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Cuny Jérôme - - 2012
The ability of (95)Mo solid-state nuclear magnetic resonance (SSNMR) spectroscopy to probe the atomic and electronic structures of inorganic molybdenum cluster materials has been demonstrated for the first time. Six cluster compounds were studied: MoBr(2), Cs(2)Mo(6)Br(14), (Bu(4)N)(2)Mo(6)Br(14), each containing the octahedral Mo(6)Br(14)(2-) cluster unit, and MoS(2)Cl(3), Mo(3)S(7)Cl(4), and MoSCl that ...
Achee Nicole - - 2012
ABSTRACT: BACKGROUND: Current efforts are underway to quantify the chemical concentration in a treated air space to determine the minimum effective concentration that elicits a spatial repellent (deterrent) response in a vector population. Such information will facilitate identifying the optimum active ingredient (AI) dosage and intervention coverage important for the ...
Le Beyec Johanne - - 2012
Context:Severe early-onset obesity with major hyperphagia associated with hypogonadotropic hypogonadism is recognized as the main clinical presentation of leptin (LEP) or LEP receptor (LEPR) gene complete deficiency. In a few reported cases, homozygous mutations have been found in patients from consanguineous families. Care of LEPR-deficient patients is complicated because they ...
Weihberger Oliver - - 2012
Variable responses of neuronal networks to repeated sensory or electrical stimuli reflect the interaction of the stimulus' response with ongoing activity in the brain and its modulation by adaptive mechanisms such as cognitive context, network state or cellular excitability and synaptic transmission capability. Here, we focus on reliability, length, delays ...
Valtat Bérengère B INSERM, UMRS 872, Cordeliers Research Center, Paris, - - 2013
Adult β-cell dysfunction, a hallmark of type 2 diabetes, can be programmed by adverse fetal environment. We have shown that fetal glucocorticoids (GCs) participate in this programming through inhibition of β-cell development. Here we have investigated the molecular mechanisms underlying this regulation. We showed that GCs stimulate the expression of ...
Reiter Wolfgang - - 2013
We have identified Cdc55, a regulatory B subunit of protein phosphatase 2A (PP2A), as an essential activating factor for stress gene transcription in Saccharomyces cerevisiae. The presence of PP2A-Cdc55 is required for full activation of the environmental stress response mediated by the transcription factors Msn2 and Msn4. We show that ...
Levi Susannah V SV New York University, NY, USA. - - 2013
In this study, the authors aimed to investigate how differences in language ability relate to differences in processing talker information in the native language and an unfamiliar language by comparing performance for different ages and for groups with impaired language. Three groups of native English listeners with typical language development ...
Wang Zhen-Gang - - 2012
Templated synthesis has been considered as an efficient approach to produce polyaniline (PANI) nanostructures. The features of DNA molecules enable DNA template to be an intriguing template for fabrication of emeraldine PANI. In this work, we assembled HRP-mimicking DNAzyme with different artificial DNA nanostructures, aiming to manipulate the molecular structures ...
Takahashi Yasuhiro - - 2012
An 83-year-old woman with Sjögren syndrome underwent insertion of large punctal plugs in the right upper and lower puncti. Nine months later, she presented with upper canaliculitis, although the plugs were not found in the puncti. Dacryoendoscopic examination revealed punctal plug migration, granulation, and a large amount of debris in ...
Harris Nwanyanwu Kristen K Department of Ophthalmology and Visual Sciences, University of Michigan WK Kellogg Eye Center, Ann Arbor, Michigan, USA. - - 2013
Identifying individuals most at risk for diabetic retinopathy progression and intervening early can limit vision loss and reduce the costs associated with managing more advanced disease. The purpose of this study was to identify factors associated with progression from nonproliferative diabetic retinopathy (NPDR) to proliferative diabetic retinopathy (PDR). This was ...
Damiano Edward R ER 1Department of Biomedical Engineering, Boston University, Boston, MA, - - 2013
To compare three continuous glucose monitoring (CGM) devices in subjects with type 1 diabetes under closed-loop blood glucose (BG) control. Six subjects with type 1 diabetes (age 52 ± 14 years, diabetes duration 32 ± 14 years) each participated in two 51-h closed-loop BG control experiments in the hospital. Venous ...
Bartha E E Karolinska Institute, CLINTEC, Division of Anaesthesiology, Karolinska University Hospital, Huddinge B31, Stockholm, Sweden. - - 2013
Patients with proximal femoral fracture (PFF) are at high risk of postoperative complications. Goal-directed haemodynamic treatment (GDHT) in other high-risk surgical patients reduces postoperative complications. We aimed to compare effects of GDHT and routine fluid treatment (RFT) on postoperative outcomes after PFF surgery. PFF patients (≥70 yr) were enrolled in ...
Xiao Linlin - - 2012
Among different surface cues, the settlement of cells and larvae of marine macrofouling organisms has been found to be strongly influenced by surface microtopographies. In this article, the settlement of zoospores of the green alga Ulva linza on a surface topographic gradient has been investigated. 'Honeycomb' gradient structures with feature ...
Liu Yan - - 2012
Chronic liver diseases are frequent and potentially life threatening for humans. The underlying aetiologies are divers, ranging from viral infections, autoimmune disorders, intoxications (including alcohol abuse) to imbalanced diets. Although at early stage of disease the liver regenerates in the absence of the insult, advanced stages cannot be healed and ...
Ma Chien-Hui - - 2013
The Saccharomyces cerevisiae 2 micron plasmid exemplifies a benign but selfish genome, whose stability approaches that of the chromosomes of its host. The plasmid partitioning locus STB (stability locus) displays certain functional analogies with centromeres along with critical distinctions, a significant one being the absence of the kinetochore complex at ...
Lopez Faye L FL Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA. - - 2013
High serum phosphorus levels have been linked with vascular calcification and greater cardiovascular morbidity and mortality. We assessed whether serum phosphorus was associated with the atrial fibrillation (AF) incidence in a large community-based cohort in the United States. Our analysis included 14,675 participants (25% black, 45% men) free of AF ...
Christie-Oleza Joseph Alexander - - 2013
Transposition of the insertion sequence (IS) ISPpu12 is actively induced after conjugative interaction. The transposase of this IS can act in trans on structures flanked by inverted repeats similar to those of the transposon. Based on that fact, an ISPpu12-based minitransposon, miniUIB, has been constructed in order to biotechnologically exploit ...
Chen Shaojie - - 2012
AIMS: The aim of this study was to investigate the predictive ability of paced QRS duration (pQRSd) for heart failure events among patients receiving right ventricular apical pacing (RVAP). METHODS AND RESULTS: A total of 194 patients with complete atrioventricular block receiving pacemaker treatment were enrolled and stratified to group ...
Kang Kwi Young - - 2013
To determine the longitudinal effects of TNF inhibitors on BMD and radiographic progression in patients with AS and to assess independent factors associated with increased BMD in the lumbar spine. Sixty-three patients with AS were included. Twenty-six patients were treated with TNF inhibitors and 37 were not. BMD in the ...
Davies Melanie M Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. - - 2013
This multicenter, open-label, parallel-arm study compared the efficacy and safety of exenatide once weekly (EQW) with titrated insulin detemir in patients with type 2 diabetes inadequately controlled with metformin (with or without sulfonylureas). Patients were randomized to EQW (2 mg) or detemir (once or twice daily, titrated to achieve fasting ...
Li Sheng S State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, - - 2013
Peroxisome proliferator-activated receptor γ (PPARγ), a subgroup of ligand-activated nuclear receptors, plays critical roles in cell cycle regulation, differentiation, apoptosis, and invasion. PPARγ is involved in tumorigenesis and is a potent target for cancer therapy. PPARγ transactivation of KLF4 has been demonstrated in various studies; however, how PPARγ regulates KLF4 ...
Egan Kathleen L KL Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, United States. - - 2013
Use of prescription stimulants used to treat Attention Deficit/Hyperactivity Disorder (ADHD) for reasons other than prescribed, known as non-medical use, is a growing problem among undergraduates. Previous studies show that non-medical prescription stimulant (NMPS) users consume more alcohol than individuals who do not use NMPS. However, research on simultaneous use ...
Williams Karen Patricia KP Department of Obstetrics, Gynecology & Reproductive Biology, College of Human Medicine Michigan State University, East Lansing, MI 48824, USA. - - 2013
Although breast and cervical cancer deaths have declined due to early screening, detection, and more effective treatment, racial and ethnic disparities persist. This paper describes the study design and baseline characteristics of a randomized controlled trial (RCT) evaluating the effectiveness of the Kin Keeper(SM) Cancer Prevention Intervention, a family-focused educational ...
Hata Yoshinobu - - 2012
A ciliated muconodular papillary tumor has been reported to be a peripheral low-grade malignant tumor, consisting of ciliated columnar cells and goblet cells with basaloid cell proliferation. Although ciliated muconodular papillary tumors have not yet been classified according to the World Health Organization classification, they can pose diagnostic and therapeutic ...
Katsumata Kiyomitsu - - 2013
ASP2151 (amenamevir) is a helicase-primase inhibitor against herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus. Here, to determine and analyze the correlation between the pharmacodynamic (PD) and pharmacokinetic (PK) parameters of ASP2151, we examined the PD profile of ASP2151 using in vitro plaque reduction assay and a murine ...
Iizuka Daisuke - - 2012
Aberrant expression of microRNAs (miRNAs) is frequently associated with a variety of cancers, including breast cancer. We and others have demonstrated that radiation-induced rat mammary cancer exhibits a characteristic gene expression profile and a random increase in aberrant DNA copy number, however, the role of aberrant miRNA expression is unclear. ...
Capitini Christian M CM Blood and Marrow Transplant Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. - - 2013
Tumor-targeted vaccines represent a strategy to enhance the graft-versus-leukemia effect after allogeneic blood and marrow transplantation (BMT). We have previously shown that graft-versus-host disease (GVHD) can negatively impact quantitative responses to vaccines. Using a minor histocompatibility Ag-mismatched BMT (B6 → B6 × C3H.SW) followed by adoptive transfer of HY-specific T ...
Chen Stefanie Hartman SH Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, - - 2013
Previously, we published a method for creating a novel DNA substrate, the double Holliday junction substrate. This substrate contains two Holliday junctions that are mobile, topologically constrained and separated by a distance comparable with conversion tract lengths. Although useful for studying late stage homologous recombination in vitro, construction of the ...
Yamaji Daisuke - - 2013
The transcription factors Signal Transducer and Activator of Transcription (STAT) 5A/B mediate prolactin-induced mammary development during pregnancy. However, it is not clear how the different processes, expansion and maturation of alveolar precursor cells and the differential induction of milk protein genes are regulated on a molecular level. We have used ...
Fromentin Claire C Institut National de Recherche Agronomique, Centre de Recherche en Nutrition Humaine d'Ile-de-France, UMR914 Nutrition Physiology and Ingestive Behaviour, Paris, - - 2013
Dietary proteins are believed to participate significantly in maintaining blood glucose levels, but their contribution to endogenous glucose production (EGP) remains unclear. We investigated this question using multiple stable isotopes. After overnight fasting, eight healthy volunteers received an intravenous infusion of [6,6-²Hâ‚‚]-glucose. Two hours later, they ingested four eggs containing ...
Lum Terry Y TY Department of Social Work and Social Administration, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. - - 2013
Little is known about mental health disorders (MHDs) and their associated health care expenditures for the dual eligible elders across long-term care (LTC) settings. We estimated the 12-month diagnosed prevalence of MHDs among dual eligible older adults in LTC and non-LTC settings and calculated the average incremental effect of MHDs ...
Loh Yong-Hwee E YH School of Biology, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Georgia, - - 2013
Cichlid fishes have evolved tremendous morphological and behavioral diversity in the waters of East Africa. Within each of the Great Lakes Tanganyika, Malawi, and Victoria, the phenomena of hybridization and retention of ancestral polymorphism explain allele sharing across species. Here, we explore the sharing of single nucleotide polymorphisms (SNPs) between ...
VanDevanter Donald R DR Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. - - 2013
Increased chronic therapy use and improved cystic fibrosis (CF) patient health should be accompanied by reduced pulmonary exacerbation-associated antibiotic treatment incidence. Treatment incidence rates and associated sign/symptom scores from 1995-2005 were studied in Epidemiologic Study of CF patients by route ( IV) and age (<6, 6-12, 13-17, ≥ 18 years). ...
Bandyopadhyay Anindita - - 2012
In order to accommodate the physiologically incompatible processes of photosynthesis and nitrogen fixation within the same cell, unicellular nitrogen fixing cyanobacteria have to maintain a dynamic metabolic profile in the light as well as the dark phase of a diel cycle. The transition from the photosynthetic to the nitrogen-fixing phase ...
Searl Jeff - - 2012
PURPOSE: This study compared articulatory contact pressure (ACP), oral air pressure (Po) and speech acoustics for conversational versus clear speech. The relationship of these measures to listener perception also was assessed. METHOD: Twelve adults with normal speech produced monosyllables in a phrase using conversational and clear speech. Target phonemes were ...
Manjunath G - - 2012
The echo state property is a key for the design and training of recurrent neural networks within the paradigm of reservoir computing. In intuitive terms, this is a passivity condition: a network having this property, when driven by an input signal, will become entrained by the input and develop an ...
Yang S-Y - - 2012
BACKGROUND: /st>The aim of this prospective trial was to investigate the ability of pulse pressure variation (PPV) and corrected flow time (FTc) to predict fluid responsiveness in the prone position. METHODS: /st>Forty-four patients undergoing lumbar spine surgery in the prone position on a Wilson frame were prospectively studied. PPV and ...
Ferrer Rebecca A - - 2012
Worry and risk perceptions are generally found to be independently associated with health-promoting behaviors, although it is unknown whether they interact in ways that potentially dampen the effect of either construct on behavior. In this hypothesis-generating study, cancer-related worry and risk perception, and their interaction, were used to predict odds ...
Khorsandi Maziar M Department of Cardiothoracic Surgery, University Hospital of South Manchester Wythenshawe Hospital, Manchester, UK. - - 2013
A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was whether there is any role for resuscitative emergency department thoracotomy in severe blunt trauma. Emergency thoracotomy is an accepted intervention for patients with penetrating cardiothoracic trauma. However, its role in blunt trauma ...
Berdnikovs Sergejs S Division of Allergy and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, - - 2013
Pulmonary eosinophilia is a consistent hallmark of allergic lung inflammation. Infiltration of eosinophils into ovalbumin (OVA)-challenged lungs is dependent on the adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells. Ligation of VCAM-1 activates endothelial cell protein tyrosine phosphatase 1B (PTP1B), which is required for VCAM-1-dependent leukocyte migration in ...
Arcos María - - 2012
ABSTRACT Background: The involvement of voltage-dependent calcium channels and reactive oxygen species in the pathophysiology of neuropathic pain might justify the preventative administration of antioxidant enzymes, at low doses, in combination with gabapentin (GaP) to maximize its analgesic effect in an experimental model of neuropathic pain in rats. Methods: This ...
Chen Yuhong - - 2012
Context:Schistosome antigens modulate host metabolic profiles and reduce the risk of diabetes in experimental animals. This association has not previously been examined in humans.Objective:The objective of the study was to evaluate whether previous schistosome infection (PSI) is related to the development of diabetes and metabolic syndrome.Design, Setting, and Participants:A cross-sectional ...
Wright Courtney A - - 2012
PURPOSE: The effects of Enhanced Milieu Teaching (EMT; Hancock & Kaiser, 2006) blended with Joint Attention, Symbolic Play and Emotional Regulation (JASPER; Kasari, Freeman, & Paparella, 2006) to teach spoken words and manual signs (Words + Signs) to young children with Down syndrome (DS) were evaluated in this study. METHOD: ...
Hare Matthew J L MJ Baker IDI Heart and Diabetes Institute, Melbourne, Australia. - - 2013
To determine whether glucose-independent differences in HbA1c exist between people of African, South Asian, and Chinese ethnicities. Data from 6,701 people aged 19-78 years, without known diabetes, from Mauritius, and participating in the population-based Non-Communicable Disease Surveys of the main island and the island of Rodrigues were included. Participants were ...
Shah Sonia S University College London Genetics Institute, University College London, London, United - - 2013
Carotid intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with risk of coronary heart disease events. Statins reduce progression of CIMT and coronary heart disease risk in proportion to the reduction in low-density lipoprotein cholesterol. However, interventions targeting triglycerides (TGs) or high-density lipoprotein cholesterol (HDL-C) have produced inconsistent ...
Singh Birendra - - 2013
Haemophilus influenzae protein E (PE) is a multifunctional adhesin involved in direct interactions with lung epithelial cells and host proteins, including plasminogen and the extracellular matrix proteins vitronectin and laminin. We recently crystallized PE and successfully collected X-ray diffraction data at 1.8 Å. Here, we solved the structure of a ...
Razafinarivo Norosoa J NJ UMR DIADE, IRD, BP, Montpellier cedex, France. - - 2013
The coffee genus (Coffea) comprises 124 species, and is indigenous to the Old World Tropics. Due to its immense economic importance, Coffea has been the focus of numerous genetic diversity studies, but despite this effort it remains insufficiently studied. In this study the genetic diversity and genetic structure of Coffea ...
Schwingshackl Andreas A Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA. - - 2013
We recently proposed a role for the two-pore-domain K(+) (K2P) channel Trek-1 in the regulation of cytokine release from mouse alveolar epithelial cells (AECs) by demonstrating decreased interleukin-6 (IL-6) secretion from Trek-1-deficient cells, but the underlying mechanisms remained unknown. This study was designed to investigate the mechanisms by which Trek-1 ...
Abi-Ghanem Josephine - - 2013
Site-specific recombinases (SSRs) can perform DNA rearrangements, including deletions, inversions and translocations when their naive target sequences are placed strategically into the genome of an organism. Hence, in order to employ SSRs in heterologous hosts, their target sites have to be introduced into the genome of an organism before the ...
Geerdens Candida - - 2012
Frailty models account for the clustering present in event time data. A proportional hazards model with shared frailties expresses the hazard for each subject. Often a one-parameter gamma distribution is assumed for the frailties. In this paper, we construct formal goodness-of-fit tests to test for gamma frailties. We construct a ...
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