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Results 501 - 550 of 2635
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Zhang Guo-Hua - - 2012
Computational investigations of the thermochemical stability and kinetic persistence of binary S(x)N(y) compounds, SN(2), S(2)N(2), S(3)N(2), S(4)N(2), SN(4), S(2)N(4), S(3)N(4), and S(4)N(4), explain why some S(x)N(y) stoichiometries exist but not others. There is no direct link between the Hückel 4n + 2 π-electron count rule and the computed heats of ...
Lammers Andrew R - - 2012
Arboreal animals frequently change directions during locomotion on tree branches, trunks, or twigs. Linear and rotational impulses required to change direction and rotate the body while running are largely unexplored. We trained Siberian chipmunks (Tamias sibiricus) to run on narrow cylindrical trackways. The first trackway was straight and the second ...
Chung Eric - - 2012
Introduction.  The implantation of inflatable penile prosthesis (IPP) with simultaneous manual penile remodeling allows for men to undergo a single procedure aimed at correcting both the penile deformity/curvature and erectile dysfunction (ED). Aim.  To evaluate the clinical outcomes and patient satisfaction in men with Peyronie's disease (PD) and ED who ...
Aroua Safwan - - 2012
The 1,3-dipolar cycloaddition of the azomethine ylide (Prato reaction) with M3N@Ih-C80 (or M3N@C80, M = Sc, Lu, Y, Gd) was carried out to obtain fulleropyrrolidine bis-carboxylic acid derivatives as scaffolds to prepare various functional M3N@C80 materials. The formation of two monoadduct isomers (called [6,6]- and [5,6]-adducts) were detected by HPLC ...
Nelson Elana M - - 2012
OBJECTIVE:To investigate the nature of the interaction between selective serotonin reuptake inhibitors (SSRIs) and tramadol to mitigate or avoid serotonin syndrome.DATA SOURCES:PubMed, Ovid MEDLINE, and International Pharmaceutical Abstracts from January 1990 to August 2012 were searched. Key words used were tramadol, antidepressive agents, antidepressants, drug interactions, selective serotonin uptake inhibitors, ...
Rakovic Aleksandar A Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, 23562 Lübeck, - - 2013
Mutations in the E3 ubiquitin ligase Parkin and the mitochondrial PTEN-induced putative kinase 1 (PINK1) have been identified to cause autosomal recessive forms of familial Parkinson disease, with PINK1 functioning upstream of Parkin in a pathway important for the maintenance of mitochondrial function and morphology. Upon the loss of the ...
Doria Filippo F Dipartimento di Chimica, Università di Pavia, V.le Taramelli 10, 27100 Pavia, - - 2013
Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.
Palaoro LA - - 2012
Hypothyroid rats show alterations in the mobility of sperm recovered from their epididymides. The AgNOR technique, immunohistochemistry and transmission electron microscopy were used to investigate changes in epithelial cells from epididymides of rats treated with (131)I. Counting of NORs did not permit detection of changes in the proliferative capacity of ...
Choi Sangkook - - 2012
The sensitive structural dependence of the optical properties of single-walled carbon nanotubes, which are dominated by excitons and tunable by changing diameter and chirality, makes them excellent candidates for optical devices. Because of strong many-electron interaction effects, the detailed dependence of the optical oscillator strength f(s) of excitons on nanotube ...
D'Agosta Roberto - - 2012
Research on thermoelectrical energy conversion, the reuse of waste heat produced by some mechanical or chemical processes to generate electricity, has recently gained some momentum. The calculation of the electronic parameters entering the figure of merit of this energy conversion, and therefore the discovery of efficient materials, is usually performed ...
Clarke Richard W - - 2012
There is an intrinsic repulsion between glass and cell surfaces that allows non-invasive scanning ion conductance microscopy (SICM) of cells and which must be overcome in order to form the gigaseals used for patch clamping investigations of ion channels. However, the interactions of surfaces in physiological solutions of electrolytes, including ...
Tel Jurjen - - 2012
In human peripheral blood, four populations of DCs can be distinguished, plasmacytoid DCs (pDCs) and CD16(+), CD1c(+), and BDCA-3(+) myeloid DCs (mDCs), each with distinct functional characteristics. DCs have the unique capacity to cross-present exogenously encountered Ags to CD8(+) T cells. Here we studied the ability of all four blood ...
Li Luo - - 2012
Abstract OBJECTIVE-To evaluate the association between the vascular endothelial growth factor (VEGF) polymorphism and the risk of recurrent spontaneous miscarriage (RSM). METHODS-The participants enrolled included 227 RSM patients and 232 women with normal fertility. We examined the potential association between RSM and 13 single nucleotide polymorphisms (SNPs, rs699947, rs1570360, rs2010963, ...
Gadhia Monika M MM Perinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, - - 2013
Amino acids and glucose acutely stimulate fetal insulin secretion. In isolated adult pancreatic islets, amino acids potentiate glucose-stimulated insulin secretion (GSIS), but whether amino acids have this same effect in the fetus is unknown. Therefore, we tested the effects of increased fetal amino acid supply on GSIS and morphology of ...
Caillaud M-C - - 2012
Filamentous phytopathogens form sophisticated intracellular feeding structures called haustoria in plant cells. Pathogen effectors are likely to play a role in the establishment and maintenance of haustoria additional to their more characterized role of suppressing plant defense. Recent studies suggest that effectors may manipulate host transcription or other nuclear regulatory ...
Liang Liang - - 2012
PURPOSE: Behcet's disease (BD) is a chronic systemic inflammatory disorder of unknown etiology. Toll-like receptors (TLRs) are critical in the innate immune response to microbial invaders. In this study we investigated the role of TLRs in the pathogenesis of BD. METHODS: TLR2/4 expression, IL-1β and reactive oxygen species (ROS) production ...
Zhang Lei - - 2012
The biological function of Tripartite Motif 39 (TRIM39) remains largely unknown. In this study, we report that TRIM39 regulates the steady-state levels of p21 and is a pivotal determinant of cell fate. Ablation of TRIM39 leads to destabilization of p21 and increased G1/S transition in unperturbed cells. Furthermore, DNA damage-induced ...
Yamana Ryota - - 2012
Proteome analyses of human induced pluripotent stem cells (iPSC) were carried out on a liquid chromatography-tandem mass spectrometry system using meter-scale monolithic silica-C18 capillary columns without prefractionation. Tryptic peptides from five different iPSC lysates and three different fibroblast lysates (4 μg each) were directly injected onto a 200 cm long, ...
Cheung Kin-Fai - - 2012
BACKGROUND: Previous reports from these authors found that activation of peroxisome proliferator-activated receptor gamma (PPARγ) suppressed hepatocellular carcinoma (HCC). This study sought to identify the molecular target of PPARγ and characterize its antitumor effect in HCC. METHODS: Optimal PPARγ binding activity was obtained using the PPARγ agonist rosiglitazone (100 μM) ...
Kozuka Hiromitsu - - 2012
A versatile technique for fabricating transparent ceramic thin films on plastics has been proposed, where the crystallization and densification of films are guaranteed by a firing process. The technique comprises (i) the deposition of a precursor gel film by spin-coating on a silicon substrate that is coated beforehand with a ...
Desai Chintan S CS Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University,Chicago, Illinois 60611, - - 2013
The authors sought to determine the prevalence, prospective risk markers, and prognosis associated with diastolic dysfunction in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. The CARDIA Study cohort includes approximately equal proportions of white and black men and women. The authors collected data on risk markers at ...
Basu Partha P Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15228, USA. - - 2013
The oxygen atom transfer reactivity (OAT) of dioxo-Mo(VI) complexes of hydrotrispyrazolyl borate (hydrotris(3,5-dimethylpyrazolyl)borate, Tp(Me2); hydrotris(3-isopropylpyrazol-1-yl)borate, Tp(iPr)) with tertiary phosphines (PMe(3), PMe(2)Ph, PEt(3), PEt(2)Ph, PBu(n)(3), PMePh(2), or PEtPh(2)) has been investigated. In acetonitrile, these reactions proceed via the formation of a phosphoryl intermediate complex that undergoes a solvolysis reaction. We report ...
Jones Sara B SB Yale School of Public Health, New Haven, CT 06520, - - 2013
Physical activity is associated with improved breast cancer survival, but the underlying mechanisms, possibly including modification of the inflammatory state, are not well understood. We analyzed changes in interleukin (IL)-6, C-reactive protein (CRP), and TNF-α in a randomized controlled trial of exercise in postmenopausal breast cancer survivors. Seventy-five women, recruited ...
Wallace D J - - 2013
Safety data were pooled and analyzed from one phase 2 and two phase 3 double-blind, placebo-controlled, repeat-dose systemic lupus erythematosus (SLE) trials of belimumab 1, 4 (phase 2 only), and 10 mg/kg. Types and rates of adverse events (AEs) were similar across treatment groups. Rates of patients experiencing any serious AE ...
Levine Laurence A - - 2012
Introduction.  Peyronie's disease (PD) refers to a penile deformity that is associated with sexual dysfunction. Aim.  To provide recommendations and Standard Operating Procedures (SOPs) based on best evidence for diagnosis and treatment of PD. Methods.  Medical literature was reviewed and combined with expert opinion of the authors. Main Outcome Measures.  ...
Nikolov Miroslav - - 2012
To faithfully execute diverse biological programs all cells need to access and distribute their genomes in a highly organized way. In the nucleus of eukaryotic cells DNA is packed with histone proteins into chromatin. The originating nucleo-protein complex is the regulatory platform for all genetic processes. Of these, posttranslational modifications ...
Donzelli Sonia - - 2013
Nitroxyl (HNO) donors have potential benefit in the treatment of heart failure and other cardiovascular diseases. 1-Nitrosocyclohexyl acetate (NCA), a new HNO donor, in contrast to the classic HNO donors Angeli's salt and isopropylamine NONOate, predominantly releases HNO and has a longer half-life. This study investigated the vasodilatative properties of ...
Schaming Delphine - - 2012
An electrosynthesis process has allowed the formation of four oligomers, containing three, four, or five macrocycles. This method is based on the nucleophilic attack of porphyrins substituted by several pendant pyridyl groups to the electrogenerated radical cation of zinc β-octaethylporphyrin (ZnOEP), according to an ECEC processes. Thus, a control of ...
Han Jae Hyo - - 2012
This review presents recent advances in synthetic methods and structural transformations of colloidal 2D layered metal chalcogenide nanocrystals. Planar 2D anisotropy and interlayer van der Waals gaps are the important characteristics of these nanocrystals for pristine disc, plate or sheet morphologies. These 2D nanocrystals undergo unique chemical transformations upon exposure ...
Bonnelye E - - 2012
Estrogen receptor related receptor alpha (ERRα) is an orphan nuclear receptor with sequence homology to the estrogen receptors, ERα/β, but it does not bind estrogen. ERRα not only plays a functional role in osteoblasts but also in osteoclasts and chondrocytes. As well, the ERRs, including ERRα, can be activated by ...
Chang Hung-Yu - - 2013
Data regarding the long-term outcome of catheter ablation in patients with nonpulmonary vein (NPV) ectopy initiating atrial fibrillation (AF) are limited. We aimed to evaluate the long-term result of patients with AF who had NPV triggers and underwent catheter ablation. The study included 660 consecutive patients (age 54 ± 11 ...
Zhang Jingtao - - 2012
A primary consideration when developing lipid nanoparticle (LNP) based small interfering RNA (siRNA) therapeutics is formulation polydispersity or heterogeneity. The level of heterogeneity of physicochemical properties within a pharmaceutical batch could greatly affect the bioperformance, quality, and ability of a manufacturer to consistently control and reproduce the formulations. This article ...
Bovi Michele - - 2012
A novel lectin was purified from the fruiting bodies of king bolete mushrooms (Boletus edulis, also called porcino, cep or penny bun). The lectin was structurally characterized: its amino acid sequence and three dimensional structure were determined. The new protein is a homodimer and each protomer folds as β-trefoil domain ...
Mildner Alexander - - 2012
The mononuclear phagocyte system comprises cells as diverse as monocytes, macrophages and dendritic cells (DCs), which collectively play key roles in innate immune responses and the triggering of adaptive immunity. Recent studies have highlighted the role of growth and transcription factors in defining developmental pathways and lineage relations within this ...
Ou Zhimin Z Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou 510080, - - 2013
The retinoid-related orphan receptors (RORs) were postulated to have functions in tissue development and circadian rhythm. In this study, we revealed a novel function of RORα (NR1F1) and RORγ (NR1F3) in regulating the human hydroxysteroid sulfotransferase (SULT2A1), a phase II conjugating enzyme known to sulfonate bile acids, hydroxysteroid dehydroepiandrosterone, and ...
Estévez Verónica - - 2012
A sequential multicomponent process involving the high-speed vibration milling of ketones with N-iodosuccinimide and p-toluenesulfonic acid, followed by addition of a mixture of primary amines, β-dicarbonyl compounds, cerium(iv) ammonium nitrate and silver nitrate afforded polysubstituted, functionalized pyrroles. This one-pot, solid-state process can be considered as the coupling of an α-iodoketone ...
Li Lu - - 2012
A very facile, general, and reproducible method is developed for the controlled synthesis of discrete and monodisperse concentric and eccentric poly(acrylic acid) (PAA)-coated nanostructures in a large-scale, independent of their size, geometry, or composition. Interestingly, the reversible structural transformation between concentricity and eccentricity can be easily achieved, which is determined ...
Reidunsdatter Randi J - - 2012
Introduction. Fatigue after treatment for breast cancer (BC) is common, but poorly understood. We examined the fatigue levels during first year after radiotherapy (RT) according to the extent of RT (local or locoregional), hormonal therapy (HT) and chemotherapy (CT). The impact of comorbidity was also explored. Moreover, we compared fatigue ...
Alves Tp - - 2012
SUMMARY External cervical resorption (ECR) is a sequela of dentoalveolar trauma that may cause functional, esthetic, and psychologic alterations. The aim of this study was to report a successful multidisciplinary treatment approach performed in a 12-year-old patient who presented with posttraumatic ECR associated with extensive opened cavity, pulp necrosis, and ...
Jenner Matthew - - 2012
Branching out: The substrate specificity profiles for a range of ketosynthase (KS) domains from trans-AT PKSs are reported. Evidence is provided that a sterically demanding amino acid residue adjacent to the active-site Cys residue confers specificity towards non-β-methyl-branched substrates.
Zhang Mingzhi - - 2012
To explore association of hypertension with coexistence of inflammation and endothelial dysfunction and abnormal metabolism, a community-based study was conducted among Mongolian people in China. Demographic characteristics and lifestyle risk factors were investigated, blood pressure, body weight and waist circumference were measured, fasting blood samples were obtained to measure blood ...
Marcucci Fabrizio F Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita', Roma, Italy. - - 2013
Monoclonal antibodies (mAb) have become a mainstay in tumor therapy. Clinical responses to mAb therapy, however, are far from optimal, with many patients presenting native or acquired resistance or suboptimal responses to a mAb therapy. MAbs exert antitumor activity through different mechanisms of action and we propose here a classification ...
Wu Si-Hai - - 2012
Recent investigations on polypyridine transition-metal complexes as potential molecular wires have provided new impetus for these long-studied and well-established systems. Using bridging ligands 2,3-di(2-pyridyl)-5,6-diphenylpyrazine (dpdpz) and 2,3,5,6-tetrakis(2-pyridyl)pyrazine (tppz), a tetrametallic cyclometalated ruthenium complex has been prepared and characterized, with each metal having one Ru-C bond. The electronic properties of this ...
Chen Frank F Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, - - 2013
Functional defects in ATPase class I type 8B membrane 1 (ATP8B1 or familial intrahepatic cholestasis 1, FIC1) lead to cholestasis by mechanism(s) that are not fully understood. One proposed pathophysiology involves aberrant signaling to the bile acid sensor, the farnesoid X receptor (FXR), via protein kinase C ζ (PKCζ). The ...
Marcus Dawn A DA Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. - - 2013
Anecdotal reports suggest that changes in dog behavior might be used to predict impending migraine episodes. This survey was designed to investigate how companion dogs react to migraines that occur in their owners. Online survey was available from January 4-31, 2012. Survey was conducted through SurveyMonkey, with links to the ...
Rapezzi Claudio - - 2012
In 2008, The ESC Working Group on Myocardial and Pericardial Diseases proposed an updated classification of cardiomyopathies based on morphological and functional phenotypes and subcategories of familial/genetic and non-familial/non-genetic disease. In this position statement, we propose a framework for the clinical approach to diagnosis in cardiomyopathies based on the recognition ...
Mahmoudi Elham - - 2012
Objectives.To compare racial/ethnic disparities in access to physician services among older adults in 2000 and 2007 and to identify potential factors driving the changes observed.Method.Using 2000 and 2007 Medical Expenditure Panel Survey data, we examine 2 measures of access for adults aged 65 and older: whether the individual reports of ...
Ferraresi Sany Rose - - 2012
Introduction.  Polycystic ovary syndrome (PCOS) appears to be related to sexual dysfunction, especially if associated with obesity. However, it is not clear whether obesity per se is an independent factor for sexual dysfunction. We hypothesized that obese polycystic ovary syndrome (OPCOS) patients have poorer sexual function than controls and nonobese ...
Yin Yuan - - 2012
In this paper, nano-TiO2 was functionalized by different methods and its genetoxicity and cytotoxicity were studied in detail. The genetoxicity of nano-TiO2 was evaluated by observing its interactions with pUC19 plasmid DNA at a single molecule level using atomic force microscopy. The results show that, with the assistance of UVA ...
Karaman E - - 2012
SUMMARY Aim : To compare the retention rates of a nanofilled occlusal fissure sealant placed with the use of an etch-and-rinse or a self-etch adhesive over 48 months. Materials and Methods : The authors enrolled 244 teeth, each with no restoration or sealant and no detectable caries, from 16 patients. ...
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