Search Results
Results 51 - 100 of 1334
1 2 3 4 5 6 7 8 9 10 >
Chatzi Katerina E - - 2013
More than one-third of cellular proteomes traffic into and across membranes. Bacteria have invented several sophisticated secretion systems that guide various proteins to extracytoplasmic locations and in some cases inject them directly into hosts. Of these, the Sec system is ubiquitous, essential and by far the best understood. Secretory polypeptides ...
Callahan Damien M - - 2013
This review considers evidence that the clinical condition of heart failure alters skeletal muscle protein synthesis and/or breakdown to promote skeletal muscle wasting and functional decrements that ultimately contribute to the symptomology of the disease. Advanced HF is frequently accompanied by muscle atrophy and a cachectic phenotype. Protein metabolic derangements ...
Becker Dawn Marie - - 2013
Night-shift nurses receive fewer educational opportunities and less administrative support than do day-shift staff, tend to be newer, with less experience and fewer resources, and experience greater turnover rates, stress, and procedural errors. In an attempt to bridge the gap between day- and night-shift nursing, a night-shift clinical nurse specialist ...
Lasham Annette - - 2013
Hanahan and Weinberg have proposed the 'hallmarks of cancer' to cover the biological changes required for the development and persistence of tumours [Hanahan and Weinberg (2011) Cell 144, 646-674]. We have noted that many of these cancer hallmarks are facilitated by the multifunctional protein YB-1 (Y-box-binding protein 1). In the ...
Maggio Marcello - - 2013
Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes such as physical disability, poor quality of life, and death. Sarcopenia is a multifactorial process involving the decline of androgens, including dehydroepiandrosterone sulphate (DHEAS) and testosterone. The ...
Kelly Stephen L - - 2013
Multidisciplinary team (MDT) care is widely accepted as best practice for patients with head and neck cancer, although there is little evidence that MDT care improves head and neck cancer related outcomes. This study aims to determine the impact of MDT care on measurable clinical quality indicators (CQIs) associated with ...
Gullón-Rivera Angel L - - 2013
This multi-method multi-informant study assessed 105 Puerto Rican kindergartners' sense of self-worth in family relationships as coded from their responses to the Attachment Story Completion Task (ASCT). The ASCT scores were compared with responses to two other age-appropriate self-evaluation measures (the Cassidy Puppet Interview and the Pictorial Scales of Social ...
Asher Annamarie - - 2013
Mobilizing critically ill patients in the intensive care unit requires careful planning and attention to detail. The risks involved in mobilizing these patients include dislodging equipment, injury to the patient, injury to the caregivers, and physiologic decompensation of the patient. To carry out the activity safely, the therapist and the ...
Schweitzer Jörn - - 2013
Precise spatiotemporal control of axon guidance factor expression is a prerequisite for formation of functional neuronal connections. Although Netrin/Dcc- and Robo/Slit-mediated attractive and repulsive guidance of commissural axons have been extensively studied, little is known about mechanisms controlling mediolateral positioning of longitudinal axons in vertebrates. Here, we use a genetic ...
Little Milta O - - 2013
Skin ulcerations cause significant morbidity and mortality, while driving up healthcare utilization and costs. Interventions to prevent ulcers and improve wound healing times are needed to reduce the burden on patients and healthcare systems. It has been well established that weight loss, protein-calorie malnutrition, and dehydration are risk factors for ...
Sanders Rogier W - - 2013
In the absence of a vaccine or a cure, identification of novel HIV-1 inhibitors remains important. A paper in Retrovirology describes a rationally designed bi-specific protein that irreversibly damages the viral envelope glycoprotein complex via a two-punch mechanism. In contrast to traditional drugs that inhibit essential steps in the viral ...
Gallinetti Jordan - - 2013
DR (dietary restriction), or reduced food intake without malnutrition, is associated with extended longevity, improved metabolic fitness and increased stress resistance in a wide range of organisms. DR is often referred to as calorie restriction, implying that reduced energy intake is responsible for its widespread and evolutionarily conserved benefits. However, ...
Maningat Patricia P The Rockefeller University, New York, NY 10065, USA. - - 2013
Statins are highly effective drugs prescribed to millions of people to lower LDL-cholesterol and decrease cardiovascular risk. The benefits of statin therapy seen in randomized clinical trials will only be replicated in real-life if patients adhere to the prescribed treatment regimen. But, about half of patients discontinue statin therapy within ...
Weasner Bonnie M BM Department of Biology, Indiana University, Bloomington, IN 47405, - - 2013
The eye-antennal disc of Drosophila gives rise to numerous adult tissues, including the compound eyes, ocelli, antennae, maxillary palps and surrounding head capsule. The fate of each tissue is governed by the activity of unique gene regulatory networks (GRNs). The fate of the eye, for example, is controlled by a ...
Fox Donald T DT Department of Pharmacology and Cancer Biology, and Department of Cell Biology, Duke University, Durham, NC 27710, USA. - - 2013
Polyploid cells have genomes that contain multiples of the typical diploid chromosome number and are found in many different organisms. Studies in a variety of animal and plant developmental systems have revealed evolutionarily conserved mechanisms that control the generation of polyploidy and have recently begun to provide clues to its ...
Ridker Paul M PM Center for Cardiovascular Disease Prevention and the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. - - 2013
The recent JUPITER trial demonstrated that potent statin therapy reduces by 50 % the risk of heart attack and stroke among men and women with low levels of low-density lipoprotein (LDL)-cholesterol who are at increased vascular risk due to elevated levels of C-reactive protein (CRP), a biomarker of low-grade systemic ...
Hirata Akihiro A Division of Animal Experiment, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu, 501-1194, - - 2013
There is a gradient of β-catenin expression along the colonic crypt axis with the highest levels at the crypt bottom. In addition, colorectal cancers show a heterogeneous subcellular pattern of β-catenin accumulation. However, it remains unclear whether different levels of Wnt signalling exert distinct roles in the colonic epithelium. Here, ...
Jain Deepali - - 2013
Medulloblastoma accounts for only 1% of all adult CNS tumors. Recently, we have encountered a case of medulloblastoma in a 26 year old man with divergent differentiation including myoblastic, glial, osteoblastic and chondroblastic differentiation. Here we present the results of immunohistochemical staining using several specific antibodies with a discussion and ...
Manini Todd M TM Institute of Aging and the Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida 32611, USA. - - 2013
Age-related muscle weakness causes a staggering economic, public, and personal burden. Most research has focused on internal muscular mechanisms as the root cause to strength loss. Here, we briefly discuss age-related impairments in the brain and peripheral nerve structures that may theoretically lead to muscle weakness in old age. Neuronal ...
Ka I - - 2012
A pulsed laser ablation based approach is developed on page 6289 by My Ali El Khakani and co-workers for the direct synthesis of nanohybrid structures consisting of single-wall carbon nanotubes (SWCNTs) decorated with PbS quantum dots (PbS-QDs). By varying the laser ablation conditions, the size of the PbS-QDs together with ...
Han Mingu - - 2012
A new approach to improve the power conversion efficiency of polymer bulkheterojunction solar cells by the formation of an embedded passivation layer is demonstrated. In the Communication on page 6311, Ji-Woong Park and co-workers report a simple method to generate silica-like layers along the three-dimensionally intertwined P(3) HT/PCBM interface by ...
Golipour Azadeh - - 2012
Reprogramming of somatic cells to a pluripotent state via expression of Oct4, Klf4, Myc, and Sox2 is a multistep process involving phased changes in gene expression. Here, we focus on the later stages of reprogramming, termed maturation and stabilization. We show that the stabilization phase and the acquisition of pluripotency ...
Stensmyr Marcus C - - 2012
Flies, like all animals, need to find suitable and safe food. Because the principal food source for Drosophila melanogaster is yeast growing on fermenting fruit, flies need to distinguish fruit with safe yeast from yeast covered with toxic microbes. We identify a functionally segregated olfactory circuit in flies that is activated ...
- - 2012
Alastair Sloan, speaker at the 2012 BDA Christmas Lecture, describes a regenerative future for dentistry, the standing of UK dental research and his scientific heroes.
Laskowski Agnieszka I - - 2012
Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs). Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA degradation.
Daley George Q - - 2012
The 2012 Nobel Prize in Medicine or Physiology recognizes the architects of two of the great paradigm-shifting discoveries of the last half-century of biology. In experiments performed nearly 50 years apart, Gurdon and Yamanaka made feasible the reawakening of pluripotency inherent in all cells and challenged forever our notions of ...
Richardson Dr Riina - - 2012
Objective To assess the risk of variant Creutzfeldt-Jakob Disease (vCJD) associated with dental treatment.Design Case-control study, investigation of links between cases.Setting National CJD surveillance, general dental practice and practice boards in Great Britain, 2008-2009.Methods Variant CJD cases were recruited from all those referred between May 1995 and August 2009 (n ...
Kato Kazuto - - 2012
Alongside the scientific barriers to the clinical translation of stem cell research are ethical and regulatory hurdles. Some of these challenges described by the Ethics and Public Policy Committee at the ISSCR Tenth Annual Meeting are presented here.
Mantovani Alberto - - 2012
Two studies in this issue of Cell Stem Cell highlight context-dependent roles for MSCs in controlling tumor growth. Lee et al. (2012) show that preactivated MSCs have antitumor effects upon adoptive transfer in vivo, and Ren et al. (2012) show that tumor-resident MSCs can promote tumor growth by influencing macrophages.
Chen P - - 2012
Objective The aim of the current study was to investigate the psychosocial impact of dental aesthetics among patients who received anterior implant-supported prostheses.Methods The current study is a cross-sectional evaluation involving 115 individuals who had gone through treatment at the dental clinics of general hospitals. Participants completed the Chinese version ...
Ahmad Irfan - - 2012
Objective The aim of the current study was to investigate the psychosocial impact of dental aesthetics among patients who received anterior implant-supported prostheses.Methods The current study is a cross-sectional evaluation involving 115 individuals who had gone through treatment at the dental clinics of general hospitals. Participants completed the Chinese version ...
Itakura Eisuke - - 2012
The lysosome is a degradative organelle, and its fusion with other organelles is strictly regulated. In contrast to fusion with the late endosome, the mechanisms underlying autophagosome-lysosome fusion remain unknown. Here, we identify syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome. Stx17 localizes to the ...
- - 2012
'...in the metabolically abnormal group, the decline on the global score (measuring cognition) was faster among obese... than among normal weight individuals.'
Kale Justin - - 2012
Regulation of apoptosis by Bcl-2 family proteins is a paradigm for complex protein-protein and protein-membrane systems. Elucidating the molecular mechanisms of these interactions in vitro in live cells and in animal studies has been significantly enhanced by using fluorescence techniques.
Mason Chris - - 2012
During Q2-Q3 2012, the cell therapy industry benefited from a number of positive external influences including advantageous changes to future FDA regulation, but stock market activity was highly mixed. The FDA approved two more products and an appreciable number of public-company-sponsored clinical trials are progressing through phases 1-3.
Jaeger Philipp A - - 2012
An accurate prediction of how extrinsic stimuli influence changes in gene expression has been challenging. In this issue, Nagano and colleagues successfully model genome-wide mRNA expression changes under variable environmental conditions in rice, raising hopes that scientists will soon be able to predict genome-wide transcriptional responses in a variety of ...
Pemberton M N - - 2012
Immunological reactions to chlorhexidine, including allergy (Type I hypersensitivity) and allergic contact dermatitis/stomatitis (Type IV hypersensitivity), have been recognised for many years. This potential safety issue, however, is not well known within dentistry. The purpose of this paper is to alert dentists and dental care professionals to the potential of ...
Sontheimer Erik J - - 2012
In ciliates, small RNAs have been shown to target foreign sequences for silencing via elimination from the somatic genome. Fang et al. now reveal a set of Piwi-interacting RNAs (piRNAs) in Oxytricha trifallax that likewise enable genomic self versus nonself discrimination, this time by specifying self sequences for genome retention.
- - 2012
Botulinum toxin (BoNT) to facilitate 'muscle relaxation', in combination with a 'light' filler for 'dermal treatment' and a 'heavy' filler for 'lifting capacity'.
Molesworth A M - - 2012
Objective To assess the risk of variant Creutzfeldt-Jakob Disease (vCJD) associated with dental treatment.Design Case-control study, investigation of links between cases.Setting National CJD surveillance, general dental practice and practice boards in Great Britain, 2008-2009.Methods Variant CJD cases were recruited from all those referred between May 1995 and August 2009 (n ...
- - 2012
For those on bisphosphonates, the response to orthodontic forces should be ascertained before embarking on complex treatment.
Baldi Sandro - - 2012
Bacteria lack many of the features that eukaryotic cells use to compartmentalize cytoplasm and membranes. In this issue, Schlimpert et al. describe a new mechanism of spatial confinment in the bacterium Caulobacter crescentus that prevents the exchange of soluble and membrane proteins between the stalk and cell body.
Okita Yasutaka - - 2012
In this issue of Cell Stem Cell, Buckley et al. (2012) show that the ubiquitin-proteasome system (UPS) regulates pluripotency in embryonic stem cells and induced pluripotent stem cells, opening the door to a better understanding at the system level of protein dynamics responsible for the maintenance and induction of pluripotency.
Guerrieri A - - 2012
The detection of carious lesions is focused on the identification of early mineral changes to allow the demineralisation process to be managed by non-invasive interventions. The methods recommended for clinical diagnosis of initial carious lesions are discussed and illustrated. These include the early detection of lesions, evaluation of the extent ...
Nagano Atsushi J - - 2012
Determining the drivers of gene expression patterns is more straightforward in laboratory conditions than in the complex fluctuating environments where organisms typically live. We gathered transcriptome data from the leaves of rice plants in a paddy field along with the corresponding meteorological data and used them to develop statistical models ...
Vuillaumier-Barrot Sandrine - - 2012
Cobblestone lissencephaly is a peculiar brain malformation with characteristic radiological anomalies. It is defined as cortical dysplasia that results when neuroglial overmigration into the arachnoid space forms an extracortical layer that produces agyria and/or a "cobblestone" brain surface and ventricular enlargement. Cobblestone lissencephaly is pathognomonic of a continuum of autosomal-recessive ...
Talkowski Michael E - - 2012
Large intergenic noncoding (linc) RNAs represent a newly described class of ribonucleic acid whose importance in human disease remains undefined. We identified a severely developmentally delayed 16-year-old female with karyotype 46,XX,t(2;11)(p25.1;p15.1)dn in the absence of clinically significant copy number variants (CNVs). DNA capture followed by next-generation sequencing of the translocation ...
Lyssiotis Costas A - - 2012
The rewiring of metabolism in cancer is thought to result from hyperactivation of signaling pathways that instruct cells to grow. Sebastian et al. show that loss of the tumor suppressor SIRT6 transforms cells by activating tumor metabolism. This occurs independently of mutations in canonical growth signaling pathways and reveals a tumorigenic ...
Kagan Jonathan C JC Harvard Medical School and Division of Gastroenterology, Children's Hospital Boston, Boston, MA 02115, USA. - - 2012
There are at least five families of microbe-detection receptors that function to detect and eradicate potentially infectious microorganisms that enter multicellular eukaryotes. While a multitude of proteins regulating innate immune signal transduction have already been defined, continuous genetic screening for regulators of innate immunity may not yield as significant insight ...
Xiong Wei W The Dorris Neuroscience Center, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, - - 2012
Hair cells are mechanosensors for the perception of sound, acceleration, and fluid motion. Mechanotransduction channels in hair cells are gated by tip links, which connect the stereocilia of a hair cell in the direction of their mechanical sensitivity. The molecular constituents of the mechanotransduction channels of hair cells are not ...
1 2 3 4 5 6 7 8 9 10 >