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Priest N D - - 2013
ABSTRACT: The good neutron economy and online refueling capability of the CANDU® heavy water moderated reactor (HWR) enable it to use many different fuels such as low enriched uranium (LEU), plutonium, or thorium, in addition to its traditional natural uranium (NU) fuel. The toxicity and radiological protection methods for these ...
Cheng Yi - - 2013
We propose an efficient group sequential monitoring rule for clinical trials. At each interim analysis both efficacy and futility are evaluated through a specified loss structure together with the predicted power. The proposed design is robust to a wide range of priors, and achieves the specified power with a saving ...
Sato Y - - 2013
Idiopathic portal hypertension (IPH) is a condition of non-cirrhotic portal hypertension without a known cause of liver disease. Obliterative portal venopathy is regarded as the primary lesion, which is responsible for the pre-sinusoidal block of hepatic blood flow leading to the development of IPH. The disease pathogenesis of IPH seems ...
Witt Arnaud - - 2013
Children with intellectual disabilities (ID) and controls were exposed to an incidental learning phase, where half of the participants received highly implicit instructions at test while the other half received explicit instructions. When learning was assessed for simple chunks of information, children with ID performed better with implicit instructions than ...
Dian D - - 2013
PankoMab-GEX™ is a novel humanized and glycooptimized antibody, which recognizes a novel specific tumour epitope of MUC1 (TA-MUC1). The aim of this study was to evaluate PankoMab-GEX™ binding to a variety of ovarian cancer specimens (n=156) and to normal ovarian tissue. In addition, PankoMab-GEX™ staining was compared to that of ...
Ditsch Nina N Department of Obstetrics and Gynecology - Großhadern, Ludwig-Maximilians University, Munich, Germany. - - 2013
There is evidence that breast cancer patients suffer from thyroid disorders. However, the relation between thyroid receptor (TR) expression and breast cancer remains unknown so far. Therefore, the aim of this study was an immunohistochemical analysis of TR expression in breast cancer patients. The expression of the combined antibody TRalpha1 ...
Rifkin Dena E DE Division of Nephrology, University of California, San Diego, CA, USA. - - 2013
Older adults with chronic kidney disease have a high rate of uncontrolled hypertension. Home monitoring of blood pressure (BP) is an integral part of management, but requires that patients bring records to clinic visits. Telemonitoring interventions, however, have not targeted older, less technologically-skilled populations. Veterans with stage 3 or greater ...
Estrella Michelle M MM Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. - - 2013
Natural history studies suggest increased risk for kidney function decline with HIV infection, but few studies have made comparisons with HIV-uninfected women. We examined whether HIV infection treated with highly active antiretroviral therapy (HAART) remains associated with faster kidney function decline in the Women's Interagency HIV Study. HIV-infected women initiating ...
Chiavarino Barbara - - 2013
Infrared multiple photon dissociation (IRMPD) spectroscopy of cis-[Pt(NH(3))(2)(G)Cl](+) and cis-[Pt(NH(3))(2)(A)Cl](+) ions (where A is adenine and G is guanine) has been performed in two spectral regions, 950-1900 and 2900-3700 cm(-1). Quantum chemical calculations at the B3LYP/LACV3P/6-311G** level yield the optimized geometries and IR spectra for the conceivable isomers of cis-[Pt(NH(3))(2)(G)Cl](+) ...
Gourraud Jean-Baptiste - - 2013
The aim of this study was to identify families affected by early repolarization syndrome (ERS) and to determine the mode of transmission of the disease. Early repolarization (ER) has recently been linked to idiopathic ventricular fibrillation. Familial inheritance of the disease has been suggested but not demonstrated. We screened relatives ...
Metra Marco - - 2013
The aim of this study was to assess the effects of serelaxin on short-term changes in markers of organ damage and congestion and relate them to 180-day mortality in patients with acute heart failure. Hospitalization for acute heart failure is associated with high post-discharge mortality, and this may be related ...
Li Xinlei - - 2013
Skelemin, a myosin-associated protein in skeletal muscle, has been demonstrated to interact with integrin α(IIb)β(3) in nonmuscle cells during initial stages of cell spreading. The significance of this interaction and the role of skelemin in integrin signaling and cytoskeletal reorganization were investigated in this study. We established a series of ...
Collins Sean P SP Vanderbilt University, Nashville, Tennessee 37232, USA. - - 2013
Approximately 800,000 times a year, an emergency physician admits a patient with symptomatic heart failure (HF). Yet only a minority of emergency department patients with HF are severely ill as a result of pulmonary edema, myocardial ischemia, or cardiogenic shock. The majority of patients are not in need of an ...
Cunningham Robert R Department of Chemistry & School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, - - 2013
Cerebrospinal fluid (CSF) is a low protein content biological fluid with a dynamic range spanning at least 9 orders of magnitude in protein content and is in direct contact with the brain. A modified IgY-14 immunodepletion treatment was performed to enhance analysis of the low volumes of CSF that are ...
Pressly Eric D ED Materials Research Laboratory, University of California, Santa Barbara, CA 93106, - - 2013
Atrial natriuretic peptide has been recently discovered to have anticancer effects via interaction with cell surface natriuretic peptide receptor A (NPRA) and natriuretic peptide clearance receptor (NPRC). In a preclinical model, NPRA expression has been identified during tumor angiogenesis and may serve as a potential prognostic marker and target for ...
Chan Leslie W LW Department of Bioengineering, University of Washington, Seattle, WA 98195, - - 2013
Molecular imaging, the visualization of molecular and cellular markers, is a promising method for detection of dysplasia and early cancer in the esophagus and can potentially be used to identify regions of interest for biopsy or tumor margins for resection. EGFR is a previously reported cell surface receptor with stepwise ...
Xu Lin L WUT-Harvard Joint Nano Key Laboratory, Wuhan University of Technology, Wuhan 430070, - - 2013
Functional kinked nanowires (KNWs) represent a new class of nanowire building blocks, in which functional devices, for example, nanoscale field-effect transistors (nanoFETs), are encoded in geometrically controlled nanowire superstructures during synthesis. The bottom-up control of both structure and function of KNWs enables construction of spatially isolated point-like nanoelectronic probes that ...
Nagy Gergely György - - 2013
The incidence of Clostridium difficile associated enteral disease shows dramatic increase worldwide, with appallingly high treatment costs, mortality figures, recurrence rates and treatment refractoriness. It is not surprising, that there is significant interest in the development and introduction of alternative therapeutic strategies. Among these only stool transplantation (or faecal bacteriotherapy) ...
Bak Mihály M Országos Onkológiai Intézet Budapest. - - 2013
The methods available for the diagnosis of lung cancer include radiologic, cytologic and pathologic procedures. The aim of this study was to determine the quality assurance of CT guided fine needle aspiration cytology of lung nodules. Cytology results were rated to 4 categories (positive; suspicious; negative; not representative). All cytology ...
Suri Sunjay - - 2013
Coinciding treatment with periods of accelerated skeletal growth and maturation might be advantageous in clinical practice. Better understanding of the concordance between skeletal and chronologic ages during the period that children frequently receive orthodontic treatment is needed. The literature on skeletal age determination from hand-wrist radiographs lacks reports based on ...
Kuang Bin - - 2013
The purposes of this research were to investigate the long-term responses of mandibular condylar cartilage to experimentally induced disordered occlusion and to evaluate changes in the expression of the SDF-1/CXCR4 axis. Experimentally induced disordered occlusions were created in 8-week-old female Sprague-Dawley rats by orthodontic methods. After 24 weeks, remodeling of ...
Werber D - - 2013
Timely outbreak detection is a major objective of the surveillance of food-borne infections. In this regard molecular subtyping is a very useful tool for several bacterial pathogens, e.g. enterohemorrhagic E. coli (EHEC), Listeria monocytogenes and various serotypes of non-typhoidal Salmonella. The basis is the characterization of patient isolates by molecular methods, ...
Samalavicius Narimantas Evaldas - - 2013
Rectovaginal fistula (RVF) is one of the intractable complications following chemoradiation and total mesorectal excision (TME) for rectal cancer. It is supposed that there is a strong possibility of this complication occurring in patients after radiation therapy and having underlying sepsis. We describe herein two female patients (73 and 40 ...
Wiranto Matthew G - - 2013
Digital 3-dimensional models are widely used for orthodontic diagnosis. The aim of this study was to assess the validity, reliability, and reproducibility of digital models obtained from the Lava Chairside Oral scanner (3M ESPE, Seefeld, Germany) and cone-beam computed tomography scans of alginate impressions for tooth-width measurements and the Bolton ...
Dilip Javali Tarun - - 2013
This is the first reported case of a Dormia basket being dislodged outside the ureter into the retroperitoneum during intracorporeal lithotripsy.
Meijer Julia H - - 2013
ABSTRACT: The current study investigated whether candidate cognitive endophenotypes may be used to validate a schizo-obsessive subtype. Using within-subject random effect regression analyses and cross-trait cross-relative analyses, we evaluated the association between obsessive-compulsive symptoms (OCSs) and cognitive performance in 984 patients with nonaffective psychosis (22.5% with OCSs), 973 unaffected siblings ...
Tyystjärvi Esa - - 2013
Photoinhibition of Photosystem II (PSII) is the light-induced loss of PSII electron-transfer activity. Although photoinhibition has been studied for a long time, there is no consensus about its mechanism. On one hand, production of singlet oxygen ((1)O(2)) by PSII has promoted models in which this reactive oxygen species (ROS) is ...
Sarrafzadegan Nizal - - 2013
This study evaluated the outcome of a comprehensive, community-based healthy lifestyle program on cardiometabolic risk factors. The Isfahan Healthy Heart Program (IHHP) was a comprehensive action-oriented, multi-component intervention with a quasi-experimental design and reference area.   IHHP targeted the population-at-large (n = 2,180,000) in three districts in central Iran. Data ...
Chaux Alcides - - 2013
To evaluate immunohistochemical expression of phosphatase and tensin homolog (PTEN) and mammalian target of rapamycin (mTOR) pathway members in pT1 urothelial carcinomas treated by transurethral resection and to determine if immunohistochemistry can be used to predict prognosis. Formalin-fixed, paraffin-embedded tissue samples from 156 patients with pT1 urothelial carcinoma treated by ...
Park Hee Jin - - 2013
Small ubiquitin-like modifier (SUMO) is a small (∼12kDa) protein that occurs in all eukaryotes and participates in the reversible posttranslational modification of target cellular proteins. The three-dimensional structure of SUMO and ubiquitin (Ub) are superimposable although there is very little similarity in their primary amino acid sequences. In all organisms, ...
Gottvall Maria - - 2013
The aim of this study was to explore the relational aspects of the consent process for HPV vaccination as experienced by school nurses, based on the assumption that individuals have interests related to persons close to them, which is not necessarily to be apprehended as a restriction of autonomy; rather ...
Lau Catherine K - - 2013
The prevalence of impacted second molars is low, varying from 0% to 2.3%. The etiology of an impaction can involve systemic, local, and periodontal factors, as well as a developmental disruption of the tooth germ. A number of surgical and orthodontic treatment options have been suggested in the literature, including ...
Rossmann C - - 2013
Based on theories and empirical results from communication science, the present paper provides an overview of the role of mass media in risk communication. It is guided by the following questions: How do risk issues find their way into the media and how does the media depict them? How do ...
Zack Barry - - 2013
This field report describes Health through Wall's experience working in the largest men's prison in Haiti. Though there have been many reports of prison peer health education programs, this field report further describes how peers can increase the (self-reported) interest and uptake of HIV testing. More than 400 anonymous surveys ...
Haroutiunian Simon - - 2013
Persistent postsurgical pain (PPSP) is a frequent and often disabling complication of many surgical procedures. Nerve injury-induced neuropathic pain (NeuP) has repeatedly been proposed as a major cause of PPSP. However, there is a lack of uniformity in NeuP assessment across studies, and the prevalence of NeuP may differ after ...
Schweiger B - - 2013
For many years, the Working Group on Influenza (AGI) has been the most important influenza surveillance system in Germany. An average sample of the population is covered by both syndromic and virological surveillance, which provides timely data regarding the onset and course of the influenza wave as well as its ...
Hebar Alexandra - - 2013
The last decades were characterized by enormous technological advances resulting in a better understanding of disease pathologies and improvement of treatment strategies. The development of targeted drugs, whose beginning can be traced back to Paul Ehrlich's theory of the 'magic bullet' approximately 100 years ago, is today widely appraised as ...
Balmaks Reinis - - 2013
For the first time, we studied molecular epidemiology of respiratory syncytial virus in hospitalized children in Latvia. During the study period, ten unique group A and three group B strains were identified and assigned to a single genotype within each group-GA2 for group A and BA-IV for group B.
Kiani Javad - - 2013
Diabetic neuropathy is one of the most common complications of diabetes mellitus, of which it's most prevalent form is chronic sensorimotor neuropathy. The aim of this study is to assess the prevalence of diabetic peripheral neuropathy (DPN) and its associated risk factors among diabetic patients who reside in Hamedan, Iran. ...
Bentov Yaakov - - 2013
In recent years, social and cultural trends have resulted in women delaying childbirth, thereby leading to reproductive senescence as a growing public health problem. We discuss potential etiologies for age-related female reproductive decline. We bring supportive evidence to the central role of mitochondrial dysfunction and oxygen radicals in the process ...
Hashiguchi Mitsuko - - 2013
The microtubule (MT)-associated protein tau attaches to neuronal MT networks and regulates their integrity. The phosphorylation state of tau alters its binding activity. MT integrity is maintained by the phosphorylation state of tau, which is under the control of the kinase-phosphatase balance. This control requires the proper regulation of topographical ...
Donahue Laurence A - - 2013
To evaluate the toxicity and response to radioembolization with yttrium-90 ((90)Y) glass microspheres in patients with hepatocellular carcinoma (HCC) and existing transjugular intrahepatic portosystemic shunts (TIPS). For treatment of unresectable HCC, 12 patients with a patent TIPS underwent a total of 21 infusions of (90)Y. Toxicity within 90 days of ...
Bach-Gansmo Fiona Linnea - - 2013
Rats display little to no haversian remodeling of cortical bone. This fact, combined with the endochondral formation of cortical bone, means that rat femoral cortical bone contains highly mineralized cartilage islands in a central band of mid-femoral cross sections. We demonstrate that these islands have a significantly higher degree of ...
Primožič Jasmina - - 2013
The success of maxillary expansion should not be assessed solely by the elimination of the teeth in crossbite; it should also be defined as the reestablishment of normal maxillary growth. The aim of this research was to quantify longitudinal palatal changes in children treated for maxillary constriction associated with functional ...
Rafiei Tabatabaei Sedigheh - - 2013
In Iran, the measles, mumps and rubella vaccine (MMR) is administered in a two-dose protocol where the first dose is scheduled at 12 months of age. This study aims to determine the efficacy of the MMR vaccine by testing IgM and IgG antibody levels 4 - 7 weeks after primary ...
Ess Michael - - 2013
Elevated serum phosphate levels are associated with excess risk for cardiovascular mortality in patients with and without chronic kidney disease and with increased risk for incident heart failure. We determined the association of serum phosphate concentrations with disease severity and long-term outcome in patients with overt heart failure. Clinical and ...
Fawzi Mounir H - - 2013
ABSTRACT: We aimed to investigate the relation of trauma profile to schizophrenia psychopathology in a sample of Egyptian drug-naïve adolescent patients with first-episode schizophrenia. In addition, a hypothesized mediating effect of brain-derived neurotrophic factor (BDNF) in this relation was formally tested. We assessed 74 eligible outpatients using the Positive and ...
Segool Natasha K - - 2013
: The purpose of the study was to examine how access factors affect prescribing practices of psychotropic medications among pediatricians. More specifically, the aim of the current study was to examine differences in the treatment of mental and behavioral health problems among children and adolescents across small nonmetropolitan, regional, metropolitan, ...
Mishra Shashikant - - 2013
A 68-year-old woman was diagnosed to have a left-to-right L-shaped crossed-fused kidney with staghorn calculi in both renal moieties on evaluation for abdominal pain. She underwent supine percutaneous nephrolithotomy using 3 tracts in 3 stages. By using 3-dimensional reconstructed computed tomography urogram, proper preoperative planning, appropriate patient positioning, ultrasound-guided access, ...
Chen Si - - 2013
This report describes the treatment of a 16-year-old girl with a severe transverse dental arch discrepancy resulting from a mildly constricted maxillary arch and an overexpanded mandibular arch. The patient had a Class I skeletal relationship, a high mandibular plane angle, a Class III molar relationship, bilateral posterior crossbites, and ...
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