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Results 701 - 750 of 2633
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Gooday C - - 2012
AIMS: To develop an antibiotic foot formulary for the empirical treatment of diabetes-related foot infections presenting to our service. Subsequently, to asses costs associated with the introduction of our protocol, in particular to assess the effect on admissions avoidance and any cost savings achieved. METHODS: We reviewed several existing antibiotic ...
Dawes Lucy Jean - - 2012
PURPOSE: Cataract surgery is blighted by posterior capsule opacification (PCO). Our aim was to understand the biological basis for age-related differences in PCO/wound healing rates. METHODS: Human capsular bags were prepared by sham cataract surgery on donor lenses. FGF and HGF levels were determined using ELISA. Protein synthesis rates were ...
Gomez Daniel R - - 2012
BACKGROUND: Nausea and vomiting (N/V) during chemotherapy can have profound clinical and economic consequences. Effective antiemetic agents are available for prophylaxis, but barriers may prevent their use. For this population-based study, the authors assessed the rates of antiemetic prophylaxis use, and predictors of such use, among patients who were receiving ...
Klein Marina B - - 2012
BACKGROUND: The recent availability of new direct acting antivirals (DAAs) for HCV treatment which dramatically increase sustained virologic response rates for genotype 1 HCV infection has brought new optimism with respect to curative HCV treatment for HIV-HCV co-infected patients. We describe the characteristics of co-infected patients who could be eligible ...
Li Meng - - 2012
Splitting the C-C bond is the main obstacle to electrooxidation of ethanol (EOR) to CO2. We recently demonstrated that the ternary PtRhSnO2 electrocatalyst can accomplish that reaction at room temperature with Rh having a unique capability to split the C-C bond. In this article we report the finding that Ir ...
Sheffield Chava - - 2012
PURPOSE: The United States faces a growing population of older adults and accompanying functional disabilities, coupled with constrained public resources and diminishing informal supports. A variety of interventions that aim to improve client outcomes have been studied, but to date, there is limited translational research that examines the efficacy of ...
Wellenzohn Bernd - - 2012
Virtual Screening in a huge collection of virtual combinatorial libraries has led to the identification of two new structural classes of GPR119 agonists with submicromolar in-vitro potencies. Herein, we describe the Virtual Screening process involving Feature Trees fragment space searches followed by a 3D post-processing step. The in-silico findings were ...
Jozkowski Kristen N - - 2012
Introduction.  Exogenous lubricant use in the United States is common among women; however, there is little empirical research describing women's perceptions of lubricants, lubricant use, and vaginal wetness or dryness during penile-vaginal intercourse or other sexual behaviors. Aims.  To assess women's perceptions about lubricant use, women's perceptions about vaginal wetness ...
Delhaas Tammo - - 2012
We investigated whether myonuclear number increases in proportion to the increase in fiber size during maturational growth of skeletal muscle. Thoraco-abdominal muscle tissue was obtained from twenty 6-day to 15-year-old boys and girls during cardiothoracic surgery. Cross-sections were stained by anti-laminin for the basal lamina and by DAPI to identify ...
Shishilov Oleg N - - 2012
Reactions of Pd(4)(NO)(4)(CF(3)CO(2))(4) with olefins were studied, this Pd-cluster was shown to promote the oxidation of olefins into ketones, which were found as ketonyl ligands in complex products of the reaction; 6-nuclear palladium clusters with carboxylate and ketonyl ligands Pd(6)(μ-Cl)(x)(μ-CF(3)CO(2))(4)(μ,κ(2)-CH(2)C(O)CMe(3))(6-x) were characterized by XRD analysis.
Capponi Simona - - 2012
The nature of the glass transition, the transformation of a liquid into a disordered solid, still remains one of the most intriguing unsolved problems in materials science. Recent models rationalize crucial features of vitrification with the presence of medium-range ordered regions coexisting with the isotropic liquid. Here, in line with ...
Xu Feng - - 2012
Various methods have been developed for calling single-nucleotide polymorphisms from next-generation sequencing data. However, for satisfactory performance, most of these methods require expensive high-depth sequencing. Here, we propose a fast and accurate single-nucleotide polymorphism detection program that uses a binomial distribution-based algorithm and a mutation probability. We extensively assess this ...
Dekker T J A - - 2012
BackgroundSeveral studies have assessed the concordance of estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) status between core needle biopsy (CNB) and resection specimens, usually in small patient series and with discordant results.Patients and methodsER and HER2 status determined on CNB and tissue micro-arrays of resected tumors ...
Asimakopoulos Alexandros George - - 2012
Benzotriazole (BTR) and benzothiazole (BTH) derivatives are used in a wide variety of industrial and consumer products and have been reported to occur in the environment. Owing to a lack of analytical methods, human exposure to BTR and BTH is still unknown. In this study, a liquid chromatography-electrospray ionization tandem ...
Thirunavukkarasu Vedhagiri S - - 2012
Ruthenium complexes enabled first C(sp(2))-H bond oxygenations of aromatic ketones with excellent functional group tolerance, and broad scope as well as high chemoselectivity and site selectivity.
Huang Liping - - 2012
A small organic molecule phenylacetonitrile promoted chemoselective cyclization of (chromen-3-yl)alkynylnitriles to generate a novel tetracyclic or tricyclic chromone scaffold has been discovered. Importantly, the phenylacetonitrile serves as an anion transfer reagent changing the normal reaction of the substrate.
Long Quan - - 2012
The present report describes a case of nephrotic syndrome (NS) with invasive thymoma. A male patient was hospitalized for severe edema with reduced urine output. He had a history of thymectomy and radiotherapy because of invasive thymoma 4 years before the development of NS. Renal biopsy displayed minimal change disease ...
Hansson Emma - - 2012
Abstract Purpura fulminans (PF) is a rapidly progressing, potentially life-threatening condition characterised by disseminated intravascular coagulation (DIC) and haemorrhagic infarction of the skin. Plastic surgical treatment of PF has never been reported in Scandinavia. The aim of this report was to review plastic surgical treatment of PF and the long-term ...
Baig R B Nasir - - 2012
The use of magnetic nanoparticles (MNPs) as a catalyst support in organic synthesis is summarized. The recovery of expensive catalysts after catalytic reaction and reusing them without losing their activity is an essential feature in the sustainable process development. The aim of this article is to highlight the progress in ...
Gürbüz Elif I - - 2012
Hold the water: The hemicellulose fraction of lignocellulose can be converted into furfural in high yields (80 %) using solid acid catalysts (H-mordenite) in a monophasic system with γ-valerolactone (GVL) as the solvent. Furfural degradation reactions are decreased significantly when the water concentration in GVL is minimized, thus resulting in high ...
Niibori Yosuke - - 2012
Different places may share common features, but are coded by distinct populations of CA3 neurons in the hippocampus. Here we show that chemical or genetic suppression of adult neurogenesis in the hippocampus impairs this population-based coding of similar (but not dissimilar) contexts. These data provide a neural basis for impaired ...
García-Simón Cristina - - 2012
The metal-directed supramolecular synthetic approach has paved the way for the development of functional nanosized molecules. In this work, we report the preparation of the new nanocapsule 3⋅(CF(3) SO(3) )(8) with a A(4) B(2) tetragonal prismatic geometry, where A corresponds to the dipalladium hexaazamacrocyclic complex Pd-1, and B corresponds to ...
Li Huili - - 2012
Nitric oxide (NO) is a bioregulator of apoptosis, which has both antiapoptotic and proapoptotic functions. However, the molecular mechanisms responsible for its opposite biological effects are not fully understood. Recent advances in the study of protein S-nitrosylation may provide novel insights into the regulation of apoptotic signaling by NO. S-nitrosylation ...
Kuan Seah Ling - - 2012
Nanocarriers which can facilitate cell uptake are highly attractive for therapeutic purposes. We describe the synthesis of a core-shell biohybrid consisting of a human serum albumin (HSA) core that serves as a reservoir for hydrophobic drugs and a cationized shell region consisting of ethynyl-G2.0-PAMAM and ethynyl-G3.0-PAMAM dendrons as candidates for ...
Fejerskov Betina - - 2012
Hydrogel biomaterials based on poly(vinyl alcohol), PVA, have an extensive history of biomedical applications yet in their current form suffer from significant shortcomings, such as lack of mechanism of biodegradation and poor opportunities in controlled drug release. We investigate physical hydrogels of PVA as surface adhered materials and present biodegradable ...
Itoh Takeshi - - 2012
A major problem after clinical autologous islet transplantation (AIT) is the difficulty in achieving insulin independence. To follow up on our demonstration in a murine model that high-mobility group box 1 (HMGB1) was released from islets and involved in early loss of transplanted islets, we tested the role of HMGB1 ...
Skinner D - - 2012
In children, the effectiveness of preventive therapy (PT) for tuberculosis (TB) will always be dependent upon the care giver's behaviour, as this determines adherence. We briefly describe the knowledge, attitudes and intended behaviours in care givers of young children referred for PT in a resource-constrained setting with high TB rates. ...
Matsuo Kiyoshi - - 2012
Abstract The levator and frontalis muscles lack interior muscle spindles, despite consisting of slow-twitch fibres that involuntarily sustain eyelid-opening and eyebrow-raising against gravity. To compensate for this anatomical defect, this study hypothetically proposes that initial voluntary contraction of the levator fast-twitch muscle fibres stretches the mechanoreceptors in Müller's muscle and ...
Milroy Lech-Gustav - - 2012
Small-molecule modulation of protein-protein interactions (PPIs) is one of the most exciting but also difficult fields in chemical biology and drug development. As one of the most important "hub" proteins with at least 200 - 300 interaction partners the 14-3-3 proteins are an especially fruitful case for PPI intervention. Here, ...
Switzer Jeffrey A - - 2012
Background-A hub-and-spoke telestroke network is an effective way to extend quality acute stroke care to remote hospitals and to improve patient outcomes. This study assessed the cost-effectiveness of a telestroke network in the management of acute ischemic stroke from the perspectives of a network, a hub hospital, and a spoke ...
Delgado Teresa C - - 2012
Dietary fructose can benefit or hinder glycemic control depending on the quantity consumed and these contrasting effects are reflected by alterations in postprandial hepatic glycogen synthesis. Recently, we showed that (2)H-enrichment of glycogen positions 5 and 2 from deuterated water ((2)H(2)O) informs direct and indirect pathway contributions to glycogenesis in ...
Gupta P - - 2012
Although the initial results of patients who have had left atrial appendage (LAA) occlusion devices implanted have been promising, there have been associated complications requiring surgical intervention. We report a case of a LAA occlusion device migrating into the left ventricle requiring cardiac surgery to retrieve it.
Martin K - - 2012
BACKGROUND: /st>Once aprotinin was no longer available for clinical use, ε-aminocaproic acid (EACA) and tranexamic acid became the only two options for antifibrinolytic therapy. We compared aprotinin and EACA with respect to their blood-sparing efficacy and other major clinical outcome criteria in infants undergoing cardiac surgery. METHODS: /st>We retrospectively analysed ...
Yang Zhen-Quan - - 2012
The aim of this study was to evaluate the probiotic effects of Lactobacillus strains against Vibrio parahaemolyticus causing gastroenteritis. Six-week-old ICR mice were pretreated with four Lactobacillus strains at three dosages, and then challenged with V. parahaemolyticus TGqx01 (serotype O3:K6). The results showed that V. parahaemolyticus TGqx01 caused severe intestinal fluid accumulation ...
Tosi G - - 2012
Macroscopic quantum states can be easily created and manipulated within semiconductor microcavity chips using exciton-photon quasiparticles called polaritons. Besides being a new platform for technology, polaritons have proven to be ideal systems to study out-of-equilibrium condensates. Here we harness the photonic component of such a semiconductor quantum fluid to measure ...
Emenike Bright U - - 2012
The conformational populations of cis-1,3-cyclopentanedicarboxylic acid (1) and its mono- and dianion were established in DMSO solution by comparing the vicinal proton-proton coupling constants (3JHH) obtained in solution to their theoretical counterparts. Geometries used for 3JHH theoretical estimation (using Karplus-type equations) were obtained from optimized structures at the B3LYP/6-31G(2d,2p) level. ...
Yang Yangyang - - 2012
We demonstrate a novel strategy for constructing multidirectional programmed two-dimensional (2-D) DNA nanostructures in various unique patterns by introducing photoresponsive oligonucleotides (Azo-ODNs) into hexagonal DNA origami structures, and examined the regulation of repeated assembly and disassembly of the DNA nanostructures by different photoirradiation conditions in a programmed manner. Hexagonal DNA ...
La Colla Anabela - - 2012
17β-estradiol (E2) protects several non-reproductive tissues from apoptosis, including skeletal muscle. We have shown that E2 at physiological concentrations prevented apoptosis induced by H(2)O(2) in C2C12 skeletal myoblasts. As we also demonstrated the presence of ERs in mitochondria, the present work was focused on the effects of E2 on this ...
Beauchamp Alison - - 2012
OBJECTIVE: To investigate whether attendance at cardiac rehabilitation (CR) independently predicts all-cause mortality over 14 years and whether there is a dose-response relationship between the proportion of CR sessions attended and long-term mortality. DESIGN: Retrospective cohort study. SETTING: CR programmes in Victoria, Australia PATIENTS: The sample comprised 544 men and ...
Nørskov Jens K - - 2012
"… The quest for the materials genome-the properties of a material that define its functional properties-has started. This signifies a transition to a new era of materials research where large amounts of materials data become available. The expectation is that this will significantly speed up the discovery of new materials ...
Grasman Keith A - - 2012
Previous studies have shown inexplicable declines in breeding waterbirds within western New York/New Jersey Harbor between 1996 and 2002 and elevated polychlorinated dibenzo-p-dioxins and polychlorinated biphenyls (PCBs) in double-crested cormorant (Phalacrocorax auritus) eggs. The present study assessed associations between immune function, prefledgling survival, and selected organ chlorine compounds and metals ...
Yuki Masahiro - - 2012
Although stoichiometric transformations using transition metal-N(2) complexes have been well investigated towards the goal of nitrogen fixation under mild reaction conditions, only a few examples of the catalytic transformations of N(2) using transition metal-N(2) complexes as catalysts have been reported. In almost all the catalytic systems, the use of Mo ...
Campbell Michelle L - - 2012
BACKGROUND:Guidelines recommend that agents other than vancomycin be considered for some types of infection due to methicillin-resistant Staphylococcus aureus (MRSA) when the minimum inhibitory concentration (MIC) to vancomycin is 2 μg/mL or more. Alternative therapeutic options include daptomycin and linezolid, 2 relatively new and expensive drugs, and trimethoprim/sulfamethoxazole (TMP/SMX), an ...
Gulin J E N - - 2012
OBJECTIVES: Antifungal triazole derivatives have been studied as possible alternatives for the treatment of Chagas' disease. Voriconazole has demonstrated in vitro activity against Trypanosoma cruzi, but its efficacy in vivo has not yet been tested. We aimed to determine the effect of voriconazole in a murine model of acute T. ...
Wu Songfang - - 2012
Cancer cells have distinct metabolism that highly depends on glycolysis instead of mitochondrial oxidative phosphorylation alone, known as aerobic glycolysis. Pyruvate kinase (PK), which catalyzes the final step of glycolysis, has emerged as a potential regulator of this metabolic phenotype. Expression of PK type M2 (PKM2) is increased and facilitates ...
Picard D - - 2012
Background:  Superficial cellulitis of the leg (erysipelas) is a frequent skin infection. Abscess formation is the most frequent local complication. Determinants of abscess formation in patients with leg cellulitis have not been clearly established yet. The aim of this study was to assess risk factors for abscess formation in patients ...
Corchado Jose Carlos - - 2012
Quasi-classical trajectory studies have been carried out for the HO + CO → H + CO2 reaction and H + CO2 inelastic collision on a recently developed global potential energy surface based on a large number of high-level ab initio points. The CO2 vibrational state distributions for these processes have ...
Makita Noriko - - 2012
Rationale: The clinical problem of loss of β-adrenergic receptor (β-AR) response, both in the pathogenesis of heart failure and during therapeutic application of β-agonists, is due at least in part to desensitization, internalization and downregulation of the receptors. In the regulation of β-AR signaling, G-protein-coupled receptor kinase 2 (GRK2) primarily ...
Matsuo Kiyoshi - - 2012
Abstract Proprioceptively innervated intramuscular connective tissues in Müller's muscle function as exterior mechanoreceptors to induce reflex contraction of the levator and occipitofrontalis muscles. In aponeurotic blepharoptosis, since the levator aponeurosis is disinserted from the tarsus, stretching of the mechanoreceptors in Müller's muscle is increased even on primary gaze to induce ...
Yamamoto Hirofumi - - 2012
Vizantin, 6,6'-bis-O-(3-nonyldodecanoyl)-α,α'-trehalose, was developed as a safe immunostimulator on the basis of a structure-activity relationship (SAR) study with trehalose 6,6'-dicorynomycolate (TDCM). It was possible to synthesize vizantin on a large scale more easily than in the case of TDCM, and the compound exhibited more potent prophylactic effect on experimental lung ...
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