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Results 251 - 300 of 2635
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Menon Vishnu - - 2012
This is the first report of inactivation of xyloglucanase from Thermomonospora sp by pepstatin A, a specific inhibitor towards aspartic proteases. The steady state kinetics revealed a reversible, competitive, two-step inhibition mechanism with IC ( 50 ) and K ( i ) values of 3.5 ± 0.5 μM and 1.25 ± 0.5 μM respectively. The rate ...
Naylor R M RM Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, - - 2013
Aging is the main risk factor for most chronic diseases, disabilities, and declining health. It has been proposed that senescent cells--damaged cells that have lost the ability to divide--drive the deterioration that underlies aging and age-related diseases. However, definitive evidence for this relationship has been lacking. The use of a ...
Caro M A - - 2012
We explore the calculation of the elastic properties of zinc-blende and wurtzite semiconductors using two different approaches: one based on stress and the other on total energy as a function of strain. The calculations are carried out within the framework of density functional theory in the local density approximation, with ...
Weinstock Matthew - - 2012
Abstract Extramedullary disease (EMD), defined as a clonal plasmacytic infiltrate at anatomic sites distant from the bone marrow or adjacent soft tissue in a patient with underlying multiple myeloma, is present in a significant percentage of patients with multiple myeloma at some point during the course of their disease. The ...
Schmidt Martin - - 2012
Both cardiac computed tomography (CT) and interventional electrophysiology (EP) have evolved considerably in recent years. Technical improvements in CT have significantly reduced the radiation dose in cardiac applications. This imaging technology plays an important role in preprocedural planning and guidance of the procedures in many EP centers worldwide. Furthermore, CT ...
Shimizu Katsuhiko - - 2012
The purpose of this study was to clarify the distribution of epidermal growth factor receptor (EGFR) mutations between primary tumors (PT) and metastatic lymph node (MLN) in patients with resected non-small cell lung cancer (NSCLC) and to identify a better predictive marker of the response to EGFR tyrosine kinase inhibitor ...
Mendez M F B - - 2012
The objective of this study was to evaluate the addition of IGF-I to pig insemination doses stored at 15°C, in conjunction with the addition of different amounts of vitamin E (α-tocopherol). Semen samples (n = 12) from four boars were treated by the addition of different concentrations of vitamin E, ...
Bleicher K - - 2012
Though bone loss tends to accelerate with age there are modifiable factors that may influence the rate of bone loss even in very old men. INTRODUCTION: The aim of this 2-year longitudinal study was to examine potential predictors of change in total hip bone mineral density (BMD) in older men. ...
Wen Lv - - 2012
PURPOSE: The aim of this study was to investigate the effect of tamoxifen (TAM), methoxyprogesterone acetate (MPA) and their combined treatment on cisplatin-resistant ovarian cancer SKOV3/DDP cells, as well as the potential mechanisms. METHODS: MTT assay was used to investigate the effect of different concentrations (0.01, 0.1, 1, 10 and ...
Hoff Paula P Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, - - 2013
Two of the most common joint diseases are rheumatoid arthritis (RA) and osteoarthritis (OA). Cartilage degradation and erosions are important pathogenetic mechanisms in both joint diseases and have presently gained increasing interest. The aim of the present study was to investigate the effects of the synovial fluid environment of OA ...
Corli O - - 2012
BACKGROUND: Dealing with cancer pain implies assessing the intensity and other attributes of pain and identifying appropriate outcomes and endpoints to evaluate the effect of treatments. METHODS: In the context of an observational longitudinal prospective study, 1461 painful cancer patients were evaluated at baseline and weekly over 4 weeks. Four ...
Sànchez-Nogué B - - 2012
The common sole, Solea solea (Linneus, 1758), and the Senegalese sole, Solea senegalensis (Kaup, 1858), are two important commercial species that coexist in the NW Mediterranean. In order to assess the species' ability to respond to chemical insults, a comparison of activities on enzymes involved in xenobiotic metabolism was carried ...
Roberts S Craig - - 2012
McCullough et al. propose an evolved cognitive revenge system which imposes retaliatory costs on aggressors. They distinguish between this and other forms of punishment (e.g., those administered by judges) which are not underpinned by a specifically designed evolutionary mechanism. Here we outline mechanisms and circumstances through which the revenge system ...
Gao Hua - - 2012
This study aims to establish pilocarpine-induced rat model of status epilepticus (SE), observe the activity of calpain I in the rat hippocampus and the subsequent neuronal death, and explore the relationship between calpain I activity and neuronal death in the hippocampus. Fifty-eight adult male Wistar rats were assigned randomly into ...
Noelken Robert - - 2012
AIM: The aim of this study was to evaluate soft and hard tissue alterations around implants placed in healed, sloped ridge sites. MATERIALS AND METHODS: In this prospective multi-center study, 65 patients between 20 and 74 years of age and with a need for a single tooth replacement were included. All ...
Cavalieri Simona S Università di Torino, Department of Medical Sciences & Azienda Ospedaliera Città della Salute e della Scienza, Turin, - - 2013
Recent development of next-generation DNA sequencing (NGS) techniques is changing the approach to search for mutations in human genetic diseases. We applied NGS to study an A-T patient in which one of the two expected mutations was not found after DHPLC, cDNA sequencing and MLPA screening. The 160-kb ATM genomic ...
Brooks-Russell Ashley A Prevention Research Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-7510, USA. - - 2013
This study identified classes of developmental trajectories of physical dating violence victimization from grades 8 to 12 and examined theoretically-based risk factors that distinguished among trajectory classes. Data were from a multi-wave longitudinal study spanning 8th through 12th grade (n = 2,566; 51.9 % female). Growth mixture models were used ...
Stan Claudiu A - - 2012
Hydrodynamic lift forces offer a convenient way to manipulate particles in microfluidic applications, but there is little quantitative information on how non-inertial lift mechanisms act and compete with each other in the confined space of microfluidic channels. This paper reports measurements of lift forces on nearly spherical drops and bubbles, ...
Huang Kai - - 2012
A cost-effective biosorbent was prepared by a green chemical modification process from muskmelon peel by saponification with alkaline solution of Ca(OH)(2). Its adsorption behavior for lead ions was investigated and found to exhibit excellent adsorption properties. Results showed that the optimal equilibrium pH range for 100 % adsorption is from 4 ...
Fujisawa Yasuhiro - - 2012
Abstract Objective To show the efficacy of taxane-based chemotherapy for the treatment of cutaneous angiosarcoma. Methods A case-control study comparing patients who received taxanes without wide local excision (group A, n=5) and patients who received conventional surgery-based therapy (group B, n=8) in one university hospital in eastern Japan. Data were ...
Amin Najaf N Unit of Genetic Epidemiology, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The - - 2013
Personality traits are complex phenotypes related to psychosomatic health. Individually, various gene finding methods have not achieved much success in finding genetic variants associated with personality traits. We performed a meta-analysis of four genome-wide linkage scans (N=6149 subjects) of five basic personality traits assessed with the NEO Five-Factor Inventory. We ...
Wadsworth Samuel J - - 2012
Human beings come in all shapes and sizes. Heterogeneity makes life interesting, but leads to inter-individual variation in disease susceptibility and response to therapy. One major health challenge is to develop "personalised medicine"; therapeutic interventions tailored to an individual to ensure optimal treatment of disease. Asthma is a heterogeneous disease ...
Ostensson Karin - - 2012
Dairy production is not traditional in Vietnam. The farmers have little practical knowledge and udder health control is generally lacking. In order to give the farmers appropriate advice, knowledge about the distribution of udder pathogens is crucial. The aim of the study was to investigate the prevalence of sub-clinical mastitis ...
Motoyama Satoru S Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan. - - 2013
More than 40 % of patients with submucosal esophageal squamous cell carcinoma (ESCC) have lymph node metastasis. Furthermore, the potential presence of undetectable metastasis before treatment prompts surgeons to be aggressive with respect to lymph node dissection. Extending the indication for endoscopic resection, a minimally invasive treatment, to superficial ESCCs will ...
O'Connor Kieran - - 2012
We propose that revenge responses are often influenced more by affective reactions than by deliberate decision making as McCullough et al. suggest. We review social psychological evidence suggesting that justice judgments and reactions may be determined more by emotions than by cognitions.
Elliott Rohan A - - 2012
Background Hospitalisation often leads to increased medication regimen complexity for older patients; increased complexity is associated with medication non-adherence. There has been little research into strategies for reducing the impact of hospitalisation on medication regimen complexity. Objective To investigate the impact of pharmacist medication review, together with an educational intervention ...
Zetterqvist Maria - - 2012
Research comparing adolescents engaging in suicidal and non-suicidal self-injury (NSSI), both separately and in combination, is still at an early stage. The purpose of the present study was to examine overlapping and distinguishable features in groups with different types of self-injurious behaviors, using a large community sample of 2,964 (50.6 % ...
Mamindy-Pajany Yannick - - 2012
A soil column adsorption-desorption study was performed on an agricultural calcareous soil to determine the impact of sewage sludge spreading on nickel mobility. Ni adsorption experiments were followed by desorption tests involving the following liquid extractants: water, calcium (100 mg/L), oxalic acid (525 mg/L equivalent to 100 mg carbon/L), and sludge extracts (0.5 ...
Smit M N - - 2012
Feeding n-3 long-chain polyunsaturated fatty acids (LCPUFA) to gilts or sows has shown different responses to litter growth, pre-weaning mortality and subsequent reproductive performance of the sow. Two hypotheses were tested: (1) that feeding a marine oil-based supplement rich in protected n-3 LCPUFAs to gilts in established gestation would improve ...
Dimitriou Ioannis - - 2012
PURPOSE: Although laparoscopic appendectomy (LA) for acute appendicitis (AA) is widely performed, the value of LA for the treatment of complicated appendicitis (CA) is still controversially discussed. METHODS: In a retrospective study, we analyzed the clinical records of 404 patients who underwent LA or conversion (intention-to-treat group) or open appendectomy ...
Orasan Remus Aurel - - 2012
PURPOSE: The study of online hemodiafiltration (HDF) benefits over high-flux hemodialysis (HD) raises great interest. The purpose was to compare clinical and laboratory parameters in patients treated with HD who were switched to HDF. METHODS: Forty-eight HD patients (study group) were switched to HDF, while other 521 patients remained on ...
Koehler Fabian M - - 2012
Graphene is a two-dimensional crystalline carbon allotrope that has fascinated researchers worldwide and has extended the interest in carbon structures such as fullerenes and nanotubes. In this Account, we use electrical characterization tools to study chemistry on supported graphene. These experiments elucidate the way covalently bound phenyl units can change ...
Bräuner Elvira V - - 2012
Radon-222 gas arises from the radioactive decay of radium-226 and has a 3.8 day half-life. This gas percolates up through soil into buildings, and if it is not evacuated there can be much higher exposure levels indoors than outdoors, which is where human exposure occurs. Radon exposure is classified as ...
Eroldo─čan Tufan O - - 2012
Monounsaturated fatty acids (MUFA)-rich and n-6 polyunsaturated fatty acid (n-6 PUFA)-rich vegetable oils are increasingly used as fish oil replacers for aquafeed formulation. The present study investigated the fatty acid metabolism in juvenile European sea bass (Dicentrarchus labrax, 38.4 g) fed diets containing fish oil (FO, as the control treatment) or ...
Schmudde I - - 2012
The pathways underlying dendritic cell (DC) activation in allergic asthma are incompletely understood. Here we demonstrate that adoptive transfer of ovalbumin-pulsed wild-type (wt) but not of C5a receptor-deficient (C5aR(-/-)) bone marrow (BM)-derived DCs (BMDCs) induced mixed T helper type 2 (Th2)/Th17 maladaptive immunity, associated with severe airway hyperresponsiveness, mucus production, ...
Che Brita Ngum - - 2012
ABSTRACT: Phytanic acid (PA) is a bioactive compound found in milk which is derived from the phytol chain of chlorophyll and the content of PA in milk-fat depends on the availability of phytol from feed. In this study, the content of PA diastereomers was analyzed in milk sampled from five ...
Rojas Alex - - 2012
Two imidazolium cations containing a benzyl group, 1-benzyl-3-methylimidazolium and 1-benzyl-2,3-dimethylimidazolium, generally produce the large pore zeolite MTW when used as structure directing agents in the synthesis of pure silica zeolites by the fluoride route. When working at low water contents only the smallest of these cations is able to crystallize ...
Krak K K Institute of Botany, Academy of Sciences of the Czech Republic, Průhonice, Czech - - 2013
Phylogeny reconstruction based on multiple unlinked markers is often hampered by incongruent gene trees, especially in closely related species complexes with high degrees of hybridization and polyploidy. To investigate the particular strengths and limitations of chloroplast DNA (cpDNA), low-copy nuclear and multicopy nuclear markers for elucidating the evolutionary history of ...
Decani Sem - - 2012
Abstract Topical corticosteroids are considered first-line therapy in patients with cronic inflammatory oral mucosal diseases, among them clobetasol propionate is one of the most widely used in oral medicine. Under physiological conditions, the transmucosal application is characterized by a significantly greater absorption than the skin application. Contrary to the many ...
Flaten Gøril Eide - - 2012
Camptothecin (CPT) represents a potent anticancer drug. However, its therapeutic use is impaired by both drug solubility, hydrolysis, and protein interactions in vivo. Use of liposomes as a drug-formulation approach could overcome some of these challenges. The aim of this study was to perform a mechanistic study of the incorporation ...
McManus B M - - 2012
BACKGROUND: Infants and toddlers with developmental difficulties represent a heterogeneous group who often receives early intervention (EI). Notable population heterogeneity exists and complicates unmet need and effectiveness research. However, a mix of relatively homogeneous clinically policy relevant 'subgroups' may create the apparent heterogeneity. To date, methodological challenges have impeded identifying ...
Sato Yumi - - 2012
S. Isono Recent evidence suggests the possible development of difficult mask ventilation in patients with obstructive sleep apnea. Based on our current understanding of the pathophysiology of pharyngeal airway obstruction in obstructive sleep apnea patients, we conclude that anesthesiologists can decrease respiratory complications during anesthesia induction by conducting careful pre-induction ...
Barron M C - - 2012
SUMMARY Introduced brushtail possums (Trichosurus vulpecula) are wildlife maintenance hosts for Mycobacterium bovis in New Zealand, often living sympatrically with other potential hosts, including wild red deer (Cervus elaphus scoticus). Population control of possums has been predicted to eradicate tuberculosis (TB) from New Zealand wildlife; however, there is concern that ...
Liu H - - 2012
The aim of this review of the literature was to assess the biological effects of occlusal trauma on the stomatognathic system focusing on animal studies. However, there are no conclusive explanations on the association between occlusal trauma and disease of the stomatognathic system. A literature survey was performed using the ...
Hashimoto Makoto - - 2012
PURPOSE: To establish if preoperative arterial blood lactate (Lac) is a factor related to hospital death for patients with a ruptured abdominal aortic aneurysm (rAAA). METHODS: The subjects were 55 patients who underwent surgery for an rAAA in a single institution between July, 2000 and November, 2009. Patients were divided ...
Mammino Liliana - - 2012
Hyperjovinol A (2-methyl-1-(2,4,6-trihydroxy-3-(3-hydroxy-3,7-dimethyloct-6-enyl)phen yl)propan-1-one) is an acylated phloroglucinol isolated from Hypericum Jovis and exhibiting antioxidant properties comparable with those of the most common antioxidant drugs. The study models the compound's antioxidant ability through its ability to coordinate a Cu(2+) ion and reduce it to Cu(+). Complexes with a Cu(2+) ion ...
Bailey J J University of Leicester, Department of Biology, Leicester, UK. - - 2013
Chromosome counts of plants grown from open-pollinated seed from Japanese knotweed around the world have revealed the presence of extensive hybridisation with both native and other introduced taxa. These hybrids fit into three categories: inter- and intraspecific hybrids involving the taxa of Fallopia section Reynoutria (giant knotweeds), hybrids between Japanese ...
McCullough Michael E - - 2012
Minimizing the costs that others impose upon oneself and upon those in whom one has a fitness stake, such as kin and allies, is a key adaptive problem for many organisms. Our ancestors regularly faced such adaptive problems (including homicide, bodily harm, theft, mate poaching, cuckoldry, reputational damage, sexual aggression, ...
Yu Junchi - - 2012
Transcription factor (TF) and microRNA (miRNA) are two best characterized gene regulators that have been found to play an important role in gene regulation. However, high throughput screening the interaction relationships between transcription factors, microRNAs, and target genes in gliomas remains rare. Using GSE16666 and GSE13091 datasets downloaded from Gene ...
Manz Thomas A - - 2012
In recent years, several methods have been developed that partition the electron density among atoms using spherically symmetric atomic weights. D. E. P. Vanpoucke, P. Bultinck, and I. Van Driessche (J. Comput. Chem. 2012, doi: 10.1002/jcc.23088) recently reported a periodic implementation of the Hirshfeld-I method that uses a combination of ...
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