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Caillaud M-C - - 2012
Filamentous phytopathogens form sophisticated intracellular feeding structures called haustoria in plant cells. Pathogen effectors are likely to play a role in the establishment and maintenance of haustoria additional to their more characterized role of suppressing plant defense. Recent studies suggest that effectors may manipulate host transcription or other nuclear regulatory ...
Liang Liang - - 2012
PURPOSE: Behcet's disease (BD) is a chronic systemic inflammatory disorder of unknown etiology. Toll-like receptors (TLRs) are critical in the innate immune response to microbial invaders. In this study we investigated the role of TLRs in the pathogenesis of BD. METHODS: TLR2/4 expression, IL-1β and reactive oxygen species (ROS) production ...
Yamana Ryota - - 2012
Proteome analyses of human induced pluripotent stem cells (iPSC) were carried out on a liquid chromatography-tandem mass spectrometry system using meter-scale monolithic silica-C18 capillary columns without prefractionation. Tryptic peptides from five different iPSC lysates and three different fibroblast lysates (4 μg each) were directly injected onto a 200 cm long, ...
Cheung Kin-Fai - - 2012
BACKGROUND: Previous reports from these authors found that activation of peroxisome proliferator-activated receptor gamma (PPARγ) suppressed hepatocellular carcinoma (HCC). This study sought to identify the molecular target of PPARγ and characterize its antitumor effect in HCC. METHODS: Optimal PPARγ binding activity was obtained using the PPARγ agonist rosiglitazone (100 μM) ...
Kozuka Hiromitsu - - 2012
A versatile technique for fabricating transparent ceramic thin films on plastics has been proposed, where the crystallization and densification of films are guaranteed by a firing process. The technique comprises (i) the deposition of a precursor gel film by spin-coating on a silicon substrate that is coated beforehand with a ...
Levine Laurence A - - 2012
Introduction.  Peyronie's disease (PD) refers to a penile deformity that is associated with sexual dysfunction. Aim.  To provide recommendations and Standard Operating Procedures (SOPs) based on best evidence for diagnosis and treatment of PD. Methods.  Medical literature was reviewed and combined with expert opinion of the authors. Main Outcome Measures.  ...
Nikolov Miroslav - - 2012
To faithfully execute diverse biological programs all cells need to access and distribute their genomes in a highly organized way. In the nucleus of eukaryotic cells DNA is packed with histone proteins into chromatin. The originating nucleo-protein complex is the regulatory platform for all genetic processes. Of these, posttranslational modifications ...
Finlay Margaret - - 2012
ABSTRACT: Bovine papillomavirus type 1 infects not only cattle but also equids and is a causative factor in the pathogenesis of commonly occurring equine sarcoid tumours. Whilst treatment of sarcoids is notoriously difficult, cisplatin has been shown to be one of the most effective treatment strategies for sarcoids. In this ...
Ma Wei - - 2012
By infusing a perfluoropolyether lubricating liquid into a nano-textured alumina gel film that was modified with perfluoroalkylphosphonic acid, an omniphobic coating with low hysteresis for both polar and non-polar liquids was prepared.
Kamath Ganesh V - - 2012
BACKGROUND:Bankart repair with multiple anchor holes concentrated in the anterior-inferior glenoid may contribute to glenoid weakening and potentially may induce glenoid failure. PURPOSE:To compare the biomechanical strength of a Bankart repair construct that used 3 single-loaded suture anchors versus a repair construct that used 2 double-loaded suture anchors. STUDY DESIGN:Comparative ...
Milazzo Mary L - - 2012
Abstract A total of 3941 rodents were captured during a 46-month prospective (mark-recapture) study on the ecology of Catarina virus in southern Texas. Antibody reactive against Catarina virus was found in 73 (11.9%) of 611 southern plains woodrats (Neotoma micropus) and none of 3330 other rodents; strains of Catarina virus ...
Musters A M - - 2012
BACKGROUND: Supportive care is regularly offered to women with recurrent miscarriages (RMs). Their preferences for supportive care in their next pregnancy have been identified by qualitative research. The aim of this study was to quantify these supportive care preferences and identify women's characteristics that are associated with a higher or ...
Hamdani Nazha - - 2012
AIMS: Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Key alterations in HFpEF include increased left ventricular (LV) stiffness and abnormal relaxation. We hypothesized that myofilament protein phosphorylation and function are deranged in experimental HFpEF vs. normal myocardium. Such alterations may involve the ...
Wittich Christopher M - - 2012
Improving professional attitudes and behaviors requires critical self reflection. Research on reflection is necessary to understand professionalism among medical students. The aims of this prospective validation study at the Mayo Medical School and Cleveland Clinic Lerner College of Medicine were: (1) to develop and validate a new instrument for measuring ...
Mandl P - - 2012
OBJECTIVES: To evaluate the metrological properties of composite disease activity indices in rheumatoid arthritis (RA), utilizing information derived from clinical, grey-scale (GS) and Power Doppler (PD) ultrasound examination. To assess the classification of patients according to disease activity using such indices. METHODS: This ancillary study utilized data from a prospective, ...
Nakamura Ryosuke - - 2012
The ultrafast structural dynamics in the electronic excited state of photoactive yellow protein (PYP) is studied by femtosecond stimulated Raman spectroscopy. Stimulated Raman spectra in the electronic excited state, S(1), can be obtained by using a Raman pump pulse in resonance with the S(1)-S(0) transition. This is confirmed by comparing ...
Chereji Elizabeth - - 2012
The disposable soma theory proposes a trade-off between fertility and longevity but existing findings on this association have been mixed. This study used data from 15,622 twins born between 1901 and 1925 ascertained from the population-based Swedish Twin Registry to test the child-longevity association and whether it is accounted for ...
Bird Clare - - 2012
Pelagic nitrogen fixation makes an important contribution to the fixed nitrogen budget of the world's oceans. Filamentous and unicellular cyanobacteria are significant players in this process but less is known of the potential activity of heterotrophic diazotrophs, although they are present and can be quite numerous in the nitrogen-deplete surface ...
Cho Eunsoo - - 2012
The purpose of this study was to examine the role of a dynamic assessment (DA) of decoding in predicting responsiveness to Tier 2 small-group tutoring in a response-to-intervention model. First grade students (n = 134) who did not show adequate progress in Tier 1 based on 6 weeks of progress ...
Koutentis Panayiotis A - - 2012
The thermolysis of several N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-n-amines (where n = 2, 3 and 4) gives a mixture of thiazolopyridine-2-carbonitriles in low to moderate yields. Introduction, by design, of a chlorine substituent at the C2 or C4 position of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-3-amine and other selected azines enables a BnEt(3)NI mediated ANRORC style ring transformation that ...
Konishi Yohei - - 2012
Spectral dip formation at arbitrary wavelengths and the corresponding multicolour changes were achieved by using plasmonic Au nanoparticles on TiO(2), based on plasmon-induced charge separation and a coordination effect of iodide ions. The dips were stable in air under white light, in marked contrast to the case of conventional Ag ...
Lu Li-Chun - - 2012
BACKGROUND: Hospital volume for several major operations is associated with treatment outcomes. In this study, the authors explored the influence of hospital radiofrequency ablation (RFA) volume on the prognosis of patients who received RFA for hepatocellular carcinoma (HCC). METHODS: The authors searched for all patients who were diagnosed with stage ...
Gungor Ahmet Yalcin - - 2012
Abstract Objective: To evaluate the effects of different bleaching methods on the shear bond strength (SBS) of orthodontic brackets. Materials and Methods: Forty-five freshly extracted premolars were randomly divided into three groups (n  =  15 per group). In group I, bleaching was performed with the office bleaching method. In group ...
Gerhardt Alana - - 2012
Therapeutic proteins formulated in prefilled syringes lubricated with silicone oil come in contact with silicone oil-water interfaces for their entire shelf lives. Thus, the interactions between protein and silicone oil were studied to determine the effect of silicone oil on a monoclonal antibody's stability, both at the interface and in ...
Spratte Julia - - 2012
Heparins have been shown to be beneficial for the prevention of habitual miscarriages and repeated implantation failure, independently of their function as anticoagulants. The pro-inflammatory cytokine tumor necrosis factor (TNF)-α plays a role in the pathogenesis of these early pregnancy complications. Therefore, we examined the impact of heparin on TNF-α ...
Kim Tae Min - - 2012
BACKGROUND: This study was undertaken to evaluate the prognostic value of quantitative metabolic parameters in [(18) F]2-fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET) for diffuse large B cell lymphoma (DLBCL). METHODS: A total of 140 DLBCL patients underwent FDG-PET scans before rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy. The maximal standardized ...
Wiedmer Susanne K - - 2012
CE has matured into a well-known and much used separation technique, with applications covering more or less all types of samples. EKC, which originally was developed for the separation of uncharged compounds, is still today under much development, with main focus on finding the perfect or ideal carriers (pseudo-stationary phase) ...
Jorge J P - - 2012
In this study, a three-dimensional finite element (FE) model based on the specific anatomy of a patient presenting a femoroacetabular impingement of the 'cam'-type is developed. The FE meshes of the structures of interest are obtained from arthrographic magnetic resonance images. All soft tissues are considered linear elastic and isotropic, ...
Mitchard Terri - - 2012
An outcome and statistical review of male reproductive performance assessed by including a mating phase within 6-month general toxicity studies in the Han Wistar rat was undertaken. The basic study design was 16-20 animals per group dosed for approximately 9 weeks before pairing the male rats with undosed females. This ...
Tierney Marie - - 2012
OBJECTIVE: Measuring physical activity in people with rheumatoid arthritis (RA) is of increasing importance in light of the increased mortality in this population due to cardiovascular disease. Validation of activity monitors in specific populations is recommended to ensure the accuracy of physical activity measurement. Thus, the purpose of this study ...
Panetta Rosemarie - - 2012
Neuromedin U (NMU) plays an important role in a number of physiological processes, but the relative contribution of its two known receptors, NMUR1 & NMUR2, is still poorly understood. Here we report the existence of a SNP T(1022)→A (Val(341)→Glu) in the third exon of the rat Nmur1 gene that leads ...
Rombolá C A - - 2012
Introduction A few models for pneumonectomy in rats have been described, and in most of these, anesthesia includes orotracheal intubation, which increases morbidity and mortality and also adds technical complexity. Models without tracheal intubation but with injectable anesthesia are difficult to reproduce, however, and lead to a lengthy postoperative-recovery period with ...
Lund Marianne Nissen - - 2012
The impacts of pasteurization of a lager beer on protein composition and the oxidative stability were studied during storage at 22°C for 426 days in the dark. Pasteurization clearly improved the oxidative stability of beer determined by ESR spectroscopy, whereas it had a minor negative effect on the volatile profile ...
Denning David W - - 2012
Allergic bronchopulmonary aspergillosis (ABPA) complicates asthma and may lead to chronic pulmonary aspergillosis (CPA) yet global burdens of each have never been estimated. Antifungal therapy has a place in the management of ABPA and is the cornerstone of treatment in CPA, reducing morbidity and probably mortality. We used the country-specific ...
Wu Jian X - - 2012
Several factors with complex interactions influence the physical stability of solid dispersions, thus highlighting the need for efficient experimental design together with robust and simple multivariate model. Design of Experiments together with ANalysis Of VAriance (ANOVA) model is one of the central tools when establishing a design space according to ...
Moreno G E - - 2012
BACKGROUND: Central venous oxygen saturation (ScvO2) remains the gold standard surrogate for tissue oxygen extraction in paediatric cardiac surgery. Near-infrared spectroscopy (NIRS) has been developed as a non-invasive diagnostic tool for regional oxygen saturation. The aim was to compare regional oxygen saturation measured by NIRS with ScvO2 in postoperative paediatric ...
Khan Mohammad R - - 2012
Aflatoxins AFB1, AFB2, AFG1, and AFG2 are toxic secondary metabolites produced by Aspergillus flavus and Aspergillus parasiticus and posses a potential threat to food safety. In the present work, liquid-liquid extraction and ultraperformance LC-MS/MS method has been applied for the determination of four naturally occurring aflatoxins AFB1, AFB2, AFG1, and ...
Kianbakht Saeed - - 2012
Abstract Objective: To evaluate the effects of major and minor depression during pregnancy on the maternal and neonatal immunities. Methods: Peripheral venous blood from depressed women and cord venous blood from their neonates taken simultaneously and immediately after parturition were used. The serum levels of immunoglobulins IgG, IgM and IgA ...
Utsuki Satoshi - - 2012
This study was an immunohistological study of IgG4-positive cell infiltration in 6 cases of hypertrophic pachymeningitis excluding secondary hypertrophic pachymeningitis caused by infectious diseases such as aspergillosis. The cases included 5 males and 1 female, ranging in age from 36 to 82 years (mean, 55 years). A biopsy was performed ...
Wang Yongshi - - 2012
OBJECTIVES: The propensity for aortic aneurysm and dissection bestows bicuspid aortic valves (BAVs), the most common congenital cardiac abnormality, a potentially lethal aspect and considerable clinical concern. In the present study, we attempted to better characterize BAV patients with acute type A aortic dissection (AAD). METHODS: Data from 288 consecutive ...
Schrader Thomas O - - 2012
Two distinct and scalable enantioselective approaches to the tricyclic indole (R)-2-(7-hydroxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate, an important synthon for a preclinical S1P(1) receptor agonist, are reported. Route 1 employs a modified version of Smith's modular 2-substituted indole synthesis as the key transformation. Route 2 involves a highly enantioselective CuH-catalyzed 1,4-hydrosilylation as the stereodefining step. ...
Toczek A - - 2012
BACKGROUND: Scaling up treatment for multidrug-resistant tuberculosis is a global health priority. However, current treatment regimens are long and associated with side effects, and default rates are consequently high. This systematic review aimed to identify strategies for reducing treatment default.METHODS: We conducted a systematic search up to May 2012 to ...
Colorado J - - 2012
This paper presents a novel bat-like unmanned aerial vehicle inspired by the morphing-wing mechanism of bats. The goal of this paper is twofold. Firstly, a modelling framework is introduced for analysing how the robot should manoeuvre by means of changing wing morphology. This allows the definition of requirements for achieving ...
Tzikas Stergios - - 2012
OBJECTIVE: To evaluate mid-regional pro-adrenomedullin (MR-proADM) and mid-regional pro-atrial natriuretic peptide (MR-proANP) as prognostic biomarkers in a representative 'real world' cohort of patients with suspected acute coronary syndrome (ACS). DESIGN: Prospective observational multicentre cohort study. SETTING: Chest pain units of three major hospitals in Germany from 2007 to 2008. PATIENTS: ...
Zhang Guo-Hua - - 2012
Computational investigations of the thermochemical stability and kinetic persistence of binary S(x)N(y) compounds, SN(2), S(2)N(2), S(3)N(2), S(4)N(2), SN(4), S(2)N(4), S(3)N(4), and S(4)N(4), explain why some S(x)N(y) stoichiometries exist but not others. There is no direct link between the Hückel 4n + 2 π-electron count rule and the computed heats of ...
Lammers Andrew R - - 2012
Arboreal animals frequently change directions during locomotion on tree branches, trunks, or twigs. Linear and rotational impulses required to change direction and rotate the body while running are largely unexplored. We trained Siberian chipmunks (Tamias sibiricus) to run on narrow cylindrical trackways. The first trackway was straight and the second ...
Chung Eric - - 2012
Introduction.  The implantation of inflatable penile prosthesis (IPP) with simultaneous manual penile remodeling allows for men to undergo a single procedure aimed at correcting both the penile deformity/curvature and erectile dysfunction (ED). Aim.  To evaluate the clinical outcomes and patient satisfaction in men with Peyronie's disease (PD) and ED who ...
Aroua Safwan - - 2012
The 1,3-dipolar cycloaddition of the azomethine ylide (Prato reaction) with M3N@Ih-C80 (or M3N@C80, M = Sc, Lu, Y, Gd) was carried out to obtain fulleropyrrolidine bis-carboxylic acid derivatives as scaffolds to prepare various functional M3N@C80 materials. The formation of two monoadduct isomers (called [6,6]- and [5,6]-adducts) were detected by HPLC ...
Ileri Nazar - - 2012
Millimeter sized arrays of uniformly-distributed nanopores (180-220 nm) were created in thin (200 nm) silicon nitride membranes using interferometric lithography. Molecular transport properties of the fabricated devices were investigated experimentally and compared with those of state-of-the-art polycarbonate track etched membranes. Two similarly-sized proteins, bovine serum albumin (BSA) and bovine hemoglobin ...
Thomas John Meurig - - 2012
A new age dawned when 22-year-old William Lawrence Bragg realized that the observations of X-ray diffraction by a crystal can be interpreted very simply as arising from the reflection of the X-rays by planes of atoms in the crystal. In the 100 years since this insight X-ray diffraction has transformed ...
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