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Mehlhorn Grit - - 2012
A prototype system for computer-assisted colposcopic diagnosis (CAD) currently achieves a high level of accuracy of 80% (sensitivity 85%, specificity 75%) for the automatic assessment of colposcopic images. This pilot study investigated whether this type of CAD system is, in principle, capable of influencing the quality of the examiner's assessment. ...
Kamada Minori - - 2012
Urocortin and corticotropin-releasing factors (CRFs) and their receptors are expressed in many organs, including the central nervous system. In this study, the expression of mRNAs of urocortin 1, 2, 3, and CRF and CRF receptors 1 and 2 in malignant glioma, was examined. The RNAs of human and rat glioma ...
Park Hai-Lin - - 2012
Image-guided vacuum-assisted breast biopsy (VABB) is used for detecting breast lesions in South Korea. However, no clear guidelines for VABB exist. A 53-item survey was administered to members of the Korean Breast Cancer Society between July 27 and August 27, 2010. Among 62 respondents, 87.1% had performed VABB, with 63.0% ...
Cooks Tomer - - 2012
We developed a new method of brachytherapy, termed diffusing alpha-emitters radiation therapy (DaRT), based on the use of intratumoral (224)Ra-loaded wires, which release short-lived alpha-emitting atoms by recoil. Here, we examined their ability to destroy and control the development of several human-derived tumors implanted in athymic mice. The experiments were ...
Okuda Kentaro - - 2012
Acute chemotherapy-associated exacerbation of interstitial lung disease (ILD) can occur in patients with non-small cell lung cancer (NSCLC). The safety and efficacy of cytotoxic chemotherapy has not yet been established for NSCLC with ILD. Thus, patients with advanced NSCLC with ILD usually receive only best supportive care. The aim of ...
Mora Mabel - - 2012
Introduction. No published material on the preva lence of celiac disease (CD) in the pediatric population of Argentina has been found up to date. Objective. To estimate the prevalence of CD in a pediatric population (hospital-based sample) from 5 urban districts of Argentina. Methods. In a cross-sectional descriptive study, we ...
Zanetta Adrián - - 2012
In children, extrinsic compression of the trachea is usually due to vascular origin, and less frequently caused by tumors, heart diseases, cysts and abscesses. Vascular rings are congenital anomalies of the aortic arch and its branches that compress the trachea and/or esophagus to varying degrees. Although these congenital anomalies are ...
Rappa Francesca - - 2012
Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by 'mistake'. In the latter case, the chaperone is structurally ...
Mesmin Cédric - - 2012
The specific forms of described protein biomarkers that occur in human blood are not yet fully established. Even though B-type natriuretic peptide (BNP) and N-terminal proBNP are now well known markers of heart failure and other cardiac disorders, several studies yielded highly controversial results reporting various truncated, multimerized or modified ...
Haque Rebecca - - 2012
To validate the Queen's University Ophthalmoscopy Objective Structured Clinical Examination (OSCE) Checklist (QUOOC) by correlating the score derived from this instrument to the ability of a candidate to correctly identify retinal pathology. Educational Instrument Validation Study. Thirteen second-year medical students and 4 ophthalmology residents participated in an OSCE station examining ...
Cheng Vincent Chi-Chung - - 2012
The environmental sources associated with community-acquired or nosocomial legionellosis were not always detectable in the mainland of China and Hong Kong, China. The objective of this study was to illustrate the control measures implemented for nosocomial and community outbreaks of legionellosis, and to understand the environmental distribution of legionella in ...
- - 2012
The ED at The Aroostook Medical Center (TAMC) in Presque Isle, ME, is a level II trauma center. It is the largest in the region, with only 89 beds. It has undergone a transformation in recent months, with average wait times to see a provider going from four to five ...
Delnoij Thijs S R - - 2012
Massive pulmonary embolism poses a therapeutic challenge, especially when thrombolytics are controversial. We describe the complicated course of an exceptional case of massive pulmonary embolism exhibiting paradoxic embolization with a thrombus lodged in the foramen ovale. Thrombolysis was considered contraindicated and surgical intervention was performed. Postoperatively, persistent pulmonary hypertension and ...
Agote Robertson Luis Arturo - - 2012
During 2009, 564 children died in Argentina from 0 to 14 in traffic accidents. The mortality rate for road accidents is 56/100 000 inhabitants and is 858% when compared to Sweden, the country with the lowest rate. Fifty percent were children transported in cars, 30% in heavy duty vehicles, 16.3% ...
Pasello Giulia - - 2012
Aim: The objective of this study was the retrospective evaluation of tolerability and activity of pemetrexed with carboplatin (AC) or cisplatin (AP) as neoadjuvant chemotherapy in a consecutive series of patients with malignant pleural mesothelioma (MPM). Patients with operable MPM received three cycles of AC or AP followed by surgery ...
Chen Zhi-Fen - - 2012
The role of tumor-infiltrating lymphocytes (TILs) in the immunopathogenesis of individual cancer is not clear and is a challenge for anti-tumor immunotherapy. This study aimed to investigate the effects of interleukin (IL)-18 and -12 on cytotoxic functions of TILs. TILs from postoperative gastric cancer patients were costimulated with IL-18 and ...
Lenglinger Johannes - - 2012
Esophageal adenocarcinoma results from gastroesophageal reflux and develops along a sequence involving non-dysplastic Barrett's esophagus (NDBE), low- (LGD) and high-grade dysplasia (HGD). We aimed to examine the reported annual cancer risk for NDBE in persons with symptoms of gastroesophageal reflux disease, i.e. symptomatic NDBE. Our study reviewed seven population-based studies ...
Mulassi Andrés H - - 2012
Introduction. The objective was to study different social networks of adolescents regarding the use of tobacco, alcohol use or obesity, in order to know to what extent friends and schoolmates influenced them in keeping or quitting these habits. Materials and Methods. Two hundred and ninety six adolescents aged 14-18 years ...
Boudoulas Konstantinos Dean - - 2012
Objective: Compare vascular complications and incidence of bleeding of Impella 2.5 and intra-aortic balloon pump (IABP) in high-risk percutaneous coronary interventions (PCI). Background: Large arterial sheath size for device insertion is associated with vascular and/or bleeding complications; gastrointestinal bleeding may also occur with anti-coagulation use. Methods: Patients with an acute ...
Krockenberger Mathias - - 2012
Ovarian cancer is generally thought of as a cancer with poor prognosis. However, prognostic appraisal of the disease is based on tumor stages, surgical features or sensibility towards platinum-based chemotherapy. There are data that also grant immunological parameters such as CD8(+) T-lymphocyte-(CD8 T-cell) infiltration in tumor tissue, a prognostic role. ...
Rey-Ares Lucila - - 2012
Introduction. Cervical cancer is the third most common cancer worldwide. The human papilloma virus (HPV) has been identifed as the etiologic agent of cervical and other anogenital cancers. The aim was to perform a systematic review and meta-analysis to evaluate the efficacy and safety of HPV vaccines in preventing cervical ...
Tamanaka Taichi - - 2012
Wilms' tumor gene WT1 is highly expressed in leukemia and in various types of solid tumors and exerts an oncogenic function. Thus, WT1 protein is a most promising tumor-associated antigen. We have been successfully performing WT1 vaccination with a 9-mer modified WT1(235) peptide, which has one amino acid substitution (M→Y) ...
Lee Yoo-Young - - 2012
Aim: To determine whether the use of high-intensity focused ultrasound (HIFU) ablation combined with cisplatin, compared with HIFU ablation, and cisplatin alone, facilitates tumor necrosis and reduces tumor volume in an animal model. The cervical cancer cell line SiHa was cultured and injected subcutaneously into female BALB/c nude mice. Animals ...
Chappell Derek L - - 2012
Background: Renin catalyzes the conversion of angiotensinogen to angiotensin I (Ang I), the first and rate-limiting step in the renin-angiotensin-aldosterone system. Plasma renin activity (PRA) is an important target engagement biomarker in the clinical development of renin inhibitors. We have developed and validated an improved PRA assay that incorporates an ...
Wang Zhi-Gang - - 2012
Vibrio vulnificus (Vv) is an estuarine bacterium that can cause primary septicemia as well as serious wound infections. However, little is known about the mechanisms by which Vv infects dendritic cells (DCs) and its effects on cytoskeleton. In this study, we aimed to investigate the invasion, internalization, and the organelles ...
Takahashi Tsunehiro - - 2012
Triplet combination chemotherapy has the potential to improve the prognosis of patients with unresectable gastric cancer. We conducted a phase I trial of triplet combination chemotherapy consisting of paclitaxel, cisplatin, and S-1 (PCS) for unresectable gastric cancer. Patients with metastatic or incurable disease were enrolled. S-1 was administered on days ...
Gao Jie - - 2012
Venous thromboembolism is known to be an important social and health care problem because of its high incidence among patients who undergo surgery. Studies on the mechanical prophylaxis of thromboembolism after gynaecological pelvic surgery are few. The aim of our study was to evaluate the effect of mechanical thromboembolism prophylaxis ...
Reardon Gregory - - 2012
Treatment of venous thromboembolism (VTE) in long-term care (LTC) settings has received little empirical study. Among residents with VTE in nursing homes, this analysis evaluated frequency of anticoagulant use, the proportion of residents newly started on warfarin who persisted on therapy (≥3 months), and the association of key resident characteristics, ...
Scuderi Gianluca - - 2012
To evaluate the correlation between tear osmolarity and blood levels of 17-β estradiol, estrone, and testosterone in postmenopausal women with dry eye syndrome, and to assess the efficacy and safety of oral supplementation with phytoestrogens, lipoic acid, and eicosapentaenoic acid in this population. Cross-sectional study including 66 postmenopausal women with ...
Wang Zhi-Hui - - 2012
Boanmycin hydrochloride, a new antitumor agent, has a short half-life and fast clearance speed in vivo. The aim of this research was to investigate the effectiveness of peritumor injection of boanmycin hydrochloride within temperature-sensitive gel in situ using Hep-G2 hepatoma nude mice model. Nude mice with human Hep-G2 tumor in ...
Nyström Hanna - - 2012
The tumour stroma is an important modulator of cancer cell behaviour. The aim of this study was to compare the stromal composition between primary colorectal cancer (CRC) and colorectal liver metastases (CLM). The stromal composition in matched tissue sections of CRC and subsequent CLM was analysed, and related to clinical ...
- - 2012
Several new studies presented at ACEP's scientific meeting in October poke holes in the conventional wisdom that frequent ED users are abusing the ED for routine health care needs. Instead, investigators say patients typically have urgent or emergent concerns, regardless of their insurance status. Experts suggest that rather than trying ...
Schueler M - - 2012
Background: Elevated cardiac troponin (cTn) has been reported to occur with AVNRT. Little is known about prevalence, kinetic changes, and possible reasons of increased cTn. Methods: We evaluated 139 consecutive patients presenting with AVNRT to the emergency department between 2006 and 2010. Cardiac troponin T (cTnT) was measured serially at ...
Montgomery Anne - - 2012
A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve ...
Ciocca Mirta - - 2012
Alagille syndrome (AS) is a multisystemic disease autosomal dominant, with variable expression. The major clinical manifestations are: chronic cholestasis, congenital heart disease, posterior embryotoxon in the eye, characteristic facial phenotype, and butterfy vertebrae. AS is caused by mutations in JAGGED1 (more than 90%) and in NOTCH2. Differential diagnosis include: infections, ...
Higashida Masaharu - - 2012
Background/Aim: The objective of this study was to investigate the influence of digestive gastrointestinal absorption function on the pharmacokinetics of the orally-administered anticancer drug, Tegafur-gimestat-otastat potassium (TS-1), by measuring the plasma 5-fluorouracil (5-FU) concentration using stable isotope breath tests. Twenty-nine patients with progressive/recurrent digestive organ cancer were enrolled for this ...
Gupta Vasudha - - 2012
To survey the current inclusion criteria used for retinopathy of prematurity (ROP) screening across tertiary level 3 neonatal intensive care units (NICUs) in Canada. Clinical directors from 29 level 3 NICUs in Canada. Survey of all 29 level 3 NICUs in Canada in September 2010. The survey inquired about the ...
Ma Ding - - 2012
Cervical cancer is one of the most common malignant tumors in women. This study was designed to explore the expression profiles of microRNAs (miRNAs) and mRNAs and the gene regulation network in cervical tumorigenesis and to find candidate molecular markers and key tumorigenic genes in cervical cancer. miRNAs and mRNAs ...
Bowen Chester L - - 2012
Background: Stabilization of phase II metabolites is an important consideration during bioanalytical method development, method validation and sample analysis. Generic approaches to stabilize these metabolites during storage in liquid-based matrices include pH adjustment of samples prior to storage and/or temperature control; although a variety of other compound-specific stabilization techniques exist. ...
DU Li-Qun - - 2012
Pretreatment with chemical agents could alter the surface chemistry of the silicone gel, which makes it suitable for epithelial migration onto its surface and thus enhances the cytobiocompatibility. This study aimed to evaluate the biological response of the corneal stroma to porous silicone gel pretreated with different chemical agents in ...
Qiu Kui - - 2012
Mycophenolic acid (MPA) as an anti-proliferative immune-suppressive agent is used in the majority of immunosuppressive regimens in solid organ transplantation. This study aimed to investigate the pharmacokinetic (PK) characteristics of enteric-coated mycophenolate sodium (EC-MPS) and area under the curve (AUC) from 0 to 12 hours with limited sampling strategies (LSSs) ...
Yuan Long - - 2012
Background: A dried blood spot (DBS) bioanalysis assay involves many steps, such as the preparation of standard (STD) and QC samples in blood, the spotting onto DBS cards, and the cutting-out of the spots. These steps are labor intensive and time consuming if done manually, which, therefore, makes automation very ...
Guo Jin - - 2012
Many researches report that low socioeconomic status (SES) is associated with a higher risk of coronary heart disease (CHD). This study aimed to determine whether levels of education, family income, and other SES were associated with acute myocardial infarction (AMI) in the Chinese population, and to compare the difference in ...
Murphy Timothy F - - 2012
Some commentators have criticized bioethics as failing to engage religion both as a matter of theory and practice. Bioethics should work toward understanding the influence of religion as it represents people's beliefs and practices, but bioethics should nevertheless observe limits in regard to religion as it does its normative work. ...
Klat Jaroslav - - 2012
To evaluate the incidence of parametrial involvement in women with early-stage cervical cancer with tumour <20 mm and with negative sentinel lymph nodes (SLN). We reviewed the cases of all women who underwent radical hysterectomy and pelvic lymphadenectomy with SLN biopsy for invasive cervical cancer between April 2004 and December 2009. ...
Kim Daeik - - 2012
Background/Aim: (-)-Epicatechin is a major constituent of Bulnesia sarmienti, which is known to possess anticancer properties. Here we report that (-)-epicatechin isolated from B. Sarmienti inhibited growth and induced apoptosis of SW480 human colon cancer cells. Cells were treated with different concentrations (0, 25, 50, and 100 μmol/ml) of (-)-epicatechin. ...
Shimada Yutaka - - 2012
Aim: To understand the role of iPS inductive genes in esophageal cancer, we examined the expression of Sex determining region Y-box 2 (SOX2), Octamer-binding transcription factor 3/4 (OCT3/4), Krueppel-like factor 4 (KLF4), c-Myelocytomatosis viral oncogene (c-MYC) and Tir Na Nog (NANOG) using an esophageal squamous cell carcinoma tissue micrroarray. The ...
Karabel Duran - - 2012
Vitamin D deficiency and rickets are major health problems in developing countries. Congenital rickets is a rare form of rickets. Maternal vitamin D deficiency is the most important risk factor for vitamin D deficiency and rickets in newborns and early infancy. In this report, we presented a two-monthold infant with ...
Li Ming-Zi - - 2012
Diabetes has become one of the most common chronic diseases and the third leading cause of death in China. Many programs have been initiated at national and local levels to address the illness. However, the effect of these programs in daily outpatient clinics is still unclear. The objective of this ...
Vyas Chirayu - - 2012
We report a patient who presented with takotsubo cardiomyopathy but was misdiagnosed as an anterior wall ST elevation myocardial infarction (AWMI). We illustrate how misdiagnosis led to mismanagement by initiating intravenous inotropic agents that led to further hemodynamic compromise. Subsequent withdrawal of the inotropic agents and simultaneous administration of oral ...
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