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Results 401 - 450 of 2633
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Nana-Sinkam S P - - 2013
The discovery that noncoding components of the genome, including microRNA (miRNA or miR), can contribute to the pathogenesis of cancer has led investigators to contemplate using these molecules to guide clinical decision making. Currently, miRNA signatures are being applied in human clinical trials and miRNA-directed therapy is under way, with ...
Maserati Marc - - 2012
Summary RNA transcription, processing and translation are fundamental molecular processes required for development, growth and cell viability. Towards the functional annotation of the genome, we are engaged in a reverse genetic screen using mammalian preimplantation embryos as a model system. Here we report the essential function of four RNA processing/splicing ...
Aureli Filippo - - 2012
Humans have the cognitive abilities to implement the revenge and forgiveness systems hypothesized by McCullough et al., but the evidence suggests that simpler processes may underlie most revenge cases in humans and other animals. The mediating role of emotions can be at the basis of the flexibility needed in the ...
Gertnere Jana - - 2012
AIM: To compare 1-year results of the refractive lenticule extraction (ReLEx) flex technique performed as a commercial bilateral simultaneous procedure to a matched group of wavefront-optimized Femto-Lasik for correction of myopia and astigmatism with emphasis on contrast sensitivity and high-order aberrations (HOA). METHODS: In this retrospective study 44 eyes of ...
Fraga-Silva Rodrigo Araujo - - 2012
It is well known that the renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology of cardiovascular diseases. This is well illustrated by the great success of ACE inhibitors and angiotensin (Ang) II AT(1) blockers in the treatment of hypertension and its complications. In the past decade, the classical ...
Ruan Liang-Liang - - 2012
Aminoacyl-tRNA synthetases (aaRSs) are responsible for ensuring the fidelity of the genetic code translation by accurately linking a particular amino acid to its cognate tRNA isoacceptor. To ensure accuracy of protein biosynthesis, some aaRSs have evolved an editing process to remove mischarged tRNA. The hydrolysis of the mischarged tRNA usually ...
Edwards Paul R - - 2012
Hyperspectral cathodoluminescence imaging provides spectrally and spatially resolved information on luminescent materials within a single dataset. Pushing the technique toward its ultimate nanoscale spatial limit, while at the same time spectrally dispersing the collected light before detection, increases the challenge of generating low-noise images. This article describes aspects of the ...
Pahlavan Farzaneh - - 2012
This commentary focuses on how third parties impact the course of acts of revenge based on their world views, such as belief in a just world. Assuming this belief to be true, the following questions could be asked: (a) What are the consequences of a third party's worldview in terms ...
Parker Richard M - - 2012
A planar Bragg grating device has been developed that is capable of detecting changes in the refractive index of a wide range of fluids including solvents, acids and bases. The integration of this high precision refractive index sensor within a chemically resistant microfluidic flow system has enabled the investigation of ...
Faay Margo D M - - 2012
The Kennedy Axis V is a routine outcome measurement instrument which can assist the assessment of the short-term risk for violence and other adverse patient outcomes. The purpose of this study was to evaluate the interrater reliability and clinical utility of the instrument when used by mental health nurses in ...
Weiss Michael - - 2012
Liver modeling in pharmacokinetics has been based on outflow curves of extracellular tracers obtained in single-pass perfused rat livers. These reference curves represent the hepatic transit time densities (TTD) of tracers. Since the fractal structure of the sinusoidal network implies a TTD with power-law tail, the question is whether the ...
Goldust Mohamad - - 2012
Abstract Objective: Seborrheic dermatitis (SD) is commonly treated with anti-inflammatory products, including topical corticosteroids. This study was undertaken to compare efficiency of sertaconazole 2 % cream vs. hydrocortisone 1% cream in the treatment of seborrheic dermatitis. Methods: In this clinical trial study, Sixty patients suffering from SD were studied. Thirty ...
Stewart Tara L - - 2012
Objective: Drawing from Heckhausen and Schulz's Motivational Theory of Life-span Development, this study examined perceived control as a moderator of the protective relationship between downward social comparison and subjective well-being among older adults. Methods: Community-dwelling older adults (N = 97, 63% female, ages 79-97) were interviewed in their own homes at three ...
Watanabe Kaori - - 2012
OBJECTIVES: To investigate the clinical characteristics and risk factors of Pneumocystis jirovecii pneumonia (PCP) in rheumatoid arthritis (RA) patients treated with adalimumab. METHODS: We conducted a multicenter, retrospective, case-control study to compare RA patients treated with adalimumab with and without PCP. Data from 17 RA patients who were diagnosed with ...
Schindler Amrei - - 2012
Background: The efficacy of CBT for unipolar depressive disorders is well established, yet not all patients improve or tolerate treatment. Aims: To identify factors associated with symptomatic outcome, response, and drop-out in depressive patients under naturalistic CBT. Method: 193 patients with major depression or dysthymia were tested. Sociodemographic and clinical ...
Felicia Leona J - - 2012
Oil based nanofluid containing surfactant capped magnetite nanoparticles are synthesized by simple co-precipitation approach and their magneto-rheological properties are studied for different magnetic field strengths and volume fractions. We observe a distinct 'plateau-like region' in the shear thinning viscosity curve, under an external magnetic field, possibly due to a peculiar ...
Ledogar Justin A - - 2013
Pitheciines (Pithecia, Chiropotes, and Cacajao) are a specialized clade of Neotropical seed predators that exhibit postcanine teeth with low and rounded cusps and highly crenulated occlusal surface enamel. Data on feeding ecology show that Pithecia consumes proportionally more leaves than other pitheciine species, and comparative studies demonstrate its greater molar ...
El-Said Ghada F - - 2012
This study pointed to the assessment of the chemical composition (F, Ca, Mg, Na, K, Fe, Mn, Zn, Cu, Ni, Co, Cr, Cd, and carbohydrate) of different marine seaweeds (red, green, and brown) from the Egyptian Mediterranean Sea coast. The results showed that green seaweeds supplied better calcium sources than ...
Edwards M R - - 2012
Deficient type I interferon-β and type III interferon-λ induction by rhinoviruses has previously been reported in mild/moderate atopic asthmatic adults. No studies have yet investigated if this occurs in severe therapy resistant asthma (STRA). Here, we show that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo ...
Volpp Kevin G - - 2012
A 2009 Institute of Medicine report recommended protected sleep periods for medicine trainees on extended overnight shifts, a position reinforced by new Accreditation Council for Graduate Medical Education requirements. To evaluate the feasibility and consequences of protected sleep periods during extended duty. Randomized controlled trial conducted at the Philadelphia VA ...
Luo Yu - - 2013
Utilizing a classic stroke model in rodents, middle cerebral artery occlusion (MCAo), we describe a novel neuroregenerative approach using the repeated intranasal administration of cocaine- and amphetamine-regulated transcript (CART) peptide starting from day 3 poststroke for enhancing the functional recovery of injured brain. Adult rats were separated into two groups ...
Silverman Jeffrey A - - 2013
Vincristine (VCR) is a mainstay of treatment of hematologic malignancies and solid tumors due to its well-defined mechanism of action, demonstrated anticancer activity and its ability to be combined with other agents. VCR is an M-phase cell cycle-specific anticancer drug with activity that is concentration and exposure duration dependent. The ...
Coole Carol - - 2012
Purpose More than 40 % of working age adults with stroke fail to return to work. The work context is a key factor in return to work, but little is known about the experiences of employers in supporting employees with stroke. The aim of this study was to explore return to ...
Birdthistle Isolde - - 2012
Non-consensual sex is associated with HIV infection in Africa, but there is little longitudinal data on this association. We describe reported non-consensual sex among women over two decades in southwest Uganda, including associations with incident HIV infection. Between 1990 and 2008, individuals in a population cohort who recently seroconverted to ...
Kehler Jan - - 2013
Inhibitors of the phosphodiesterase enzyme PDE10A have been the target for extensive investigations and huge drug discovery research efforts during the recent years. Although PDE10A with its 13 years history is a relatively newly discovered target, it has been paradigmatic for the new generation of 'high efficiency drug discovery'. Several ...
Phan Phuong L - - 2013
To investigate the basic spatio-temporal gait characteristics of people with stroke whilst walking on sloped and level terrain, and to compare this performance to healthy matched adults. Fifteen community dwelling people with stroke who walked with a hemiplegic gait and a reference group of 15 adults without impairments matched for ...
Cisternino Salvatore S INSERM U705, CNRS UMR 8206, Pharmacocinétique, Faculté de Pharmacie, Sorbonne Paris Cité, Université Paris Diderot, Université Paris Descartes, 4, Avenue de l'Observatoire, 75006 Paris, France. - - 2013
Nicotine, the main tobacco alkaloid leading to smoking dependence, rapidly crosses the blood-brain barrier (BBB) to become concentrated in the brain. Recently, it has been shown that nicotine interacts with some organic cation transporters (OCT), but their influence at the BBB has not yet been assessed in vivo. In this ...
Steenbergen Peter P Mira Institute for Biomedical Technology and Technical Medicine, Biomedical Signals and Systems, University of Twente, Zuidhorst room 211, Drienerlolaan 5, Postbox 217, 7500 AE Enschede, The Netherlands. - - 2013
Various studies have shown subjects to mislocalize cutaneous stimuli in an idiosyncratic manner. Spatial properties of individual localization behavior can be represented in the form of perceptual maps. Individual differences in these maps may reflect properties of internal body representations, and perceptual maps may therefore be a useful method for ...
Gleicher Norbert N Center for Human Reproduction, New York, NY 10021, USA. - - 2013
To investigate whether androgen conversion rates after supplementation with dehydroepiandrosterone (DHEA) differ, and whether differences between patients with diminished ovarian reserve (DOR) are predictive of pregnancy chances in association with in vitro fertilization (IVF). In a prospective cohort study we investigated 213 women with DOR, stratified for age (≤ 38 ...
An Yuan Y Department of Reproductive Medicine, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, - - 2013
To evaluate whether psychological stress, as well as changes in hypothalamus-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) at different time points during a first in vitro fertilization (IVF) cycle, correlates with the reproductive outcome. A prospective study was conducted in 264 women undergoing IVF or intracytoplasmic sperm injection (ICSI) ...
Hoff Paula P Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, - - 2013
Two of the most common joint diseases are rheumatoid arthritis (RA) and osteoarthritis (OA). Cartilage degradation and erosions are important pathogenetic mechanisms in both joint diseases and have presently gained increasing interest. The aim of the present study was to investigate the effects of the synovial fluid environment of OA ...
Deray Gilbert G Department of Nephrology, Pitié Salpétrière Hospital, Bat G. Cordier, 47-83 Bd de l'hôpital, 75651 Paris cedex 13, France. - - 2013
To prospectively compare the renal safety of meglumine gadoterate (Gd-DOTA)-enhanced magnetic resonance imaging (MRI) to a control group (unenhanced MRI) in high-risk patients. Patients with chronic kidney disease (CKD) scheduled for MRI procedures were screened. The primary endpoint was the percentage of patients with an elevation of serum creatinine levels, ...
Takeuchi Hikaru - - 2012
Achievement motivation can be defined as a recurrent need to improve one's past performance. Despite previous functional imaging studies on motivation-related functional activation, the relationship between regional gray matter (rGM) morphology and achievement motivation has never been investigated. We used voxel-based morphometry and a questionnaire (achievement motivation scale) to measure ...
Motoyama Satoru S Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan. - - 2013
More than 40 % of patients with submucosal esophageal squamous cell carcinoma (ESCC) have lymph node metastasis. Furthermore, the potential presence of undetectable metastasis before treatment prompts surgeons to be aggressive with respect to lymph node dissection. Extending the indication for endoscopic resection, a minimally invasive treatment, to superficial ESCCs will ...
Dobbs Matthew B MB Department of Orthopaedic Surgery, Washington University School of Medicine and Saint Louis Shriners Hospital for Children, One Children's Place, Suite 4s20, St. Louis, MO 63110, USA, - - 2013
This CORR Insights™ is a commentary on the article ''Can a Triple Pelvic Osteotomy for Adult Symptomatic Hip Dysplasia Provide Relief of Symptoms for 25 Years?" By van Stralen and colleagues available at DOI 10.1007/s11999-012-2701-0 .
Bailey J J University of Leicester, Department of Biology, Leicester, UK. - - 2013
Chromosome counts of plants grown from open-pollinated seed from Japanese knotweed around the world have revealed the presence of extensive hybridisation with both native and other introduced taxa. These hybrids fit into three categories: inter- and intraspecific hybrids involving the taxa of Fallopia section Reynoutria (giant knotweeds), hybrids between Japanese ...
Krak K K Institute of Botany, Academy of Sciences of the Czech Republic, Průhonice, Czech - - 2013
Phylogeny reconstruction based on multiple unlinked markers is often hampered by incongruent gene trees, especially in closely related species complexes with high degrees of hybridization and polyploidy. To investigate the particular strengths and limitations of chloroplast DNA (cpDNA), low-copy nuclear and multicopy nuclear markers for elucidating the evolutionary history of ...
Campos Wuilker Knoner WK Department of Oncologic and Degenerative Spine Surgery, Rizzoli Orthopedic Institute - Bologna, Italy. - - 2013
A spinal osteoid osteoma is a rare benign tumor. The usual treatment involves complete curettage including the nidus. In the thoracic spine, conventional open surgical treatment usually carries relatively high surgical risks because of the close anatomic relationship to the spinal cord, nerve roots, and thoracic vessels, and pulmonary complications ...
Yee Lisa D LD Department of Surgery, The Ohio State University, Columbus, OH 43210, USA. - - 2013
We previously demonstrated that lifelong feeding of diets enriched in n-3 fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) significantly inhibits HER-2/neu-mediated mammary tumorigenesis in mice. Of interest is whether dietary n-3 fatty acids exert effects at early stages of mammary carcinogenesis. Seven-week-old female MMTV-HER-2/neu transgenic mice ...
Muzzi Mirko M Department of Preclinical and Clinical Pharmacology University of Florence, Florence, Italy. - - 2013
In light of the relevance of therapeutic hypothermia to stroke treatment, we investigated whether 5'-adenosine monophosphate (AMP)-dependent cooling affords protection from ischemic brain injury. We show that hypothermia by AMP is because of adenosine A1 receptor (A1R) activation and is not invariantly associated with hypotension. Inhibition of ecto-5'-nucleotidase-dependent constitutive degradation ...
Domínguez-García Moralba M Department of Chemistry, University of Puerto Rico, PO Box 9019, Mayagüez, PR 00681, - - 2013
Three new water-soluble tungstenocene derivatives were synthesized and characterized using 3-hydroxy-4-pyrone ligands, which provide aqueous stability to the complexes. The antiproliferative activities of the complexes on HT-29 colon cancer and MCF-7 breast cancer cell lines were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and showed the new tungstenocene derivatives have higher antiproliferative ...
Mathiesen Claus C Center for Healthy Aging, Department for Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark. - - 2013
Glial calcium (Ca(2+)) waves constitute a means to spread signals between glial cells and to neighboring neurons and blood vessels. These waves occur spontaneously in Bergmann glia (BG) of the mouse cerebellar cortex in vivo. Here, we tested three hypotheses: (1) aging and reduced blood oxygen saturation alters wave activity; ...
Meirmans P G PG Institute of Biodiversity and Ecosystem Dynamics, Universiteit van Amsterdam, Amsterdam, The Netherlands. - - 2013
Polyploids are traditionally classified into allopolyploids and autopolyploids, based on their evolutionary origin and their disomic or multisomic mode of inheritance. Over the past decade it has become increasingly clear that there is a continuum between disomic and multisomic inheritance, with the rate of tetrasomy differing among species and among ...
Klier C M CM Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, - - 2013
To assess rates of neonaticide after the implementation of a preventative 'anonymous delivery' law in mid-2001 in Austria. Women are allowed to access antenatal care and give birth in a hospital anonymously, without showing any ID and free of charge. Retrospective study. A complete census of police-reported neonaticides was obtained ...
Cook L M LM Faculty of Life Sciences, School of Life Sciences, University of Manchester, Manchester, UK. - - 2013
From the outset multiple causes have been suggested for changes in melanic gene frequency in the peppered moth Biston betularia and other industrial melanic moths. These have included higher intrinsic fitness of melanic forms and selective predation for camouflage. The possible existence and origin of heterozygote advantage has been debated. ...
Van't Hof A E AE Institute of Integrative Biology, University of Liverpool, - - 2013
We have constructed a linkage map for the peppered moth (Biston betularia), the classical ecological genetics model of industrial melanism, aimed both at localizing the network of loci controlling melanism and making inferences about chromosome dynamics. The linkage map, which is based primarily on amplified fragment length polymorphisms (AFLPs) and ...
Rusjan Pablo M PM Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. - - 2013
Endocannabinoid tone has recently been implicated in a number of prevalent neuropsychiatric conditions. [(11)C]CURB is the first available positron emission tomography (PET) radiotracer for imaging fatty acid amide hydrolase (FAAH), the enzyme which metabolizes the prominent endocannabinoid anandamide. Here, we sought to determine the most suitable kinetic modeling approach for ...
Novais Eduardo N EN Department of Orthopedic Surgery, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, - - 2013
Hip pain secondary to acetabular dysplasia can prevent participation in recreational activities. We retrospectively evaluated the physical activity level and pain after periacetabular osteotomy (PAO) for the treatment of symptomatic hip dysplasia. Forty-seven female and four male patients with a mean age of 27 years underwent a PAO. Physical activity ...
Cox Cheryl L CL Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA. - - 2013
Examine the construct validity, stability, internal consistency, and item-response performance of a self-report health needs assessment for adult survivors of childhood cancer. A 190-item mailed survey was completed by 1,178 randomly selected (stratified on age, diagnosis, time since diagnosis) Childhood Cancer Survivor Study participants (mean age, 39.66 [SD 7.71] years; ...
Willi Y Y Institute of Biology, Evolutionary Botany, University of Neuchâtel, Neuchâtel, Switzerland. - - 2013
According to theory, drift load in randomly mating populations is determined by past population size, because enhanced genetic drift in small populations causes accumulation and fixation of recessive deleterious mutations of small effect. In contrast, segregating load due to mutations of low frequency should decline in smaller populations, at least ...
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