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Results 201 - 250 of 2635
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Krishna A Keshav - - 2012
Assessment of metal contamination and their distribution in different grain size fractions of the surface sediments of a lake in Kazipalli industrial development area has been investigated. Since the persistent toxic metals pose serious health risks, this research concentrated on investigating the concentrations and spatial distribution of metals in and ...
Masaldan Shashank - - 2012
This study explores the link between the antiproliferative activity of emodin through the generation of reactive oxygen species (ROS) in various cancer cell lines and the expression of the androgen receptor (AR) in the prostate cancer cell lines LNCaP (androgen-sensitive) and PC-3 (androgen-refractory), as well as the pro-metastatic low-density lipoprotein ...
Poplawsky Jonathan - - 2012
We have developed a fiber-based confocal optical microscope that operates inside of a commercial scanning electron microscope (SEM) instrument (JEOL 6400; JEOL Ltd., Tokyo, Japan) enabling the excitation of a sample either by a laser or by electron beam, and hence combining the complimentary techniques of photoluminescence and cathodoluminescence. The ...
Bémeur Chantal - - 2012
A robust neuroinflammatory response characterized by microglial activation and increased brain production of pro-inflammatory cytokines is common in acute liver failure (ALF). Mechanisms proposed to explain the neuroinflammatory response in ALF include direct effects of systemically-derived proinflammatory cytokines and the effects of brain lactate accumulation on pro-inflammatory cytokine release from ...
McCoy Mark G - - 2012
McCullough et al. propose adaptations that motivate forgiveness when the potential benefits of continuing the relationship outweigh the costs incurred by the transgression. The costs incurred are definite, whereas future benefits of forgiveness are only probabilistic. This situation exposes the forgiver to cheating in the form of repeat transgression. Adaptations ...
Ljungberg Börje - - 2012
Despite contemporary innovations in systemic therapy and surgical treatment, renal cell carcinoma (RCC) remains the most lethal urologic malignancy. Still, around 20 % of patients with RCC present with metastases at diagnosis, and 40-50 % of those with localized advanced disease will ultimately progress to metastatic disease. Although the new, targeted therapy ...
King Robert - - 2012
There is evidence that creative writing forms an important part of the recovery experience of people affected by severe mental illness. In this paper, we consider theoretical models that explain how creative writing might contribute to recovery, and we discuss the potential for creative writing in psychosocial rehabilitation. We argue ...
Gibson Abraham H - - 2012
Edward O. Wilson's recent decision to abandon kin selection theory has sent shockwaves throughout the biological sciences. Over the past two years, more than a hundred biologists have signed letters protesting his reversal. Making sense of Wilson's decision and the controversy it has spawned requires familiarity with the historical record. ...
Miszalski-Jamka Tomasz - - 2012
The aim of the study was to evaluate the presence and spectrum of cardiac abnormalities identified by cardiac magnetic resonance (CMR) in subjects in clinical remission of Churg-Strauss syndrome (CSS) and granulomatosis with polyangiitis (Wegener's) (WG) with normal ECG and transthoracic echocardiography (TTE). Eleven (7 females, 4 males, mean age ...
Kirkman Matthew A - - 2012
Hyponatremia is common in neurocritical care patients and is associated with significant morbidity and mortality. Despite decades of research into the syndrome of inappropriate antidiuretic hormone (SIADH) and cerebral salt wasting (CSW), their underlying pathophysiological mechanisms are still not fully understood. This paper reviews the history behind our understanding of ...
Zhao Yunlong - - 2012
Films of the zinc tin oxide (ZTO), grown from solutions with zinc acetate dehydrate and tin(II) 2-ethylhexanoate dissolving in 2-methoxyethanol, have been used to fabricate thin film transistors (TFTs) in combination with solution-processed aluminum oxide as the gate insulator. And the non-homogeneity of the single-layer ZTO films, caused by both ...
Lucas Brian P BP Department of Medicine, Cook County Health and Hospitals System and Rush Medical College, 1900 W Polk St, Room 520, Chicago, IL 60612, USA. - - 2012
Data are sparse on the effect of varying the durations of internal medicine attending physician ward rotations. To compare the effects of 2- vs 4-week inpatient attending physician rotations on unplanned patient revisits, attending evaluations by trainees, and attending propensity for burnout. Cluster randomized crossover noninferiority trial, with attending physicians ...
Heulens Inge I Department of Medical Genetics, University of Antwerp, Antwerp, - - 2013
For a disorder as common as fragile X syndrome, the most common hereditary form of cognitive impairment, the facial features are relatively ill defined. An elongated face and prominent ears are the most commonly accepted dysmorphic hallmarks. We analysed 3D facial photographs of 51 males and 15 females with full ...
Dash Hirak R - - 2012
Bacteria are widespread in nature as they can adapt to any extreme environmental conditions and perform various physiological activities. Marine environments are one of the most adverse environments owing to their varying nature of temperature, pH, salinity, sea surface temperature, currents, precipitation regimes and wind patterns. Due to the constant ...
Olesen Anne E - - 2012
BACKGROUND: Peripherally acting opioids, particularly peripheral κ-opioid agonists, may be effective for treating visceral pain by activating receptors expressed on afferent nerves within the gut. OBJECTIVE: The objective of this study was to investigate the pharmacokinetic/pharmacodynamic profile of a novel peripherally selective κ-opioid agonist, CR665 (JNJ-38488502), and compare it to ...
Neubauer Henning - - 2012
BACKGROUND: Small-bowel MRI based on contrast-enhanced T1-weighted sequences has been challenged by diffusion-weighted imaging (DWI) for detection of inflammatory bowel lesions and complications in patients with Crohn disease. OBJECTIVE: To evaluate free-breathing DWI, as compared to contrast-enhanced MRI, in children, adolescents and young adults with Crohn disease. MATERIALS AND METHODS: ...
Simkiss D E - - 2012
Children who enter public care are among the most vulnerable in society. In addition to services for their medical needs, a focus on identifying and intervening with families in need where children are at high risk of entering public care is a public health priority. This paper aims to identify ...
Deray Gilbert G Department of Nephrology, Pitié Salpétrière Hospital, Bat G. Cordier, 47-83 Bd de l'hôpital, 75651 Paris cedex 13, France. - - 2013
To prospectively compare the renal safety of meglumine gadoterate (Gd-DOTA)-enhanced magnetic resonance imaging (MRI) to a control group (unenhanced MRI) in high-risk patients. Patients with chronic kidney disease (CKD) scheduled for MRI procedures were screened. The primary endpoint was the percentage of patients with an elevation of serum creatinine levels, ...
Johnson-Freyd Sasha - - 2012
McCullough et al. hypothesize that evolution has selected mechanisms for revenge to deter harms and for forgiveness to preserve valuable relationships. However, in highly dependent relationships, the more adaptive course of action may be to remain unaware of the initial harm rather than risk alienating a needed other. We present ...
Kehler Jan - - 2013
Inhibitors of the phosphodiesterase enzyme PDE10A have been the target for extensive investigations and huge drug discovery research efforts during the recent years. Although PDE10A with its 13 years history is a relatively newly discovered target, it has been paradigmatic for the new generation of 'high efficiency drug discovery'. Several ...
Liu Gui-Lei - - 2012
Two MOF-74 analogs with OH groups on 1D channel surfaces have been synthesized through multi-component self-assembly at room temperature. Their guest-free forms demonstrate a potential luminescent probe or sensor for small molecules, and OH-MOF-74 () also showed exceptional fluorescence quenching and enhancement behavior for different types of aromatic molecules.
Cox Cheryl L CL Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA. - - 2013
Examine the construct validity, stability, internal consistency, and item-response performance of a self-report health needs assessment for adult survivors of childhood cancer. A 190-item mailed survey was completed by 1,178 randomly selected (stratified on age, diagnosis, time since diagnosis) Childhood Cancer Survivor Study participants (mean age, 39.66 [SD 7.71] years; ...
Quental Carlos - - 2012
Finite element analyses, with increasing levels of detail and complexity, are becoming effective tools to evaluate the performance of joint replacement prostheses and to predict the behaviour of bone. As a first step towards the study of the complications of shoulder arthroplasty, the aim of this work was the development ...
Fong Gloria G Department of Integrative Medical Biology, Anatomy, Umeå University, SE-901 87, Umeå, - - 2013
Studies of human patellar and Achilles tendons have shown that primary tendon fibroblasts (tenocytes) not only have the capacity to produce acetylcholine (ACh) but also express muscarinic ACh receptors (mAChRs) through which ACh can exert its effects. In patients with tendinopathy (chronic tendon pain) with tendinosis, the tendon tissue is ...
Iglesias-Linares Alejandro - - 2012
External apical root resorption (EARR) is a frequent iatrogenic problem following orthodontic treatment in endodontically-treated teeth, about which the literature reports substantial variability in post-orthodontic treatment EARR responses. The main focus of the present study is to clarify whether variants in the interleukin-1 receptor antagonist gene coding for the IL-1ra ...
Liu Hao - - 2012
The phytochemistry, cardiovascular pharmacology, toxicology, side effect, and further development prospects of Gardenia jasminoides J. Ellis (GJE) and its main constituents crocins and iridoid glycosides were studied. Numerous studies have confirmed that crocins and iridoid glycosides had effects of antioxidation, anti-inflammatory, anti-atherosclerosis, anti-ischemic brain injuries, anti-platelet aggregation, anti-hyperglycemia, anti-hyperlipidemia, anti-hypertension, ...
Sasakawa Kôji - - 2012
Many parasitoid wasps learn host-associated cues and use them in subsequent host-searching behavior. This associative learning, namely "oviposition learning," has been investigated in many studies. However, few studies have compared multiple species, and no comparative study has previously been conducted on ectoparasitoid species. We compared the effects of oviposition learning ...
Sabounchei Seyyed Javad - - 2012
Reaction of sulfonium ylides (Me)(2)SCHC(O)C(6)H(4)R (R = H; m-NO(2); p-NO(2); p-OMe; p-Me and p-Br) with AgNO(3) in dichloromethane leads to various compounds. Single crystal X-ray diffraction analysis reveals that the adducts take 3 forms: (i) two-dimensional polymer, [AgNO(3)(Me(2)SCHC(O)C(6)H(5))](n) (), with nitrate bridges in which each nitrate coordinates to three silver ...
Van't Hof A E AE Institute of Integrative Biology, University of Liverpool, - - 2013
We have constructed a linkage map for the peppered moth (Biston betularia), the classical ecological genetics model of industrial melanism, aimed both at localizing the network of loci controlling melanism and making inferences about chromosome dynamics. The linkage map, which is based primarily on amplified fragment length polymorphisms (AFLPs) and ...
You Xiangwei - - 2012
Field trials were carried out to investigate the dissipation and residue levels of bifenthrin in wheat. After extraction with acetonitrile, the samples were cleaned up by dispersive solid-phase extraction and detected by gas chromatography-mass spectrometry. The half-lives of bifenthrin in wheat seedlings ranged from 2.4 to 10.5 days. At harvest time, ...
Guidotti Rebecca - - 2012
Cleaning and disinfection of the root canal system are some of the most important goals in endodontic therapy. The aim of this preliminary study is to assess the effectiveness of Er:YAG laser fiber in removing the smear layer produced during root canal walls instrumentation. Forty-eight single-rooted teeth were prepared with ...
Mao Xiangbing - - 2012
Leucine and leptin play important roles in regulating protein synthesis and degradation in skeletal muscles in vitro and in vivo. However, the objective of the present study was to determine whether leptin and leucine function synergistically in regulating protein metabolism of skeletal muscles. In the in vitro experiment, C2C12 myotubes ...
Wereha Tyler J - - 2012
Applying a non-developmental evolutionary metatheory to understanding the evolution of psychological capacities leads to the creation of models that mischaracterize developmental processes, misattribute genes as the source of developmental information, and ignore the myriad developmental and contextual factors involved in human decision-making. Using an evolutionary systems perspective, we argue that ...
Nath Kaushik - - 2012
Utilization of agrowaste materials for the production of activated carbon, as an excellent adsorbent with large surface area, is well established industrially, for dephenolation of wastewater. In the present work, dried pods of Prosopis cineraria-a novel and low-cost agrowaste material-were used to prepare activated carbons by zinc chloride activation. Batch ...
Meagher Katherine A - - 2012
Macular pigment (MP) is composed of lutein (L), zeaxanthin (Z) and meso-zeaxanthin (MZ). The present study reports on serum response to three different MP supplements in normal subjects (n 27) and in subjects with age-related macular degeneration (AMD) (n 27). Subjects were randomly assigned to: Group 1 (20 mg L and ...
Yu Lihua L Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, Chengdu, People's Republic of - - 2013
The most common form of Dopa-responsive dystonia (DRD) is caused by heterozygous mutations in the GTP cyclohydrolase I (GCH1) gene. We screened two unrelated, DRD-symptomatic Chinese Han individuals, for GCH1 gene mutations by direct sequencing. As the clinical manifestations of DRD are highly variable, we also explored the association between ...
Ribelles Pedro - - 2012
Human papillomavirus (HPV) is the causative agent of cervical cancer (CxCa) and the most commonly sexually transmitted pathogen worldwide. HPV type 16 (HPV-16) E7 oncoprotein is constitutively produced in CxCa and considered as a good antigen candidate for the development of new therapeutic CxCa vaccines. Here, we report the use ...
Dumont Cyrielle - - 2012
BACKGROUND: Since 2007, it is mandatory for the pharmaceutical companies to submit a Paediatric Investigation Plan to the Paediatric Committee at the European Medicines Agency for any drug in development in adults, and it often leads to the need to conduct a pharmacokinetic study in children. Pharmacokinetic studies in children ...
Deng Zhaoqun - - 2012
MicroRNAs are short non-coding RNAs that can regulate gene expression in cancer development, which makes them valuable targets for therapeutic intervention. Here we report on an approach that can not only arrest the functions of mature miRNAs by binding to them but it can also induce the "mis-processing" of the ...
Coupland L J - - 2012
SUMMARY A panel of 223 faecal samples was analysed to determine the clinical utility of the Seeplex® Diarrhea ACE Detection multiplex PCR system (Seeplex system; Seegene, Korea), a qualitative multiplexing PCR technology that enables simultaneous multi-pathogen detection of four viruses and/or ten bacteria associated with acute gastroenteritis. Conventional diagnostic methods ...
Goller Katja V - - 2012
Knowledge of coronaviruses in wild carnivores is limited. This report describes coronavirus genetic diversity, species specificity and infection prevalence in three wild African carnivores. Coronavirus RNA was recovered from fresh feces from spotted hyena and silver-backed jackal, but not bat-eared fox. Analysis of sequences of membrane (M) and spike (S) ...
Mir Hicham - - 2012
The level set method has been used for 20 years in a wide range of physical applications to track moving interfaces instead of an explicit description of the geometry. This paper studies in detail the shape of the level set function, delimiting a sub-domain in solid mechanics, with an innovative ...
Chol Christelle - - 2012
INTRODUCTION: As of January 2006, the BCG vaccine SSI® became the only BCG vaccine available for tuberculosis vaccination in France. The use of this vaccine led to significant changes in vaccination technique which were accompanied by a rapid increase in the number of adverse reactions (ADRs) reported. A national pharmacovigilance ...
Nguyen Thao T T - - 2012
Carica papaya is widely cultivated in tropical and subtropical countries and is used as food as well as traditional medicine to treat a range of diseases. Increasing anecdotal reports of its effects in cancer treatment and prevention, with many successful cases, have warranted that these pharmacological properties be scientifically validated. ...
Li Q-G QG State Key Laboratory of Crop Genetics and Germplasm Enhancement, Department of Crop Genetics and Breeding, College of Agriculture, Nanjing Agricultural University, Nanjing, - - 2013
P34, a storage protein and major soybean allergen, has undergone a functional transition from a cysteine peptidase to a syringolide receptor. An exploration of the evolutionary mechanism of this functional transition is made. To identify homologous genes of P34, syntenic network was constructed using syntenic relationships from the Plant Genome ...
Uldall Sigurd W - - 2012
Denmark offers public financed prenatal testing (PNT) to all pregnant women, but results are typically not available until after 12 weeks gestation, which is also the time limit for termination of pregnancy (TOP) on request. Committees decide on requests for later TOP. In a questionnaire survey, we investigated attitudes among ...
Gleicher Norbert N Center for Human Reproduction, New York, NY 10021, USA. - - 2013
To investigate whether androgen conversion rates after supplementation with dehydroepiandrosterone (DHEA) differ, and whether differences between patients with diminished ovarian reserve (DOR) are predictive of pregnancy chances in association with in vitro fertilization (IVF). In a prospective cohort study we investigated 213 women with DOR, stratified for age (≤ 38 ...
Pietraszewski David - - 2012
The psychology underlying revenge in an intergroup context is built around a small handful of recurrent interaction types. Analyzing the cost/benefit calculations of each agent's role within these interaction types provides a more precise way to characterize intergroup conflict and revenge. This in turn allows for more precise models of ...
Pennelli Gianmaria - - 2012
Both the morphogenesis and the molecular pathways of thyroid cancers are controversial. Programmed cell death 4 (PDCD4) is a tumor suppressor gene whose expression is controlled by miR-21. By applying immunohistochemistry for PDCD4 and both quantitative real-time PCR (qRT-PCR) and in situ hybridization for miR-21, this study explored PDCD4 expression ...
Sato S - - 2012
Although many of the biological features of microfold cells (M cells) have been known for many years, the molecular mechanisms of M-cell development and antigen recognition have remained unclear. Here, we report that Umod is a novel M-cell-specific gene, the translation products of which might contribute to the uptake function ...
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