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Choppin Sabine - - 2012
The classical Reformatsky reaction introduced for the first time in 1887 has been recognized as one among the most useful methods for C-C bond formation. Diastereoselective versions based on the use of chiral auxiliaries as well as enantioselective protocols using chiral ligands have been successfully developed during the last few ...
Wasterlain Amy S - - 2012
BACKGROUND:Platelet-rich plasma (PRP) is an autologous blood product used to treat acute and chronic tendon, ligament, and muscle injuries in over 86,000 athletes in the United States annually. The World Anti-Doping Agency (WADA) banned intramuscular PRP injections in competitive athletes in 2010 because of concerns that it may increase performance-enhancing ...
Taylor Kyle R - - 2012
Abstract To clarify how Borrelia miyamotoi is maintained in the environment in Hokkaido, we examined Ixodes persulcatus for its prevalence among wild rodents and its tick vector by detecting a portion of the borrelial flaB gene in rodent urinary bladder and blood samples, and from whole ticks. We compared B. ...
Bajaj Harsha - - 2012
The role of major porin, OmpPst1 of Providencia stuartii, in antibiotic susceptibility for two carbapenems is investigated combining high resolution conductance measurements, liposome swelling and microbiological assays. Reconstitution of single OmpPst1 into planar lipid bilayer and measuring the ion current, in the presence of imipenem, revealed a decrease in the ...
Takahashi Kei - - 2012
Chronic stress is well known to affect metabolic regulation. However, molecular mechanisms interconnecting stress response systems and metabolic regulations have yet to be elucidated. Various physiological processes, including glucose/lipid metabolism, are regulated by the circadian clock, and core clock gene dysregulation reportedly leads to metabolic disorders. Glucocorticoids, acting as end-effectors ...
Tripathy Mukta - - 2012
Microscopic integral equation theory is applied to investigate the real and Fourier space structure and phase behavior of compositionally symmetric AB Janus rods that interact via hard core excluded volume interactions and competing repulsive and attractive tail potentials. If the spatial range of the latter are short and equal, chemical ...
Cvetkovic Benjamin Z - - 2012
We present a novel microchip-based approach to combine the synthesis, characterization and utilization of different functional materials on a single platform. A two-layer microfluidic device comprising ten parallel actuated reaction chambers with volumes of a few hundred picoliters is used to localize and confine the synthesis, while the surfaces of ...
Digilio Mc - - 2012
Noncompaction of the left ventricle is a cardiomyopathy characterized by prominent left ventricular trabeculae and deep intratrabecular recesses. Associated extracardiac anomalies occur in 14 to 66% of patients of different series, while chromosomal anomalies were reported in sporadic cases. We investigated the prevalence of chromosomal imbalances in 25 syndromic patients ...
Cui Ganglong - - 2012
One reaction, two routes: Full-dimensional non-adiabatic dynamics simulations shed light on the ultrafast photoinduced Wolff rearrangement in an α-diazocarbonyl compound. The trajectories show both concerted asynchronous and stepwise processes leading to the corresponding ketene.
Li Zhifeng - - 2012
A highly sensitive one-step real-time RT-PCR method using a minor-groove-binding (MGB) probe was developed for detection and quantitation of severe febrile with thrombocytopenia syndrome virus (SFTSV). The assay could discriminate SFTSV infection from other related viral diseases in human with a minimum detection limit of 10 viral RNA copies/µl and ...
Peng Guo-Ji - - 2012
Macrocyclic PKS-NRPS hybrid metabolites represent a unique family of natural products mainly from bacteria with broad and outstanding biological activities. However, their distribu-tion in fungi has rarely been reported, and few work has been reported regarding to their nematocidal activity. Here we describe an unprecedented class of PKS-NRPS hybrid metabolites ...
Castarlenas Ricardo - - 2012
The hydrothiolation of unsaturated carbon-carbon bonds is a practical and atom-economical approach for the incorporation of sulfur into organic frameworks. In recent years, we have witnessed the development of a range of transition-metal-based catalytic systems for the control of the regio- and stereoselectivity. In this Minireview we highlight the mechanistic ...
Jiang Peng - - 2012
The structure and magnetic properties of epitaxial (Ce(x)Sr(1-x))(Ti(0.6)Fe(0.4))O(3-δ) (x = 0, 0.1, 0.2 and 0.3) and (La(x)Sr(1-x))(Ti(0.6)Fe(0.4))O(3-δ) (x = 0, 0.1, 0.2, 0.3 and 0.4) perovskite-structure thin films deposited by pulsed laser deposition on (LaAlO(3))(0.3)(Sr(2)AlTaO(6))(0.7) (LSAT) substrates are reported. Both La and Ce ions showed a dominant 3+ valence state ...
Ball Zachary T - - 2012
Chemists have long been fascinated by metalloenzymes and their chemistry. Because enzymes are essential for biological processes and to life itself, they present a key to understanding the world around us. At the same time, if chemists could harness the reactivity and selectivity of enzymes in designed transition-metal catalysts, we ...
Yue Hao - - 2012
Surface desorption atmospheric pressure chemical ionization mass spectrometry was developed as a rapid online detection technology for the chemical fingerprints of ginseng products without any sample pretreatment. More than 20 ginsenosides were detected in the ginseng tissue and identified by their tandem mass spectrometry. Data were well matched with their ...
Aeppli Christoph - - 2012
The widespread use chlorinated phenols (CPs) as a wood preservative has led to numerous contaminated sawmill sites. However, it remains challenging to assess the extent of in situ degradation of CPs. We evaluated the use of compound specific chlorine and carbon isotope analysis (Cl- and C-CSIA) to assess CP biotransformation. ...
Thomas Lily - - 2012
Medical errors continue to occur despite multiple strategies devised for their prevention. Although many safety initiatives lead to improvement, they are often short lived and unsustainable. Our goal was to build a culture of patient safety within a structure that optimised teamwork and ongoing engagement of the healthcare team. Teamwork ...
Trelease Robert B - - 2012
Web deployable anatomical simulations or "virtual reality learning objects" can easily be produced with QuickTime VR software, but their use for online and mobile learning is being limited by the declining support for web browser plug-ins for personal computers and unavailability on popular mobile devices like Apple iPad and Android ...
Muller Olivier - - 2012
BACKGROUND: TO QUANTIFY THE CHANGES IN ARTERIAL DIMENSIONS AFTER THE ACUTE CHANGES IN PRESSURE ASSOCIATED WITH PERCUTANEOUS CORONARY INTERVENTION (PCI).METHODS AND RESULTS: FORTY-EIGHT PATIENTS WITH ONE ANGIOGRAPHICALLY MODERATE-TO-SEVERE STENOSIS WERE INCLUDED IN THE STUDY. THE PRESSURE PROXIMAL AND DISTAL TO THE STENOSIS AND THE ARTERIAL DIAMETER PROXIMAL AND DISTAL TO ...
Mardani Mohammad Ali - - 2012
Background and aim:Microtia is one of the forms of ear loss and deformity. A prosthesis that is simple to apply, and which has adequate suspension and acceptable aesthetics, can be useful in the rehabilitation of patients with this deficit and can improve the social and psychological effects of patients with ...
Saxena Roli - - 2012
The present study evaluated any possible association among Interleukin-1-beta (IL-1B)-511 and IL-1 receptor antagonist (IL-1RN) variable number tandem-repeat (VNTR) genotypes, haplotypes, and IL-1B expression with risk for hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) development in India. For this, 406 subjects (153 controls, 67 inactive HBV-carriers, 65 patients with chronic-active HBV, ...
Jenista Elizabeth R - - 2012
A versatile method for generating T(2) -weighting is a T(2) -preparation module, which has been used successfully for cardiac imaging at 1.5T. Although it has been applied at 3T, higher fields (B(0) ≥ 3T) can degrade B(0) and B(1) homogeneity and result in nonuniform magnetization preparation. For cardiac imaging, blood ...
Roberts D C - - 2012
This review summarizes the literature regarding venous thromboembolism and examines the prophylaxis guidelines with relation to hand, wrist and elbow surgery. We performed an extensive literature search identifying any relevant case reports or outcome studies. Of 680 potential articles, only four contained data relevant to thrombosis after elbow, wrist and ...
Denichoux Aurélien - - 2012
Reaction of dialkylzincs with lithiated acetylenic epoxides is described to give zincates that undergo a three-carbon homologation reaction by an anti-SN2' pathway. This reaction occurs with the transfer of an alkyl or a silyl group affording allenylzinc intermediates. Allenic and/or homopropargylic alcohols are obtained upon hydrolysis. Quenching the reaction mixture ...
Kenny Amanda - - 2012
This study in Victoria, Australia examined issues that rural nurses face in the provision of psychosocial care. Researchers, across a diversity of fields, have argued that psychosocial care is inadequate. Current knowledge of psychosocial care in rural areas is limited, despite the centrality of nurses in the provision of this ...
Tan E - - 2012
The application of temporary sutures placed through the tarsus of the lower eyelid are well documented in the Oculoplastic and Dermatologic surgery literature. They are generally used as a suspension suture (Frost suture) to reduce the risk of ectropion due to wound contraction after reconstructive procedures involving the lower eyelid.(1-5) ...
Asnaghi Laura - - 2012
PURPOSE: Controlling the spread of uveal melanoma is key to improving survival of patients with this common intraocular malignancy. The Notch ligand Jag2 has been shown to be upregulated in primary tumors which metastasize, and we therefore investigated its role in promoting invasion and clonogenic growth of uveal melanoma cells. ...
Chang Chia Min - - 2012
Using the curved arrangement of Au nanobumps, the scattering of surface plasmon waves are transformed into spots at desired locations and altitudes in three-dimensional space. The light can be modulated into desired light patterns. This work is very promising for compact plasmonic circuitry, projection, live-cell imaging, optical sensing, and holography.
Smeets Daisy J H - - 2012
Novel word learning is reported to be problematic for children with severe language impairments (SLI). In this study, we tested electronic storybooks as a tool to support vocabulary acquisition in SLI children. In Experiment 1, 29 kindergarten SLI children heard four e-books each four times: (a) two stories were presented ...
Zampetti Anna - - 2012
Fabry disease (FD) is an X-linked lysosomal storage disorder caused by the deficiency of the enzyme α-galactosidase. It exhibits a wide clinical spectrum that may lead to a delayed or even missed diagnosis and the real incidence can be underestimated. We report the cases of two unrelated Italian families in ...
Sira Mano - - 2012
INTRODUCTION: Orbital exenteration is a highly disfiguring procedure which, although providing local control of invasive orbital malignancy also results in marked visual, psychological and social disability. We present three consecutive total exenteration cases over 1 year where all 3, including extended exenteration defects, were repaired by primary closure by way ...
Zhou Linsen - - 2012
The photodissociation of H2O in its B band is a prototype for non-adiabatic reaction dynamics. In addition to dissociation via the adiabatic pathway to the OH( 2) + H fragments, it also produces the OH( 2) + H fragments through two non-adiabatic pathways: the → transition via two conical intersections ...
Kojima Ryosuke - - 2012
Shine on: A new rational design strategy for near-infrared-emitting firefly luciferins that are available in vivo has been developed using intramolecular bioluminescence resonance energy transfer (BRET). The emission wavelength could be freely tuned by the choice of BRET acceptor, and NIR bioluminescence could be detected in living cells and mice ...
Weed Anna-Marie Karen - - 2012
Porous hybrid organo-silica monoliths have been prepared inside pretreated 100 μm id UV transparent fused-silica capillaries using simultaneous sol-gel transition and polymerization of 3-(methacryloyloxy)propyl trimethoxysilane in the presence of toluene as a porogen. The sol-gel reaction was catalyzed by hydrochloric acid while various photoinitiators including azobisisobutyronitrile, 2,2-dimethoxy-2-phenylacetophenone, and Irgacure 819 ...
Norris Francesca C - - 2012
Purpose: Worldwide efforts to understand developmental processes demand new high-resolution 3D imaging methods to detect the consequences of gene function in embryo development and diseases. Encouragingly, recent studies have shown that MRI contrast agents can highlight specific tissue structures in ex vivo adult mouse brains. MR imaging of mouse embryos ...
William-Faltaos Demiana - - 2012
This research aimed to quantitatively describe the natural progression of Alzheimer's disease (AD) based on ADAScog scores in patients with mild-to-moderate AD. ADAS-cog data from 10 placebo-controlled clinical trials including more than 2,400 patients with up to 72 weeks of treatment were used. Different models describing the time course of ...
Chee Soon-Phaik - - 2012
AIMS: To compare outcomes of indocyanine green angiography (ICGA) versus clinically monitored immunotherapy in Vogt-Koyanagi-Harada (VKH) disease. METHODS: Consecutive patients of Singapore National Eye Centre with VKH receiving high-dose corticosteroids within 4 weeks of onset of symptoms had therapy titrated to clinical signs of activity (controls) or ICGA findings (ICGA). ...
Larsson Christel - - 2012
Abstract Objective. The purpose of this pilot study was to evaluate the long-term clinical performance of implant-supported full-arch zirconia-based fixed dental prostheses (FDPs). Materials and methods. Ten patients received full-arch zirconia-based (Cercon) mandibular FDPs supported by four implants (Astra Tech). Nine patients received 10-unit FDPs and one patient received a ...
Díez Isabel - - 2012
Fluorescent clusters of several Ag atoms are fluorophores with a large set of attractive properties including sub-nanometer size, high fluorescence quantum yield and large Stokes shift. When formed on polymeric scaffolds they exhibit a broad range of heterogeneities in excitation and emission spectra. Addressing this issue we provide detailed spectroscopic ...
Soares Fraser - - 2012
NLRX1 is a member of the Nod-like receptor family of intracellular sensors of microbial- and danger-associated molecular patterns. NLRX1 has a N-terminal mitochondrial addressing sequence that localizes the protein to the mitochondrial matrix. Recently, conflicting reports have been presented with regard to the putative implication of NLRX1 as a negative ...
El-Mounayri Omar - - 2012
AIMS: Despite the diverse developmental origins of vascular smooth muscle cells (VSMCs), recent attempts to generate VSMCs from human embryonic stem cells (hESCs) differentiated along various lineages did not yield distinct cell phenotypes. The aim of this study was to derive and characterize functional coronary-like VSMCs from hESCs using serum-free ...
Grossman Rachel - - 2012
BACKGROUND: Awake-craniotomy allows maximal tumor resection, which has been associated with extended survival. The feasibility and safety of awake-craniotomy and the effect of extent of resection on survival in the elderly population has not been established. The aim of this study was to compare surgical outcome of elderly patients undergoing ...
Troiani Vanessa - - 2012
Neuroimaging studies have identified brain regions that respond preferentially to specific stimulus categories, including 3 areas that activate maximally during viewing of real-world scenes: The parahippocampal place area (PPA), retrosplenial complex (RSC), and transverse occipital sulcus (TOS). Although these findings suggest the existence of regions specialized for scene processing, this ...
Su Jie - - 2012
A silicogermanate, PKU-12, with the - type of zeolite framework was hydrothermally synthesized under fluoride media using diisopropylethylmethylammonium as a structure directing agent. The formation of the silicogermanate zeolite with 20-ring channels has not only extended the - family from phosphates into silicogermanates, but also demonstrated its structural diversity.
Puntoni Matteo - - 2012
Background: Inflammation and oxidative stress play a crucial role in the development of colorectal cancer (CRC) and interference with these mechanisms represents a strategy in CRC chemoprevention. Allopurinol, a safe molecular scavenger largely employed as anti-gout agent, has been shown to increase survival of patients with advanced CRC and to ...
Brennan Claire - - 2012
The regioselective methylation of a ruthenium polypyridyl complex bearing both a 1,2,4-triazolato and a pyrazine moiety is reported. In contrast to previous studies in which methylation of the 1,2,4-triazolato ring was observed, in the present system methylation takes place exclusively at the non-coordinated nitrogen of the pyrazine ring. The monomethylation ...
Pan Saibo - - 2012
The accidental ingestion of fish bones is common. However, the complication of migration wherein the fish bone penetrated through the esophagus and into the right upper lobe is extremely rare. In this case, we present a rare case of recurrent pneumonia caused by a migrated esophageal foreign body. The case ...
Hammond Billy R BR - - 2012
Purpose. A large body of research has linked macular lutein and zeaxanthin to reduced risk of degenerative eye disease. The earliest published hypothesis for the role of the pigments was not based on chronic protection but immediate function. Recent data on macular pigment (MP) have shown that screening the foveal ...
Hsu Chih-Chieh - - 2012
Candida spp. are part of the natural human microbiota, but they also represent important opportunistic human pathogens. Biofilm-associated Candida albicans infections are clinically relevant due to their high levels of resistance to traditional antifungal agents. In this study, we investigated the ability of linalool to inhibit the formation of C. ...
Jadhav Sandip V - - 2012
Numerous strategies have been developed to mimic the α-helical secondary structure using hybrid peptides containing non-natural amino acids. In contrast to the β- and α/β-hybrid peptides, very little is known about the folding patterns of hybrid peptides containing γ(4)-amino acids. Here we report the solid phase synthesis and crystallographic insight ...
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