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Ahmad Aamir A Department of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, - - 2013
Indole compounds, found in cruciferous vegetables, are potent anti-cancer agents. Studies with indole-3-carbinol (I3C) and its dimeric product, 3,3'-diindolylmethane (DIM) suggest that these compounds have the ability to deregulate multiple cellular signaling pathways, including PI3K/Akt/mTOR signaling pathway. These natural compounds are also effective modulators of downstream transcription factor NF-κB signaling ...
Meghpara Beeran B Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, - - 2013
We report a unique case of persistent scleral ulceration in a 68-year-old woman who developed eye redness, pain, and photophobia 2 days following external levator advancement with nonabsorbable suture. Slit-lamp biomicroscopy revealed an area of scleral ulceration superonasal to the limbus. The patient was treated with 6 months of topical ...
Rogers Natasha M NM Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, - - 2013
We tested the hypothesis that the matricellular protein thrombospondin-1 (TSP1), through binding to and activation of the cell receptor CD47, inhibits basal and thermal-mediated cutaneous blood flow. Abnormal and decreased cutaneous blood flow in response to temperature changes or vasoactive agents is a feature of cardiovascular disease and aging. The ...
Lemieux Steven M SM Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Rd, Unit 3092, Storrs, CT 06269, - - 2013
Receptor tyrosine kinases (RTKs) are transmembrane proteins that play a critical role in stimulating signal transduction cascades to influence cell proliferation, growth, and differentiation and they have also been shown to promote angiogenesis when they are up-regulated or mutated. For this reason, their dysfunction has been implicated in the development ...
Haas Caroline C Division of Sports Medicine, Department of Family Medicine, The Ohio State University, Columbus, OH 43221, - - 2013
This study compared the effect of immediate versus delayed massage-like compressive loading (MLL) on peak isometric torque recovery and inflammatory cell infiltration after eccentric exercise (EEX). Eighteen skeletally mature New Zealand White rabbits were instrumented with peroneal nerve cuffs for the stimulation of hindlimb tibialis anterior muscles. After a bout ...
McKeehen James N JN Rehabilitation Science and Program in Physical Therapy, University of Minnesota, Minneapolis, MN 55455, - - 2013
We tested the hypothesis that low-intensity vibration training in mice improves contractile function of hindlimb skeletal muscles and promotes exercise-related cellular adaptations. We subjected C57BL/6J mice to 6 wk, 5 d·wk, 15 min·d of sham or low-intensity vibration (45 Hz, 1.0g) while housed in traditional cages (Sham-Active, n = 8; ...
Hoffman Eric P EP Department of Integrative Systems Biology, Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC 20010, USA. - - 2013
An osteopontin (OPN; SPP1) gene promoter polymorphism modifies disease severity in Duchenne muscular dystrophy, and we hypothesized that it might also modify muscle phenotypes in healthy volunteers. Gene association studies were carried out for OPN (rs28357094) in the FAMuSS cohort (n = 752; mean ± SD age = 23.7 ± ...
Williams Paul T PT Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. - - 2013
Habitual running has been associated with reduced risk of cataract development in one prospective study. The purposes of the current analyses were to provide further evidence of this potentially important benefit of vigorous exercise and to test whether moderate exercise (e.g., walking) provides as significant and equivalent reduction in cataract ...
Hussey Sophie E SE Department of Physiology, The University of Melbourne, - - 2013
Exercise training alters protein abundance in the muscle of healthy individuals, but the effect of exercise on these proteins in patients with type 2 diabetes (T2D) is unknown. The aim of this study was to determine how exercise training alters the skeletal muscle proteome in patients with T2D. Biopsies of ...
Zhao Gaofeng G Surgical Service, Massachusetts General Hospital, Shriners Hospitals for Children, and Harvard Medical School, Boston, MA 02114, USA. - - 2013
To investigate the liver cellular apoptosis in response to burn injury and find out if statin treatment can ameliorate this process. The hypothesis is that statin may modulate apoptosis-related gene expression and thereby reduce hepatocytic apoptosis after burn injury. Mice were subjected to 30% full-thickness burn injury and then treated ...
Choeyprasert Worawut - - 2013
Cisplatin-induced ototoxicity, an important dose-limiting side effect, has proven high interindividual variability. Glutathione S-transferases (GSTs) are isoenzymes involved in cellular detoxification processes. Megalin has been demonstrated to bind aminoglycosides, known to be similar to cisplatin for their ototoxicity. The GSTs and megalin expression is genetically polymorphic, which might be responsible ...
Bonini Matteo M Department of Medicine, Lung Function Unit, Sapienza University of Rome, Rome, Italy. - - 2013
The nerve growth factor (NGF) is the main neurotrophin, which, besides being an important growth factor for nerves, plays an important role as a mediator of inflammation. Nerve growth factor has been shown to increase in relation to stress stimuli and in allergic diseases in humans as well as after ...
Sinha Manasi M Pediatric Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, - - 2013
Weight loss surgery is an increasingly common treatment option for obese adolescents, but data are limited regarding the metabolic effects of surgical weight loss procedures. We performed a retrospective review of the electronic medical record to determine metabolic outcomes for 24 adolescents and young adults ages 15 to 22 years ...
Ucar Deniz A DA Department of Surgery, University of Florida College of Medicine, Gainesville, FL, - - 2013
Pancreatic cancer is one of the most lethal diseases with no effective treatment. Previously, we have shown that FAK is overexpressed in pancreatic cancer and plays a key role in cancer cell survival and proliferation. FAK has been shown to interact with growth factor receptors including cMET and IGF-1R. As ...
Gabillard Delphine D INSERM, U897, Université Bordeaux Segalen, Bordeaux, France. - - 2013
In resource-limited countries, estimating CD4-specific incidence rates of mortality and morbidity among patients receiving antiretroviral therapy (ART) may help assess the effectiveness of care and treatment programmes, identify program weaknesses, and inform decisions. We pooled data from 13 research cohorts in 5 sub-Saharan African (Benin, Burkina Faso, Cameroon, Cote d'Ivoire, ...
Hebert Mary F MF Department of Pharmacy, University of Washington, Seattle, WA 98195-7630, - - 2013
Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that can increase the fraction of unbound tacrolimus, including but not limited to ...
Zaballos Matilde M Department of Toxicology, Complutense University, Madrid, Spain. - - 2013
The single-use Laryngeal Mask Airway (LMA) Supreme is a new supraglottic airway device. It has been reported to be reliable and easy-to-use in clinical practice; however, the anaesthetic techniques for its insertion are not standardised. The purpose of this study was to determine the ED50 of end-tidal sevoflurane concentration for ...
Buléon Clément C Caen University Hospital, Department of Anaesthesiology and Intensive Care, Caen, F-14000, France. - - 2013
Plastic single-use laryngoscope blades have been found to increase the difficulty of intubation. Metallic single-use blades may represent an alternative. To compare the rates of intubation failure at first laryngoscopy using metallic single-use, plastic single-use and metallic reusable laryngoscope blades. Randomised, superiority, single-centre, controlled trial. Operating theatres at a University ...
Wu Kang-Hsi - - 2013
Delayed hematopoietic reconstitution after cord blood transplantation (CBT) may lead to increased risk of complications and longer hospitalization. Bone marrow-derived mesenchymal stem cells (MSCs) have been found to promote engraftment after hematopoietic stem cell transplantation. However, harvesting MSCs from bone marrow involves an invasive procedure. Then again, MSCs can be ...
Eckardt Mark A - - 2013
Chemotherapeutic induction of radiation recall (RR) is a rare event in which a chemotherapeutic agent given days to years after radiation therapy causes an inflammation reaction of the tissues within the irradiated area-"recalling" increased radiation effects to that area. In this unique case, a 14-year-old girl with a synovial sarcoma ...
Meinardi Simone S Department of Chemistry, University of California Irvine, Irvine, CA, - - 2013
While much is known about the effect of chronic kidney disease (CKD) on composition of body fluids little is known regarding its impact on the gases found in exhaled breath or produced by intestinal microbiome. We have recently shown significant changes in the composition of intestinal microbiome in humans and ...
Descours Benjamin B UPMC University Paris 06, INSERM, UMRS945, AP-HP, Hôpital Pitié-Salpêtrière, Laboratoire d'immunologie cellulaire et tissulaire, Paris, - - 2013
To evaluate the contribution of CD4 T cells from blood and gut compartments to the HIV-1 reservoir, we directly quantified cell-associated HIV DNA in isolated rectal (R-) and peripheral blood (PB-) memory CD4 T cells from 11 successfully long-term treated patients. Proportion of activated (CD25(+); CD69(+); and HLA-DR(+)) and CCR5 ...
Jia Jingquan J Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, North Carolina 27710, - - 2013
Both Src and αV integrins are important for tumor growth and angiogenesis. They are interconnected and responsible for important features of the tumor phenotype including invasiveness, metastasis, angiogenesis, and resistance to apoptosis. This study examines whether combinational inhibition of both integrin and Src pathways would exert greater antiangiogenesis and antitumor ...
Jackson Akil A SSAT, St. Stephen's Centre, Chelsea & Westminster Hospital, London, United Kingdom. - - 2013
In vivo data on tenofovir (TFV), emtricitabine (FTC), and efavirenz (EFV) concentration decay after intake cessation are limited; determinations of "true" elimination half-lives (t½) have often been based on suboptimal sampling windows. Understanding these parameters is important in managing missed doses and planning HIV pre-exposure prophylaxis (PrEP). This study investigated ...
Vogl Ursula M - - 2013
Bronchiolitis obliterans (BO) is a detrimental late pulmonary complication after allogeneic hematopoietic stem cell transplantation (HCT) associated with chronic graft-versus-host disease (cGvHD). When systemic immunosuppressive treatment fails to improve, severe BO patients should be considered for lung transplantation (LuTX). We present seven patients undergoing LuTX for severe refractory BO after ...
Hanson Kevin P KP Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, - - 2013
The extracellular matrix (ECM) of the embryonic heart guides assembly and maturation of cardiac cell types and, thus, may serve as a useful template, or blueprint, for fabrication of scaffolds for cardiac tissue engineering. Surprisingly, characterization of the ECM with cardiac development is scattered and fails to comprehensively reflect the ...
Ishii Nobuyoshi - - 2013
ABSTRACT: Radioactivity from the Fukushima Daiichi Nuclear Power Plant (F-1NPP) accident in deposition samples has been monitored at the National Institute of Radiological Sciences (NIRS) in Chiba Prefecture, Japan, located about 220 km south-southwest of the F-1NPP. Sampling was carried out from 15 March 2011, two to three times a ...
Acha Robert - - 2013
ABSTRACT: A torso phantom was developed by the Lawrence Livermore National Laboratory (LLNL) that serves as a standard for intercomparison and intercalibration of detector systems used to measure low-energy photons from radionuclides, such as americium deposited in the lungs. DICOM images of the second-generation Human Monitoring Laboratory-Lawrence Livermore National Laboratory ...
Vilaragut J J - - 2013
ABSTRACT: Knowledge and lessons from past accidental exposures in radiotherapy are very helpful in finding safety provisions to prevent recurrence. Disseminating lessons is necessary but not sufficient. There may be additional latent risks for other accidental exposures, which have not been reported or have not occurred, but are possible and ...
Sakao S - - 2013
It is generally accepted that chronic thromboembolic pulmonary hypertension (CTEPH) results from pulmonary emboli originating from deep vein thrombosis. However, this consensus opinion has been challenged, and the concept that some aspects of CTEPH exacerbation might result from a small-vessel disease leading to secondary thrombosis has been suggested. In addition ...
Raamat Rein - - 2013
To compare different algorithms to determine the oscillometric mean arterial pressure. Using a computer-based model, the accuracy of five algorithms was studied: maximum amplitude algorithm, 33 and 40% formulas calculating the mean arterial pressure from oscillometrically measured systolic and diastolic pressures, and two oscillation shape-based algorithms. We examined to which ...
Ronca-Battista M - - 2013
ABSTRACT: The U.S. Environmental Protection Agency (EPA) operates an environmentally controlled chamber for purposes of exposing various radon and decay product measurement equipment to known Rn concentrations. Exposure durations range from 1 h to several months, and Rn concentrations vary between 37 and 4,440 Bq m. Radon concentrations are generated ...
Ichikawa C - - 2013
A3 was generated as an antibody recognizing somatic stem cells in rat tissues. We investigated the distribution of A3-positive cells in developing rat hair follicles by immunolabeling. A3-positive cells began to be seen in the hair germ and peg in fetuses and neonates; the positive cells were epithelial cells above ...
Bizzarri M - - 2013
Cell shape is mainly determined by biophysical constraints, interacting according to non-linear dynamics upon the basic units provided by the genome. In turn, the specific configuration a cell acquires plays a fundamental, permissive role in modulating gene expression and many other complex biological functions. Cell shape is tightly connected to ...
Manjunatha H C - - 2013
ABSTRACT: Effective atomic numbers' (Zeff) effective electron density (Nel) for human organs and tissues have been computed in the energy region of 1 keV to 100 GeV using WinXCOM. The computed data of Zeff and Nel are tabulated. The computed values are compared with previous results. The computed data of ...
Coccini T - - 2013
Potential risk associated with new nanomaterial exposure needs to be assessed. This in vivo study investigated pulmonary effects of engineered cadmium-containing silica nanoparticles Cd/SiNPs (1 mg/rat), silica SiNPs (600 μg/rat) and CdCl₂ (400 μg/rat) 1, 7 and 30 days after intratracheal instillation. Comprehensive histopathological and immunocytochemical characterization of lung damage ...
Iwaoka Kazuki - - 2013
ABSTRACT: The authors measured the ambient dose rate and activity concentration of natural radionuclides in raw materials, products, and aerosols on worksites, as well as the Rn and Rn concentrations in an unshaped refractory, a shaped refractory, and an electrocast refractory plant processing zirconium ore in Japan. Estimations were made ...
Yamaguchi Y - - 2013
New blood vessel formation is critical, not only for organ development and tissue regeneration, but also for various pathologic processes, such as tumor development and vasculopathy. The maintenance of the postnatal vascular system requires constant remodeling, which occurs through angiogenesis, vasculogenesis, and arteriogenesis. Vasculogenesis is mediated by the de novo ...
Higaki Shogo - - 2013
ABSTRACT: The reductive effect of an anti-pollinosis mask against internal exposure from radioactive materials dispersed following the Fukushima Daiichi Nuclear Disaster was investigated. A single mask was worn continuously for 18 h from 15:00 JST on 15 March to 09:00 JST on 16 March 2011 at the Hongo campus of ...
Hietanen Heikki - - 2013
Ankle blood pressure may be a useful indicator of arterial stiffness. The main aim of the present study was to examine the relationship of ankle blood pressure measured in midlife with the risk of dementia with advancing age. A secondary aim was to examine the relationship of physical exercise capacity ...
Leghrouz Amin A - - 2013
ABSTRACT: Indoor radon level measurements were carried out in 42 dwellings in Bethlehem, Palestine, using CR-39 solid state nuclear track detectors. The measurements were performed during winter and spring seasons of the year 2010, for a period ranging from 97-118 d using a total of 100 detectors. The detectors were ...
Kelava T - - 2013
Recent investigations suggest that glucagon might have a potentially important hepatoprotective activity. We investigated the effect of glucagon in a model of acetaminophen-induced liver injury. CBA male mice were injected intraperitoneally with a lethal (300 mg/kg) or sublethal (150 mg/kg) dose of acetaminophen. The liver injury was assessed by observing ...
Ditsch N - - 2013
There is evidence that breast cancer patients suffer from thyroid disorders. However, the relation between thyroid receptor (TR) expression and breast cancer remains unknown so far. Therefore, the aim of this study was an immunohistochemical analysis of TR expression in breast cancer patients. Materials and methods: The expression of the ...
Tabeie Faraj - - 2013
ABSTRACT: Use of unsealed radiopharmaceuticals in Iran's nuclear medicine centers has expanded rapidly in the last decade. As part of a nationwide survey, this study was undertaken to estimate the radiation risk due to the diagnostic nuclear medicine procedures performed in Tehran in 1999-2003. During the five years of the ...
Lopes F D T Q S - - 2013
A single instillation of porcine pancreatic elastase (PPE) results in significant airspace enlargement on the 28th day after instillation, whereas cigarette smoke (CS) exposure requires 6 months to produce mild emphysema in rodents. Considering that there are differences in the pathogenesis of parenchymal destruction in these different experimental models, it ...
Caprile Paola Francisca - - 2013
ABSTRACT: The characteristics of the thermoluminescence glow curve and dosimetric peak of LiF:Mg,Ti (TLD-100) crystals are studied, with emphasis on the evaluation of the influence of the irradiation dose and heating rate on the dosimetric peak (peak 5) trapping parameters. These parameters were obtained using a computerized deconvolution routine that ...
Moussa Hanna M - - 2013
ABSTRACT: The effective dose coefficients tabulated in Publication 80 of the International Commission on Radiological Protection (ICRP) for the radiopharmaceuticals addressed earlier in ICRP Publication 53 are based on the tissue weighting factors of ICRP Publication 60. Presumably these values are derived from the tissue dose coefficients tabulated in Publication ...
Glassford Eric - - 2013
ABSTRACT: A single, large, bulk sample of uranium-contaminated material from the dirt floor of an abandoned metal rolling mill was separated into different types and sizes of aliquots to simulate samples that would be collected during site remediation. The facility rolled approximately 11,000 tons of hot-forged ingots of uranium metal ...
Halevy O - - 2013
Absence of, or loss-of-function mutations in the dysferlin gene (dysf) result in dysferlinopathy, characterized by increased muscle inflammation, collagen deposition and deterioration in muscle function. We evaluated halofuginone efficacy in improving muscle histopathology in mice with deleted dysf transmembrane domain. Quadriceps sublumbar and longissimus muscles of 9-month-old dysf-/- mice treated ...
Estevam Marcelo - - 2013
ABSTRACT: This work investigated the viability of the portable x-ray fluorescence (PXRF) technique as a means of measuring iron levels in patients suffering from thalassemia major (beta-thalassemia) and hereditary hemochromatosis (HH or Haemochromatosis) or other iron-overload conditions. Measurements were conducted at the University Hospital Blood Center and in the Laboratory ...
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