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Results 701 - 750 of 2978
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Yoneyama Tohru - - 2012
BACKGROUND: Antibody-mediated rejection after ABO-incompatible kidney transplantation (ABO-I KTx) is a major barrier to transplantation success. The advent of immunosuppressive therapy has markedly improved graft survival in ABO-I KTx. However, compared with normal KTx, clinical conditions during ABO-I KTx are difficult to control because of overimmunosuppression. To reduce the need ...
Duarte Marcos E S - - 2012
ABSTRACT Anti-reflux barrier (ARB) resistance may be useful to test new treatments for gastroesophageal reflux (GER). The ARB has been estimated by increasing gastric yield pressure (GYP) and gastric yield volume (GYV) in animal models but has not been validated. This study aimed to develop an experimental model suitable for ...
Bent Leah Rachel - - 2012
We have shown for the first time that single cutaneous afferents in the foot dorsum have significant reflex coupling to motoneurons supplying muscles in the upper limb, particularly posterior deltoid and triceps brachii. These observations strengthen what we know from whole nerve stimulation that skin on the foot and ankle ...
Chaari Anis - - 2012
We to report clinical biological and radiologic features of rubella encephalitis in childhood and assess its prognostic impact. Our retrospective study was conducted in an intensive care unit of a university hospital in Sfax, Tunisia. Twenty-one children (age range, 1-15 years) were included. Median age was 9 years (lower and ...
Pals Carina - - 2012
PURPOSE: Fitting a cochlear implant (CI) for optimal speech perception does not necessarily optimize listening effort. This study aims to show that listening effort may change between CI processing conditions for which speech intelligibility remains constant. Methods Nineteen normal-hearing participants listened to CI simulations with varying numbers of spectral channels. ...
Bartko Philipp Emanuel - - 2012
BACKGROUND: -Decision-making in patients with low flow - low gradient aortic stenosis (LFAS) mainly depends on the actual stenosis severity and left ventricular function, which is of prognostic importance. We used two-dimensional strain parameters measured by speckle-tracking at rest and during dobutamine stress echocardiography to document the extent of myocardial ...
Wu Jiaquan - - 2012
Transforming growth factor-β Activated Kinase-1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family that regulates several signaling pathways including NF-κB signal transduction and p38 activation. TAK1 deregulation has been implicated in human diseases including cancer and inflammation. Here, we show that besides its kinase activity, ...
Rutten Erica P A - - 2012
Abstract Objective: Patients with chronic obstructive pulmonary disease (COPD) often suffer from systemic co-morbidities, including anemia. However, anemia is related to multiple outcomes in COPD and in other chronic diseases, but it's impact is underestimated in COPD. The objective of the present study was to relate anemia in patients with ...
Kawahara Hiroyuki - - 2012
BAG6 (also known as BAT3/Scythe) is a ubiquitin-like protein that is thought to participate in a variety of seemingly unrelated physiological and pathological processes, such as apoptosis, antigen presentation and the T cell response. Recent studies have shown that BAG6 is essential for the quality control of aggregation-prone polypeptide biogenesis. ...
Howland Karole A - - 2012
PURPOSE: To examine how adults with dyslexia versus adults with typical reading form lexical representations during pseudoword learning. METHOD: Twenty adults with dyslexia and 20 adults with typical reading learned meanings, spellings and pronunciations of 16 pictured pseudowords, (1/2 with regular and 1/2 with irregular grapheme-phoneme correspondences) presented first in ...
Kiuru Emilia - - 2012
Five different 2,2-disubstituted 4-acylthio-3-oxobutyl groups have been introduced as esterase-labile phosphodiester protecting groups that additionally are thermolabile. The phosphotriesters 1, 2 and 3 were prepared to determine the rate of the enzymatic and non-enzymatic removal of such groups at 37 ºC and pH 7.5 by HPLC-ESI-MS. Additionally, 1H NMR spectroscopic ...
Yoo Sang Bum - - 2012
Abstract Background: Prophylactic ileostomy is usually created at the right lower quadrant (RLQ) because of its vicinity to the ileocecal valve. In the laparoscopic procedure, however, another wound is required for stoma, resulting in a scar after takedown. This study assessed the feasibility of left-sided ileostomy (LI) at the specimen ...
Wang Tao - - 2012
Based on a regioselective tris-formylation of a tribenzotriquinacene (TBTQ) hydrocarbon, the racemic C3-symmetrical TBTQ-trialdehyde and the corresponding TBTQ-trimethanol were synthesized along with their C1-isomers. Conversion of the C3-trialdehyde to three diastereomeric TBTQ-based cryptophanes occurring in high yield enabled the preparation of the optically pure C3-symmetrical TBTQ-trialdehydes and the determination of ...
Shah Ankit B - - 2012
Abstract Background: Heart failure is characterized by recurrent decompensations and persistent symptoms that decrease quality of life. Shortness of breath and fatigue are commonly identified symptoms but there is limited data on pain in heart failure patients. The Edmonton Symptom Assessment System (ESAS) was used to identify the prevalence and ...
Menon Manoj K - - 2012
ABSTRACT: BACKGROUND: Quantifying the improvements in lower limb or quadriceps muscle mass following resistance training (RT), is an important outcome measure in COPD. Ultrasound is a portable, radiation free imaging technique that can measure the size of superficial muscles belonging to the quadriceps group such as the rectus femoris, but ...
Chen C-J - - 2012
BACKGROUND AND PURPOSE:APOE4 is the best-documented genetic risk factor for sporadic AD. Previous research showed that APOE4 is associated with increased risk of occurrence and earlier onset of AD in a gene dose-dependent manner. However, the specific role of APOE4 in processing of brain functions requires further investigation. Investigators have ...
He Zhi - - 2012
By utilizing amino allenes, aldehydes, and aryl iodides as readily available building blocks, a simple and modular synthesis of multisubstituted pyridines with flexible control over the substitution pattern has been achieved. The method employs a two-step procedure involving the preparation of "skipped" allenyl imines and a subsequent palladium-catalyzed cyclization.
Hitchcock Elaine R - - 2012
PURPOSE: This study used multiple measures of voicing acquisition in typically developing 2-year-olds to evaluate the extent to which developmental patterns based on VOT mean data differed from those based on token-by-token analyses. METHOD: Multiple repetitions of words containing initial /b p d t/ were elicited from ten English-speaking children ...
Chi Hao - - 2012
De novo peptide sequencing is the only tool for extracting peptide sequences directly from tandem mass spectrometry (MS) data without any protein database. However, neither the accuracy nor the efficiency of de novo sequencing has been satisfactory, mainly due to incomplete fragmentation information in experimental spectra. Recent advancement in MS ...
Regan Elizabeth A - - 2012
Abstract Hip fractures in the elderly have high rates of mortality and perioperative complications. Both men and COPD patients have worse mortality and complications but this may be due to more co-morbid disease. We assessed mortality and complications in a large cohort (n = 12,646) of men undergoing hip fracture ...
Albright Charles - - 2012
A hallmark of Alzheimer's disease (AD) pathology is the accumulation of brain amyloid β-peptide (Aβ), generated by γ-secretase-mediated cleavage of the amyloid precursor protein (APP). Therefore, γ-secretase inhibitors (GSIs) may lower brain Aβ and offer a potential new approach to treat AD. As γ-secretase also cleaves Notch proteins, GSIs can ...
Chen Wenhua - - 2012
Reduction of nitric oxide (NO) by acetylene (C2H2) has been investigated by temperature programmed desorption (TPD) on planar Ir(210) and faceted Ir(210) with tunable sizes of three-sided nano-pyramids exposing (311), (31-1) and (110) faces. Upon adsorption, C2H2 dissociates to form acetylide (CCH) and H species on the Ir surfaces at ...
Aita Marilyn - - 2012
Neonatal intensive care unit (NICU) light and noise may be stressful to preterm infants. This research evaluated the physiological stability of 54 infants born at 28- to 32-weeks' gestational age while wearing eye goggles and earmuffs for a 4-hour period in the NICU. Infants were recruited from four NICUs of ...
Qayed Muna - - 2012
In murine allogeneic hematopoietic cell transplantation models, inhibiting bacterial translocation stemming from conditioning-induced damage to the gut mucosa abrogates inflammatory stimulation of donor T cells, preventing acute graft-versus-host disease (AGVHD). We conducted a phase I trial to begin testing the hypothesis that rifaximin, a broadly acting oral antibiotic, would reduce ...
Keir Nancy - - 2012
ABSTRACT:: One of the major breakthroughs in the development of silicone hydrogel contact lenses has related to the ability of manufacturers to overcome the surface hydrophobicity that occurred with silicone elastomer lenses. However, the wettability of silicone hydrogel lenses continues to be of interest as a potential link between in ...
Tiemersma Sybrich - - 2012
Abstract Background: Aerosol therapy in preterm infants is challenging, as a very small proportion of the drug deposits in the lungs. Aim: Our aim was to compare efficiency of standard devices with newer, more efficient aerosol delivery devices. Methods: Using salbutamol as a drug marker, we studied two prototypes of ...
Jen Shih-Hui - - 2012
Alucone films were employed as interlayers to minimize stress caused by thermal expansion mismatch between Al2O3 films grown by atomic layer deposition (ALD) and Teflon fluorinated ethylene propylene (FEP) substrates. The alucone films were grown by molecular layer deposition (MLD) using trimethylaluminum (TMA), ethylene glycol (EG) and H2O. Without the ...
Engvall Inga-Lill - - 2012
Objective. To study the effects of low-dose prednisolone on the osteoclast-regulating proteins osteoprotegerin (OPG) and RANK ligand (RANKL) and on markers of bone resorption, 1CTP generated by MMPs and CTX-1 generated by cathepsin K, in patients with early RA in relation to inflammation and joint destruction.Methods. In 225 patients, who ...
García-Vega Yanelda - - 2012
ABSTRACT: BACKGROUND: The synergistic combination of interferon (IFN) alpha-2b and IFN gamma results in more potent in vitro biological effects mediated by both IFNs. The aim of this investigation was to evaluate by first time the pharmacokinetics and pharmacodynamics of this combination in patients with mycosis fungoides. METHODS: An exploratory, ...
Li Xuefeng - - 2012
The ingrowth core method is widely used to assess fine root (diameter < 2 mm) production but has many inherent deficiencies. In this study, we modified this method by adopting mini ingrowth cores (diameter 1.2 cm), extending sample intervals to a growing season, and developing new models to quantify the concurrent production, ...
Katsuta Tomohiro - - 2012
Fifty-four children were diagnosed as pyelonephritis caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae at the largest children's hospital in Japan. Although 32 (59%) patients were treated with antimicrobials that are ineffective against the organisms, 39 (72%) patients became afebrile ≤2 days and clinical outcome was excellent. Children with pyelonephritis caused by ...
Kyle Fiona E - - 2012
PURPOSE: We describe the development of a new Test of Child Speechreading (ToCS) specifically designed for use with deaf and hearing children. Speechreading is a skill which is required for deaf children to access the language of the hearing community. ToCS is a deaf-friendly, computer-based test that measures child speechreading ...
Spill Birgit - - 2012
Objective: To study out-patients' perception of an Integrated Care compliance program.Methods: Survey of patients enrolled in the Integrated Care program "Münchner Modell" in Munich, Germany.Results: Nā€Š=ā€Š121 patients participated in the survey. Overall patients were very satisfied with the Integrated Care program. They reported improvements in several areas of life.Conclusion: The ...
Grellepois Fabienne - - 2012
Addition of a Reformatsky reagent to alpha-aryl(alkyl) alpha-trifluoromethyl N-tert-butanesulfinyl hemiaminals, bench stable surrogates of trifluoromethyl ketoimines, provided beta-alkyl(aryl) beta-trifluoromethyl beta-amino acids derivatives in good yields and high diastereoselectivities. The N-tert-butanesulfinyl beta3,3-amino esters were further utilized as versatile intermediates for the elaboration of hetero-di- and tripeptides.
Kelly Julia L - - 2012
Abstract Earlier diagnosis of COPD is a major public health challenge as symptoms may be attributed to the normal consequences of aging. The optimum strategy for identifying patients with COPD remains to be determined. People aged 35 and over (n = 1896) on a GP practice register were randomised to ...
Fitzgerald Colleen E - - 2012
PURPOSE: Evidence for tense marking in child-directed speech varies across languages (Guasti, 2002; Legate & Yang, 2007) and speakers of a single language (Hadley, Rispoli, Fitzgerald, & Bahnsen, 2011). The purpose of this study was to better understand how parent interaction styles and register use overlap with the tense marking ...
Watanabe K - - 2012
BACKGROUND AND PURPOSE:Cavernous sinuses and draining dural sinuses or veins are often visualized on 3D TOF MRA images in patients with dural arteriovenous fistulas involving the CS. Flow signals may be seen in the jugular vein and dural sinuses at the skull base on MRA images in healthy participants, however, ...
Bodie Graham D - - 2012
This article develops a conceptualization and measure of cognitive health sophistication-the complexity of an individual's conceptual knowledge about health. Study 1 provides initial validity evidence for the measure-the Healthy-Unhealthy Other Instrument-by showing its association with other cognitive health constructs indicative of higher health sophistication. Study 2 presents data from a ...
Javins Beth - - 2012
ABSTRACT Perfluoroalkyl substances (PFAFs) are man-made chemicals used in many consumer products and have become ubiquitous in the environment. Animal studies and a limited number of human studies have demonstrated developmental effects in offspring exposed to PFAFs in utero but the implications of timing of in utero exposure have not ...
Takeda Akiko - - 2012
A wide variety of machine learning algorithms such as the support vector machine (SVM), minimax probability machine (MPM), and Fisher discriminant analysis (FDA) exist for binary classification. The purpose of this letter is to provide a unified classification model that includes these models through a robust optimization approach. This unified ...
Nuin Edurne - - 2012
New photoactive dyads have been synthesized by derivatization of cholic acid (CA) or cholesterol (Ch). These compounds have proven to be efficient tools to monitor incorporation of CA and Ch to mixed micelles (MM) and to probe the microenvironment experienced inside these entities. The outstanding capability of MM to solubilize ...
Lin Wei-Ching - - 2012
Thromboembolism presenting with malignancy is common in adults but rare in children. We describe the case of a 17-year-old boy admitted to our hospital with syncope. Computed tomography revealed thromboembolism in both the lungs. Magnetic resonance imaging found thromboembolism in the inferior vena cava and a large heterogeneous mass in ...
Ding Lina - - 2012
Photoactivatable (PA) fluorescent proteins are a new class of fluorescent proteins, in which the intensity of fluorescence is dramatically enhanced through photo-induced decarboxylation process. In the present study, the reaction mechanism of the photo-induced decarboxylation in PA-GFP was investigated by the ONIOM(QM:MM) method. The decarboxylation process starts from the first ...
Savva Yiannis A - - 2012
ABSTRACT: Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which adenosines are selectively converted to inosines in double-stranded RNA (dsRNA) substrates. A highly conserved group of enzymes, the adenosine deaminase acting on RNA (ADAR) family, mediates this reaction. All ADARs share a common domain architecture consisting of ...
Shankar J J S - - 2012
SUMMARY:For pronouncing brain death, unlike CTP, the 2-phase CTA gives no functional information and is limited by inadvertent delay of the second acquisition, which may give false-negative results. The purpose of our study was to compare CTP and CTA derived from the CTP data with the Dupas and Frampas criteria ...
Reynolds Joanna - - 2012
In many malaria-endemic areas, including Afghanistan, overdiagnosis of malaria is common. Even when using parasite-based diagnostic tests prior to treatment, clinicians commonly prescribe antimalarial treatment following negative test results. This practice neglects alternative causes of fever, uses drugs unnecessarily, and might contribute to antimalarial drug resistance. We undertook a qualitative ...
Yi Astrid - - 2012
PURPOSE: To quantify the relationships between speech intelligibility (perception) and gaze patterns under different auditory-visual conditions. METHOD: 11 subjects listened to low-context sentences spoken by a single talker while viewing the face of one or more talkers on a computer display. Subjects either maintained their gaze at a specific distance ...
Jin Sung Hwan - - 2012
The band gap properties of graphene quantum dots (GQDs) arise from quantum confinement effects and differ from those in semi-metallic graphene sheets. Tailoring the size of the band gap and understanding the band gap tuning mechanism are essential for the applications of GQDs in opto-electronics. In this study, we observe ...
Chen Xiaoyan - - 2012
Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without evidence of myasthenia gravis and without ...
Liang Lin-Fu - - 2012
Methyl sarcotroates A and B (3 and 4), two unprecedented diterpenoids possessing a tetradecahydrocyclopenta[3',4']cyclobuta[1',2':4,5]cyclonona[1,2-b]oxirene ring system, along with their probable biogenetic precursor, sarcophytonolide M (1), were isolated from the Hainan soft coral Sarcophyton trocheliophorum. Their structures were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 3 was ...
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