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Liu Tianbing T Center for Molecular Physiology Research, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue, Washington, DC 20010, USA. - - 2013
Gastrin is natriuretic, but its renal molecular targets and signal transduction pathways are not fully known. In this study, we confirmed the existence of CCKBR (a gastrin receptor) in male human renal proximal tubule cells and discovered that gastrin induced S6 phosphorylation, a downstream component of the phosphatidylinositol 3 kinase ...
Begun Alexander - - 2012
OBJECTIVES: . Markov chain models are frequently used to study the clinical course of chronic diseases. The aim of this article is to adopt statistical methods to describe the time dynamics of chronically ill patients when 2 kinds of data sets-fully and partially observable data are available. Model. We propose ...
Kearney Conor J CJ Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, - - 2013
Inhibitor of apoptosis proteins (IAPs) play a major role in determining whether cells undergo apoptosis in response to TNF as well as other stimuli. However, TNF is also highly proinflammatory through its ability to trigger the secretion of multiple inflammatory cytokines and chemokines, which is arguably the most important role ...
Niewerth Heiko - - 2013
The genes coding for quinaldine catabolism in Arthrobacter sp. strain Rue61a are clustered on the linear plasmid pAL1 in two upper pathway operons (meqABC and meqDEF) coding for quinaldine conversion to anthranilate and a lower pathway operon encoding anthranilate degradation via coenzyme A (CoA) thioester intermediates. The meqR2 gene, located ...
Sittadjody Sivanandane S Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27101, - - 2013
Although hormone replacement therapy is an option for the loss of ovarian function, hormone delivery through pharmacological means results in various clinical complications. The present study was designed to deliver sex steroids by a functional construct fabricated using encapsulation techniques. Theca and granulosa cells isolated from ovaries of 21-day old ...
Huang Fei - - 2012
This study aimed to determine the effects of the controlled release of brain-derived neurotrophic factor (BDNF) from collagen gel on rat neural stem cells (NSCs). With two groups of daily addition of BDNF and collagen gel without BDNF as controls, BDNF was tested using ELISA at different time points. In ...
Mathias Ryan - - 2012
Mesenteric lymphatic vessels actively transport lymph, immune cells, fat and other macromolecules from the intestine via a rhythmical contraction-relaxation process called lymphatic pumping. We have previously demonstrated that mesenteric lymphatic pumping was compromised in the guinea pig model of TNBS-induced ileitis, corroborating clinical and experimental observations of a dilated and/or ...
Shetty Sumangala - - 2013
Multiple conserved structural cis-acting regulatory elements have been recognized both in the coding and untranslated regions (UTRs) of the hepatitis C virus (HCV) genome. For example, the cis-element 5BSL3.2 in the HCV-coding region has been predicted to use both its apical and internal loops to interact with the X RNA ...
Blaser Martin B - - 2013
Acetogenic bacteria are able to grow autotrophically on hydrogen and carbon dioxide by using the acetyl coenzyme A (acetyl-CoA) pathway. Acetate is the end product of this reaction. In contrast to the fermentative route of acetate production, which shows almost no fractionation of carbon isotopes, the acetyl-CoA pathway has been ...
Falvo Michael J - - 2012
ABSTRACT: BACKGROUND: High rates of mental health disorders have been reported in veterans returning from deployment to Afghanistan (Operation Enduring Freedom: OEF) and Iraq (Operation Iraqi Freedom: OIF); however, less is known about physical health functioning and its temporal course post-deployment. Therefore, our goal is to study physical health functioning ...
Sanchez-Ramirez Diana C - - 2012
Objective. To examine the association of serum CRP and ESR with muscle strength in patients with knee OA.Methods. Cross-sectional data from 285 patients with knee OA from the Amsterdam Osteoarthritis (AMS-OA) cohort were analysed. CRP (mg/l) and ESR (mm/l) were measured in serum from patients' blood samples and the values ...
Aitken Rachel J RJ University of Bristol, Bristol, - - 2013
Down syndrome (DS) is associated with an increased risk of diabetes, particularly in young children. HLA-mediated risk is however decreased in children with DS and diabetes (DSD). We hypothesized that early-onset diabetes in children with DS is etiologically different from autoimmune diabetes. Clinical and immunogenetic markers of autoimmune diabetes were ...
Chatterjee Debashree D Molecular and Human Genetics Division, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology, Kolkata 700032, - - 2013
Like other Gram-negative pathogens, Vibrio cholerae, the causative agent of the diarrheal disease cholera, secretes outer membrane vesicles (OMVs). OMVs are complex entities composed of a subset of envelope lipid and protein components and play a role in the delivery of effector molecules to host cells. We previously showed that ...
Haines David E - - 2012
BACKGROUND: -Asymptomatic cerebral lesions have been observed on diffusion weighted MRI (DWI) scans shortly after catheter ablation of atrial fibrillation, but the pathogenesis of these lesions is incompletely understood. METHODS AND RESULTS: -Twelve dogs underwent selective catheterization of the internal carotid or vertebral arteries. Either a microbubbled mixture of air ...
Unger-Saldaña Karla - - 2012
ABSTRACT: BACKGROUND: This study reports the reliability and validity of a questionnaire designed to measure the time from detection of a breast cancer to arrival at a cancer hospital, as well as the factors that are associated with delay. METHODS: The proposed questionnaire measures dates for estimation of the patient, ...
Amburgey K K Department of Pediatrics, University of Michigan, Ann Arbor, MI, - - 2013
Myotubular myopathy is a subtype of centronuclear myopathy with X-linked inheritance and distinctive clinical and pathologic features. Most boys with myotubular myopathy have MTM1 mutations. In remaining individuals, it is not clear if disease is due to an undetected alteration in MTM1 or mutation of another gene. We describe a ...
Mangalmurti Nilam S NS Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, - - 2013
The receptor for advanced glycation end products (RAGE) is a multiligand pattern recognition receptor implicated in multiple disease states. Although RAGE is expressed on systemic vascular endothelium, the expression and function of RAGE on lung endothelium has not been studied. Utilizing in vitro (human) and in vivo (mouse) models, we ...
Lee Frederick J - - 2012
OBJECTIVE/DESIGN:: Raltegravir is uncommonly associated with rhabdomyolysis and grade 3-4 creatine kinase (CK) elevation. In this cross-sectional study we compared the prevalence of skeletal muscle toxicity in HIV-infected adults receiving raltegravir to a control group. METHODS:: Adults receiving combination anti-retroviral therapy were recruited consecutively. Assessments included physical examination, an exercise ...
Wang Yufang Y Molecular Pathology Unit, Center for Cancer Research and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129 , - - 2013
N-RAS is one member of a family of oncoproteins that are commonly mutated in cancer. Activating mutations in NRAS occur in a subset of colorectal cancers, but little is known about how the mutant protein contributes to the onset and progression of the disease. Using genetically engineered mice, we find ...
McIsaac R Scott RS The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. - - 2013
A general method for the dynamic control of single gene expression in eukaryotes, with no off-target effects, is a long-sought tool for molecular and systems biologists. We engineered two artificial transcription factors (ATFs) that contain Cys(2)His(2) zinc-finger DNA-binding domains of either the mouse transcription factor Zif268 (9 bp of specificity) ...
Pound Lynley D LD Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, - - 2013
Elevated fasting blood glucose (FBG) is associated with increased risk for the development of type 2 diabetes and cardiovascular-associated mortality. Genome-wide association studies (GWAS) have linked polymorphisms in G6PC2 with variations in FBG and body fat, although not insulin sensitivity or glucose tolerance. G6PC2 encodes an islet-specific, endoplasmic reticulum-resident glucose-6-phosphatase ...
Gigant Nicolas - - 2012
A convenient method for the copper(II)-catalyzed direct arylation of cyclic and nonaromatic enamides using diaryliodonium salts has been developed. The reaction demonstrates large functional group tolerance, good yields, and total regioselectivity with a C(3)-functionalization. The synthetic potential of this coupling was explored by using a range of readily accessible diaryliodonium ...
Nye Chad - - 2012
PURPOSE: The purpose of this systematic review was to evaluate the effectiveness of behavioral interventions designed to treat stuttering in children. METHOD: Studies were included for review if (1) the treatment was a behavioral intervention, (2) participants were between 2 and 18 years, (3) the design was an experimental or ...
Long Matthew E - - 2013
Francisella tularensis is a facultative intracellular bacterial pathogen and the causative agent of tularemia. After infection of macrophages, the organism escapes from its phagosome and replicates to high density in the cytosol, but the bacterial factors required for these aspects of virulence are incompletely defined. Here, we describe the isolation ...
Yoneyama Tohru - - 2012
BACKGROUND: Antibody-mediated rejection after ABO-incompatible kidney transplantation (ABO-I KTx) is a major barrier to transplantation success. The advent of immunosuppressive therapy has markedly improved graft survival in ABO-I KTx. However, compared with normal KTx, clinical conditions during ABO-I KTx are difficult to control because of overimmunosuppression. To reduce the need ...
Ma Liang - - 2013
Chronic infection with hepatitis B virus (HBV) is associated with impairment of T and NK cell immunity. This study was aimed at investigating the impact of treatment with telbivudine (LDT) on T and NK cell immunity in patients with chronic hepatitis B (CHB). A total of 54 CHB patients and ...
Duarte Marcos E S - - 2012
ABSTRACT Anti-reflux barrier (ARB) resistance may be useful to test new treatments for gastroesophageal reflux (GER). The ARB has been estimated by increasing gastric yield pressure (GYP) and gastric yield volume (GYV) in animal models but has not been validated. This study aimed to develop an experimental model suitable for ...
Bent Leah Rachel - - 2012
We have shown for the first time that single cutaneous afferents in the foot dorsum have significant reflex coupling to motoneurons supplying muscles in the upper limb, particularly posterior deltoid and triceps brachii. These observations strengthen what we know from whole nerve stimulation that skin on the foot and ankle ...
Chaari Anis - - 2012
We to report clinical biological and radiologic features of rubella encephalitis in childhood and assess its prognostic impact. Our retrospective study was conducted in an intensive care unit of a university hospital in Sfax, Tunisia. Twenty-one children (age range, 1-15 years) were included. Median age was 9 years (lower and ...
Pals Carina - - 2012
PURPOSE: Fitting a cochlear implant (CI) for optimal speech perception does not necessarily optimize listening effort. This study aims to show that listening effort may change between CI processing conditions for which speech intelligibility remains constant. Methods Nineteen normal-hearing participants listened to CI simulations with varying numbers of spectral channels. ...
Huang Chun-Feng CF Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, - - 2013
Metabolic syndrome is a multiplex disorder and puts patients on the road to type 2 diabetes and atherosclerotic cardiovascular diseases. However, a surrogate biomarker in plasma or urine in fully reflecting features of metabolic syndrome has not been explored. Urine metabolomics has potential utility in metabolic profiling because urine metabolites ...
Bartko Philipp Emanuel - - 2012
BACKGROUND: -Decision-making in patients with low flow - low gradient aortic stenosis (LFAS) mainly depends on the actual stenosis severity and left ventricular function, which is of prognostic importance. We used two-dimensional strain parameters measured by speckle-tracking at rest and during dobutamine stress echocardiography to document the extent of myocardial ...
Zishiri Edwin T ET Departments of Cardiovascular Medicine, Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, - - 2013
Implantation of implantable cardioverter defibrillator for prevention of sudden cardiac death is deferred for 90 days after coronary revascularization, but mortality may be highest early after cardiac procedures in patients with ventricular dysfunction. We determined mortality risk in postrevascularization patients with left ventricular ejection fraction ≤35% and compared survival with ...
Wu Jiaquan - - 2012
Transforming growth factor-β Activated Kinase-1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family that regulates several signaling pathways including NF-κB signal transduction and p38 activation. TAK1 deregulation has been implicated in human diseases including cancer and inflammation. Here, we show that besides its kinase activity, ...
Rutten Erica P A - - 2012
Abstract Objective: Patients with chronic obstructive pulmonary disease (COPD) often suffer from systemic co-morbidities, including anemia. However, anemia is related to multiple outcomes in COPD and in other chronic diseases, but it's impact is underestimated in COPD. The objective of the present study was to relate anemia in patients with ...
Ioka Tatsuya - - 2013
When gemcitabine was approved as an anti-cancer drug, there were limited data for Japanese patients treated with gemcitabine. Generally, advanced or metastatic pancreatic cancer patients experience poor prognosis and suffer from debilitating disease-related symptoms. Reports and information on gemcitabine use within a large patient pool will be beneficial to aid ...
Niederlechner Stefanie S Department of Anesthesiology, University of Colorado, Colorado, Aurora, CO, USA. - - 2013
Epidermal growth factor receptor (EGFR) expression and signaling can induce cellular protection after intestinal inflammation. L-Glutamine (GLN) is known to prevent apoptosis after intestinal injury by activating MAPK and phosphatidylinositol 3-kinase (PI3-K)/Akt pathways. However, the role of EGFR expression and signaling in GLN-mediated cellular protection in intestinal epithelial-6 (IEC-6) cells ...
Renner Simone S Chair for Molecular Animal Breeding and Biotechnology, Ludwig Maximilian University Munich, Munich, - - 2013
Mutations in the insulin (INS) gene may cause permanent neonatal diabetes mellitus (PNDM). Ins2 mutant mouse models provided important insights into the disease mechanisms of PNDM but have limitations for translational research. To establish a large animal model of PNDM, we generated INS(C94Y) transgenic pigs. A line expressing high levels ...
Layton J Bradley JB Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. - - 2013
Acute kidney injury (AKI) is a serious complication of cardiovascular surgery. Although some nonexperimental studies suggest that statin use may reduce postsurgical AKI, methodologic differences in study designs leave uncertainty regarding the reality or magnitude of the effect. The aim of this study was to estimate the effect of preoperative ...
Makanae Koji - - 2012
Gene overexpression beyond a permissible limit causes defects in cellular functions. However, the permissible limits of most genes are unclear. Previously, we developed a genetic method designated genetic tug-of-war (gTOW) to measure the copy number limit of overexpression of a target gene. In the current study, we applied gTOW to ...
Rzeznikiewiz Damian - - 2012
ABSTRACT: BACKGROUND: Motor vehicle collisions (MVCs) that result in one or more fatalities on the 400-series Highways represent a serious public health problem in Ontario, and were estimated to have cost $11 billion in 2004. To date, no studies have examined risk factors for fatal MVCs on Ontario's 400 series ...
Fey Marc E ME University of Kansas Medical Center, Kansas City, KS, USA. - - 2013
The authors sought to determine whether a program of 5 weekly doses of milieu communication teaching (MCT) would yield improvements in children's communication and word use compared with a once-weekly delivery of the same treatment. Sixty-four children with intellectual and communication delay were randomly assigned to receive 60-min sessions of ...
Diethe Tom - - 2012
This review examines kernel methods for online learning, in particular, multiclass classification. We examine margin-based approaches, stemming from Rosenblatt's original perceptron algorithm, as well as nonparametric probabilistic approaches that are based on the popular gaussian process framework. We also examine approaches to online learning that use combinations of kernels-online multiple ...
Blüml Victor - - 2012
Objective: To investigate the associations and connotations of the general public to psychoanalysis.Methods: A representative telephone survey was conducted in the city of Vienna. 1,205 people over 16 years of age were interviewed. As part of a fully structured interview associations to psychoanalysis were investigated by an open question. Results ...
Peng Jinsong - - 2012
An efficient "one-pot" route for the synthesis of benzo[4,5]imidazo[2,1-a] isoquinolines has been developed via nucleophilic addition of 2-aryl benzimidazoles to alkynyl bromides and subsequent palladium-catalyzed intramolecular C-H vinylation.
Egli Adrian - - 2012
BACKGROUND: Data on how different immunosuppressive drugs affect cytomegalovirus (CMV)-specific T-cell responses may help guide more rational modification of immunosuppression in patients with CMV replication. We assessed the in vitro effects of individual standard and novel immunosuppressive drugs on a broad range of CMV-specific T-cell responses. METHODS: Peripheral blood mononuclear ...
Huang Yafei Y Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, - - 2013
We re-examined the observation that γδ T cells, when transferred from mice tolerized to an inhaled conventional Ag, suppress the allergic IgE response to this Ag specifically. Using OVA and hen egg lysozyme in crisscross fashion, we confirmed the Ag-specific IgE-regulatory effect of the γδ T cells. Although only Vγ4(+) ...
Adhikari Upendra - - 2012
The natural and fundamental proclivities of interaction between a pair of peptide units is examined using high-level ab initio calculations. The NH•••O H-bonded structure is found to be the most stable configuration of the N-methylacetamide (NMA) model dimer, but only slightly more so than a stacked arrangement. The H-bonded geometry ...
Reyhan Enver - - 2012
ABSTRACT Objective: The objective of this study was to evaluate the serum and bile concentrations of cefazolin and ceftriaxone at the third and sixth hours in an experimental obstructive jaundice model and to identify the rate of excretion of these antibiotics into the bile. Material and methods: Thirty-two Wistar albino ...
Schenkwein Diana - - 2013
Integrating viral vectors are efficient gene transfer tools, but their integration patterns have been associated with genotoxicity and oncogenicity. The recent development of highly specific designer nucleases has enabled target DNA modification and site-specific gene insertion at desired genomic loci. However, a lack of consensus exists regarding a perfect genomic ...
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