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Results 601 - 650 of 2633
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He Xiaosheng - - 2012
Abstract This study was conducted to explore the effect of adipose-derived stem cells (ASCs) on the graft survival rates of fat particles in rabbits. Six domestic rabbits were used for a 3-month study; 1.4 grams of fat tissues were harvested from the bilateral inguinal regions of each animal. They were ...
Gallo Gabriele - - 2012
Aim There is still no consensus about the optimal surgical approach for esophageal replacement in the case of long-gap esophageal atresia (LGEA) or extensive corrosive strictures. The aim of this article was to perform a meta-analysis comparing the most widely used techniques for esophageal replacement in children: jejunal interposition (JI), colon ...
Mita M M - - 2012
BackgroundRidaforolimus is an inhibitor of mTOR with evidence of antitumor activity in an I.V. formulation. This multicenter, open-label, 3 + 3 design nonrandomized, dose-escalation, phase I/IIa trial was conducted to determine the safety, pharmacokinetic (PK) and pharmacodynamic parameters, maximum tolerated dose, and antitumor activity of oral ridaforolimus.Patients and methodsPatients with metastatic or ...
Zhang Qiang - - 2012
A convenient efficient method for synthesis of a flexible cyclic polyamide (cβ, 1) was developed through cyclodimerization. Electrospray ionization mass spectrometry and nuclear magnetic resonance results showed that 1 selectively binds to the c-myb G-quadruplex with high affinity, and there was no binding with the ILPR, bcl-2, and c-kit G-quadruplexes. ...
Lu Meng-Yao - - 2012
Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and can theoretically be imaged by (18)F-fluorodihydroxyphenylalanine ((18)F-FDOPA) PET, a new diagnostic tool for neuroendocrine tumors. In this study, we explored the accuracy and clinical role of (18)F-FDOPA PET in neuroblastic tumors. METHODS: From 2008 to 2011, patients ...
Helm M - - 2012
BACKGROUND: Pre-hospital tracheal intubation (TI) is an important but difficult procedure with the potential to produce hypoxaemia. The aim of this study was to determine the incidence of desaturation episodes during out-of-hospital rapid sequence induction (RSI) and TI by the medical team of a German Helicopter Emergency Medical Service (HEMS). ...
Li Han - - 2012
BACKGROUND: Vagus nerve stimulation is capable of regulating autonomic nerve function. In Traditional Chinese Medicine, the effect of auricular acupuncture (AA) is mediated by the vagus. This study was designed to investigate the effect of AA on gastrointestinal (GI) motility and the relationship of this effect with the vagus nerve. ...
Clegg William - - 2012
Five novel neutral homometallic complexes which contain the anthracen-9-olate anion have been prepared and characterised by treating anthrone with an organometallic base to induce aromatisation. Three of these complexes [(donor)·M(OC(14)H(9))](2) () are dimeric and contain sodium, lithium and potassium respectively. For and the donor is N,N,N',N'-tetramethylethylenediamine (TMEDA) whilst for it ...
Condie Joy - - 2012
BACKGROUND: As the likelihood of survival improves over time, the BW- and GA-specific boundaries of discretionary non-resuscitation should fall. HYPOTHESIS: Between 1988 and 2008 reductions in BW- and GA- specific mortality would drive a parallel reduction in BW and GA boundaries of discretionary resuscitation. METHODS: We determined the likelihood of ...
Johnson Kevin M - - 2012
PURPOSE: To optimize 3D radial ultrashort echo time MRI for high resolution whole-lung imaging. METHODS: 3D radial ultrashort echo time was implemented on a 3T scanner to investigate the effects of: (1) limited field-of-view excitation, (2) variable density readouts, and (3) radial oversampling. Improvements in noise performance and spatial resolution ...
Terryn Christine - - 2012
The spatial organization of proteins in a cell population or in tissues is an important parameter to study the functionality of biological specimens. In this article, we have focused on tight junctions which form network-like features in immunofluorescence microscopy images. Usually, the organization or disorganization of tight junctions is noticed ...
Chuang Chia-Chi - - 2012
The objective of this study was to determine the anti-inflammatory properties of grape powder (GP) or GP extract (GE). We examined 1) which polyphenol metabolites in GE were bioavailable, 2) the impact of GP and GE on glucose tolerance and inflammation in obese mice, and 3) if bioavailable polyphenols in ...
Zhu Cun - - 2012
This paper describes a synthesis of Au wavy nanowires in an aqueous solution in the presence of cetyltrimethylammonium bromide (CTAB). The resultant Au nanowires automatically separated from the solution and floated at the air/water interface. We investigated the formation mechanism by characterizing the samples obtained at different stages of the ...
Scapini Annarosa - - 2012
Abstract Objective: To test the hypothesis that malocclusion does not have an independent and negative effect on quality of life of adolescents. Materials and Methods: The cross-sectional design study comprised a sample of 519 children, aged 11 to 14 years, attending public schools in Osorio, a city in southern Brazil. One ...
Chen Chia-Hsiang - - 2012
Reaction of PPh(2)(o-C(6)H(4))(CH(2)NMeCH)C(60) () and (μ-H)(3)Re(3)(CO)(11)(NCMe) in refluxing chlorobenzene affords the monorhenium complex HRe(CO)(3)(η(3)-PPh(2)(o-C(6)H(4))(CH(2)NMeCH)C(60)) (), and the dirhenium complexes (μ-H)Re(2)(CO)(7)(μ,η(3)-PPh(o-C(6)H(4))(2)(CH(2)NMeCH)C(60)) () and (μ-H)Re(2)(CO)(5)(μ-SSOH)(μ,η(5)-PPh(2)(o-C(6)H(4))(CH(2)NMeCH)C(60)) (). The structures of have been determined by an X-ray diffraction study. The oxatrisulfanyl (-SSOH) ligand of likely arises from decomposition of CS(2) on silica gel during ...
Ramos Santiago L Ferreyra - - 2012
• Premise of the study: Microsatellite loci were developed for tucumã of Amazonas (Astrocaryum aculeatum), and cross-species amplification was performed in six other Arecaceae, to investigate genetic diversity and population structure and to provide support for natural populations management.• Methods and Results: Fourteen microsatellite loci were isolated from a microsatellite-enriched ...
Baljuls Angela - - 2012
Raf kinases function downstream of Ras proteins to activate the MEK-ERK pathway which is deregulated in a large number of human cancers. Raf inhibitors are clinically highly effective for the treatment of cancer and melanoma in particular, but have unexpected side effects that include a paradoxical activation of the ERK ...
Leyva Margarita - - 2012
Human foetal mesenchymal stem cells can be isolated from amniotic membrane (AM-hMSCs) by enzymatic digestion. The biological properties of this cell population have been characterised; however, few studies have focused on the presence of stem cell subpopulations and their differentiation potential. The aim of the present study was to isolate ...
Asberg Johnels Jakob - - 2012
Writing difficulties are common among children with attention-deficit/hyperactivity disorder (ADHD), but the nature of these difficulties has not been well studied. Here we relate behavioral, psycholinguistic, cognitive (memory/executive), and graphomotor measures to spelling skills in school-age girls with ADHD (n = 30) and an age-matched group of typically developed spellers ...
Schaming Delphine - - 2012
An electrosynthesis process has allowed the formation of four oligomers, containing three, four, or five macrocycles. This method is based on the nucleophilic attack of porphyrins substituted by several pendant pyridyl groups to the electrogenerated radical cation of zinc β-octaethylporphyrin (ZnOEP), according to an ECEC processes. Thus, a control of ...
Han Jae Hyo - - 2012
This review presents recent advances in synthetic methods and structural transformations of colloidal 2D layered metal chalcogenide nanocrystals. Planar 2D anisotropy and interlayer van der Waals gaps are the important characteristics of these nanocrystals for pristine disc, plate or sheet morphologies. These 2D nanocrystals undergo unique chemical transformations upon exposure ...
Bonnelye E - - 2012
Estrogen receptor related receptor alpha (ERRα) is an orphan nuclear receptor with sequence homology to the estrogen receptors, ERα/β, but it does not bind estrogen. ERRα not only plays a functional role in osteoblasts but also in osteoclasts and chondrocytes. As well, the ERRs, including ERRα, can be activated by ...
Zhang Jingtao - - 2012
A primary consideration when developing lipid nanoparticle (LNP) based small interfering RNA (siRNA) therapeutics is formulation polydispersity or heterogeneity. The level of heterogeneity of physicochemical properties within a pharmaceutical batch could greatly affect the bioperformance, quality, and ability of a manufacturer to consistently control and reproduce the formulations. This article ...
Bovi Michele - - 2012
A novel lectin was purified from the fruiting bodies of king bolete mushrooms (Boletus edulis, also called porcino, cep or penny bun). The lectin was structurally characterized: its amino acid sequence and three dimensional structure were determined. The new protein is a homodimer and each protomer folds as β-trefoil domain ...
Mildner Alexander - - 2012
The mononuclear phagocyte system comprises cells as diverse as monocytes, macrophages and dendritic cells (DCs), which collectively play key roles in innate immune responses and the triggering of adaptive immunity. Recent studies have highlighted the role of growth and transcription factors in defining developmental pathways and lineage relations within this ...
Estévez Verónica - - 2012
A sequential multicomponent process involving the high-speed vibration milling of ketones with N-iodosuccinimide and p-toluenesulfonic acid, followed by addition of a mixture of primary amines, β-dicarbonyl compounds, cerium(iv) ammonium nitrate and silver nitrate afforded polysubstituted, functionalized pyrroles. This one-pot, solid-state process can be considered as the coupling of an α-iodoketone ...
Li Lu - - 2012
A very facile, general, and reproducible method is developed for the controlled synthesis of discrete and monodisperse concentric and eccentric poly(acrylic acid) (PAA)-coated nanostructures in a large-scale, independent of their size, geometry, or composition. Interestingly, the reversible structural transformation between concentricity and eccentricity can be easily achieved, which is determined ...
Reidunsdatter Randi J - - 2012
Introduction. Fatigue after treatment for breast cancer (BC) is common, but poorly understood. We examined the fatigue levels during first year after radiotherapy (RT) according to the extent of RT (local or locoregional), hormonal therapy (HT) and chemotherapy (CT). The impact of comorbidity was also explored. Moreover, we compared fatigue ...
Alves Tp - - 2012
SUMMARY External cervical resorption (ECR) is a sequela of dentoalveolar trauma that may cause functional, esthetic, and psychologic alterations. The aim of this study was to report a successful multidisciplinary treatment approach performed in a 12-year-old patient who presented with posttraumatic ECR associated with extensive opened cavity, pulp necrosis, and ...
Jenner Matthew - - 2012
Branching out: The substrate specificity profiles for a range of ketosynthase (KS) domains from trans-AT PKSs are reported. Evidence is provided that a sterically demanding amino acid residue adjacent to the active-site Cys residue confers specificity towards non-β-methyl-branched substrates.
Hazan-Molina Hagai - - 2012
Abstract Objective. The aim was to review the literature on aggressive periodontitis diagnosed during or before the initiation of orthodontic treatment and to propose preventive recommendations before, during and after orthodontic treatment. Materials and methods. Literature searches of free text and MeSH terms were performed by using PubMed, Embase and ...
Wintermann Frank - - 2012
Hooking up: Subunit γ of an F-ATPase with 11 point mutations was ligated chemically from six peptides and then reconstituted with further subunits of the (αβ)(3) γ catalytic core complex. The biologically active protein with 286 residues currently represents the longest nonredundant polypeptide chain synthesized by chemical means. The yields ...
Efremenko Irena - - 2012
Metal oxides as a rule oxidize and oxygenate substrates via the Mars-van Krevelen mechanism. A well-defined α-Keggin polyoxometalate, H5PV2Mo10O40, can be viewed as an analog of discreet structure that reacts via the Mars-van Krevelen mechanism both in solution and the gas phase. Guided by previous experimental observations we have studied ...
Walker Susanna T - - 2012
Simulation-based training for healthcare providers is well established as a viable, efficacious training tool, particularly for the training of non-technical team-working skills. These skills are known to be critical to effective teamwork, and important in the prevention of error and adverse events in hospitals. However, simulation suites are costly to ...
Herrmann Joerg - - 2012
BACKGROUND: HIGH SENSITIVITY C-REACTIVE PROTEIN (HSCRP) HAS BEEN IDENTIFIED AS A PREDICTOR OF ADVERSE CARDIOVASCULAR OUTCOMES. WHETHER HSCRP IS A USEFUL BIOMARKER FOR RISK STRATIFICATION IN CONTEMPORARY PERCUTANEOUS CORONARY INTERVENTION REMAINS UNKNOWN.METHODS AND RESULTS: WE CONDUCTED A PROSPECTIVE STUDY AMONG 513 PATIENTS UNDERGOING NON-EMERGENCY PERCUTANEOUS CORONARY INTERVENTION AND EXAMINED THE ...
Gatt Alfred - - 2012
Background:The assessment of the maximum ankle dorsiflexion angle is an important clinical examination procedure. Evidence shows that the traditional goniometer is highly unreliable, and various designs of goniometers to measure the maximum ankle dorsiflexion angle rely on the application of a known force to obtain reliable results. Hence, an innovative ...
He Haiyong - - 2012
An innovative approach is developed for the high-throughput, large-area, and low-cost fabrication of reduced graphene oxide (RGO) nanoribbon networks by using electrospun polymer-based nanowires as the etching mask. Combined with their tunable, controllable structures and transmittance/conductivity properties, the as-fabricated RGO nanoribbon networks exhibit potential as transparent conductive film electrodes, for ...
Kadokura Takeshi - - 2012
Background: Darexaban is a potent direct factor Xa (FXa) inhibitor developed for prophylaxis of venous and arterial thromboembolic disease. This drug is rapidly and extensively metabolized to darexaban glucuronide (YM-222714), which is a pharmacologically active metabolite. The potential effects of food on the harmacokinetics of darexaban glucuronide after darexaban administration ...
Koh K H - - 2012
The purpose of this study was to find out whether the carpal indices measured on lateral radiographs with a slightly malpositioned wrist are the same as those measured in the true neutral position. Lateral radiographic views of 25 wrists were taken with 5° intervals from 20° of flexion to 20° ...
Newbold C James - - 2012
Concentrations of Na(+) , K(+) and Ca(2+) in the growth medium were varied within limits normally found in vivo to determine how cation concentrations affect the sensitivity of ruminal bacteria to the ionophores, monensin (a Na(+) /H(+) and K(+) /H(+) exchanger) and tetronasin (Ca(2+) /H(+) ). High [Na(+) ] (172 mM ...
Zhou Xiao-Yu - - 2012
ABSTRACT: BACKGROUND: Prognostic assessment is important for the management of patients with acute pulmonary embolism (APE). Pulmonary Embolism Severity Index (PESI) and simple PESI (sPESI) are new emerged prognostic assessment tools for APE. The aim of this meta-analysis is to assess the accuracy of the PESI and the sPESI to ...
Jung Young H - - 2012
The BK virus (BKV) can be reactivated with immunosuppressive treatment in renal allograft recipients, which can result in interstitial nephritis (BKV-associated nephropathy, BKVAN) and lead to renal allograft failure. Recently, leflunomide has been reported in some case series of BKVAN with favorable results. Most studies have included only adult patients, ...
Cochrane Stephen A - - 2012
A systematic study of the ring-closing metathesis (RCM) of unprotected oxytocin and crotalphine peptide analogues in water is reported. The replacement of cysteine with S-allyl cysteine enables RCM to proceed readily in water containing excess MgCl(2) with 30% t-BuOH as a co-solvent. The presence of the sulfur atom is vital ...
Zhang Qian-Qian - - 2012
A highly efficient asymmetric hydrogenation of α-substituted α,β-unsaturated acyclic ketones catalyzed by chiral spiro iridium complexes for the preparation of chiral 2-substituted allylic alcohols has been developed (ee up to 99.7%). This method provides a concise route to (-)-mesembrine (34% yield, 12 steps).
Savarimuthu Francis Santiyagu M - - 2012
Alterations in innate immunity that predispose to chronic obstructive pulmonary disease (COPD) exacerbations are poorly understood. We examined innate immunity gene expression in peripheral blood polymorphonuclear leukocytes (PMN) and monocytes stimulated by Haemophilus influenzae and Streptococcus pneumoniae. Thirty COPD patients (15 rapid and 15 non-rapid lung function decliners) and 15 ...
Odimegwu Clifford - - 2012
In the bid to explain reproductive health outcomes in most developing countries, men have often been seen as the cause of the problem. However, no systematic attempt has been made to examine men's perception of their own social and health needs, including how ideologies of masculinity impact men's social and ...
Waldron Bradley P - - 2012
Pre-organised tricarboxylate ligands based on 6-amino-perhydro-1,4-diazepine bind (68)Ga rapidly and selectively in acetate buffer at pH 4 to 7, forming kinetically stable complexes suitable for use in PET imaging.
Huang Huahua - - 2012
The molecular structural design learned from natural materials enables synthetic polymers with desirable and unique features to be fabricated. Inspired by spider silks, short-chain polyalanine (PA) is introduced into multiblock biopolymers with poly(ε-caprolactone) segments via a coupling reaction. As a result, PA segments in biopolymers form similar β-sheet crystals to ...
Livingston George - - 2012
One of the simplest hypotheses used to explain species coexistence is the competition-colonization trade-off, that is, species can stably coexist in a landscape if they show a trade-off between competitive and colonization abilities. Despite extensive theory, the dynamics predicted to result from competition-colonization trade-offs are largely untested. Landscape change, such ...
Dalip Janelle - - 2012
The elderly have a higher mortality rate during heat waves and may, therefore, have higher morbidity. We investigated the effects of high ambient environmental temperature on emergency department (ED) function and patient (age >64 years) morbidity. A retrospective case-control study of ED presentations at an Australian metropolitan hospital from September ...
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