac magnetic resonance imaging (CMR), we investigated the frequency and extent of MI in patients with CTO, and assessed their relationship with ...
Peng Jing J Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, - - 2013
Although estrogen and the enzymes responsible for its metabolism have been detected within the lung, the ability of this tissue to metabolize estrogen has not been demonstrated previously. The goal of this study was to characterize the profile of estrogen metabolites within the murine lung and to determine the effect ...
Bielecki Aleksander - - 2012
Abstract A new species of fish leech from Poland, Piscicola burresoni n. sp. (Piscicolidae), is described. It was found in 2007 on stones and on pike (Esox lucius L.) and chub (Leuciscus cephalus L.) in the Łyna River, Poland. The leech is small, relatively flattened, with a prominent coarctation between ...
Hyvärinen Aapo - - 2013
Independent component analysis is a probabilistic method for learning a linear transform of a random vector. The goal is to find components that are maximally independent and non-Gaussian (non-normal). Its fundamental difference to classical multi-variate statistical methods is in the assumption of non-Gaussianity, which enables the identification of original, underlying ...
Heijde Marc - - 2013
Plants require the UV-B photoreceptor UV resistance locus 8 (UVR8) for acclimation and survival in sunlight. Upon UV-B perception, UVR8 switches instantaneously from a homodimeric to monomeric configuration, which leads to interaction with the key signaling protein constitutively photomorphogenic 1 (COP1) and induction of UV-B-protective responses. Here, we show that ...
Meng Xianwei - - 2012
The application of electronic paper (e-paper) is now propelling the development of the multifunctional e-paper products. There is an extraordinary diversity of basic and applied research in pursuit of the novel e-paper. Here, we report the first achievement of a magnetic-electric dual driving e-paper, using the black magnetic electrophoretic particles ...
Wie Seong-Heon SH Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South - - 2013
HIV is able to outpace the innate immune response, including that mediated by interferon (IFN), to establish a productive infection. Primary macrophages, however, may be protected from HIV infection by treatment with type I IFN before virus exposure. The ability of HIV to modulate the type I IFN-mediated innate immune ...
Beer Lucian - - 2012
OBJECTIVES: Cardiopulmonary bypass (CPB) is known to induce a short pro- and long-lasting anti-inflammatory immune response. The anti-inflammatory protein soluble ST2 (sST2) may be involved in the pathogenesis of postoperative immune dysfunction. We investigated whether continued mechanical ventilation during CPB has an impact on postoperative serum sST2 and cytokine release. ...
- - 2013
These abstracts are presented here as prepared by the authors. The accuracy and content of each abstract remain the responsibility of the authors. In the identification number above each abstract, OPL designates an Orthopaedic Section platform presentation.J Orthop Sports Phys Ther 2013;43(1):A16-A42.
Ducrocq Gregory - - 2012
BACKGROUND: Randomized trials of antithrombotics in coronary artery disease (CAD) have identified prior stroke/TIA as a marker of increased intracranial bleeding risk. We aimed to further characterize the risk of ischemic and bleeding events associated with a history of stroke/TIA in patients with CAD. METHODS AND RESULTS: From the international ...
Monajemi Hatef - - 2013
In compressed sensing, one takes samples of an N-dimensional vector using an matrix A, obtaining undersampled measurements Y = Ax(0). For random matrices with independent standard Gaussian entries, it is known that, when is k-sparse, there is a precisely determined phase transition: for a certain region in the (k/n,n/N)-phase diagram, ...
Cho Jeff C - - 2012
Social projection and self-stereotyping are rival explanations for self-other correspondence, in which people tend to perceive a high degree of similarity between themselves and others. The present research shows that both accounts are correct-that is, that knowledge of the self and knowledge of others are mutually constraining. In Study 1, ...
Huang Szu-Chi - - 2012
Individuals have different concerns before and after they become relatively certain about a goal's attainability; hence, we propose that the presence of alternative means of goal attainment will have a distinctive impact on motivation, depending on their stage of goal pursuit. In the initial stage of goal pursuit, people are ...
Shi Lan-Xin - - 2013
Chloroplasts are the organelles of green plants in which light energy is transduced into chemical energy, forming ATP and reduced carbon compounds upon which all life depends. The expenditure of this energy is one of the central issues of cellular metabolism. Chloroplasts contain ~3,000 proteins, among which less than 100 ...
Freund L B - - 2013
The phenomenon of thermal fluctuation of a biomembrane within a stack of like membranes was introduced in a pioneering paper [Helfrich W (1978) Z Naturforsch A 33(3):305-315]. Internal energy arises in a representative membrane through elastic resistance to bending deformation, and membrane motion is further restrained through steric interaction with ...
Robinson Sean M - - 2012
The Timeline Followback (TLFB), a retrospective calendar-based measure of daily substance use, was initially developed to obtain self-reports of alcohol use. Since its inception it has undergone extensive evaluation across diverse populations and is considered the most psychometrically sound self-report measure of drinking. Although the TLFB has been extended to ...
Hale Karl J - - 2012
A new method for ketone enolate C-acylation is described which utilizes alkyl pentafluorophenylcarbonates, thiocarbonates, and thionocarbonates as the reactive acylating agents, and MgBr(2)·Et(2)O, DMAP, and i-Pr(2)NEt as the reagents for enolization. A wide range of ketones have been observed to undergo clean C-acylation via this protocol.
Raue Andreas - - 2013
Increasingly complex applications involve large datasets in combination with nonlinear and high-dimensional mathematical models. In this context, statistical inference is a challenging issue that calls for pragmatic approaches that take advantage of both Bayesian and frequentist methods. The elegance of Bayesian methodology is founded in the propagation of information content ...
Huo Hong - - 2012
Electric vehicles (EVs) and compressed natural gas vehicles (CNGVs), which are mainly coal-based and natural gas-based, are the two most widely proposed replacements of gasoline internal combustion engine vehicles (ICEVs) in China. We examine fuel-cycle emissions of greenhouse gases (GHGs), PM2.5, PM10, NOx and SO2 of CNGVs and EVs relative ...
Goissis Marcelo D - - 2012
Abstract The production of healthy, live, cloned animals by somatic cell nuclear transfer (SCNT) has been hampered by low efficiencies. Significant epigenetic changes must take place to ensure proper chromatin remodeling in SCNT. We hypothesized that exogenous expression of OCT4 in donor fibroblasts prior to its fusion with enucleated oocytes ...
Stendell-Hollis Nicole R NR Nutritional Sciences Department, University of Arizona, Tucson, Arizona, USA. - - 2013
Of postpartum women, 15%-20% retain ≥ 5 kg of their gestational weight gain, increasing risk for adult weight gain. Postpartum women are also in a persistent elevated inflammatory state. Both factors could increase the risk of obesity-related chronic disease. We hypothesized that breastfeeding women randomized to a Mediterranean-style (MED) diet ...
Dewald Andrew D - - 2012
Research has demonstrated that irrelevant suprathreshold motion stimuli that are aligned with attended targets in a separate task, fail to illicit inhibitory control in a subsequent motion direction discrimination task (Tsushima, Seitz, & Watanabe, 2008). We extended these findings to conditions involving higher exposure levels to a more salient stimulus ...
Northey Jason J JJ Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A3, - - 2013
The ErbB2 and TGFβ signaling pathways cooperate to promote the migratory, invasive, and metastatic behavior of breast cancer cells. We previously demonstrated that ShcA is necessary for these synergistic interactions. Through a structure/function approach, we now show that the phosphotyrosine-binding, but not the Src homology 2, domain of ShcA is ...
Vaughan Simon - - 2013
Progress in astronomy comes from interpreting the signals encoded in the light received from distant objects: the distribution of light over the sky (images), over photon wavelength (spectrum), over polarization angle and over time (usually called light curves by astronomers). In the time domain, we see transient events such as ...
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