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Fong Gloria G Department of Integrative Medical Biology, Anatomy, Umeå University, SE-901 87, Umeå, - - 2013
Studies of human patellar and Achilles tendons have shown that primary tendon fibroblasts (tenocytes) not only have the capacity to produce acetylcholine (ACh) but also express muscarinic ACh receptors (mAChRs) through which ACh can exert its effects. In patients with tendinopathy (chronic tendon pain) with tendinosis, the tendon tissue is ...
Xu Ajing A Department of Pharmacology, Xinhua Hospital, School of Medicine, Shanghai, - - 2013
The p38 mitogen-activated protein kinase (MAPK) plays an evolutionarily conserved role in the cellular response to microbial infection and environmental stress. Activation of p38 is mediated through phosphorylation by upstream MAPKK, which in turn is activated by MAPKKK. In the Caenorhabditis elegans, the p38 MAPK (also called PMK-1) signaling pathway ...
Hansen J J Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, New York, New York, - - 2013
Over the past 50 years, like molecular cell biology, medicine and pharmacology have been driven by a reductionist approach. The focus on individual genes and cellular components as disease loci and drug targets has been a necessary step in understanding the basic mechanisms underlying tissue/organ physiology and drug action. Recent ...
Thomas Dennis G DG Computational and Statistical Analytics Division, Pacific Northwest National Laboratory, Richland, WA 99352, - - 2013
Implicit solvent models are popular for their high computational efficiency and simplicity over explicit solvent models and are extensively used for computing molecular solvation properties. The accuracy of implicit solvent models depends on the geometric description of the solute-solvent interface and the solvent dielectric profile that is defined near the ...
Takahashi K H KH Research Core for Interdisciplinary Sciences, Okayama University, Okayama, - - 2013
Biological clocks regulate various behavioural and physiological traits; slower circadian clocks are expected to slow down the development, suggesting a potential genetic correlation between the developmental period and circadian rhythm. However, a correlation between natural genetic variations in the developmental period and circadian rhythm has only been found in Bactrocera ...
Hamilton M G MG School of Plant Science, University of Tasmania, Hobart, Tasmania, Australia. - - 2013
The possible drivers and implications of an observed latitudinal cline in disease resistance of a host tree were examined. Mycosphaerella leaf disease (MLD) damage, caused by Teratosphaeria species, was assessed in five Eucalyptus globulus (Tasmanian blue gum) common garden trials containing open-pollinated progeny from 13 native-forest populations. Significant population and ...
Soangra Rahul R School of Biomedical Engineering and Sciences, Virginia Tech Wake Forest University, Blacksburg, VA 24061, - - 2013
Patients with end stage renal diseases (ESRD) undergoing hemodialysis (HD) have high morbidity and mortality due to multiple causes; one of which is dramatically higher fall rates than the general population. In spite of the multiple efforts aiming to decrease the high mortality and improve quality of life in ESRD ...
Xiang Jin Yu JY Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, Missouri 63110, - - 2013
A general molecular mechanics (MM) model for treating aqueous Cu(2+) and Zn(2+) ions was developed based on valence bond (VB) theory and incorporated into the atomic multipole optimized energetics for biomolecular applications (AMOEBA) polarizable force field. Parameters were obtained by fitting MM energies to that computed by ab initio methods ...
Thaipisuttikul Papan P Comprehensive Center on Brain Aging, Alzheimer Disease Center, New York University Langone Medical Center, New York, NY, - - 2013
Capgras syndrome is characterized by the recurrent, transient belief that a person has been replaced by an identical imposter. We reviewed clinical characteristics of Dementia with Lewy Bodies (DLB) patients with Capgras syndrome compared to those without Capgras. We identified 55 consecutive DLB patients (11 cases with Capgras syndrome (DLB-C) ...
Melton L J LJ 3rd Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. - - 2013
Adjusting for age, sex, and precipitating cause, the relative risk of death was increased following fractures at most skeletal sites. This study aims to determine long-term survival following fractures due to any cause at each skeletal site. In a historical cohort study, 2,901 Olmsted County, MN, USA, residents ≥35 years ...
Jolivet C C Johann Heinrich von Thünen Institut vTI, Institute of Forest Genetics, D-22927 Grosshansdorf, Germany. - - 2013
Genetic diversity strongly influences populations' adaptability to changing environments and therefore survival. Sustainable forest management practices have multiple roles including conservation of genetic resources and timber production. In this study, we aimed at better understanding the variation in genetic diversity among adult and offspring individuals, and the effects of mating ...
Haasl Ryan J RJ Laboratory of Genetics, University of Wisconsin, Madison, WI, - - 2013
We use genotype data from the Marshfield Clinical Research Foundation Personalized Medicine Research Project to investigate genetic similarity and divergence between Europeans and the sampled population of European Americans in Central Wisconsin, USA. To infer recent genetic ancestry of the sampled Wisconsinites, we train support vector machines (SVMs) on the ...
Dominick Sally A SA Moores Cancer Center, University of California, San Diego, La Jolla, CA, - - 2013
Lymphedema is a significant health problem faced by a large percentage of breast cancer survivors. The Women's Healthy Eating and Living (WHEL) Study has a unique dataset collected after the completion of breast cancer treatment, which allowed a focused analysis of risk factors for breast cancer-related lymphedema. Participant characteristics, treatment ...
Sun Hokeun H Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, - - 2013
The matched case-control designs are commonly used to control for potential confounding factors in genetic epidemiology studies especially epigenetic studies with DNA methylation. Compared with unmatched case-control studies with high-dimensional genomic or epigenetic data, there have been few variable selection methods for matched sets. In an earlier paper, we proposed ...
Bin Abd Razak Hamid Rahmatullah HR Department of Orthopaedic Surgery, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore. - - 2013
In Asia, obesity has reached epidemic proportions and physicians are likely to face a burden of obesity-related disorders, of which osteoarthritis of the knee is one. However, it is unclear whether obesity affects improvement of conventional TKAs in Asian patients. We therefore asked whether obese patients with a BMI of ...
Naylor R M RM Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, - - 2013
Aging is the main risk factor for most chronic diseases, disabilities, and declining health. It has been proposed that senescent cells--damaged cells that have lost the ability to divide--drive the deterioration that underlies aging and age-related diseases. However, definitive evidence for this relationship has been lacking. The use of a ...
Smith Lucas R LR Department of Bioengineering, University of California, San Diego, CA, - - 2013
Satellite cells are the stem cells residing in muscle responsible for skeletal muscle growth and repair. Skeletal muscle in cerebral palsy (CP) has impaired longitudinal growth that results in muscle contractures. We hypothesized that the satellite cell population would be reduced in contractured muscle. We compared the satellite cell populations ...
Brooks-Russell Ashley A Prevention Research Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-7510, USA. - - 2013
This study identified classes of developmental trajectories of physical dating violence victimization from grades 8 to 12 and examined theoretically-based risk factors that distinguished among trajectory classes. Data were from a multi-wave longitudinal study spanning 8th through 12th grade (n = 2,566; 51.9 % female). Growth mixture models were used ...
Cavalieri Simona S Università di Torino, Department of Medical Sciences & Azienda Ospedaliera Città della Salute e della Scienza, Turin, - - 2013
Recent development of next-generation DNA sequencing (NGS) techniques is changing the approach to search for mutations in human genetic diseases. We applied NGS to study an A-T patient in which one of the two expected mutations was not found after DHPLC, cDNA sequencing and MLPA screening. The 160-kb ATM genomic ...
Fiorentino Francesco F GENOMA- Molecular Genetics Laboratory, Rome, Italy. - - 2013
In this study, we aimed to explore the utility of chromosomal microarray analysis (CMA) in groups of pregnancies with a priori low risk for detection of submicroscopic chromosome abnormalities, usually not considered an indication for testing, in order to assess whether CMA improves the detection rate of prenatal chromosomal aberrations. ...
Yu Lihua L Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, Chengdu, People's Republic of - - 2013
The most common form of Dopa-responsive dystonia (DRD) is caused by heterozygous mutations in the GTP cyclohydrolase I (GCH1) gene. We screened two unrelated, DRD-symptomatic Chinese Han individuals, for GCH1 gene mutations by direct sequencing. As the clinical manifestations of DRD are highly variable, we also explored the association between ...
Amin Najaf N Unit of Genetic Epidemiology, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The - - 2013
Personality traits are complex phenotypes related to psychosomatic health. Individually, various gene finding methods have not achieved much success in finding genetic variants associated with personality traits. We performed a meta-analysis of four genome-wide linkage scans (N=6149 subjects) of five basic personality traits assessed with the NEO Five-Factor Inventory. We ...
Arora Kamaldeep - - 2012
A term male infant born by normal vaginal delivery was diagnosed to have holoprosencephaly on antenatal ultrasound, which was confirmed by postnatal MRI as alobar holoprosencephaly figure). Clinical examination revealed no microcephaly or dysmorphism, except flat nasal bridge.
Yuan Chun-Mao - - 2012
Eight new limonoids, khayseneganins A-H (1-8), and 31 known limonoids were isolated from the leaves and twigs of Khaya senegalensis. The structures of the new compounds were elucidated by 2D-NMR spectroscopy and mass spectrometry, and the absolute configuration of 1 was determined by the CD exciton chirality method. Compounds 9, ...
Bhadaniya Amit R - - 2012
The present study was carried out to evaluate the effects of exposure at different doses of acephate on hematology, blood biochemistry, oxidative stress and immune system of Wistar rats. The experiment was carried out on 40 Wistar rats, which were divided in four groups. Animals of the three treatment groups ...
Festini Sara B - - 2012
Names are more difficult to remember than other personal information such as occupations. The current research examined the influence of assigned point value on memory and metamemory judgements for names and occupations to determine whether incentive can improve recall of proper names. In Experiment 1 participants studied face-name and face-occupation ...
Pastorello Elide A - - 2012
Fennel allergy has been rarely reported and the association with peach allergy has never been described. Our aim was to: i)study the correlation between symptoms severity to peach and fennel, ii)identify fennel allergens and the role of rPru p3 antibodies in severe reactions to fennel. In 148 pts with peach ...
Moulton Patricia L - - 2012
With the passage of the Affordable Care Act and the development of a National Workforce Commission, multiple entities have increased their interest in collecting standardized health care workforce data at the state and national levels. In a tight budget environment, developing data sets which collect the minimum needed information that ...
Busch Annegret P - - 2012
Protection of biological compounds, e.g. enzymes, viruses or even whole cells, against degradation is very important for many applications. Embedding of such compounds into polymer matrices is a straightforward common method. However, in biotechnology and medicine there is a great interest to prepare micro- and nanosized shells around the biocomponents ...
Liang Jen-Feng - - 2012
ObjectiveTo investigate whether cluster headache (CH) was a risk factor for depression in a nationwide population-based follow-up study.BackgroundThere are few studies about the relationship between CH and depression, and prior research has been limited by cross-sectional studies or small sample sizes.MethodsWe identified 673 CH patients from the Taiwan National Health ...
Nowosielski Krzysztof - - 2012
Introduction.  Unlike male sexual function, which is relatively easy to assess, female sexual function is still a diagnostic challenge. Although numerous new measurements for female sexual dysfunction (FSD) have recently been developed, the Female Sexual Function Index (FSFI) remains the gold standard for screening. It has been validated in more ...
Reed S J - - 2012
BACKGROUND: /st>Positron emission tomography studies in human subjects show that propofol-induced unconsciousness in humans is associated with a reduction in thalamic blood flow, suggesting that anaesthesia is associated with impairment of thalamic function. A recent study showed that antagonism of propofol-induced unconsciousness by the anticholinesterase physostigmine is associated with a ...
Munk T - - 2012
BACKGROUND: Undernutrition and insufficient energy and protein intake is a common problem in hospitalised patients. The aim of this pilot study was to investigate whether a novel hospital menu would be an effective strategy for increasing nutritional intake in patients at nutritional risk. METHODS: A historically controlled intervention pilot study ...
Everard Mark - - 2012
A narrow technocentric focus on a few favoured ecosystem services (generally provisioning services) has led to ecosystem degradation globally, including catchment systems and their capacities to support human wellbeing. Increasing recognition of the multiple benefits provided by ecosystems is slowly being translated into policy and some areas of practice, though ...
Kaski Diego - - 2012
A 45-year-old woman on etanercept for rheumatoid arthritis presented with an acute right Bell palsy and auricular herpetic rash (Ramsey Hunt syndrome). Despite IV acyclovir, she developed headache, vertigo, severe vomiting, and evidence of a right peripheral audiovestibular loss (figure 1, A and B, video 1 on the Neurology® Web ...
Hong Bo - - 2012
Rauvolfia verticillata (Lour.) Baill. (also called Luofumu in Chinese) is commonly used in traditional Chinese medicine for lowering blood pressure. In this study, a high-performance liquid chromatography assay using ultraviolet detection is described for the simultaneous measurement of the five bioactive indole alkaloids (sarpagine, yohimbine, ajmaline, ajmalicine and reserpine) in ...
Gao Qiang - - 2012
In this paper, we report a simple approach for fabricating scalable flexible tactile sensors using a nanofiber assembly of regioregular poly(3-hexylthiophene) (P3HT). Uniform P3HT nanofibers are obtained through a continuous electrospinning process using a homogeneous solution of high-molecular-weight P3HT. The P3HT nanofibers are oriented by collecting them on a rotating ...
Lopez Tony - - 2012
A 16-year-old girl is admitted with a paracetamol overdose, but refuses treatment. This article explores the legal, ethical and practical aspects of this case, which led ultimately to an application to the court for a judicial order.
Sarvottam Kumar - - 2012
Abstract Objective: To investigate the effect of a short-term yoga-based lifestyle intervention on risk factors for cardiovascular disease (CVD) and markers of inflammation and endothelial function in overweight and obese men. Design: Nonrandomized prospective lifestyle intervention study with pre-post design. Setting and location: Integral Health Clinic, an outpatient facility providing ...
Drechsler Christiane - - 2012
BackgroundSudden cardiac death is common and accounts largely for the excess mortality of patients on maintenance dialysis. It is unknown whether aldosterone and cortisol increase the incidence of sudden cardiac death in dialysis patients.Methods and resultsWe analysed data from 1255 diabetic haemodialysis patients participating in the German Diabetes and Dialysis ...
Gad Shayne C - - 2012
Gold nanoshells (155 nm in diameter with a coating of polyethylene glycol 5000) were evaluated for preclinical biocompatibility, toxicity, and biodistribution as part of a program to develop an injectable device for use in the photothermal ablation of tumors. The evaluation started with a complete good laboratory practice (GLP) compliant ...
Palladino Pasquale - - 2012
A novel method for cleaving from resin and removing acid-labile protecting groups for the Fmoc solid-phase peptide synthesis is described. 0.1 N HCl in hexafluoroisopropanol or trifluoroethanol cleanly and rapidly removes the tert-butyl ester and ether, Boc, trityl, and Pbf groups and cleaves the common resin linkers: Wang, HMPA, Rink ...
Feng Bao-Hua - - 2012
A stable inherited rice spotted-leaf mutant HM47 derived from an EMS-induced IR64 mutant bank was identified. The mutant expressed hypersensitive response (HR)-like symptoms throughout its whole life from the first leaf to the flag leaf, without pathogen invasion. Initiation of the lesions was induced by light under natural summer field ...
Caillaud M-C - - 2012
Filamentous phytopathogens form sophisticated intracellular feeding structures called haustoria in plant cells. Pathogen effectors are likely to play a role in the establishment and maintenance of haustoria additional to their more characterized role of suppressing plant defense. Recent studies suggest that effectors may manipulate host transcription or other nuclear regulatory ...
Liang Liang - - 2012
PURPOSE: Behcet's disease (BD) is a chronic systemic inflammatory disorder of unknown etiology. Toll-like receptors (TLRs) are critical in the innate immune response to microbial invaders. In this study we investigated the role of TLRs in the pathogenesis of BD. METHODS: TLR2/4 expression, IL-1β and reactive oxygen species (ROS) production ...
Yamana Ryota - - 2012
Proteome analyses of human induced pluripotent stem cells (iPSC) were carried out on a liquid chromatography-tandem mass spectrometry system using meter-scale monolithic silica-C18 capillary columns without prefractionation. Tryptic peptides from five different iPSC lysates and three different fibroblast lysates (4 μg each) were directly injected onto a 200 cm long, ...
Cheung Kin-Fai - - 2012
BACKGROUND: Previous reports from these authors found that activation of peroxisome proliferator-activated receptor gamma (PPARγ) suppressed hepatocellular carcinoma (HCC). This study sought to identify the molecular target of PPARγ and characterize its antitumor effect in HCC. METHODS: Optimal PPARγ binding activity was obtained using the PPARγ agonist rosiglitazone (100 μM) ...
Kozuka Hiromitsu - - 2012
A versatile technique for fabricating transparent ceramic thin films on plastics has been proposed, where the crystallization and densification of films are guaranteed by a firing process. The technique comprises (i) the deposition of a precursor gel film by spin-coating on a silicon substrate that is coated beforehand with a ...
Levine Laurence A - - 2012
Introduction.  Peyronie's disease (PD) refers to a penile deformity that is associated with sexual dysfunction. Aim.  To provide recommendations and Standard Operating Procedures (SOPs) based on best evidence for diagnosis and treatment of PD. Methods.  Medical literature was reviewed and combined with expert opinion of the authors. Main Outcome Measures.  ...
Nikolov Miroslav - - 2012
To faithfully execute diverse biological programs all cells need to access and distribute their genomes in a highly organized way. In the nucleus of eukaryotic cells DNA is packed with histone proteins into chromatin. The originating nucleo-protein complex is the regulatory platform for all genetic processes. Of these, posttranslational modifications ...
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