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Results 201 - 250 of 2977
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Kong Jiang-Ti JT Department of Anesthesia, Division of Pain Medicine, Stanford Neuroscience and Pain Laboratory, Stanford University, Palo Alto, California 94304, - - 2013
Temporal summation (TS) refers to the increased perception of pain with repetitive noxious stimuli. It is a behavioral correlate of wind-up, the spinal facilitation of recurring C-fiber stimulation. In order to utilize TS in clinical pain research, it is important to characterize TS in a wide range of individuals and ...
St Sauver Jennifer L JL Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, - - 2013
To describe the prevalence of nonacute conditions among patients seeking health care in a defined US population, emphasizing age, sex, and ethnic differences. The Rochester Epidemiology Project (REP) medical records linkage system was used to identify all residents of Olmsted County, Minnesota, on April 1, 2009, who had consented to ...
Sepanlou Sadaf G SG Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences Tehran, - - 2013
The Gastro-Esophageal Malignancies in Northern Iran (GEMINI) research project is an example of recent progress in health research in Iran. The original aim of this project was to identify etiologic factors and prevention measures for upper gastrointestinal cancers in Northern provinces of Iran, but its achievements have gone much beyond ...
Kalmbach Keri Horan KH Department of Obstetrics and Gynecology, New York University, Langone Medical Center, New York City, New York, - - 2013
Telomeres mediate biologic aging in organisms as diverse as plants, yeast, and mammals. We propose a telomere theory of reproductive aging that posits telomere shortening in the female germ line as the primary driver of reproductive aging in women. Experimental shortening of telomeres in mice, which normally do not exhibit ...
Manning Danielle K DK Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, - - 2013
A missense mutation in mouse Nek8, which encodes a ciliary kinase, produces the juvenile cystic kidneys (jck) model of polycystic kidney disease, but the functions of Nek8 are incompletely understood. Here, we generated a Nek8-null allele and found that homozygous mutant mice die at birth and exhibit randomization of left-right ...
Taylor Bryan J BJ Division of Cardiovascular Diseases, College of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. - - 2013
The mechanisms underlying the reactive component of pulmonary hypertension (PH) in heart failure (HF) are unclear. We examined whether resting systemic oxygen levels are related to pulmonary hemodynamics in HF. Thirty-nine HF patients underwent right heart catheterization. Subsequently, patients were classified as having: 1) no PH (n = 12); 2) passive PH ...
Sengupta Jyoti N JN Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI 53226, - - 2013
The nociceptive transmission under pathological chronic pain conditions involves transcriptional and/or translational alteration in spinal neurotransmitters, receptor expressions, and modification of neuronal functions. Studies indicate the involvement of microRNA (miRNA) - mediated transcriptional deregulation in the pathophysiology of acute and chronic pain. In the present study, we tested the hypothesis ...
Reddy A Srinivas AS Integrated Molecular Discovery Laboratory, Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX, - - 2013
In recent years, even with remarkable scientific advancements and a significant increase of global research and development spending, drugs are frequently withdrawn from markets. This is primarily due to their side effects or toxicities. Drug molecules often interact with multiple targets, coined as polypharmacology, and the unintended drug-target interactions could ...
Koppe Laetitia L Hospices Civils de Lyon, Department of Nephrology, Hôpital E Herriot, Lyon, - - 2013
The mechanisms underlying the insulin resistance that frequently accompanies CKD are poorly understood, but the retention of renally excreted compounds may play a role. One such compound is p-cresyl sulfate (PCS), a protein-bound uremic toxin that originates from tyrosine metabolism by intestinal microbes. Here, we sought to determine whether PCS ...
Teeninga Nynke N Department of Pediatrics, Division of Nephrology, Erasmus University Medical Centre—Sophia Children’s Hospital, Rotterdam, The Netherlands. - - 2013
Prolonged prednisolone treatment for the initial episode of childhood nephrotic syndrome may reduce relapse rate, but whether this results from the increased duration of treatment or a higher cumulative dose remains unclear. We conducted a randomized, double-blind, placebo-controlled trial in 69 hospitals in The Netherlands. We randomly assigned 150 children ...
Kiblawi Zeina N ZN LA BioMed Institute, Harbor-UCLA Medical Center, David Geffen School of Medicine, Los Angeles, CA 90502, - - 2013
To assess for the increased risk of attention-deficit hyperactivity disorder (ADHD) in young children with prenatal methamphetamine exposure from the multicenter, longitudinal Infant Development, Environment, and Lifestyle (IDEAL) study. The IDEAL study enrolled 412 mother-infant pairs at 4 sites (Tulsa, OK; Des Moines, IA; Los Angeles, CA; and Honolulu, HI). ...
Liang De-Yong DY Department of Anesthesiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA. - - 2013
Repeated administration of opioids such as morphine induces persistent behavioral changes including opioid-induced hyperalgesia (OIH), tolerance, and physical dependence. In the current work we explored how the balance of histone acetyltransferase (HAT) versus histone deacetylase (HDAC) might regulate these morphine-induced changes. Nociceptive thresholds, analgesia, and physical dependence were assessed during ...
Chang Richard R Radiology and Imaging Sciences Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. - - 2013
Seven patients with venous thrombosis and contraindications to traditional thrombolytic therapy, consisting of recent intracranial surgery, recent pineal or retroperitoneal hemorrhage, active genitourinary or gastrointestinal bleeding, epidural procedures, and impending surgery, were successfully treated with a modified thrombolytic regimen. To improve safety, prolonged continuous infusions of tissue plasminogen activator (tPA) ...
Gogate Parikshit P Dr. Gogate's Eye Clinic; Lions NAB Eye Hospital, Miraj, - - 2013
Refractive errors (RE) are the most common cause of avoidable visual impairment in children. But benefits of visual aids, which are means for correcting RE, depend on the compliance of visual aids by end users. To study the compliance of spectacle wear among rural school children in Pune district as ...
Pirmohamed Munir M Department of Molecular and Clinical Pharmacology, Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. - - 2013
The delivery of more personalized medicinecould be accelerated by addressing the substantial differences in the level of evidence required for the inclusion of pharmacogenetic tests in treatment guidelines, drug labelling and reimbursement schemes compared with that needed for non-genetic diagnostic tests.
Lee Michael C MC Centre for Functional MRI ofBrain (FMRIB), Department of Clinical Neurology, University of Oxford, Oxford, UK. - - 2013
Cannabis is reported to be remarkably effective for the relief of otherwise intractable pain. However, the bases for pain relief afforded by this psychotropic agent are debatable. Nonetheless, the frontal-limbic distribution of cannabinoid receptors in the brain suggests that cannabis may target preferentially the affective qualities of pain. This central ...
Geisberg Carrie A CA Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6300, USA. - - 2013
Breast cancer (BC) treatments can cause heart failure (HF) in a subset of patients. ACC/AHA guidelines classify patients receiving cardiotoxic medications as stage A, a high-risk population for the development of HF. Circulating neuregulin (NRG) correlates with outcomes in stage C and D HF. We examined the levels of NRG ...
Parekh Arti A Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, - - 2013
To report the relative incidence of the perceived reduction in penile size across prostate cancer treatment modalities and to describe its effect on quality of life and treatment regret. The incidence of patient complaints about reduced penile size was calculated for 948 men in the Comprehensive, Observational, Multicenter, Prostate Adenocarcinoma ...
Benchikh El Fegoun Amine A Department of Urology, University Hospital Bichat Claude Bernard, Assistance Publique Hôpitaux de Paris, University Paris VII, Paris, France. - - 2013
To assess the quality of specimens obtained from prostate biopsies performed by urology residents and evaluate the number of procedures required to perform high-quality transrectal ultrasound (TRUS)-guided prostate biopsies. Between 2006 and 2009, 770 patients underwent TRUS-guided prostate biopsies in our academic center. During the 6 semesters of this period, ...
Cutting Laurie E LE Education and Human Development, Education and Brain Research Laboratory, Vanderbilt University, Nashville, Tennessee 37203, USA. - - 2013
Although an extensive literature exists on the neurobiological correlates of dyslexia (DYS), to date, no studies have examined the neurobiological profile of those who exhibit poor reading comprehension despite intact word-level abilities (specific reading comprehension deficits [S-RCD]). Here we investigated the word-level abilities of S-RCD as compared to typically developing ...
Jakubczyk Andrzej A Department of Psychiatry, Medical University of Warsaw, Warsaw, - - 2013
Impulsivity is an important risk factor of severe course of alcohol dependence. However, the significance of environmental determinants of impulsivity has been underestimated. The aim of this study was to identify psychosocial factors increasing the level of impulsivity in alcoholics. Levels of impulsivity were measured in 304 alcohol-dependent patients. The ...
Huang Li - - 2012
Aim:To investigate the effects of anti-caries DNA vaccine-induced salivary secretory immunoglobulin A (S-IgA) antibodies on Streptococcus mutans (S. mutans) adherence and biofilms formation in vitro.Methods:Adult female Wistar rats were intranasally immunized with the anti-caries DNA vaccine pGJA-P/VAX. Their saliva samples were collected at different times after the immunization, and S-IgA ...
Park Young Woon - - 2012
Abstract Background: Propranolol has recently become a successful first-line therapy in the treatment of infantile hemangiomas(IHs). Objective: To evaluate and analyze our experience of propranolol treatment for IHs. Methods: A retrospective, observational study was conducted. Medical records were reviewed. To evaluate the outcome of treatment, serial digital photographs using a ...
Zhang Dian-Cai - - 2012
Aim:Gemcitabine has been increasingly prescribed for the treatment of gallbladder cancer. However, the response rate is low. The aim of this study is to determine whether icariin, a flavonoid isolated from Epimedi herba, could potentiate the antitumor activity of gemcitabine in gallbladder cancer.Methods:Human gallbladder carcinoma cell lines GBC-SD and SGC-996 ...
Allen Caley - - 2012
Ionic liquids have been proposed to induce a mechanistic change in the reaction pathway for the fundamentally important base-induced β-elimination class compared to conventional solvents. The role of the reaction medium in the elimination of 1,1,1-tribromo-2,2-bis(3,4-dimethoxyphenyl)ethane via two bases, piperidine and pyrrolidine, has been computationally investigated using methanol and the ...
Hwang Ee Taek - - 2012
In the present study, we report on enzyme-assisted formation of biomineralized amorphous calcium phosphate nanocomposites (ACP-NCs). About 100-200 nm sizes of the spherical porous enzyme-assisted ACP-NCs were successfully synthesized via double reverse microemulsion, but no ACP-NCs formed without the enzyme. It is believed that the enzyme was used as an ...
Zhang Rui - - 2012
Purification of nucleic acids from low quantity of bacterial cells in minute volume is im- portant in many clinical and biological applications. We developed a novel microfluidic liquid phase nucleic acid purification chip to selectively isolate DNA or RNA from bacterial cell in the range of 5000 down to a ...
Sebekova Katarina - - 2012
Abstract As a main excretory organ kidney is predisposed to direct/indirect injury. We addressed the potential nephrotoxic effects following expositions of healthy rats to nanoparticles (NPs)-loads relevant to humans in a situation of 100% bioavailability. Up to 4 weeks after administration, a single i.v. bolus of oleate-coated ultra-small superparamagnetic iron ...
Shan Tzu-Ray - - 2012
The dependence of the reaction initiation mechanism of pentaerythritol tetranitrate (PETN) on shock orientation and shock strength is investigated with molecular dynamics simulations using a reactive force field and the multiscale shock technique. In the simulations, a single crystal of PETN is shocked along [110], [001], and [100] orientations with ...
Ottaway Josh - - 2012
An essential part to calibration is establishing the analyte calibration reference samples. These samples must characterize the sample matrix and measurement conditions (chemical, physical, instrumental, and environmental) of any sample to be predicted. Calibration usually requires measuring spectra for numerous reference samples in addition to determining the corresponding analyte reference ...
Ouyang Runhai - - 2012
Understanding Ostwald ripening and disintegration of supported metal particles under operating conditions have been of central importance in the study of sintering and dispersion of heterogeneous catalysts for long term industrial implementation. To achieve a quantitative description of these complicated processes, an atomistic and generic theory taking into account of ...
Vuojola Johanna - - 2012
The study of biomolecular interactions is at the heart of biomedical research. Fluorescence and Förster resonance energy-transfer (FRET) are potent and versatile tools in studying these interactions. Fluorescent proteins enable genetic encoding which facilitates their use in recombinant protein and in vivo applications. To eliminate the autofluorescence background encountered in ...
Hill Jonathan Patrick - - 2012
Two complementary examples of porphyrin nanoarchitectonics are presented. Fabrication of binary molecular monolayers using two different porphyrin molecules tetrakis(3,5-di-t-butyl-4-hydroxyphenyl)porphyrin (1) and tetrakis(4-pyridyl)porphyrin (2) by deposition in ultrahigh vacuum was demonstrated. Two unusual heteromolecular monolayer structures were observed with one exhibiting good separation of 1 molecules within the monolayer. Also, a ...
Hanson Kevin - - 2012
The extracellular matrix (ECM) of the embryonic heart guides assembly and maturation of cardiac cell types and thus may serve as a useful template, or blueprint, for fabrication of scaffolds for cardiac tissue engineering. Surprisingly, characterization of the ECM with cardiac development is scattered and fails to comprehensively reflect spatiotemporal ...
Gold Brian - - 2012
Recently, we have identified two strategies for selective transition state (TS) stabilization in catalyst-free azide/alkyne cycloadditions. In particular, the transition states for the formation of both 1,4- and 1,5-isomers can be stabilized via hyperconjugative assistance for the C…N bond formation whereas the 1,5-TS can be stabilized via C-H…X H-bonding interactions. ...
von Boehmer Harald - - 2012
Forkhead box P3 (FOXP3)-expressing regulatory T (T(Reg)) cells have a pivotal role in the regulation of immune responses and in the maintenance of immunological self-tolerance. These cells have emerged as attractive targets for strategies that allow the steering of immune responses in desired directions - arming the immune system to ...
La Vignera Sandro - - 2012
Although alcohol is widely used, its impact on the male reproductive function is still controversial. Over the years, many studies have investigated the effects of alcohol consumption on sperm parameters and male infertility. This article reviews the main preclinical and clinical evidences. Studies conducted on the experimental animal have shown ...
Manna Angelo - - 2012
ABSTRACT: Fractional exhaled nitric oxide (FeNO) is a non invasive method for assessing the inflammatory status of children with airway disease. Different ways to measure FeNO levels are currently available. The possibility of measuring FeNO levels in an office setting even in young children, and the commercial availability of portable ...
Fabre Bruno - - 2012
The deposition of gold and platinum nanoparticles (NPs) on hydrogen-terminated Si(100) (Si(100)-H) surfaces has been performed by galvanic displacement using fluoride-free sub-mM metallic salt solutions. The scanning electron microscopy (SEM) images showed the formation of oblate hemispherical NPs, with an average diameter of ca. 40 nm and an average height ...
Rehammar Robert - - 2012
We demonstrate an electrically tunable 2D photonic crystal array constructed from vertically aligned carbon nanofibers. The nanofibers are actuated by applying a voltage between adjacent carbon nanofiber pairs grown directly on metal electrodes, thus dynamically changing the form factor of the photonic crystal lattice. The change in optical properties is ...
Sarker Swapan Chandra - - 2012
The purpose of the study was to identify the potential risk factors for subclinical mastitis (SCM) in lactating dairy cows in Bangladesh. A cross-sectional study was carried out on randomly selected 212 smallholder dairy farms of Sadar upazilas of Rangpur, Mymensingh, and Satkhira districts of Bangladesh during January to October ...
Hentschel Mario - - 2012
We construct chiral plasmonic molecules by assembling two individual chiral centers. Interestingly, depending on the exact arrangement of the centers, all combinations result in a chiral compound with a strong chiral optical response. Furthermore, we demonstrate that the overall circular dichrosim (CD) is determined by the response of the individual ...
Ismail Sahar A - - 2012
Abstract Abstract Background: Vitiligo patients repeatedly experience disinterest from the medical world regarding their disease as it does not cause physical impairment. Several therapeutic options are available for vitiligo management. Objectives: To study vitiligo management strategy in Jeddah, Saudi Arabia (KSA) as indicated by dermatologists and as experienced by patients. ...
Kim Hyo Won - - 2012
Material surface engineering has attracted great interest in important applications, including electronics, biomedicine, and membranes. More recently, dopamine has been widely exploited in solution-based chemistry to direct facile surface modification. However, unsolved questions remain about the chemical identity of final products, their deposition kinetics and binding mechanism. In particular, the ...
Iwamura Munetaka - - 2012
Structural dynamics involving tight Au-Au bond formation of excited-state oligomers [Au(CN)(2)(-)](n) was studied using picosecond/femtosecond time-resolved emission and absorption spectroscopy. With selective excitation of the trimer ([Au(CN)(2)(-)](3)) in aqueous solutions, transient absorption due to the excited-state trimer was observed around 600 nm. This transient exhibited a significant intensity increase (τ ...
Celik Orcun - - 2012
The higher frequency of varicocele in men with infertility has drawn attention and resulted in increased research at the molecular level towards treatments. The aim of this study was to investigate the role of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its receptors in varicocele-induced testicular dysfunction in an ...
Hong Xin - - 2012
The mechanism and origins of selectivities in [Ni(NHC)]-catalyzed intramolecular (5+2) cycloadditions and homo-ene reactions of vinylcyclopropanes (VCPs) and alkynes have been studied using density functional theory. The preferred mechanism involves oxidative alkyne-alkene cyclization to form a metallacyclopentene intermediate, in contrast to cyclopropane cleavage pathway in the reaction with Rh(I) catalysts. ...
Rawolle Monika - - 2012
The degree of filling of titania nanostructures with a solid hole-conducting material is important for the performance of solid-state dye-sensitized solar cells (ssDSSCs). Different ways to infiltrate the hole-conducting polymer poly(3-hexylthiophene) (P3HT) into titania structures, both, granular structures as they are already applied commercially, and tailored sponge nanostructures, are investigated. ...
Goubet Nicolas - - 2012
For self-assembled nanocrystals in 3D superlattices, called supracrystals, the crystalline structure of the metal nanocrystals (either single domain or polycrystallines) or nanocrystallinity, is likely to induce significant changes in the physical properties. Previous studies demonstrated that spontaneous nanocrystallinity segregation takes place in colloidal solution upon self-assembling of 5 nm dodecanethiol-passivated ...
Park Bumsoo - - 2012
To analyze if clinically insignificant prostate cancer (CIPC) is more frequently detected with repeat prostate biopsies, we retrospectively analyzed the records of 2146 men diagnosed with prostate cancer after one or more prostate biopsies. The patients were divided into five groups according to the number of prostate biopsies obtained, e.g. ...
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