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Gamage N M - - 2012
Paget's disease (PD) of the bone is a disorder of bone remodelling that may be polyostotic or monostotic. Although development of a sarcoma in PD is well-recognised, it is less well recognised that pseudosarcomas in bone and soft tissue can also arise in this condition. In this report we document ...
Borgquist Signe - - 2012
The role of estrogen receptor beta (ERβ) in breast cancer has been investigated since its identification in 1996. Studies based on protein expression have indicated that ERβ is a favorable prognostic marker. Further, ERβ expression is lower in obese breast cancer patients. Fewer studies have focused on the prognostic impact ...
Wang Wei - - 2012
The objective of this study was to correlate the expression pattern of candidate genes with the intramuscular fat (IMF) content and fatty acid composition of the Longissimus dorsi muscle of Duroc × Shanzhu commercial crossbred pigs. Animals of both sexes were slaughtered at a body weight of about 90 kg. The ...
Ionov Ilya D - - 2012
RATIONALE: Extrapyramidal motor signs are the major features of Parkinson's disease (PD). It is unclear whether there is a link between these signs and such PD-associated factors as brain somatostatin deficiency and aging. OBJECTIVES: This study aimed to examine whether an inhibition of the brain somatostatin system can initiate catalepsy, ...
Rorat Marta - - 2012
BACKGROUND: Cases of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are increasing in the pediatric population. Their growing prevalence coincides with the obesity epidemic. Assessment of the incidence requires liver biopsies on a representative population sample, which are hampered by the absence of indications for invasive examination on ...
Alemayehu Gezahegn - - 2012
Risks of introduction of lumpy skin disease (LSD) through traded Borena bulls to market chain and its consequences were assessed. The assessment used the framework that has been recommended by the World Animal Health Organization (OIE) for risk analysis. Likelihoods for release and exposure were estimated by a qualitative scale ...
Black Lee - - 2013
The primary goal of breast and ovarian cancer screening is to minimize the cases of advanced disease and therefore its mortality rate. For hereditary breast and ovarian cancer, one method to reach this goal is to disseminate genetic risk information among family members. However, experience tells us that this information ...
Vignola-Gagné Etienne - - 2013
Increasing the rate of biomedical research that is relevant to clinical innovation has been an intensifying concern of the research community and of policy-makers. In response, some of these actors have recently promoted varied approaches they label as translational research (TR) and translational medicine. This movement started in the USA ...
Canis Martin - - 2012
The objective of this study is to assess the feasibility of transoral laser microsurgery (TLM) in the treatment of squamous cell cancer of the tonsil and to report the oncological and functional outcomes, using retrospective chart review in the setting of single-institute, academic tertiary referral center. Between October 1987 and ...
Yan S Betty - - 2012
The HGF/MET signaling pathway regulates a wide variety of normal cellular functions that can be subverted to support neoplasia, including cell proliferation, survival, apoptosis, scattering and motility, invasion, and angiogenesis. MET over-expression (with or without gene amplification), aberrant autocrine or paracrine ligand production, and missense MET mutations are mechanisms that ...
Miyamoto Kei - - 2012
Proper regulation of transcription is essential for cells to acquire and maintain cell identity. Transcriptional activation plays a central role in gene regulation and can be modulated by introducing transcriptional activators such as transcription factors. Activators act on their specific target genes to induce transcription. Reprogramming experiments have revealed that ...
Udayakumaran Suhas - - 2013
Aplasia cutis is a rare developmental anomaly usually involving the calvarium, associated with a variable extent of defective formation of the scalp. Adams-Oliver syndrome is a condition mainly characterized by the congenital absence of skin, known as "aplasia cutis" which is usually limited to the vertex scalp and transverse limb ...
Yamazaki Hiroyuki - - 2012
The ethanol extract of an Indonesian marine sponge Lamellodysidea herbacea inhibited the activity of protein tyrosine phosphatase 1B (PTP1B), an important target enzyme for the treatment of type II diabetes. Bioassay-guided isolation yielded a known polybromodiphenyl ether (1) as a sole bioactive component. The structure of 1 was confirmed by ...
Belforte F S - - 2013
The toll-like receptor 4 (TLR4) plays a key role in the activation of innate immune response participating in the recognition of lipopolysaccharides. Changes in the innate immune response are involved in the pathogenesis of some metabolic disorders such as metabolic syndrome and type 2 diabetes mellitus (Met-S and T2DM). It ...
Maeshima Etsuko - - 2012
We have investigated the prevalence of dry mouth among patients with autoimmune diseases other than Sjögren's syndrome. One hundred and forty-four patients, excluding patients with primary Sjögren's syndrome, were enrolled in this study. The volume of saliva secreted was measured with the screening technique for estimation of salivary flow, which ...
Vimercati Sara Laura SL Bioengineering Department, Politecnico di Milano, p.zza Leonardo da Vinci 32, 20133, Milan, Italy. - - 2013
Slow movements and atypical patterns of muscle activation are well-known features of Down Syndrome (DS). Some studies attribute these features to a deficit in voluntary motor commands and preprogramming of actions, that lead subjects with DS to be more reliant on feedback control. In the present study, we evaluated the ...
Steinberg Fabian F Institute of Physiology and Anatomy, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany. - - 2013
We have documented before that human grasping movements executed in an everyday-like context differ from those in a typical laboratory context. The differences were reduced by factor analysis to five orthogonal factors; we took this as evidence that at least five distinct sensorimotor functions are context-dependent. To better understand how ...
Vlassoff Michael - - 2012
This article presents estimates based on the research conducted in 2010 of the cost to the Ugandan health system of providing post-abortion care (PAC), filling a gap in knowledge of the cost of unsafe abortion. Thirty-nine public and private health facilities were sampled representing three levels of health care, and ...
Venkataraman Meenakshi M Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai, 400098, - - 2013
The objective of the present study was to formulate stable silver sulfadiazine (SSD) nanosuspensions and nanogels suitable for topical delivery with a view to increase bactericidal activity in burn therapy. SSD nanosuspensions were formulated using the microprecipitation-high-pressure homogenization technique. An optimized microsuspension of 0.5% SSD formulated with 6% Cremophor EL ...
Janssens S S Center for Medical Genetics Ghent, University Hospital Ghent, De Pintelaan 185, 9000, Ghent, Belgium, - - 2014
Recent technological developments in molecular genetics facilitate the large-scale detection of inherited genetic disorders and allow an increasing number of genetic conditions to be screened for (American College of Medical Genetics 2012). This technological evolution creates the background which makes reflection necessary about the desirability to offer community-based (preconception) carrier ...
Srour Mayer M Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, - - 2013
To evaluate the anatomical and functional outcomes of intravitreal dexamethasone implant in patients with macular edema (ME) secondary to retinitis pigmentosa (RP). Three patients (four eyes), aged 24 to 46 years, presented with refractory ME secondary to RP. Intravitreal dexamethasone implant (Ozurdex) was administered to treat ME. The anatomical (central ...
Kiyatkin Eugene A EA In-Vivo Electrophysiology Unit, Behavioral Neuroscience Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA. - - 2013
Most neuroactive drugs affect brain metabolism as well as systemic and cerebral blood flow, thus altering brain temperature. Although this aspect of drug action usually remains in the shadows, drug-induced alterations in brain temperature reflect their metabolic neural effects and affect neural activity and neural functions. Here, I review brain ...
Hyberts Sven G SG Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, - - 2013
It is well established that non-uniform sampling (NUS) allows acquisition of multi-dimensional NMR spectra at a resolution that cannot be obtained with traditional uniform acquisition through the indirect dimensions. However, the impact of NUS on the signal-to-noise ratio (SNR) and sensitivity are less well documented. SNR and sensitivity are essential ...
Madani Tahereh T Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, No 12 East Hafez Avenue, Tehran, - - 2013
To compare the number of oocytes per follicles in ovulation induction with 10,000 IU urinary hCG (uhCG) and two different doses of recombinant hCG (rhCG) in women undergoing intracytoplasmic sperm injection (ICSI) cycles. This study was a prospective, randomized controlled trial which was performed on 180 primary infertile women undergoing ...
Domingo-Fernandez Raquel R Department of Cancer Genetics, Royal College of Surgeons in Ireland, Dublin, - - 2013
Neuroblastoma is a highly heterogeneous tumor accounting for 15 % of all pediatric cancer deaths. Clinical behavior ranges from the spontaneous regression of localized, asymptomatic tumors, as well as metastasized tumors in infants, to rapid progression and resistance to therapy. Genomic amplification of the MYCN oncogene has been used to predict ...
Wu Xilong X University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neuroscience and Cell Biology, 683 Hoes Ln. W., Piscataway, New Jersey 08854, - - 2013
Potassium (K(+)) channels are targets of reactive oxygen species in the aging nervous system. KCNB1 (formerly Kv2.1), a voltage-gated K(+) channel abundantly expressed in the cortex and hippocampus, is oxidized in the brains of aging mice and of the triple transgenic 3xTg-AD mouse model of Alzheimer's disease. KCNB1 oxidation acts ...
Lugassy Claire C Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles (UCLA) Medical Center, Los Angeles, CA, USA, - - 2013
The interaction of tumor cells with the tumor vasculature is mainly studied for its role in tumor angiogenesis and intravascular metastasis of circulating tumor cells. In addition, a specific interaction of tumor cells with the abluminal surfaces of vessels, or angiotropism, may promote the migration of angiotropic tumor cells along ...
Tol Menno B MB Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, - - 2013
Pentameric ligand-gated ion channels (LGICs) play an important role in fast synaptic signal transduction. Binding of agonists to the β-sheet-structured extracellular domain opens an ion channel in the transmembrane α-helical region of the LGIC. How the structurally distinct and distant domains are functionally coupled for such central transmembrane signaling processes ...
Nishizawa Yuichiro Y Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, chuo-ku, Kobe, 650-0017, - - 2013
Although the patella reduced or everted position has recently been recognised as an important factor influencing soft tissue balance during assessment in total knee arthroplasty (TKA), the influence of patella height on soft tissue balance has not been well addressed. Therefore, the relationship between soft tissue balance and patella height ...
Barnes J C JC School of Economic, Political and Policy Sciences, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA. - - 2013
Researchers typically analyze samples of twin pairs in order to decompose trait variance into genetic and environmental components. This methodological technique, referred to as twin-based research, rests on several assumptions that must be satisfied in order to produce unbiased results. While research has analyzed the tenability of certain assumptions such ...
McCall Andrew A AA Department of Otolaryngology, Eye and Ear Institute, University of Pittsburgh, Room 519, Pittsburgh, PA 15213, - - 2013
The dorsolateral reticular formation of the caudal medulla, the lateral tegmental field (LTF), participates in generating vomiting. LTF neurons exhibited complex responses to vestibular stimulation in decerebrate cats, indicating that they received converging inputs from a variety of labyrinthine receptors. Such a convergence pattern of vestibular inputs is appropriate for ...
Xiao-Yan Chen C Human Reproductive Center, the First Affiliated Hospital of Sun Yat-Sen University, No.58 Zhongshan 2nd Road, Guangzhou, - - 2013
To investigate the stability and repeatability of electrochemiluminescence immunoassay (ECLIA) for beta-hCG detection in embryo spent culture media. To evaluate the correlation between the viability of preimplantation embryo and beta-hCG profile by the new assay. In a retrospective study, a total of 357 spent culture media from day1 to day5 ...
Philip Benjamin A BA Department of Neuroscience, Brown University, Providence, RI, USA. - - 2013
Primary motor cortex (MI) and parietal area PE both participate in cortical control of reaching actions, but few studies have been able to directly compare the form of kinematic encoding in the two areas simultaneously during hand tracking movements. To directly compare kinematic coding properties in these two areas under ...
Geerdens Candida - - 2012
Frailty models account for the clustering present in event time data. A proportional hazards model with shared frailties expresses the hazard for each subject. Often a one-parameter gamma distribution is assumed for the frailties. In this paper, we construct formal goodness-of-fit tests to test for gamma frailties. We construct a ...
Begun Alexander - - 2012
OBJECTIVES: . Markov chain models are frequently used to study the clinical course of chronic diseases. The aim of this article is to adopt statistical methods to describe the time dynamics of chronically ill patients when 2 kinds of data sets-fully and partially observable data are available. Model. We propose ...
Sun Wenfang - - 2012
Pt(II) complexes bearing 4-(7-(benzothiazol-2'-yl)-9,9-diethyl-fluoren-2-yl)-2,2':6',2''-terpyridine or 4-(7-(benzothiazol-2'-yl)-9,9-diethyl-fluoren-2-yl)ethynyl-2,2':6',2''-terpyridine ligand exhibit strong reverse saturable absorption in the visible spectral region, and large two-photon initiated excited-state absorption in the near-IR region. They are promising broadband nonlinear absorbing materials from visible to the near-IR region. The extended π-conjugation in complex 2 that has a C≡C ...
Corro Ramos Isaac - - 2012
BACKGROUND: The Dutch reimbursement procedure for expensive drugs requires the submission of a baseline cost-effectiveness (CE) analysis and a research plan for the period of temporary reimbursement to estimate the real-life cost-effectiveness after 4 years. The Dutch guidelines recommend a value-of-information analysis to identify the critical parameters to be studied ...
Cutroneo Paola Maria - - 2012
Acute cerebellar ataxia is the most common cause of childhood ataxia, usually resulting from infections or vaccinations. Cases of acute cerebellar ataxia have been reported as a consequence of several viral and bacterial infections as well as immunizing agents, such as varicella, influenza, hepatitis B, and diphtheria-pertussis-tetanus vaccines. Although immunization ...
Dahm Katharine - - 2012
The regional classification method developed to classify 3-D fluoresce spectra, referred to by Li et al. 2012 as the fluorescence regional integration (FRI) method, was criticized in response to the Environmental Science and Technology publication "Identifying Well Contamination through the use of 3-D Fluorescence Spectroscopy to Classify Coalbed Methane Produced ...
Inomata Masafumi - - 2012
In Western countries, the standard treatment for locally advanced rectal cancer is preoperative chemoradiotherapy followed by total mesorectal excision. However, in Japan, the treatment results without preoperative chemoradiotherapy are by no means inferior; therefore, extrapolation of the results of preoperative treatment in Western countries to Japan is controversial. We consider ...
Shimoi Norihiro - - 2012
To obtain optimal field emission (FE) properties, it is important to evaluate FE parameters including the electron emission site α and the field enhancement factor β. However, it is difficult to evaluate α quantitatively because the emitting electrons cannot be observed directly. The authors have aimed to analyze this site ...
Castañeda-Gómez Jhon - - 2012
Reinvestigation of the CHCl(3)-soluble extract from aerial parts of Ipomoea purga was carried out to identify mammalian multidrug-resistance inhibitors. Preparative-scale recycling HPLC was used to purify four new resin glycosides, purgins II (1) and III (2) in addition to purginosides III (3) and IV (4), as well as the known ...
Pitts Margaret Jane - - 2012
In 2009, Virginia became the first state in the United States to enact a school vaccine mandate for the human papillomavirus (HPV), putting it at the forefront of the national HPV vaccine mandate controversy. It is critical to explore the public response and sensemaking where the mandate has already been ...
Noun Peter - - 2012
BACKGROUND:: The impact of pandemic (H1N1) 2009 influenza on immunocompromised patients in western countries has been described, but reports from pediatric patients in the Middle East or Arab countries are deficient. In this study, we describe the clinical characteristics of children with hematological malignancies and laboratory-proven H1N1 influenza. PATIENTS AND ...
San-Juan Rafael - - 2012
BACKGROUND: Epstein-Barr virus (EBV) DNAemia (EBVd) may be a surrogate marker of the net state of immunosuppression after solid organ transplantation (SOT). METHODS: A sample of 81 SOT recipients (53 renal, 21 liver, and 7 cardiac) from our institution (2003-2004) surviving more than 180 days was analyzed. EBVd was monitored ...
Zhang Jing - - 2012
Fullerene/sulfur-bridged annulene cocrystals with a two-dimensional segregated alternating layer structure were prepared by a simple solution-process. Continuing π-π interactions exited both in donor and acceptor layers as revealed by single crystal analysis, which serve as transporting paths for holes and electrons separately. The ambipolar transport behaviors were demonstrated with single ...
Cuny Jérôme - - 2012
The ability of (95)Mo solid-state nuclear magnetic resonance (SSNMR) spectroscopy to probe the atomic and electronic structures of inorganic molybdenum cluster materials has been demonstrated for the first time. Six cluster compounds were studied: MoBr(2), Cs(2)Mo(6)Br(14), (Bu(4)N)(2)Mo(6)Br(14), each containing the octahedral Mo(6)Br(14)(2-) cluster unit, and MoS(2)Cl(3), Mo(3)S(7)Cl(4), and MoSCl that ...
Achee Nicole - - 2012
ABSTRACT: BACKGROUND: Current efforts are underway to quantify the chemical concentration in a treated air space to determine the minimum effective concentration that elicits a spatial repellent (deterrent) response in a vector population. Such information will facilitate identifying the optimum active ingredient (AI) dosage and intervention coverage important for the ...
Le Beyec Johanne - - 2012
Context:Severe early-onset obesity with major hyperphagia associated with hypogonadotropic hypogonadism is recognized as the main clinical presentation of leptin (LEP) or LEP receptor (LEPR) gene complete deficiency. In a few reported cases, homozygous mutations have been found in patients from consanguineous families. Care of LEPR-deficient patients is complicated because they ...
Weihberger Oliver - - 2012
Variable responses of neuronal networks to repeated sensory or electrical stimuli reflect the interaction of the stimulus' response with ongoing activity in the brain and its modulation by adaptive mechanisms such as cognitive context, network state or cellular excitability and synaptic transmission capability. Here, we focus on reliability, length, delays ...
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