Search Results
Results 251 - 300 of 1335
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Ishizuka Mitsuru - - 2012
The aim of this study was to investigate whether menatetrenone (MNT) suppresses hepatocellular carcinoma (HCC) recurrence in patients undergoing hepatectomy. Between January 2005 and September 2009, 101 patients who underwent curative hepatectomy for primary HCC were enrolled in the study. Patients were divided into two groups: a non-MNT group (n=51), ...
Hanet Marie-Sophie - - 2012
To review published clinical studies having compared fluoroquinolones with fortified antibiotics in the treatment of bacterial keratitis. Systematic review of randomized and nonrandomized trials published between 1991 and 2011, and meta-analysis of efficacy results. Eight randomized and 5 nonrandomized studies comparing the efficacy and safety of fortified antibiotics or fluoroquinolones ...
Liu Fu-Peng - - 2012
Amputation-free survival (AFS) has been recommended as the gold standard for evaluating No-Option Critical Limb Ischemia (NO-CLI) therapy. Early-phase clinical trials suggest that autologous bone-marrow derived cells (BMCs) transplantation may have a positive effect on patients with NO-CLI, especially decreasing the incidence of amputation. However, the BMCs therapeutic efficacy remains ...
Rappa Francesca - - 2012
Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by 'mistake'. In the latter case, the chaperone is structurally ...
Mesmin Cédric - - 2012
The specific forms of described protein biomarkers that occur in human blood are not yet fully established. Even though B-type natriuretic peptide (BNP) and N-terminal proBNP are now well known markers of heart failure and other cardiac disorders, several studies yielded highly controversial results reporting various truncated, multimerized or modified ...
Haque Rebecca - - 2012
To validate the Queen's University Ophthalmoscopy Objective Structured Clinical Examination (OSCE) Checklist (QUOOC) by correlating the score derived from this instrument to the ability of a candidate to correctly identify retinal pathology. Educational Instrument Validation Study. Thirteen second-year medical students and 4 ophthalmology residents participated in an OSCE station examining ...
Cheng Vincent Chi-Chung - - 2012
The environmental sources associated with community-acquired or nosocomial legionellosis were not always detectable in the mainland of China and Hong Kong, China. The objective of this study was to illustrate the control measures implemented for nosocomial and community outbreaks of legionellosis, and to understand the environmental distribution of legionella in ...
Vyas Chirayu - - 2012
We report a patient who presented with takotsubo cardiomyopathy but was misdiagnosed as an anterior wall ST elevation myocardial infarction (AWMI). We illustrate how misdiagnosis led to mismanagement by initiating intravenous inotropic agents that led to further hemodynamic compromise. Subsequent withdrawal of the inotropic agents and simultaneous administration of oral ...
Marton Ingrid - - 2012
Aim: To determine the predictive value of HIF-1α and VEGF-C in primary neuroendocrine breast cancers (NEBC) and their correlation with other clinico-pathological characteristics of NEBC. HIF-1α and VEGF-C were determined immunohistochemically in tissue samples from 31 cases of NEBC. The HIF-1α expression in NEBC was predominantly negative, with only 5 ...
Aravidis Christos - - 2012
The molecular events leading to the development of ovarian cancer are not well-established. Defects of the retinoblastoma protein (pRb)/cyclin-D1/p16 pathway have been shown to play a critical role in the development of human malignancies. In particular, the p16/cyclin-dependent kinase inhibitor 2A (CDKN2A) gene located on chromosomal region 9p21 frequently is ...
Galván María Eugenia - - 2012
Introduction. There is currently a deficiency of physicians in pediatric intensive care units (PICU). The cause of this deficit is multifactorial, although the burnout phenomenon has been described as relevant. Objective. To analyze the situation of human resource in the pediatric intensive care units in Argentina and measure the level ...
Kröger Edeltraut - - 2012
Two cholinesterase inhibitors (ChEIs), rivastigmine and galantamine, are used to treat Alzheimer disease in the Netherlands. Several adverse cardiac events have been reported for these medications. We aimed to assess if the use of ChEIs increased the risk of cardiac events in the Netherlands. A cohort crossover study of the ...
Zhang Jingli - - 2012
Background/Aim: To determine if early passage tumor cells obtained from patients with mesothelioma continue to express the tumor differentiation antigen mesothelin and their sensitivity to the anti-mesothelin immunotoxin SS1P. Cell cultures were established from ascites or pleural effusion of 6 peritoneal and 3 pleural mesothelioma patients, respectively. These cells were ...
Everman Kelly R - - 2012
To investigate the histopathologic causes of canalicular obstruction in a case series of patients treated by canalicular trephination for symptomatic epiphora. A university and private practice retrospective chart review. The study involved 12 consecutive patients who underwent unilateral canalicular trephination with tissue retrieval for the treatment of canalicular obstruction. Canalicular ...
Chen Xin - - 2012
The difference of cardiovascular effects between rosiglitazone and pioglitazone treatment for diabetic patients has not been thoroughly studied. We performed a meta-analysis to compare the risk of cardiovascular adverse effects in patients with type 2 diabetes treated with rosiglitazone compared to pioglitazone. The Cochrane Library, PubMed, and Embase were searched ...
McCrady Barbara S - - 2012
Women's experiences as professionals and behavior therapists have changed considerably in the past 40 years. The author describes early challenges and experiences of discrimination as a young female professional. Although women's opportunities have improved considerably, women still experience unique career challenges and choices. The author provides some suggestions for women's ...
- - 2012
The following reviewers generously gave their time and expertise to provide reviews during the past 12 months. The * denotes reviewers who provided multiple reviews or other exceptional assistance.
Heidegger Isabel - - 2012
Aim: We retrospectively analyzed the risk associated with undergrading Gleason score 6 (GS6) prostate cancer (PCa) at biopsy, in patients with preoperative PSA levels of 2-3,99 and 4-10 ng/ml. A total of 674 patients with needle biopsy-diagnosed GS6 PCa, who underwent radical prostatectomy (RP) between 1995 and 2011, were evaluated. ...
Dackiewicz Nora - - 2012
Patient safetyin the operating room is a topic of universal concern. Several studies support the existence of a high percentage of complications and a high mortality rate in surgical procedures (0.5 to 5%). The World Health Organization (WHO) has proposed the implementation of surgical check list in order to improve ...
Stojak Marta - - 2012
Background/Aim: In the search for new derivatives of anthracycline antibiotics, formamidinodaunorubicins containing in the amidine group either a morpholine moiety (DAUFmor) or a hexamethyleneimine moiety (DAUFhex) were synthesized. The biological effects of daunorubicin (DAU), DAUFmor and DAUFhex were compared. The experiments were performed on human acute lymphoblastic leukemia MOLT-4 cells ...
Dijksman Jessica - - 2012
One hundred and eighty scientists from industry and academia discussed the progress in emerging technologies approaching regulated bioanalysis, with a focus on what potential hurdles prevent them becoming broadly accepted by industry and regulators. The conference delegates agreed that moving innovative technologies forward can only be achieved by providing solid ...
Marín Gustavo Roberto - - 2012
An adolescent with acute lymphoblastic leukemia developed an early and severe tumor lysis syndrome with acute kidney injury after a low and single dose of steroids. Renal dysfunction was attributed primarily to phosphate nephropathy with nephrocalcinosis due to extreme elevations of phosphate in blood. Urinary alkalinization probably contributed to this ...
Guo Li-Xin - - 2012
Coronary heart disease is the main complication of type 2 diabetes mellitus; its incidence is closely related to microalbuminuria. The aim of this study was to investigate the correlation between the urinary albumin excretion rate and the incidence and severity of coronary heart disease in elderly type 2 diabetes mellitus ...
Gu Hui-Wen - - 2012
Background: Metoprolol (MET) is a β1-adrenoceptor antagonist, which is widely used in the treatment of cardiovascular diseases, and α-hydroxymetoprolol (α-OHM) is its hydroxylated metabolite. Owing to their similar structures, optimization of the condition for the chromatography approach, which is in common use for determination, is both time consuming and laborious. ...
Han Yu-Bing - - 2012
Glucagon-like peptide-1 (GLP-1) reduces fatty acid-induced beta-cell lipotoxicity in diabetes; however, the explicit mechanisms underlying this process are not fully understood. This study was designed to investigate the involvement of microRNA, which regulates gene expression by the sequence-specific inhibition of mRNA transcription in the GLP-1 mediation of beta-cell function. The ...
Pettigrew Christopher A - - 2012
Reactive oxygen species (ROS) and oxidative stress are related to tumour progression, and high levels of ROS have been observed in prostate tumours compared to normal prostate. ROS can positively influence AKT signalling and thereby promote cell survival. The aim of this project was to establish whether the ROS generated ...
Cooks Tomer - - 2012
We developed a new method of brachytherapy, termed diffusing alpha-emitters radiation therapy (DaRT), based on the use of intratumoral (224)Ra-loaded wires, which release short-lived alpha-emitting atoms by recoil. Here, we examined their ability to destroy and control the development of several human-derived tumors implanted in athymic mice. The experiments were ...
Okuda Kentaro - - 2012
Acute chemotherapy-associated exacerbation of interstitial lung disease (ILD) can occur in patients with non-small cell lung cancer (NSCLC). The safety and efficacy of cytotoxic chemotherapy has not yet been established for NSCLC with ILD. Thus, patients with advanced NSCLC with ILD usually receive only best supportive care. The aim of ...
Mora Mabel - - 2012
Introduction. No published material on the preva lence of celiac disease (CD) in the pediatric population of Argentina has been found up to date. Objective. To estimate the prevalence of CD in a pediatric population (hospital-based sample) from 5 urban districts of Argentina. Methods. In a cross-sectional descriptive study, we ...
Mehta Sangeeta S Division of Critical Care, Department of Medicine and Interdepartmental Mount Sinai Hospital and University of Toronto, Toronto, Canada. - - 2012
Protocolized sedation and daily sedation interruption are 2 strategies to minimize sedation and reduce the duration of mechanical ventilation and intensive care unit (ICU) stay. We hypothesized that combining these strategies would augment the benefits. To compare protocolized sedation with protocolized sedation plus daily sedation interruption in critically ill patients. ...
Fogarty Andrea S - - 2012
Objective: To describe television news coverage between 2005 and 2010 of alcohol, health and relevant alcohol-control policies, with a view to informing policy advocacy. Methods: A content analysis of all alcohol stories archived by the Australian Health News Research Collaboration. We recorded what triggered a news item, the main topics ...
Cameron Michael P - - 2012
Objectives: To explore the cross-sectional association between alcohol outlet density and police events in Manukau City, New Zealand. Methods: Using data for the Census Area Unit (suburb) level, per-capita measures of alcohol outlet density for January 2009 were calculated for off-licence outlets, clubs and bars, and restaurants and cafés. Data ...
Goller Jane L - - 2012
Objective: To measure chlamydia testing and positivity rates among 16-39 year olds attending Aboriginal Community Controlled Health Services (ACCHSs). Methods: Retrospective non-identifiable computerised records containing consultation and chlamydia testing data were collected for patients (16-39 years) attending eight ACCHSs during 2008-09 in urban, regional and remote settings for the Australian ...
D'Onise Katina - - 2012
Objectives: There is limited epidemiological data on the performance of different refrigerator types for vaccine storage in the real world. This study aims to measure if the introduction of purpose-built vaccine refrigerators has reduced the cost of vaccine losses in South Australia. Methods: Data were taken from a register for ...
Scholes-Balog Kirsty E - - 2012
Objective: In Australia, many health researchers and policy makers are advocating for mandated warning labels on alcoholic beverages. Alcohol-related harms are of particular concern among adolescents. The aim of this article was to review the available literature and evaluate the impact of alcohol warning labels on adolescent drinking, knowledge and ...
Pledger Megan M Health Services Research Centre, Victoria University of Wellington, New Zealand. - - 2012
To compare two surveys conducted in 2007 and 2009, of the food and nutrition environment in New Zealand primary schools. A sample of primary schools was asked about foods and beverages provided or sold to students or used for fundraising, and nutrition-related policies and procedures. Comparisons were made between school ...
Kumagai Atsushi - - 2012
Looking back at the Great East Japan Earthquake on March 11, 2011, besides further studying the appropriateness of the initial response and post-countermeasures against the severe Fukushima nuclear accident, the importance of the epidemiological study in human health risk management and the comprehensive radiation protection standard need to be emphasized; ...
Li Chang-Fa - - 2012
To observe the clinical efficacy on superior cluneal nerve entrapment syndrome treated by relaxation therapy of in-row multi-needling technique. One hundred and twenty cases were randomized into a multi-needling group, an acupotomy group and a conventional acupuncture group, 40 cases in each one. In the multi-needling group, the perpendicular or ...
Wessels Ronni - - 2012
Vulvar squamous cell carcinoma (VSCC) is a gynecological cancer with an incidence of two to three per 100,000 women. VSCC arises from vulvar intraepithelial neoplasia (VIN), which is diagnosed through painful punch biopsy. In this study, optical coherence tomography (OCT) is used to differentiate between normal and VIN tissue. We ...
Terry Ken - - 2012
Doctor-led accountable care organizations are proliferating at a surprising rate. Experts say physicians still need hospitals to participate and that both sides can benefit.
Gao Dian-Jun - - 2012
To investigate the relationship between Y chromosome microdeletions and human spermatogenesis in infertile men with varicocele (VC). We divided 174 infertile VC patients into groups A (with azoospermia, n = 47) , B (with severe oligozoospermia, n=57) and C (with mild oligozoospermia, n=70), and enlisted 28 fertile males and 26 ...
Rothe Thomas - - 2012
A darkfield scattering microscope has been constructed that enables both angular and spectrally resolved measurements of elastic scattering patterns. The comparison of the angular and spectral resolution modes is shown in detail. Angular patterns of the backscattered light by homogeneous polystyrene spheres were measured at 57 wavelengths and the diameters ...
Nadiarnykh Oleg - - 2012
Nonlinear optical imaging modalities (multiphoton excited fluorescence, second and third harmonic generation) applied in vivo are increasingly promising for clinical diagnostics and the monitoring of cancer and other disorders, as they can probe tissue with high diffraction-limited resolution at near-infrared (IR) wavelengths. However, high peak intensity of femtosecond laser pulses ...
Zhu An-Ning - - 2012
Through consultation of the historical literatures on Mr. CHEN Ying-long, investigating his teaching experiences in Xiamen Hospital of TCM and Xiamen University, the characteristics of his educational idea on acupuncture-moxibustion, are found as follows: great significance is found in the dissemination of Chengjiang acupuncture school in Minnan area of China ...
Shimura Hiroki - - 2012
Thyroid dysfunction induces clinical problems even in the stage of subclinical. Patients with clinical signs suggesting thyroid dysfunction, as well as pregnant women, should be examine their thyroid function despite the high prevalence, 7-10% of adults. Thyroid nodules, most of which should not be treated blindly, are frequently found in ...
Zhu Jie - - 2012
To explore the feasibility of ultra-rapid freezing of human spermatozoa in the cryogenic vial with different concentrations of sucrose solution. We divided 40 normal semen samples prepared with the routine swim-up technique into 6 aliquots, 1 as the control and the other 5 cryopreserved with sucrose solution at the concentrations ...
Ieiri Tamio - - 2012
Recent progress and present situation of the thyroid function tests and the thyroid autoantibody tests were reviewed with some author's opinion. Recent clinical laboratory examinations using immunoassay are mainly non-isotopic full-automatic assay with various kinds of methodological principal. These bring us difficulties of the standardization of the tests. On the ...
Jiao Yong-Zheng - - 2012
To investigate the effects of Yijing Recipe on sperm apoptosis and mitochondrial membrane potential (MMP) in patients with idiopathic oligoathenoteratospermia. Using the self-control method, we examined sperm apoptosis and MMP in 30 patients with oligoathenoteratospermia before and after treated with Yijing Recipe. The rates of early sperm apoptosis (AV +/PI ...
Akamizu Takashi - - 2012
Thyrotoxic storm is a life-threatening condition requiring emergency treatment. Neither its epidemiological data nor diagnostic criteria have been fully established. We clarified the clinical and epidemiological characteristics of thyroid storm using nationwide surveys and then formulate diagnostic criteria for thyroid storm. To perform the nationwide survey on thyroid storm, we ...
Nishikawa Mitsushige - - 2012
Various drugs may cause thyroid dysfunction. The drugs which may cause thyrotoxicosis include interferon, molecular-targeted agents, amiodarone, thyroid hormone itself and so on. Those which cause hypothyroidism include anti-thyroid drugs, lithium and iodine etc. which inhibit thyroid hormone synthesis and secretion, and dopamine etc. which block TSH secretion. Those drugs ...
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