Search Results
Results 451 - 500 of 1606
< 5 6 7 8 9 10 11 12 13 14 15 >
Roberts Tara L - - 2013
SMG1 is a member of the phosphoinositide kinase-like kinase family of proteins that includes ATM, ATR, and DNA-PK, proteins with known roles in DNA damage and cellular stress responses. SMG1 has a well-characterized role in nonsense-mediated decay as well as suggested roles in the DNA damage response, resistance to oxidative ...
Conrady Deborah G - - 2013
Staphylococcal bacteria, including Staphylococcus epidermidis and Staphylococcus aureus, cause chronic biofilm-related infections. The homologous proteins Aap and SasG mediate biofilm formation in S. epidermidis and S. aureus, respectively. The self-association of these proteins in the presence of Zn(2+) leads to the formation of extensive adhesive contacts between cells. This study ...
Heinz Hendrik - - 2012
The complexity of molecular recognition and assembly of biotic-abiotic interfaces at a scale of 1 to 1000 nm can be understood more effectively using simulation tools along with laboratory instrumentation. We discuss current capabilities and limitations of atomistic force fields and explain a strategy to obtain dependable parameters for inorganic ...
Wong Daryl B - - 2012
The vibrational dynamics of the antisymmetric and symmetric stretching modes of very low concentration spatially isolated D2O molecules in the Room Temperature Ionic Liquid (RTIL) 1-butyl-3-methylimidazolium hexafluorophosphate (BmImPF6) were examined using two dimensional infrared (2D IR) vibrational echo spectroscopy and infrared pump-probe experiments. In BmImPF6, D2O's antisymmetric and symmetric stretching ...
Hayden Joshua A JA Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
Calprotectin (CP) is a transition metal-chelating antimicrobial protein of the calcium-binding S100 family that is produced and released by neutrophils. It inhibits the growth of various pathogenic microorganisms by sequestering the transition metal ions manganese and zinc. In this work, we investigate the manganese-binding properties of CP. We demonstrate that ...
Promeneur Dominique - - 2013
Tragically common among children in sub-Saharan Africa, cerebral malaria is characterized by rapid progression to coma and death. In this study, we used a model of cerebral malaria appearing in C57BL/6 WT mice after infection with the rodent malaria parasite Plasmodium berghei ANKA. Expression and cellular localization of the brain ...
Ritchie Stuart J - - 2012
Recent reports suggest a causal relationship between education and IQ, which has implications for cognitive development and aging-education may improve cognitive reserve. In two longitudinal cohorts, we tested the association between education and lifetime cognitive change. We then tested whether education is linked to improved scores on processing-speed variables such ...
Foucher Frédéric - - 2012
Abstract Opaline silica was detected, with Raman spectroscopy, in carbonaceous microfossils (especially Myxococcoides) in silicified filamentous microbial mats within dolomitized conglomerates of the Draken Formation (-800 to -700 Ma). High-resolution electron microscopy (HRTEM) and microprobe analyses were used to confirm the nature of this phase in the quartz matrix of the ...
Raffa Kenneth F - - 2013
Warming climate has increased access of native bark beetles to high-elevation pines that historically received only intermittent exposure to these tree-killing herbivores. Here we show that a dominant, relatively naïve, high-elevation species, whitebark pine, has inferior defenses against mountain pine beetle compared with its historical lower-elevation host, lodgepole pine. Lodgepole ...
Chen Xin X Basic Science Program, Science Applications International Corporation-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA. - - 2013
Several lines of evidence indicate the instability of CD4(+)Foxp3(+) regulatory T cells (Tregs). We have therefore investigated means of promoting the stability of Tregs. In this study, we found that the proportion of Tregs in mouse strains deficient in TNFR2 or its ligands was reduced in the thymus and peripheral ...
Lipovskii Andrey - - 2012
Mid-range structure of glasses of the glass-forming system xNb2O5-(60-x)P2O5-40Na2O, with x varying from 0 to 40, has been investigated by Raman spectroscopy and electrooptical Kerr measurements. It has been found that the mid-range inhomogeneities in the glasses under study vary with x and their compositions and structures dramatically differ from ...
Van den Akker Alithe L - - 2012
This study investigated relations among children's personality types, trajectories of internalizing and externalizing problems, and overreactive parenting across 6 years. Latent Class Analysis of the Big 5 personality dimensions (modeled as latent factors, based on mother, father and teacher reports) for 429 children (mean age 8 years at Time 1) ...
Chou Hui-Tzu Grace - - 2012
Abstract With the spread of Facebook among people in many countries, some companies have started using applicants' Facebook profiles as a criterion of personnel selection, in an effort to identify good workers among job applicants. However, how using Facebook is connected to individuals' relationships with coworkers and work attitudes is ...
Kochanowski Karl - - 2013
Regulation of metabolic operation in response to extracellular cues is crucial for cells' survival. Next to the canonical nutrient sensors, which measure the concentration of nutrients, recently intracellular "metabolic flux" was proposed as a novel impetus for metabolic regulation. According to this concept, cells would have molecular systems ("flux sensors") ...
Kantomaa Marko T MT LIKES-Research Center for Sport and Health Sciences, FI-40720 Jyväskylä, Finland. - - 2013
The global epidemic of obesity and physical inactivity may have detrimental implications for young people's cognitive function and academic achievement. This prospective study investigated whether childhood motor function predicts later academic achievement via physical activity, fitness, and obesity. The study sample included 8,061 children from the Northern Finland Birth Cohort ...
Stasiewicz Paul R - - 2012
Pretreatment changes in alcohol use challenges the assumption that the major portion of the change process occurs after treatment entry. Greater understanding of the behavior change process prior to treatment has the potential to improve our understanding of behavioral changes during treatment. In this study, participants (N = 45) were ...
D Amore Meredith M - - 2012
ABSTRACT: BACKGROUND: Despite the vast literature examining disparities in medical care, little is known about racial/ethnic and mental health disparities in sexual health care. The objective of this study was to assess disparities in safe sex counseling and resultant behavior among a patient population at risk of negative sexual health ...
Stern Chadly - - 2012
In the present research, we investigated whether, because of differences in cognitive style, liberals and conservatives would differ in the process of categorizing individuals into a perceptually ambiguous group. In 3 studies, we examined whether conservatives were more likely than liberals to rely on gender inversion cues (e.g., feminine = ...
Subramaniam Arvind R - - 2013
The genetic code underlying protein synthesis is a canonical example of a degenerate biological system. Degeneracies in physical and biological systems can be lifted by external perturbations, thus allowing degenerate systems to exhibit a wide range of behaviors. Here we show that the degeneracy of the genetic code is lifted ...
Swarup Shilpa S Department of Genetics, WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695-7614, - - 2013
Understanding the relationship between genetic variation and phenotypic variation for quantitative traits is necessary for predicting responses to natural and artificial selection and disease risk in human populations, but is challenging because of large sample sizes required to detect and validate loci with small effects. Here, we used the inbred, ...
Leikina Evgenia - - 2013
Myoblast fusion into multinucleated myotubes is a crucial step in skeletal muscle development and regeneration. Here, we accumulated murine myoblasts at the ready-to-fuse stage by blocking formation of early fusion intermediates with lysophosphatidylcholine. Lifting the block allowed us to explore a largely synchronized fusion. We found that initial merger of ...
Walden A T - - 2013
Rotary analysis decomposes vector motions on the plane into counter-rotating components, which have proved particularly useful in the study of geophysical flows influenced by the rotation of the Earth. For stationary random signals, the motion at any frequency takes the form of a random ellipse. Although there are numerous applications ...
Heyman Gail D - - 2012
Children's reasoning about the credibility of positive and negative evaluations of academic performance was examined. Across 2 studies, 7- and 10-year-olds from the United States and China (N = 334) judged the credibility of academic evaluations that were directed toward an unfamiliar peer. In Study 1, participants from China responded ...
De Leo Joseph Anthony - - 2012
Given the widespread use of the Internet, researchers have begun to examine the personal and social consequences associated with excessive online involvement. The present study examined college students' problematic Internet use (PIU) behaviors within the framework of Jessor and Jessor's (1977) problem-behavior theory. Its specific aim was to investigate the ...
James Dustin K - - 2012
Graphene's unique physical and electrical properties (high tensile strength, Young's modulus, electron mobility, and thermal conductivity) have led to its nickname of "super carbon." Graphene research involves the study of several different physical forms of the material: powders, flakes, ribbons, and sheets and others not yet named or imagined. Within ...
Rau Nathan J - - 2012
The electronic structures of phenylnitrenes with anionic π-donating substituents are investigated by using mass spectrometry and electronic structure calculations. Reactions of para-CH2-substituted phenylnitrene formed by dissociative deprotonation of p-azidotoluene, with CS2 and NO indicate that it has a closed-shell singlet ground state, whereas reactions of p-oxidophenylnitrene formed by dissociative deprotonation ...
Legant Wesley R WR Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, - - 2013
Recent methods have revealed that cells on planar substrates exert both shear (in-plane) and normal (out-of-plane) tractions against the extracellular matrix (ECM). However, the location and origin of the normal tractions with respect to the adhesive and cytoskeletal elements of cells have not been elucidated. We developed a high-spatiotemporal-resolution, multidimensional ...
Laukka Erika J - - 2012
Associations between genotypes and cognitive outcomes may provide clues as to which mechanisms cause individual differences in old-age cognitive performance. We investigated the effects of five polymorphisms on cognitive functioning in a population-based sample of 2,694 persons without dementia (60-102 years). A structural equation model (SEM) was fit to the ...
Lee Young Lim - - 2012
We tested whether the presence of symmetry improves shape discrimination across changes in viewpoint and lighting for smoothly curved 3D objects. We constructed symmetric and asymmetric versions of random 3D shapes by manipulating their spherical harmonic representations. Matched objects had the same power spectra and appear highly similar except for ...
Kuerbis Alexis A Department of Mental Health Policy and Services Research, Research Foundation for Mental Hygiene, - - 2013
Despite ample research demonstrating the role of motivation and self-efficacy in predicting drinking in the context of abstinence, little research explicitly explores their role in the context of moderation, and none have utilized daily diary methods. The purpose of this study was to (a) explore the concordance between global self-report ...
Shallcross Amanda J AJ Department of Psychology, University of Denver, - - 2013
Although aging involves cognitive and physical declines, it is also associated with improved emotional well-being, particularly lower negative affect. However, the relationship between age and global negative affect, versus discrete negative emotions, and the pathways that link age to lower negative affect are not well understood. We hypothesize that 1 ...
Stewart David J - - 2013
Visible light excitation of the ligand-bridged assembly [(bpy)(2)Ru(a)(II)(L)Ru(b)(II)(bpy)(OH(2))(4+)] (bpy is 2,2'-bipyridine; L is the bridging ligand, 4-phen-tpy) results in emission from the lowest energy, bridge-based metal-to-ligand charge transfer excited state (L(-•))Ru(b)(III)-OH(2) with an excited-state lifetime of 13 ± 1 ns. Near-diffusion-controlled quenching of the emission occurs with added HPO(4)(2-) and ...
Stoddard Steven T - - 2013
Dengue is a mosquito-borne disease of growing global health importance. Prevention efforts focus on mosquito control, with limited success. New insights into the spatiotemporal drivers of dengue dynamics are needed to design improved disease-prevention strategies. Given the restricted range of movement of the primary mosquito vector, Aedes aegypti, local human ...
Heidel Florian H FH Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, - - 2013
A unique characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSCs and potentially also in leukemia stem cells. Recently, studies have shed light on developmental molecules and evolutionarily conserved signals as regulators of ...
Roberts S - - 2013
In this paper, we offer a gentle introduction to Gaussian processes for time-series data analysis. The conceptual framework of Bayesian modelling for time-series data is discussed and the foundations of Bayesian non-parametric modelling presented for Gaussian processes. We discuss how domain knowledge influences design of the Gaussian process models and ...
Yang Hong - - 2012
While water and sanitation are now recognized as a human right by the United Nations, monitoring inequality in safe water access poses challenges. This study uses survey data to calculate household socio-economic-status (SES) indices in seven countries where national drinking-water quality surveys are available. These are used to assess inequalities ...
Lu Yun-Hai - - 2012
In the allopolyploid Brassica napus, we obtained a petal-closed flower mutation by ethyl methanesulfonate mutagenesis. Here, we report cloning and characterization of the Bn-CLG1A (CLG for cleistogamy) gene and the Bn-clg1A-1D mutant allele responsible for the cleistogamy phenotype. Bn-CLG1A encodes a RINGv E3 ubiquitin ligase that is highly conserved across ...
Fierson Walter M - - 2013
This statement revises a previous statement on screening of preterm infants for retinopathy of prematurity (ROP) that was published in 2006. ROP is a pathologic process that occurs only in immature retinal tissue and can progress to a tractional retinal detachment, which can result in functional or complete blindness. Use ...
Saba Joseph - - 2012
Abstract The objective was to develop and validate a multilateral index to determine patient ability to pay for medication in low- and middle-income countries. Primary data were collected in 2009 from 117 cancer patients in China, India, Thailand, and Malaysia. The initial tool included income, expenditures, and assets-based items using ...
Little Max A - - 2013
Recent advances in our ability to watch the molecular and cellular processes of life in action--such as atomic force microscopy, optical tweezers and Forster fluorescence resonance energy transfer--raise challenges for digital signal processing (DSP) of the resulting experimental data. This article explores the unique properties of such biophysical time series ...
Cohen Philip P MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, United Kingdom. - - 2013
Over the past 15 years protein kinases have become the pharmaceutical industry's most important class of drug target in the field of cancer. Some 20 drugs that target kinases have been approved for clinical use over the past decade, and hundreds more are undergoing clinical trials. However, the recent approval ...
Zalesskiy Sergey S - - 2012
Soluble gold pre-catalysts, aimed for homogeneous catalysis, under certain conditions may form nanoparticles, which dramatically change the mechanism and initiate different chemistry. The present study addresses the question of designing of gold catalysts taking into account possible interconversions and contamination at the homogeneous/heterogeneous systems interface. It was revealed that accurate ...
Zhang Qibin Q Biological Sciences Division and the 2 Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA. - - 2013
Using global liquid chromatography-mass spectrometry (LC-MS)-based proteomics analyses, we identified 24 serum proteins that were significantly variant between those with type 1 diabetes (T1D) and healthy controls. Functionally, these proteins represent innate immune responses, the activation cascade of complement, inflammatory responses, and blood coagulation. Targeted verification analyses were performed on ...
Fisher Cynthia D - - 2012
We predict real-time fluctuations in employees' positive and negative emotions from concurrent appraisals of the immediate task situation and individual differences in performance goal orientation. Task confidence, task importance, positive emotions, and negative emotions were assessed 5 times per day for 3 weeks in an experience sampling study of 135 ...
Tomasik Tomasz - - 2012
Aims:The aims of this study were (1) to explore physicians' self-reported treatment of patients with dyslipidemia and (2) to identify intercountry differences and associations between physicians' characteristics and treatment patterns. METHODS: A cross-sectional survey was performed in primary health care in 9 Central and Eastern European countries. An anonymous questionnaire, ...
Bullwinkle Tammy J TJ Department of Microbiology, Ohio State University, Columbus, Ohio 43210, - - 2013
Post-translational modification of bacterial elongation factor P (EF-P) with (R)-β-lysine at a conserved lysine residue activates the protein in vivo and increases puromycin reactivity of the ribosome in vitro. The additional hydroxylation of EF-P at the same lysine residue by the YfcM protein has also recently been described. The roles ...
Corona Ligiana Pires - - 2012
OBJECTIVE: to examine the association between weight change and the incidence of disability in activities of daily living (ADL) among elderly women. METHOD: In 2006, 227 women aged ≥75 years and independent in ADL were selected from SABE Study (Health, Well-being, and Aging) in Sao Paulo, Brazil. The dependent variable ...
Schlegel Rebecca J - - 2012
The present research used multiple methods to examine the hypothesis that perceived true self-knowledge and decision satisfaction are inextricably linked together by a widely held "true-self-as-guide" lay theory of decision making. Consistent with this proposition, Study 1 found that participants rated using the true self as a guide as more ...
Kozak Karol - - 2012
Large-scale RNA interference experiments, especially the ones based on short-interfering RNA (siRNA) technology have become increasingly popular over the past years. Obviously, the sequence (and structure) of the corresponding siRNA is a key factor in obtaining reliable results in these large-scale studies, and the companies use a variety of algorithms ...
Rodriguez Pamela C PC Department of Chemistry, Columbia University, New York, NY 10027, - - 2013
We recently introduced fluorescent false neurotransmitters (FFNs) as optical tracers that enable the visualization of neurotransmitter release at individual presynaptic terminals. Here, we describe a pH-responsive FFN probe, FFN102, which as a polar dopamine transporter substrate selectively labels dopamine cell bodies and dendrites in ventral midbrain and dopaminergic synaptic terminals ...
< 5 6 7 8 9 10 11 12 13 14 15 >