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Vu T H Khanh - - 2012
PURPOSE: Primary uveal melanoma with a poor prognosis contain high numbers of infiltrating macrophages, especially of the M2 phenotype, as well as lymphocytes. We wondered whether local inflammatory responses were affected by irradiation and therefore determined the presence of inflammatory cells in uveal melanoma enucleated after prior irradiation. Methods: We ...
Wu Qiong - - 2012
AIMS: To isolate highly effective aerobic As(V)-reducing bacteria from arsenic(As)-contaminated soils in Northwest China and to identify their dynamic As(V) reduction processes and genomic detoxification mechanisms. METHODS AND RESULTS: Enrichment cultures were performed aerobically in TYEG medium in the presence of As(V). Strain SXB isolated from soil in Shanxi Province, ...
Shapaval V - - 2012
AIMS: The objective of the study was to evaluate a high-throughput liquid microcultivation protocol and FTIR spectroscopy for differentiation of food spoilage filamentous fungi. METHODS AND RESULTS: For the study, fifty nine food-related fungal strains were analyzed. The cultivation of fungi was performed in liquid medium in the Bioscreen C ...
Bell James - - 2012
For people seeking treatment, the course of heroin addiction tends to be chronic and relapsing, and longer duration of treatment is associated with better outcomes. Heroin addiction is strongly associated with deviant behaviour and crime, and the objectives in treating heroin addiction have been a blend of humane support, rehabilitation, ...
Marott S C W - - 2012
AIMS: Activation of angiotensin II receptor type 1 (AT(1)) has been shown to mediate the structural and electrical remodelling of the atrial myocardium associated with atrial fibrillation. We hypothesized that AT(1) genotypic variation is associated with atrial fibrillation or diseases predisposing to atrial fibrillation such as hypertension, heart failure, ischemic ...
He Rongrui - - 2012
Flexible Si p-i-n junction fibers made by high pressure chemical vapor deposition offer new opportunities in textile photovoltaics and optoelectronics, as exemplified by their photovoltaic properties, gigahertz bandwidth for photodetection, and ability to waveguide light.
Schweitzer Ryan W - - 2012
The acceptability of ceramic filters for point-of-use water treatment depends not only on the quality of the filtered water, but also on the quantity of water the filters can produce. This paper presents two mathematical models for the hydraulic performance of ceramic water filters under typical usage. A model is ...
Ryan Jennifer M - - 2012
Over the past 35 years, the outlook for a patient presenting with acute liver failure (ALF) has changed beyond all recognition. A patient presenting in 1984 had an 80 % likelihood of succumbing to intracranial hypertension. Today due to dramatic improvements in intensive care in dedicated liver transplant units, this has been ...
Burant Aniela - - 2012
Carbon capture and storage is a promising strategy for mitigating the CO2 contribution to global climate change. The large scale implementation of the technology mandates better understanding of the risks associated with CO2 injection into geologic formations and the subsequent interactions with groundwater resources. The injected supercritical CO2 (sc-CO2) is ...
Geva Esther - - 2012
The overall objective of this article is to examine how oral language abilities relate to reading profiles in English language learners (ELLs) and English as a first language (EL1) learners, and the extent of similarities and differences between ELLs and EL1s in three reading subgroups: normal readers, poor decoders, and ...
Jensen Christopher - - 2012
Platinum clusters supported on KL zeolites were characterized by EPR, HRTEM, and EXAFS. Two kinds of hydrogen chemisorption experiments both result in a saturation value of 2.9 hydrogen atoms per platinum atom, significantly more than that reported so far. A hydrogen coverage-dependent cluster restructuring is suggested.
Nicolai Annegret - - 2012
In ectotherms, the temperature changes that accompany climate shifts, microhabitat changes, and species range extensions can have profound effects on the performance of organisms. The aim of this laboratory study on the terrestrial invasive gastropod Cornu aspersum was to investigate the effect of dietary calcium source on egg shell structure ...
Sauermann Robert - - 2012
OBJECTIVES: Ertapenem pharmacokinetics were determined in the interstitium of healthy tissue and of infected tissue of patients suffering from diabetic foot infections, to evaluate if antibiotic concentrations at the target site are sufficient to achieve bacterial killing. PATIENTS AND METHODS: Nine patients with diabetic foot infections received 1 g of ...
Linder Nehama - - 2012
AIM: Vancomycin is widely used to treat late-onset coagulase-negative Staphylococcus (CoNS) sepsis in very-low-birth-weight (VLBW) infants. Although vancomycin is associated with a risk of toxicity and bacterial resistance, the appropriate duration of use has not been established. This study sought to investigate the association between the duration of vancomycin therapy ...
Ahlers Sabine Jgm - - 2012
AIM: The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected healthy volunteers' pain sensitivity upon experimental pain stimuli. The relevance of these findings in morphine-treated postoperative cardiac patients undergoing painful healthcare procedures is unknown. Therefore, the aim of this study was to investigate whether the COMT Val158Met polymorphism increases pain sensitivity in morphine-treated ...
Groarke Annmarie - - 2012
OBJECTIVE: This randomized controlled trial examines whether a briefer cognitive-behavioural (CBT) stress management intervention than the norm can reduce stress and distress and enhance benefit finding in women with breast cancer. It further aims to identify characteristics of those women most likely to benefit from the intervention. DESIGN AND METHOD: ...
Wennberg Maria - - 2012
ABSTRACT: BACKGROUND: Fish consumption and intake of omega-3 fatty acids from fish are associated with a lower risk of cardiovascular disease. However, a prospective study from northern Sweden showed that high consumption of fish is associated with an increased risk of stroke in men, but not in women. The current ...
Bogavac M - - 2012
Abstract Objectives: To find out if determination of IL-4, IL-13 and IL-6 in amniotic fluid (AF) and serum in mid-pregnancy can be used as predictors of preterm delivery. Material and methods: The research has comprised 88 pregnant women at 16-24 weeks of gestation, who were subjected to early amniocentesis. Levels ...
Near Jamie - - 2012
Purpose: To investigate factors that influence the multiplet pattern observed in J-difference editing of gamma-aminobutyric acid (GABA). Methods: Density matrix simulations were applied to investigate the shape of the 3 ppm GABA multiplet as a function of the editing sequence's slice-selective refocusing pulse properties, in particular bandwidth, transition width, and ...
Funck-Brentano Thomas - - 2012
OBJECTIVE: This study aimed to assess the ability of ultrasonography (US) to predict radiographic damage in early arthritis. METHODS: ESPOIR is a multicentric cohort of early arthritis (i.e. ò 2 swollen joints between 6 weeks and 6 months). US synovitis in B mode and power Doppler (PD) and erosions were ...
Zimorski Verena - - 2012
The human pathogen Trichomonas vaginalis harbors hydrogenosomes, organelles of mitochondrial origin that generate ATP through hydrogen-producing fermentations. They contain neither genome nor translation machinery, but approximately 500 proteins that are imported from the cytosol. In contrast to well-studied organelles like Saccharomyces mitochondria, very little is known about how proteins are ...
Zhang Chunjuan - - 2012
A ZIF-9-67 hybrid membrane on α-Al(2)O(3) support was prepared using mixed-linker synthesis. The gas permeation and selectivity data demonstrate that this membrane may have potential applications for efficient CO(2) capture from several industrial mixtures.
Santos-Carvalho Ana - - 2012
PURPOSE. Neuropeptide Y (NPY) is one of the most abundant peptides in the central nervous system (CNS), including the retina. This peptide activates various different G-coupled receptors (NPY Y(1), Y(2), Y(4) and Y(5)) that are also present in the retina. However, the localization of NPY receptors in the several types ...
Singhal Pallavi - - 2012
Cervical cancer is one of the most common gynecological malignancies that causes a serious health problem worldwide. The aim of the present study was to analyze the association of p53 codon72 (arginine/proline) polymorphism (rs1042522) and Murine Double Minute 2 (MDM2) SNP309 T/G (rs2279744) with the advancement of cervical cancer by ...
Patel Anisha N - - 2012
Graphite-based electrodes (graphite, graphene and nanotubes) are used widely in electrochemistry, and there is a long-standing view that graphite step edges are needed to catalyze many reactions, with the basal surface considered to be inert. Herein, this model is tested directly, for the first time, using scanning electrochemical cell microscopy ...
Yang Chuan-Lu - - 2012
Using the multi-reference configuration interaction method with a Davidson correction and a large orbital basis set (aug-cc-pV5Z), we obtain an energy grid that includes 17,000 points for the construction of a new analytical potential energy surface (APES) for the N((2)D) + H(2)(X(1)Σ(g)(+))->NH(X(3)Σ(-)) + H((2)S) reaction. The APES containing 145 parameters ...
Latronico Mario - - 2012
The reactivity of the phosphinito bridged Pt(i) complex [(PHCy(2))Pt(1)(μ-PCy(2)){κ(2)P,O-μ-P(O)Cy(2)}Pt(2)(PHCy(2))](Pt-Pt) () towards Au(i) and Ag(i) electrophiles was explored. Treatment of with AuCl yielded the dichloro Pt(ii) complex [(Cl)(PHCy(2))Pt(μ-PCy(2)){κ(2)P,O-μ-P(O)Cy(2)}Pt(Cl)(PHCy(2))] (), while [Au(PPh(3))Cl] in thf (or toluene) caused ligand exchange resulting in the formation of [(PPh(3))Pt(μ-PCy(2)){κ(2)P,O-μ-P(O)Cy(2)}Pt(PHCy(2))](Pt-Pt) () and [(PPh(3))Pt(μ-PCy(2)){κ(2)P,O-μ-P(O)Cy(2)}Pt(PPh(3))](Pt-Pt) (). With [Au(PPh(3))OTf] (independently ...
Dimova Dilyana - - 2012
A library of 484 imidazole-based candidate inhibitors was tested against a panel of 24 protein kinases. The resulting activity data have been systematically analyzed to search for compounds that effectively differentiate between kinases. Six imidazole derivatives with high kinase differentiation potential were identified. Nearest neighbor analysis revealed the presence of ...
Menzen Tim - - 2012
Differential scanning fluorimetry (DSF) is successfully used as a high-throughput screening method for the analysis of the protein melting temperature (T(m) ) in the development of therapeutic monoclonal antibody (MAb) formulations. Typically, surfactants are utilized in MAb formulations as a stabilizer, but the commonly applied polarity-sensitive dye SYPRO® Orange shows ...
Abdelmaaboud Mohamed - - 2012
Abstract Background: Preterm and growth-restricted babies are at high risk of milk intolerance and necrotising enterocolitis, as well as post-natal growth failure. Objective: To evaluate the effects of an "early" enteral feeding regimen, starting on day 2 after birth compared to late enteral feeding, starting on day 6 after birth ...
Bagai Sampada - - 2012
The aggregation of DNA molecules induced by cationic polymers is of importance to applications in gene delivery. In this work, we performed a series of umbrella sampling molecular dynamics simulations to calculate the potential of mean force (PMF) between two DNA molecules in the presence of polyethylenimine (PEI) molecules using ...
Rasmussen Jeppe Grøndahl - - 2012
Background: Treatment of myocardial infarction with bone marrow-derived mesenchymal stem cells and recently also adipose-derived stem cells has shown promising results. In contrast to clinical trials and their use of autologous bone marrow-derived cells from the ischemic patient, the animal myocardial infarction models are often using young donors and young, ...
Jaskolski Dariusz J - - 2012
The aim of our study was to evaluate the frequency of deletions on chromosomes 1, 9, 10, 14, 18 and 22 in 75 benign and 15 atypical meningiomas and correlate them with clinical findings. Paired normal and tumor DNA samples were analyzed for loss of heterozygosity (LOH), using 24 microsatellite ...
Chan Cliffton - - 2012
BACKGROUND: Musculoskeletal problems are common in professional orchestral musicians, and little is known about effective prevention strategies. Exercise is suggested to help in reducing work-related upper limb disorders and accordingly a trial of a specific exercise programme for this population was planned. Formative and process evaluation procedures were undertaken during ...
Rajan Deepa S - - 2012
A 10-month-old full-term baby girl was transferred to our tertiary care hospital for respiratory distress and hypoxemia. Developmental history revealed significant motor delay. On physical examination, she was noted to be hypotonic, to be dysmorphic with macroglossia, and to have hepatomegaly.
Sanghamitra Nusrat J M - - 2012
Bioinorganic chemistry is of growing importance in the fields of nanomaterial science and biotechnology. Coordination of metals by biological systems is a crucial step in intricate enzymatic reactions such as photosynthesis, nitrogen fixation and biomineralization. Although such systems employ protein assemblies as molecular scaffolds, the important roles of protein assemblies ...
Morton James D - - 2012
PURPOSE: To use sheep with an autosomal dominant gene for cortical cataract as an animal model to evaluate novel macrocyclic calpain inhibitors with potential for the medical treatment of human cataract. METHODS: The macrocyclic aldehyde CAT811, previously identified as a calpain inhibitor that prevents calcium-induced opacification in cultured sheep lenses, ...
Domiciano Ds - - 2012
OBJECTIVE: Vertebral fractures(VF) are associated with higher morbidity and mortality. Since 70% of VF are clinically silent, a radiologic image of the spine has to be acquired for the diagnosis. The aim of this study was to compare the performance of Vertebral Fracture Assessment(VFA) by DXA with X-ray to identify ...
Moreau Jonathan - - 2012
In this work, the physico-chemical phenomena occurring during equilibrium impregnation of Anderson-like decamolybdocobaltate H4Co2Mo10O386- heteropolyanions aqueous solutions over γ-Al2O3 were described in details crossing chemical analysis, pH measurements, Raman and UV-Vis spectra. For a surface density lower than 2.5 Mo atoms nm-2, the buffering effect of the support leads to ...
Wong Weng Kit - - 2012
Background: Chronic toxoplasmosis has been shown to be strongly associated with a range of neuropsychiatric effects including schizophrenia and suicide. However there have not been any prospective, community-based studies of the neuropsychiatric effects of acute toxoplasmosis in adult immunocompetent patients. Methods: Adult patients with a positive serum IgM anti-Toxoplasma gondii ...
Hamano Nobuhito - - 2012
Encapsulating anticancer drugs in liposomes improves their therapeutic window by enhancing antitumor efficacy and reducing side effects. To devise more effective liposomal formulations for antitumor therapy, many research groups have tried to develop tumor-targeting liposomes with enhanced drug release. Previously, we developed doxorubicin (Dox)-encapsulated AG73 peptide-modified liposomes (AG73-Dox), which targeted ...
Kisch Horst - - 2012
Preceding work on photoelectrochemistry at semiconductor single-crystal electrodes has formed the basis for the tremendous growth in the three last decades in the field of photocatalysis at semiconductor powders. The reason for this is the unique ability of inorganic semiconductor surfaces to photocatalyze concerted reduction and oxidation reactions of a ...
Shao Heng - - 2012
Despite many experimental and clinical studies conducted on distraction osteogenesis (DO) in the past decade, changes in the surrounding tissues that occur after the procedure remains poorly understood. To study the biochemical changes of recovery in nerve tissues upon DO-induced nerve injury, we prepared a rabbit model of tibia lengthening ...
Gooday C - - 2012
AIMS: To develop an antibiotic foot formulary for the empirical treatment of diabetes-related foot infections presenting to our service. Subsequently, to asses costs associated with the introduction of our protocol, in particular to assess the effect on admissions avoidance and any cost savings achieved. METHODS: We reviewed several existing antibiotic ...
Dawes Lucy Jean - - 2012
PURPOSE: Cataract surgery is blighted by posterior capsule opacification (PCO). Our aim was to understand the biological basis for age-related differences in PCO/wound healing rates. METHODS: Human capsular bags were prepared by sham cataract surgery on donor lenses. FGF and HGF levels were determined using ELISA. Protein synthesis rates were ...
Gomez Daniel R - - 2012
BACKGROUND: Nausea and vomiting (N/V) during chemotherapy can have profound clinical and economic consequences. Effective antiemetic agents are available for prophylaxis, but barriers may prevent their use. For this population-based study, the authors assessed the rates of antiemetic prophylaxis use, and predictors of such use, among patients who were receiving ...
Klein Marina B - - 2012
BACKGROUND: The recent availability of new direct acting antivirals (DAAs) for HCV treatment which dramatically increase sustained virologic response rates for genotype 1 HCV infection has brought new optimism with respect to curative HCV treatment for HIV-HCV co-infected patients. We describe the characteristics of co-infected patients who could be eligible ...
Li Meng - - 2012
Splitting the C-C bond is the main obstacle to electrooxidation of ethanol (EOR) to CO2. We recently demonstrated that the ternary PtRhSnO2 electrocatalyst can accomplish that reaction at room temperature with Rh having a unique capability to split the C-C bond. In this article we report the finding that Ir ...
Sheffield Chava - - 2012
PURPOSE: The United States faces a growing population of older adults and accompanying functional disabilities, coupled with constrained public resources and diminishing informal supports. A variety of interventions that aim to improve client outcomes have been studied, but to date, there is limited translational research that examines the efficacy of ...
Shimon Ginath - - 2012
Abstract Objective: To describe the normal appearance and the growth of the fetal vermis, pons and midline brainstem by ultrasound from 18 weeks of gestation to term in order to produce developmental nomograms. Methods: Serial ultrasound examinations of the fetal brain were performed in 21 fetuses between 18 and 39 ...
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