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Van De Voort Tyler J TJ Department of Human Oncology, University of Wisconsin-Madison, Madison 53705. WI, - - 2013
In this study, an agonistic anti-CD40 monoclonal antibody was combined with monophosphoryl lipid A (MPL), a nontoxic derivative of lipopolysaccharide and agonist of toll-like receptor-4, to assess the immunomodulatory and antitumor synergy between the 2 agents in mice. Anti-CD40 was capable of priming macrophages to subsequent ex vivo activation by ...
Layfield Joshua P JP Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, - - 2013
The vibrational Stark effect provides insight into the roles of hydrogen bonding, electrostatics, and conformational motions in enzyme catalysis. In a recent application of this approach to the enzyme ketosteroid isomerase (KSI), thiocyanate probes were introduced in site-specific positions throughout the active site. This paper implements a quantum mechanical/molecular mechanical ...
Zampetti A A Department of Dermatology, Policlinico, A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy. - - 2013
Fabry disease (FD) is an X-linked lysosomal storage disorder (LSD) caused by the deficiency of the enzyme α-galactosidase. It exhibits a wide clinical spectrum that may lead to a delayed or even missed diagnosis and the real incidence can be underestimated. We report the cases of two unrelated Italian families ...
Karatas Hacer H Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, - - 2013
Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase, and targeting the MLL1 enzymatic activity has been proposed as a novel therapeutic strategy for the treatment of acute leukemia harboring MLL1 fusion proteins. The MLL1/WDR5 protein-protein interaction is essential for MLL1 enzymatic activity. In the present ...
Gregory Katherine E KE Boston College, W.F. Connell School of Nursing, 140 Commonwealth Avenue, Chestnut Hill, Massachusetts 02467, - - 2013
Robust methodologies for the analysis of fecal material will facilitate the understanding of gut (patho)physiology and its role in health and disease and will help improve care for individual patients, especially high-risk populations, such as premature infants. Because lipidomics offers a biologically and analytically attractive approach, we developed a simple, ...
Kazane Stephanie A SA Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United - - 2013
With the recent clinical success of bispecific antibodies, a strategy to rapidly synthesize and evaluate bispecific or higher order multispecific molecules could facilitate the discovery of new therapeutic agents. Here, we show that unnatural amino acids (UAAs) with orthogonal chemical reactivity can be used to generate site-specific antibody-oligonucleotide conjugates. These ...
Lewis K L M - - 2013
We report simulations of the two-dimensional electronic spectroscopy of the Q(y) band of the D1-D2-Cyt b559 photosystem II reaction center at 77 K. We base the simulations on an existing Hamiltonian that was derived by simultaneous fitting to a wide range of linear spectroscopic measurements and described within modified Redfield ...
Lien Evan C EC Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, - - 2013
The ability of cells to sense and respond appropriately to changing environmental conditions is often mediated by signal transduction pathways that employ mitogen-activated protein kinases (MAPKs). In the yeast Saccharomyces cerevisiae, the high-osmolarity glycerol (HOG) and filamentous growth (FG) pathways are activated following hyperosmotic stress and nutrient deprivation, respectively. Whereas ...
Arthurs O J OJ Great Ormond Street Hospital for Children, London, WC1N 3JH, UK. - - 2013
The position of the conus medullaris is considered abnormal if it ends below lumbar vertebrae three (L3) at birth. We used magnetic resonance imaging (MRI) to measure the position of the conus in post-mortem foetuses, to investigate the timing of normal ascent. The position of the conus in 84 post-mortem ...
Shi Huilin H Department of Chemistry, Indiana University, 800 Kirkwood Ave., Bloomington, Indiana 47405, United - - 2013
Oxidative modifications can have significant effects on protein structure in solution. Here, the structures and stabilities of oxidized ubiquitin ions electrosprayed from an aqueous solution (pH 2) are studied by ion mobility spectrometry-mass spectrometry (IMS-MS). IMS-MS has proven to be a valuable technique to assess gas phase and in many ...
Li Dan D Department of Radiology, Molecular Imaging Center, University of Southern California, Los Angeles, California 90033, United - - 2013
Accumulating evidence suggests that EphB4 plays key roles in cancer progression in numerous cancer types. In fact, therapies focusing on EphB4 have become potentially important components of various cancer treatment strategies. However, tumor sensitivity to EphB4 suppression may not be uniform for different cancers. In this study, we developed near-infrared ...
Woessner David W DW Department of Pharmacology and Toxicology, University of Utah College of Pharmacy, Salt Lake City, Utah 84108, United - - 2013
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by expression of the fusion gene BCR-ABL following a chromosomal translocation in the hematopoietic stem cell. Therapeutic management of CML uses tyrosine kinase inhibitors (TKIs), which block ABL-signaling and effectively kill peripheral cells with BCR-ABL. However, TKIs are not curative, and ...
Bergvall Niklas N Novartis Pharma AG, Basel, Switzerland. - - 2013
Fingolimod and natalizumab have the same European Union licence for the treatment of relapsing multiple sclerosis, and are considered by the Committee for Medicinal Products for Human Use (CHMP) to have broadly similar efficacy. A cost-minimization analysis was performed to compare differences in treatment costs between fingolimod and natalizumab from ...
McClintock Carlee S CS Graduate School of Genome Science and Technology, University of Tennessee-Oak Ridge National Laboratory, 37830, United - - 2013
Oxidative protein surface mapping has become a powerful approach for measuring the solvent accessibility of folded protein structures. A variety of techniques exist for generating the key reagent (i.e., hydroxyl radicals) for these measurements; however, these approaches range significantly in their complexity and expense of operation. This research expands upon ...
van Rijn Patrick P DWI an der RWTH Aachen e.V., Lehrstuhl für Makromolekulare Materialien und Oberflächen, RWTH Aachen University, Forckenbeckstrasse 50, D-52074 Aachen, - - 2013
We describe an in-depth investigation on the dynamics and assembly behavior at polar-apolar interfaces of ferritin-PNIPAAm conjugates (poly-N-isopropylacrylamide). The stabilization of oil-water interfaces by the modified ferritin was investigated by dynamic surface tension measurements and compared to the individual components of the bionanoparticle conjugate, namely, unmodified ferritin and pure PNIMAAm ...
Bartholomä Mark D MD Division of Nuclear Medicine and Molecular Imaging, Boston Children's Hospital, Boston, Massachusetts 02115, - - 2012
We recently reported the development of the 2-[(18)F]fluoroethyl ester of rhodamine B as a potential positron emission tomography (PET) tracer for myocardial perfusion imaging. This compound, which was prepared using a [(18)F]fluoroethyl prosthetic group, has significant uptake in the myocardium in rats but also demonstrates relatively high liver uptake and ...
Ocsoy Ismail I Center for Research at the Bio/Nano Interface, Department of Chemistry and Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611, - - 2013
Although many different nanomaterials have been tested as substrates for laser desorption and ionization mass spectrometry (LDI-MS), this emerging field still requires more efficient multifuncional nanomaterials for targeting, enrichment, and detection. Here, we report the use of gold manganese oxide (Au@MnO) hybrid nanoflowers as an efficient matrix for LDI-MS. The ...
Judd Evan T ET Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, - - 2012
Shewanella oneidensis cytochrome c nitrite reductase (soNrfA), a dimeric enzyme that houses five c-type hemes per protomer, conducts the six-electron reduction of nitrite and the two-electron reduction of hydroxylamine. Protein film voltammetry (PFV) has been used to study the cytochrome c nitrite reductase from Escherichia coli (ecNrfA) previously, revealing catalytic ...
Roberts Maegan E - - 2012
Screening for the Muir-Torre variant of Lynch Syndrome (LS) using Mismatch Repair (MMR) gene immunohistochemistry (IHC) on sebaceous neoplasms (SNs) is technically feasible. To date, research into the clinical utility of MMR IHC for this indication is limited. We conducted a retrospective chart review of 90 patients with MMR IHC ...
Kermanian Fatemeh - - 2012
There is an abundance of evidence showing that repeated use of 3,4-methlylenedioxymethamphetamine (MDMA; ecstasy) is associated with brain dysfunction, memory disturbance, locomotor hyperactivity, and hyperthermia. MDMA is toxic to both the serotonergic neurons and dopaminergic system. Adenosine is an endogenous purine nucleoside with a neuromodulatory function in the central nervous ...
Balcom Jessica R - - 2012
A limited amount of research indicates patient requests play a major role in genetic counselors' self-disclosure decisions and that disclosure and non-disclosure responses to patient requests may differentially affect genetic counseling processes. Studies further suggest patient requests may be more common in prenatal settings, particularly when counselors are pregnant. Empirical ...
Nitsche-Schmitz D Patric - - 2012
Otherwise uncomplicated infections with Streptococcus pyogenes can cause two insidious immune sequelae known as post-streptococcal glomerulonephritis (PSGN) and acute rheumatic fever (ARF). These diseases follow with a latency of a few weeks or months after primary infection and are responsible for high mortality and morbidity. PSGN has also been linked ...
Jiang Jingwei - - 2012
AIM: The aim was to compare the efficacy and toxicity of paclitaxel plus platinum (TP) with gemcitabine plus platinum (GP) in untreated advanced non-small-cell lung cancer by a meta-analysis. METHODS: An extensive literature search was performed for relevant randomized controlled trials. Studies were evaluated for eligibility and quality, and then ...
Canullo Luigi - - 2012
AIM: To assess and characterize pollution micro-particles and bacterial growth on customized titanium abutments after steaming, ultrasonic and plasma cleaning treatments. MATERIALS AND METHODS: Thirty commercially available implant abutments, after customization, were randomly divided into 3 groups of 10 and cleansed by steam (considered as control group), ultrasonic cleaning (test ...
Khlebnikov Vsevolod - - 2012
Platinum(ii) complexes comprising abnormal diimidazolylidene ligands were synthesized from cis-PtMe(2)(DMSO)(2) using microwave-assisted double C-H bond activation. NMR analysis revealed an unusual solvolysis process, induced by coordinating solvents such as DMSO and MeCN, which has not been observed in related normal dicarbene complexes. NMR and IR spectroscopy and crystallographic analysis of ...
Pinquart Martin - - 2012
The present meta-analysis integrates results from 127 papers on attachment stability towards mothers and fathers, respectively, from infancy to early adulthood. More than twenty-one thousand attachments (n = 21,072) and 225 time intervals were explored, ranging from half a month to 29 years (348 months). An overall coefficient of r = .39 between times ...
Fatfouta Ramzi - - 2012
We focus on two aspects: First, we argue that it is necessary to include implicit forgiveness as an additional adaptive behavioral option to the perception of interpersonal transgressions. Second, we present one possible way to investigate the cognitive-affective underpinnings of revenge and forgiveness: a functional MRI (fMRI) approach aiming at ...
Lee Shu-Chen - - 2012
Dietary pattern changes may be one of the key factors associated with increasing asthma prevalence. Observational studies have found negative associations between fruit, vegetable and fish consumption and risk of asthma. Experimental studies have also shown that probiotics can modulate the immune system. However, each dietary component exhibits a modest ...
Holbrook Colin - - 2012
We question whether the postulated revenge and forgiveness systems constitute true adaptations. Revenge and forgiveness are the products of multiple motivational systems and capacities, many of which did not exclusively evolve to support deterrence. Anger is more aptly construed as an adaptation that organizes independent mechanisms to deter transgressors than ...
Li Yue - - 2012
In this paper, we focus on the multiple-channel reactions of CH(2)XO (X = F, Cl, Br) radicals with the NO radical by means of direct dynamic methods. All structures of the stationary points were obtained at the MP2/6-311+G(d,p) level and vibrational frequency analysis was also performed at this level of ...
Jiang Bo - - 2012
Fibroblasts can be reprogrammed by ectopic expression of reprogramming factors to yield induced pluripotent stem (iPS) cells that are capable of transdifferentiating into diverse types of somatic cell lines. In this study, we examined if functional cardiomyocytes (CMs) can be produced from mouse cardiac fibroblasts (CFs), using iPS cell factor-based ...
Yardley Sarah - - 2012
This paper addresses the question 'what are the variables influencing social interactions and learning during Authentic Early Experience (AEE)?' AEE is a complex educational intervention for new medical students. Following critique of the existing literature, multiple qualitative methods were used to create a study framework conceptually orientated to a socio-cultural ...
Crisp Richard J - - 2012
McCullough et al. argue that humans possess evolved computational systems for implementing retaliatory behavior that both deters aggression and promotes subsequent reconciliation. However, they do not apply this analysis to the sphere of intergroup relations. We believe their model can be usefully extended to this domain and discuss why this ...
Olayiwola Ibiyemi O - - 2012
OBJECTIVE: The present study was conceived in response to a perceived lack of data about the nutritional status of free-living elderly Yoruba people living in a poor urban area in south-western Nigeria. The major focus was to assess the micronutrient status of elderly Yoruba people living in a slum of ...
Yu Rongjun - - 2012
McCullough et al. argue that revenge has a future-oriented function, that is, to deter future harms by changing other individuals' incentives toward the self. Recent research has shown that people seek revenge even when harms are unintentional. This commentary reports these results and proposes that revenge may also serve to ...
Crosby Edward - - 2012
PURPOSE: The purpose of this narrative review is to discuss the impact of clinical practice guidelines on the outcomes of care and patient safety. PRINCIPAL FINDINGS: The care provided to patients has a high degree of variability, including some care that is discordant with available evidence. This inconsistency has implications ...
Walczyk Wiktoria - - 2012
To date, TM AFM (tapping mode or intermittent contact mode Atomic Force Microscopy) is the most frequently applied direct imaging technique to visualize surface nanobubbles at the solid-aqueous interface. On the one hand, AFM is the only profilometric technique that provides estimates of the bubbles' nanoscopic dimensions. On the other ...
Petrović Zoran - - 2012
A total of 84 European hares collected from eleven Serbian regions investigated upon cadmium (Cd) and zinc (Zn) presence. Strong statistically significant correlations between Cd concentrations in kidney and liver were registered in animals older than 12 months. Significant differences between Zn concentrations in liver in comparison to kidney were found ...
Shigemori Suguru - - 2012
Proteins from buckwheat (Fagopyrum esculentum) are strong allergens that can cause serious symptoms, including anaphylaxis, in patients with hypersensitivity. In this study, we successfully developed a modified lactic acid bacterial vector (pNSH) and a recombinant strain of Lactococcus lactis NZ9000 (NZ9000) that produced a major allergenic storage protein of buckwheat, ...
Wu Yujun - - 2012
When several treatment arms are administered along with a control arm in a trial, dropping the non-promising treatments at an early stage helps to save the resources and expedite the trial. In such adaptive designs with treatment selection, a common selection rule is to pick the most promising treatment, for ...
Erdman Natasha - - 2012
Previously, imaging and analysis with cathodoluminescence (CL) detectors required using high accelerating voltages. Utilization of lower accelerating voltage for microanalysis has the advantages of reduced beam-specimen interaction volume, and thus better spatial resolution, as well as reduction in electron beam induced damage. This article will highlight recent developments in field ...
Anninga Jakob K - - 2012
Osteosarcomas of hands or feet are rare, and seemingly these cases differ in presentation and behavior compared to those in usual locations. The clinico-pathological presentation of patients with osteosarcomas of the hand or foot was studied and compared with published cases. Forty osteosarcomas were identified among 4,221 cases, representing 0.95 % ...
Wen Lv - - 2012
PURPOSE: The aim of this study was to investigate the effect of tamoxifen (TAM), methoxyprogesterone acetate (MPA) and their combined treatment on cisplatin-resistant ovarian cancer SKOV3/DDP cells, as well as the potential mechanisms. METHODS: MTT assay was used to investigate the effect of different concentrations (0.01, 0.1, 1, 10 and ...
Corli O - - 2012
BACKGROUND: Dealing with cancer pain implies assessing the intensity and other attributes of pain and identifying appropriate outcomes and endpoints to evaluate the effect of treatments. METHODS: In the context of an observational longitudinal prospective study, 1461 painful cancer patients were evaluated at baseline and weekly over 4 weeks. Four ...
Sànchez-Nogué B - - 2012
The common sole, Solea solea (Linneus, 1758), and the Senegalese sole, Solea senegalensis (Kaup, 1858), are two important commercial species that coexist in the NW Mediterranean. In order to assess the species' ability to respond to chemical insults, a comparison of activities on enzymes involved in xenobiotic metabolism was carried ...
Roberts S Craig - - 2012
McCullough et al. propose an evolved cognitive revenge system which imposes retaliatory costs on aggressors. They distinguish between this and other forms of punishment (e.g., those administered by judges) which are not underpinned by a specifically designed evolutionary mechanism. Here we outline mechanisms and circumstances through which the revenge system ...
Gao Hua - - 2012
This study aims to establish pilocarpine-induced rat model of status epilepticus (SE), observe the activity of calpain I in the rat hippocampus and the subsequent neuronal death, and explore the relationship between calpain I activity and neuronal death in the hippocampus. Fifty-eight adult male Wistar rats were assigned randomly into ...
Kitagawa Sayuri - - 2012
PURPOSE OF WORK: To elucidate the mechanisms of high performance by soy peptides during yeast fermentation in low temperature stress conditions and to identify a type of soy peptide that is suitable for yeast fermentation at low temperatures during brewing. The growth of a tryptophan auxotrophic yeast strain in a ...
Wallace Bret D - - 2012
Xenobiotic compounds undergo a critical range of biotransformations performed by the phase I, II, and III drug-metabolizing enzymes. The oxidation, conjugation, and transportation of potentially harmful xenobiotic and endobiotic compounds achieved by these catalytic systems are significantly regulated, at the gene expression level, by members of the nuclear receptor (NR) ...
Weichenthal Scott - - 2012
Few studies have examined indoor air quality in First Nations communities and its impact on cardiorespiratory health. To address this need, we conducted a cross-over study on a First Nations reserve in Manitoba, Canada including 37 residents in 20 homes. Each home received an electrostatic air filter and a placebo ...
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