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Baldwin Kathleen M - - 2013
: Before integrating advanced practice registered nurse (APRN) case management, we compared managed Medicare clients' hospital admissions for 12 months prior to and 12 months after registered nurse (RN) or social worker case management. : Our clients are cared for by a multispecialty physician group and five local hospitals. : ...
Vandenkerkhof Elizabeth G - - 2013
: Many studies have reported putative factors for the development of chronic pain after surgery. However, advances in knowledge about the etiology and prognosis of chronic postsurgical pain (CPSP) could be gained by improving methodology within studies of surgical pain. The purpose of this study was to review predictive factors ...
Pieper P G - - 2013
Hypertrophic cardiomyopathy (HCM) is increasingly being diagnosed in pregnant women. Women with HCM generally tolerate pregnancy well. The risk is however higher in women who are symptomatic before pregnancy or in those with severe left ventricular outflow tract obstruction. The incidence of arrhythmias does not appear to be increased during ...
Bretthauer M - - 2013
Cancer screening has the potential to prevent or reduce incidence and mortality of the target disease, but may also be harmful and have unwanted side-effects. This review explains the basic principles of cancer screening, common pitfalls in evaluation of effectiveness and harms of screening, and summarizes the evidence for effects ...
Powell Suzanne K - - 2013
Medical-monitoring devices, wearables, and mobile medical apps are currently being approved by the U.S. Food and Drug Administration, and millions more are in development. Although many will be important tools in achieving better health care outcomes, there are many ethical, legal, and human issues to consider.
Carneiro-Pla Denise - - 2013
High-resolution ultrasonography has become mandatory while evaluating patients with thyroid nodules. Although B-mode and Doppler ultrasonography are highly sensitive for diagnosis of thyroid lesions, they lack specificity in differentiating benign from malignant nodules. Ultrasound elastography has proven valuable in discriminating these lesions. This review discusses recent findings regarding the use ...
Pereira Branca - - 2013
Advances in the health system and medical sciences are continuously pushing the barrier of life-expectancy. As a consequence, humans are being increasingly afflicted by age-associated diseases, such as cancer. The challenge now lies in understanding the mechanisms underlying ageing in order to reduce the lifetime risk for cancer. In long-lived ...
van den Berge M - - 2013
Asthma is a chronic respiratory disease, characterized by airway obstruction and inflammation. Increasing evidence shows that the small airways contribute significantly to the clinical expression and severity of asthma. Traditionally, high levels of disease activity are thought to be necessary before symptoms occur in the small airways because of their ...
Halderman Francie - - 2013
This case describes how returning veterans can be supported and healed through holistic nursing care, trauma informed care and a range of evidence based complementary and integrative therapies.
Clark Carey S - - 2013
Reiki is a hands-on healing modality that is practiced to support patients' healing process at more than 800 hospitals in the United States. This article explores the educational outcomes of an RN-BSN Reiki course as an aspect of an integral-holistic curriculum experience.
Gantayet Arpita - - 2013
The freshwater zebra mussel (Dreissena polymorpha) is a notorious biofouling organism. It adheres to a variety of substrata underwater by means of a proteinaceous structure called the byssus, which consists of a number of threads with adhesive plaques at the tips. The byssal proteins are difficult to characterize due to ...
Gray Deborah C - - 2013
Relationships between primary care patients' herbal use and influencing factors were examined. Most felt that herbals were safer than prescription medications and preferred their use. There were significant relationships between perceived herbal safety and efficacy and other motivational factors with use. Supplement cost and demographics were less predictive of use.
Muliira Joshua Kanaabi - - 2013
Therapeutic touch (TT) is a valid nursing intervention but some patients feel uncomfortable with it because of personal beliefs. This commentary presents observations and experiences of the use of TT during care of Muslim patients in the Sultanate of Oman. There is need to teach nursing students deliberate steps when ...
Al-Semari Abdulaziz - - 2013
In this report, we describe a kindred consisting of five affected males presenting with many of the well-recognized features of Aarskog-Scott syndrome. The diagnosis, which was confirmed by the identification of a novel nonsense mutation of FGD1, was associated with the presence of a symmetric distal arthropathy with electromyographic signs ...
Koren Mary Elaine - - 2013
This qualitative study examines the spiritual needs of staff nurses. Focus group participants discussed "care of the patient" and "care of self." We use theory to argue that self-care is essential for the care of both nurses and patients, and spirituality is the foundation of nurses' work.
Jo Kae-Hwa - - 2013
The purpose of this study was to identify the perceived attitudes of Korean nurses toward forgiveness on the basis of their social and cultural background. Q methodology was used to explore the typology of perceived attitudes. Four types of attitudes toward forgiveness were identified: obstinate, concessive, progressive, and receptive.
Eichler Deanna - - 2013
: This process improvement project was to determine whether a telephone intervention could be successful in reducing readmission rates and to discover whether a screening tool accurately determines patients at high risk for readmission. : :
Miodonski Kathleen - - 2013
PURPOSE/OBJECTIVES:: The director of case management is one of health care's leadership positions most frequently in demand. The lack of qualified and effective case management leaders will continue to be an issue for organizations for years to come, influenced by increasing pressures on health care reimbursement and the aging case ...
Altomare D F - - 2013
An effective screening tool for colorectal cancer is still lacking. Analysis of the volatile organic compounds (VOCs) linked to cancer is a new frontier in cancer screening, as tumour growth involves several metabolic changes leading to the production of specific compounds that can be detected in exhaled breath. This study ...
Silverman Ronald H - - 2013
While visualization of the retina and choroid has made great progress, functional imaging techniques have been lacking. Our aim was to utilize acoustic radiation force impulse (ARFI) response to probe functional properties of these tissues. A single element 18-MHz ultrasound transducer was focused upon the retina of the rabbit eye. ...
Dobri Nicoleta - - 2013
Excessive accumulation of lipofuscin is associated with pathogenesis of atrophic age-related macular degeneration (AMD) and Stargardt disease. Pharmacologic inhibition of the retinol-induced interaction of retinol-binding protein 4 (RBP4) with transthyretin (TTR) in the serum may decrease the uptake of serum retinol to the retina and reduce formation of lipofuscin bisretinoids. ...
Hu Yang - - 2013
Choroidal neovascularization (CNV) is a severe complication of AMD. The Wnt signaling pathway has been shown to mediate angiogenesis. The purpose of this study was to investigate the pathogenic role of the Wnt pathway in CNV and explore the therapeutic potential of a novel Wnt signaling inhibitor in CNV. Adult ...
Grippo Tomas M - - 2013
To characterize the 24-hour pattern of intraocular pressure (IOP) in untreated ocular hypertensive (OHTN) patients. IOP measurements were taken every 2 hours during a 24-hour period from 15 untreated OHTN patients (ages 41-77 years). Measurements were both sitting and supine (diurnal) and supine only (nocturnal). Mean diurnal and nocturnal IOPs ...
Zhu Yanli - - 2013
The Wlds mutation affords protection of retinal ganglion cell (RGC) axons in retinal ischemia and in inducible and hereditary preclinical models of glaucoma. We undertook the present study to determine whether the Nmnat1 portion of the chimeric protein provides axonal and somatic protection of RGCs in models of ischemia and ...
Hassemer Eryn L - - 2013
During mammalian embryonic eyelid closure ADAM17 has been proposed to play a role as a transactivator of epidermal growth factor receptor (EGFR) signaling by shedding membrane bound EGFR ligands. However, ADAM17 also sheds numerous other ligands, thus implicating ADAM17 in additional molecular pathways. The goal of this study was to ...
Gao Junyuan - - 2013
Previous experiments showed that mouse lenses have an intracellular hydrostatic pressure that varied from 335 mm Hg in central fibers to 0 mm Hg in surface cells. Model calculations predicted that in larger lenses, all else equal, pressure should increase as the lens radius squared. To test this prediction, lenses ...
Li Li Li LL Department of Surgery, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, - - 2013
We aimed to examine the association between in vitro fertilization (IVF) and risk of cancers through conducting a meta-analysis of cohort studies. Relevant studies were identified by using PubMed, ISI Web of knowledge, and Scopus through March 2012. Reference lists from retrieved articles were also reviewed. We included historical cohort ...
Kostyuk V A VA Belarus State University, Minsk, - - 2013
Excessive exposure to solar UVA and UVB radiation is widely considered to cause skin cancers such as squamous cell carcinoma and basalioma. Direct UVB damage to skin cell DNA as well as UV-induced chronic skin inflammation, accelerated keratinocyte proliferation, inhibited apoptosis, and immunosuppression seem to underlie the UV-induced carcinogenesis. Also, ...
Joyce Michael J MJ Nemours Children's Clinic, Jacksonville, FL, - - 2013
Children with acute lymphocytic leukemia who fail to enter remission have a poor prognosis. In a previous study, 9 of 14 children with induction failure entered remission after teniposide (VM26) plus cytosine arabinoside (Ara-C). We attempted to confirm these results. Twenty children received teniposide (200 mg/m/day IV) for 3 days ...
McRae Reagan R School of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, - - 2013
Synchrotron X-ray fluorescence microscopy of non-synchronized NIH 3T3 fibroblasts revealed an intriguing redistribution dynamics that defines the inheritance of trace metals during mitosis. At metaphase, the highest density areas of Zn and Cu are localized in two distinct regions adjacent to the metaphase plate. As the sister chromatids are pulled ...
Correia Andrew W AW From the Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, - - 2013
In recent years (2000-2007), ambient levels of fine particulate matter (PM2.5) have continued to decline as a result of interventions, but the decline has been at a slower rate than previous years (1980-2000). Whether these more recent and slower declines of PM2.5 levels continue to improve life expectancy and whether ...
Sanz-Ortega Julian J Translational Surgical Pathology, National Institutes of Health, Bethesda, MD 20892, - - 2013
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a hereditary cancer syndrome in which affected individuals are predisposed to the development of multiple leiomyomas of the skin and uterus and aggressive forms of kidney cancer. Affected individuals harbor a germline heterozygous loss-of-function mutation of the fumarate hydratase (FH) gene. Uterine ...
Barr Kristen M KM Department of Pediatrics, Section of Hematology-Oncology, Medical College of Wisconsin 53226, - - 2013
When tumor vaccines are administered as cancer immunotherapy, cellular interactions at the vaccine site are crucial to the generation of antitumor immunity. Examining interactions at the vaccine site could provide important insights to the success or failure of vaccination. Our laboratory previously showed that while administration of a cell-based vaccine ...
Nakazawa Yozo Y Center for Cell and Gene Therapy, Department of Pediatrics, Molecular Virology and Microbiology, Houston, TX, - - 2013
The piggyBac transposon system is a promising nonviral method to genetically modify T cells for immunotherapeutic applications. To evaluate the regulation and stability of transgene expression in human T cells modified with piggyBac-transposons, peripheral blood mononuclear cells were nucleofected with transposase and an enhanced green fluorescence protein (eGFP)-expressing transposon. Single-cell ...
Howe Laura D LD From the MRC Centre for Causal Analyses in Translational Epidemiology, School of Social & Community Medicine, University of Bristol, Bristol, UK. - - 2013
Although cohort members tend to be healthy and affluent compared with the whole population, some studies indicate this does not bias certain exposure-outcome associations. It is less clear whether this holds when socioeconomic position (SEP) is the exposure of interest. As an illustrative example, we use data from the Avon ...
Preston Samuel H SH Population Studies Center, University of Pennsylvania, Philadelphia, PA 19103, USA. - - 2013
There is great interest in understanding the role of weight dynamics over the life cycle in predicting the incidence of disease and death. Beginning with a Medline search, we identify, classify, and evaluate the major approaches that have been used to study these dynamics. We identify four types of models: ...
Van De Voort Tyler J TJ Department of Human Oncology, University of Wisconsin-Madison, Madison 53705. WI, - - 2013
In this study, an agonistic anti-CD40 monoclonal antibody was combined with monophosphoryl lipid A (MPL), a nontoxic derivative of lipopolysaccharide and agonist of toll-like receptor-4, to assess the immunomodulatory and antitumor synergy between the 2 agents in mice. Anti-CD40 was capable of priming macrophages to subsequent ex vivo activation by ...
Ramos Carlos A CA Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, TX77030, USA. - - 2013
Vaccines prevent human papillomavirus (HPV)-associated cancer but, although these tumors express foreign, viral antigens (E6 and E7 proteins), they have little benefit in established malignancies, likely due to negative environmental cues that block tumor recognition and induce T-cell anergy in vivo. We postulated that we could identify mechanisms by which ...
Melnik S S Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Muthgasse 18, 1190 Vienna, - - 2013
Plants and plant cells have been used to produce many diverse and valuable recombinant proteins, including subunit vaccines, antibodies and antibody fragments, hormones, blood products, cytokines and enzymes. Different plant species and platforms have been explored as production hosts, each with unique properties in terms of production timescales, environmental containment, ...
Layfield Joshua P JP Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, - - 2013
The vibrational Stark effect provides insight into the roles of hydrogen bonding, electrostatics, and conformational motions in enzyme catalysis. In a recent application of this approach to the enzyme ketosteroid isomerase (KSI), thiocyanate probes were introduced in site-specific positions throughout the active site. This paper implements a quantum mechanical/molecular mechanical ...
Karatas Hacer H Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, - - 2013
Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase, and targeting the MLL1 enzymatic activity has been proposed as a novel therapeutic strategy for the treatment of acute leukemia harboring MLL1 fusion proteins. The MLL1/WDR5 protein-protein interaction is essential for MLL1 enzymatic activity. In the present ...
Gregory Katherine E KE Boston College, W.F. Connell School of Nursing, 140 Commonwealth Avenue, Chestnut Hill, Massachusetts 02467, - - 2013
Robust methodologies for the analysis of fecal material will facilitate the understanding of gut (patho)physiology and its role in health and disease and will help improve care for individual patients, especially high-risk populations, such as premature infants. Because lipidomics offers a biologically and analytically attractive approach, we developed a simple, ...
Kazane Stephanie A SA Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United - - 2013
With the recent clinical success of bispecific antibodies, a strategy to rapidly synthesize and evaluate bispecific or higher order multispecific molecules could facilitate the discovery of new therapeutic agents. Here, we show that unnatural amino acids (UAAs) with orthogonal chemical reactivity can be used to generate site-specific antibody-oligonucleotide conjugates. These ...
Lewis K L M - - 2013
We report simulations of the two-dimensional electronic spectroscopy of the Q(y) band of the D1-D2-Cyt b559 photosystem II reaction center at 77 K. We base the simulations on an existing Hamiltonian that was derived by simultaneous fitting to a wide range of linear spectroscopic measurements and described within modified Redfield ...
Lien Evan C EC Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, - - 2013
The ability of cells to sense and respond appropriately to changing environmental conditions is often mediated by signal transduction pathways that employ mitogen-activated protein kinases (MAPKs). In the yeast Saccharomyces cerevisiae, the high-osmolarity glycerol (HOG) and filamentous growth (FG) pathways are activated following hyperosmotic stress and nutrient deprivation, respectively. Whereas ...
Arthurs O J OJ Great Ormond Street Hospital for Children, London, WC1N 3JH, UK. - - 2013
The position of the conus medullaris is considered abnormal if it ends below lumbar vertebrae three (L3) at birth. We used magnetic resonance imaging (MRI) to measure the position of the conus in post-mortem foetuses, to investigate the timing of normal ascent. The position of the conus in 84 post-mortem ...
Shi Huilin H Department of Chemistry, Indiana University, 800 Kirkwood Ave., Bloomington, Indiana 47405, United - - 2013
Oxidative modifications can have significant effects on protein structure in solution. Here, the structures and stabilities of oxidized ubiquitin ions electrosprayed from an aqueous solution (pH 2) are studied by ion mobility spectrometry-mass spectrometry (IMS-MS). IMS-MS has proven to be a valuable technique to assess gas phase and in many ...
Li Dan D Department of Radiology, Molecular Imaging Center, University of Southern California, Los Angeles, California 90033, United - - 2013
Accumulating evidence suggests that EphB4 plays key roles in cancer progression in numerous cancer types. In fact, therapies focusing on EphB4 have become potentially important components of various cancer treatment strategies. However, tumor sensitivity to EphB4 suppression may not be uniform for different cancers. In this study, we developed near-infrared ...
Woessner David W DW Department of Pharmacology and Toxicology, University of Utah College of Pharmacy, Salt Lake City, Utah 84108, United - - 2013
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by expression of the fusion gene BCR-ABL following a chromosomal translocation in the hematopoietic stem cell. Therapeutic management of CML uses tyrosine kinase inhibitors (TKIs), which block ABL-signaling and effectively kill peripheral cells with BCR-ABL. However, TKIs are not curative, and ...
McClintock Carlee S CS Graduate School of Genome Science and Technology, University of Tennessee-Oak Ridge National Laboratory, 37830, United - - 2013
Oxidative protein surface mapping has become a powerful approach for measuring the solvent accessibility of folded protein structures. A variety of techniques exist for generating the key reagent (i.e., hydroxyl radicals) for these measurements; however, these approaches range significantly in their complexity and expense of operation. This research expands upon ...
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