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Kartal Boran - - 2012
Anaerobic ammonium oxidizing (anammox) bacteria primarily grow by the oxidation of ammonium coupled to nitrite reduction, using CO(2) as the sole carbon source. Although they were neglected for a long time, anammox bacteria are encountered in an enormous species (micro)diversity in virtually any anoxic environment that contains fixed-nitrogen. It has ...
Luo Qianyi Q Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, - - 2012
Basic leucine zipper (bZip) transcription factors regulate cellular gene expression in response to a variety of extracellular signals and nutrient cues. Although the bZip domain is widely known to play significant roles in DNA binding and dimerization, recent studies point to an additional role for this motif in the recruitment ...
Kim Young-Chan YC Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, - - 2013
We examined the role of ATP binding by six different ATPase subunits (Rpt1-6) in the cellular assembly and molecular functions of mammalian 26 S proteasome. Four Rpt subunits (Rpt1-4) with ATP binding mutations were incompetent for cellular assembly into 26 S proteasome. In contrast, analogous mutants of Rpt5 and Rpt6 ...
Bond Lyndal - - 2012
BACKGROUND: People living in areas of multiple deprivation are more likely to smoke and less likely to quit smoking. This study examines the effect on smoking and intention to quit smoking for those who have experienced housing improvements (HI) in deprived areas of Glasgow, UK, and investigates whether such effects ...
Li Songling - - 2012
Transcription-induced chimaeric transcripts, the potential post-transcriptional processing products, might reflect the spatial proximity of actively transcribed genes co-localized in transcription factories. A growing number of expression data deposited in databases provide us with the raw material for screening such chimaeric transcripts and using them as the probes to identify interactions ...
Xu Meihong - - 2012
With the multifaceted activities of nucleotides, there is a history of safe consumption of dietary nucleotides (NTs) in the human diet. This study investigated the multigenerations cumulative toxicity on rats' development after weaning. Weaning rats (F0) were fed with NTs at the dosage of 0.01, 0.04, 0.16, 0.64, and 1.28% ...
Srivastava Tarak - - 2012
Secondary hyperparathyroidism from inadequate calcium absorption in the gut, is the underlying pathophysiology for rachitic changes in hereditary vitamin D resistant rickets (HVDRR). We describe a novel use of Cinacalcet to treat a child with HVDRR in whom conventional modes of therapy had to be discontinued. Cinacalcet therapy with high ...
Dobner Bianca Carola - - 2013
The aim of this study was to assess the efficacy of adalimumab in patients with active non-infectious uveitis in three different centres. In a retrospective study we identified patients from our databases who were treated with adalimumab. The composite outcome measure for efficacy included reduction of macular oedema by optic ...
Enoki Ryosuke - - 2012
The circadian pacemaker in the hypothalamic suprachiasmatic nucleus (SCN) is a hierarchical multioscillator system in which neuronal networks play crucial roles in expressing coherent rhythms in physiology and behavior. However, our understanding of the neuronal network is still incomplete. Intracellular calcium mediates the input signals, such as phase-resetting stimuli, to ...
Zhang Ling-yun LY Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, No. 22 Qi-Xiang-Tai Road, Tianjin 300070, - - 2013
MicroRNAs (miRNAs) are considered to be regulators of various biological processes in cancers, including the epithelial to mesenchymal transition (EMT), which is a key factor in cancer metastasis. In this study, we aimed to clarify the potential roles of miR-490-3p in hepatocellular carcinoma (HCC) cells. Using real-time quantitative RT-PCR, we ...
Oner Sukru Sadik SS Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina 29425, - - 2013
Group II activators of G-protein signaling (AGS) serve as binding partners for Gα(i/o/t) via one or more G-protein regulatory (GPR) motifs. GPR-Gα signaling modules may be differentially regulated by cell surface receptors or by different nonreceptor guanine nucleotide exchange factors. We determined the effect of the nonreceptor guanine nucleotide exchange ...
De Swaef Tom T Department of Applied Ecology and Environmental Biology, Laboratory of Plant Ecology, Ghent University, Ghent, Belgium. - - 2013
Upward water movement in plants via the xylem is generally attributed to the cohesion-tension theory, as a response to transpiration. Under certain environmental conditions, root pressure can also contribute to upward xylem water flow. Although the occurrence of root pressure is widely recognized, ambiguity exists about the exact mechanism behind ...
Zhou Linsen - - 2012
The photodissociation of H2O in its B band is a prototype for non-adiabatic reaction dynamics. In addition to dissociation via the adiabatic pathway to the OH( 2) + H fragments, it also produces the OH( 2) + H fragments through two non-adiabatic pathways: the → transition via two conical intersections ...
Kojima Ryosuke - - 2012
Shine on: A new rational design strategy for near-infrared-emitting firefly luciferins that are available in vivo has been developed using intramolecular bioluminescence resonance energy transfer (BRET). The emission wavelength could be freely tuned by the choice of BRET acceptor, and NIR bioluminescence could be detected in living cells and mice ...
Weed Anna-Marie Karen - - 2012
Porous hybrid organo-silica monoliths have been prepared inside pretreated 100 μm id UV transparent fused-silica capillaries using simultaneous sol-gel transition and polymerization of 3-(methacryloyloxy)propyl trimethoxysilane in the presence of toluene as a porogen. The sol-gel reaction was catalyzed by hydrochloric acid while various photoinitiators including azobisisobutyronitrile, 2,2-dimethoxy-2-phenylacetophenone, and Irgacure 819 ...
Norris Francesca C - - 2012
Purpose: Worldwide efforts to understand developmental processes demand new high-resolution 3D imaging methods to detect the consequences of gene function in embryo development and diseases. Encouragingly, recent studies have shown that MRI contrast agents can highlight specific tissue structures in ex vivo adult mouse brains. MR imaging of mouse embryos ...
William-Faltaos Demiana - - 2012
This research aimed to quantitatively describe the natural progression of Alzheimer's disease (AD) based on ADAScog scores in patients with mild-to-moderate AD. ADAS-cog data from 10 placebo-controlled clinical trials including more than 2,400 patients with up to 72 weeks of treatment were used. Different models describing the time course of ...
Chee Soon-Phaik - - 2012
AIMS: To compare outcomes of indocyanine green angiography (ICGA) versus clinically monitored immunotherapy in Vogt-Koyanagi-Harada (VKH) disease. METHODS: Consecutive patients of Singapore National Eye Centre with VKH receiving high-dose corticosteroids within 4 weeks of onset of symptoms had therapy titrated to clinical signs of activity (controls) or ICGA findings (ICGA). ...
Sauermann Robert - - 2012
OBJECTIVES: Ertapenem pharmacokinetics were determined in the interstitium of healthy tissue and of infected tissue of patients suffering from diabetic foot infections, to evaluate if antibiotic concentrations at the target site are sufficient to achieve bacterial killing. PATIENTS AND METHODS: Nine patients with diabetic foot infections received 1 g of ...
Groarke Annmarie - - 2012
OBJECTIVE: This randomized controlled trial examines whether a briefer cognitive-behavioural (CBT) stress management intervention than the norm can reduce stress and distress and enhance benefit finding in women with breast cancer. It further aims to identify characteristics of those women most likely to benefit from the intervention. DESIGN AND METHOD: ...
Jia Husen H Plant Sciences Division, Research School of Biology, Australian National University, Canberra, Australian Capital Territory 0200 - - 2013
This study resolved correlations between changes in xanthophyll pigments and photosynthetic properties in attached and detached shade-grown avocado (Persea americana) leaves upon sun exposure. Lutein epoxide (Lx) was deepoxidized to lutein (L), increasing the total pool by ΔL over 5 h, whereas violaxanthin (V) conversion to antheraxanthin (A) and zeaxanthin ...
Wennberg Maria - - 2012
ABSTRACT: BACKGROUND: Fish consumption and intake of omega-3 fatty acids from fish are associated with a lower risk of cardiovascular disease. However, a prospective study from northern Sweden showed that high consumption of fish is associated with an increased risk of stroke in men, but not in women. The current ...
Bogavac M - - 2012
Abstract Objectives: To find out if determination of IL-4, IL-13 and IL-6 in amniotic fluid (AF) and serum in mid-pregnancy can be used as predictors of preterm delivery. Material and methods: The research has comprised 88 pregnant women at 16-24 weeks of gestation, who were subjected to early amniocentesis. Levels ...
Zhao Mei M Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611-0370, - - 2013
Vitamin B-6 deficiency has been reported to alter n-6 and n-3 fatty acid profiles in plasma and tissue lipids; however, the mechanisms underlying such metabolic changes remain unclear. The objective of this study was to determine the effects of vitamin B-6 restriction on fatty acid profiles and fatty acid synthesis ...
Near Jamie J Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Canada; FMRIB Centre, University of Oxford, Oxford, - - 2013
To investigate factors that influence the multiplet pattern observed in J-difference editing of gamma-aminobutyric acid (GABA). Density matrix simulations were applied to investigate the shape of the 3 ppm GABA multiplet as a function of the editing sequence's slice-selective refocusing pulse properties, in particular bandwidth, transition width, and flip angle. ...
Funck-Brentano Thomas - - 2012
OBJECTIVE: This study aimed to assess the ability of ultrasonography (US) to predict radiographic damage in early arthritis. METHODS: ESPOIR is a multicentric cohort of early arthritis (i.e. ò 2 swollen joints between 6 weeks and 6 months). US synovitis in B mode and power Doppler (PD) and erosions were ...
Zimorski Verena - - 2012
The human pathogen Trichomonas vaginalis harbors hydrogenosomes, organelles of mitochondrial origin that generate ATP through hydrogen-producing fermentations. They contain neither genome nor translation machinery, but approximately 500 proteins that are imported from the cytosol. In contrast to well-studied organelles like Saccharomyces mitochondria, very little is known about how proteins are ...
Qiu Ling - - 2012
Many applications proposed for graphene require multiple sheets be assembled into a monolithic structure. The ability to maintain structural integrity upon large deformation is essential to ensure a macroscopic material which functions reliably. However, it has remained a great challenge to achieve high elasticity in three-dimensional graphene networks. Here we ...
Blaine James W - - 2012
The growing concern over the potential use of biological agents as weapons and the continuing work of the Biological Weapons Convention has promoted an interest in establishing national biological laboratory biosafety and biosecurity monitoring programs. The challenges and issues that should be considered by governments, or organizations, embarking on the ...
Wu Shu-I - - 2012
ObjectiveTo investigate inpatient mortality and the use of invasive diagnostic and revascularization procedures after acute myocardial infarction (AMI) in people with schizophrenia and bipolar disorder.MethodsA case-control study was nested within the first AMI episodes between 1996 and 2007 using nationwide data. Participants with schizophrenia or bipolar disorder were compared with ...
Sacre Julian W JW School of Medicine, The University of Queensland, Brisbane, Australia. - - 2013
QT Variability and Sympathetic Dysinnervation.  The mechanism of adverse prognosis attributable to proarrhythmic cardiac sympathetic dysinnervation in patients with type 2 diabetes is incompletely understood. This study sought the association of cardiac sympathetic dysinnervation with temporal instability of ventricular repolarization assessed by beat-to-beat QT interval variability.  (123) I-metaiodobenzylguanidine ((123) I-MIBG) ...
Norton Peter J - - 2012
OBJECTIVE: The present study examines the effectiveness of a 12-week transdiagnostic cognitive-behavioral group in reducing comorbid diagnoses. METHOD: Data from 79 treatment completers (60.8% women; M age = 32.57 years) during three previous trials of transdiagnostic cognitive behavior therapy (CBT) were examined to compare treatment effects between those with and without ...
Ashida Akira - - 2012
We report the use of threedimensional computational analysis of chloride channel 5 (ClC-5) based on a novel mutation, L266V, identified in a 15-year-old Japanese boy with Dent's disease. Since both leucine and valine are branched-chain amino acids, it has not been proved conclusively whether L266V mutation is actually responsible for ...
Stephansen Anne B - - 2012
For a molecule to survive evolution and to become a key building block in Nature, photochemical stability is essential. The photolytically weak S-S bond does not immediately seem to possess that ability. We mapped the real time motion of the two sulfur radicals that result from disulfide photolysis on the ...
Zhang Tongwen - - 2012
APOBEC3s are a family of cytidine deaminases involved in innate cellular immunity against virus including hepatitis B virus (HBV). A germline deletion across APOBEC3A and APOBEC3B (A3B) genes results in complete removal of the A3B coding region and destroys A3B expression. To determine whether this deletion affects susceptibility to HBV ...
Gorjánácz Mátyás M European Molecular Biology Laboratory; Heidelberg, Germany. - - 2013
The transitions between the successive cell cycle stages depend on reversible protein phosphorylation events. The phosphorylation state of every protein within a cell is strictly determined by spatiotemporally controlled kinase and phosphatase activities. Nuclear disassembly and reassembly during open mitosis in higher eukaryotic cells is one such process that is ...
Xu Hao - - 2012
While imidazolium-based ionic liquids (ILs) combined with oxygen-containing anions were proposed as the potential solvents for the selective separation of acetylene (C2H2) and ethylene (C2H4), the detailed mechanism at the molecular level is still not well understood. The present work focuses on a most effective IL for removing C2H2 from ...
Jung Joohye - - 2012
We propose solution-processed In-Ga-Zn-O (IGZO) thin-film transistors (TFTs) with multi-stacked active layers for detecting artificial deoxyribonucleic acid (DNA). Enhanced sensing ability and stable electrical performance of TFTs were achieved through use of multi-stacked active layers. Our IGZO TFT had a turn-on voltage (Von) of -0.8 V and a sub-threshold swing ...
Shi Yandong - - 2012
ABSTRACT: BACKGROUND: Optimizing the safety and efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is of clinical relevance. Serum starvation in vitro and short-term food starvation in vivo both stress cells by the sudden depletion of paracrine growth stimulation. METHODS: The effects of serum starvation on CDDP toxicity were ...
Pierro Maria M Department of Pediatrics, Cardiovascular Research Center and Pulmonary Research Group, School of Human Development, Women and Children's Health Research Institute, University of Alberta, Edmonton, - - 2013
Bronchopulmonary dysplasia (BPD) remains a main complication of extreme prematurity and currently lacks efficient treatment. Rat bone marrow-derived mesenchymal stem cells (MSC) prevent lung injury in an oxygen-induced model of BPD. Human cord is an advantageous source of stem cells that is especially appealing for the treatment of neonatal diseases. ...
Miller Shawn M - - 2012
The absolute configurations of primary amines were assigned using a kinetic resolution strategy with Mioskowski's enantioselective 1-(R,R) and 2-(S,S) acylating agents. A simple mnemonic was developed to determine the configuration. A pseudoenantiomeric pair of reagents, 1-(R,R) and 2-(S,S)-d(3), was prepared and used to assay primary amines on a micromolar scale. ...
Zeng Wei - - 2012
Recently, FDA approved the clinical use of autologous fibroblasts (LAVIV(TM)) for the improvement of nasolabial fold wrinkles in adults. The use of autologous fibroblasts for dermal and subcutaneous defects augmentation represents a potentially exciting natural alternative to the use of other filler materials for its long-term corrective ability and absence ...
McGuinness Naomi - - 2012
Raynaud's phenomenon of the nipple is an unusual cause of severe nipple pain. Precipitants for Raynaud's phenomenon of the nipple are known to be cold temperatures, caffeine, and emotional stress. Nipple pain is quoted as the most common cause of cessation of breastfeeding. It is important that lactation consultants and ...
Leclerc Eric - - 2012
Fluoro-C-glycosides and fluoro-carbasugars are a particular subclass of hydrolytically stable glycomimetics that are expected to have different, hopefully improved properties thanks to the stereoelectronic features of the fluoroalkyl moiety. This review summarizes the studies devoted to the synthesis of such structures as well as the studies regarding their conformational behaviour ...
Eschenauer Gregory A GA Department of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. - - 2013
We studied whether fluconazole or echinocandin treatment of Candida glabrata fungaemia results in superior outcomes. A multicentre, retrospective study was performed with 224 adult patients who received ≥ 5 days of therapy with either fluconazole or an echinocandin as their first antifungal treatment after collection of a blood culture that ...
Choppin Sabine - - 2012
The classical Reformatsky reaction introduced for the first time in 1887 has been recognized as one among the most useful methods for C-C bond formation. Diastereoselective versions based on the use of chiral auxiliaries as well as enantioselective protocols using chiral ligands have been successfully developed during the last few ...
Wasterlain Amy S - - 2012
BACKGROUND:Platelet-rich plasma (PRP) is an autologous blood product used to treat acute and chronic tendon, ligament, and muscle injuries in over 86,000 athletes in the United States annually. The World Anti-Doping Agency (WADA) banned intramuscular PRP injections in competitive athletes in 2010 because of concerns that it may increase performance-enhancing ...
Taylor Kyle R - - 2012
Abstract To clarify how Borrelia miyamotoi is maintained in the environment in Hokkaido, we examined Ixodes persulcatus for its prevalence among wild rodents and its tick vector by detecting a portion of the borrelial flaB gene in rodent urinary bladder and blood samples, and from whole ticks. We compared B. ...
Bajaj Harsha - - 2012
The role of major porin, OmpPst1 of Providencia stuartii, in antibiotic susceptibility for two carbapenems is investigated combining high resolution conductance measurements, liposome swelling and microbiological assays. Reconstitution of single OmpPst1 into planar lipid bilayer and measuring the ion current, in the presence of imipenem, revealed a decrease in the ...
Takahashi Kei - - 2012
Chronic stress is well known to affect metabolic regulation. However, molecular mechanisms interconnecting stress response systems and metabolic regulations have yet to be elucidated. Various physiological processes, including glucose/lipid metabolism, are regulated by the circadian clock, and core clock gene dysregulation reportedly leads to metabolic disorders. Glucocorticoids, acting as end-effectors ...
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