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Zhou Yide - - 2013
Approximately 5% of the population worldwide suffer from varieties of noise-induced hearing loss (NIHL). Prevention and early identification remain the best methods of approaching NIHL. Over the years, numerous methods of improving the outcome in patients presenting with NIHL have been evaluated; however, these are far from sufficient. The present ...
Broeders Joris A JA Discipline of Surgery, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia. - - 2013
To investigate late objective outcomes 14 years after laparoscopic anterior 180-degree partial versus Nissen fundoplication. Clinical outcomes from randomized clinical trials suggest good outcomes for anterior 180-degree partial fundoplication, with similar control of reflux symptoms and less side effects, compared with Nissen fundoplication. However, objective outcomes at late follow-up have ...
Jones Deborah L DL Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1400 NW 10th Avenue, Miami, FL 33136, USA. - - 2013
Few HIV prevention interventions focus on sexual risk reduction as mutual process determined by couple members, though risk behaviors are inter-dependent. This trial examined the impact of substance use, history of sexual trauma, and intimate partner violence on sexual risk associated with participation in a risk reduction intervention. HIV seroconcordant ...
Attarian David E DE Department of Orthopaedic Surgery, Duke University Hospital and Health System, Duke Medicine Plaza-Page Road, 4709 Creekstone Road, Suite 200, Durham, NC 27703, USA. - - 2013
Developing a high-efficiency operating room (OR) for total joint arthroplasty (TJA) in an academic setting is challenging given the preexisting work cultures, bureaucratic road blocks, and departmental silo mentalities. Also, academic institutions and aligned surgeons must have strategies to become more efficient and productive in the rapidly changing healthcare marketplace ...
Sohn Seo Young SY Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of - - 2013
A low-iodine diet (LID) is usually recommended for a week or two before radioactive iodine (RAI) ablation therapy in papillary thyroid cancer (PTC) patients after total thyroidectomy. However, it is still controversial whether an LID affects ablation outcomes. We therefore evaluated the association between urinary iodine excretion and the rate ...
Zeng Yi Y Center for the Study of Aging and Human Development and Geriatric Division of Medical School, Population Research Institute, Duke University, Box 3003, Durham, NC 27710, USA. - - 2013
This article presents the core methodological ideas and empirical assessments of an extended cohort-component approach (known as the "ProFamy model"), and applications to simultaneously project household composition, living arrangements, and population sizes-gender structures at the subnational level in the United States. Comparisons of projections from 1990 to 2000 using this ...
Gropman Andrea L AL Department of Pediatrics and Neurology, Children's National Medical Center and the George Washington University of the Health Sciences, Washington, DC 20010, USA. - - 2013
Mutations in either nuclear DNA or mitochondrial DNA can result in disruption of oxidative phosphorylation and lead to mitochondrial dysfunction. Mitochondrial disease manifestations occur predominantly in the central nervous system, peripheral nervous system, and/or involve several organ systems. The consequences range from manifestations of a single organ or tissues, such ...
Williams Melonie M Vanderbilt University, Nashville, TN 37240-7817, - - 2013
Recent research using change-detection tasks has shown that a directed-forgetting cue, indicating that a subset of the information stored in memory can be forgotten, significantly benefits the other information stored in visual working memory. How do these directed-forgetting cues aid the memory representations that are retained? We addressed this question ...
- - 2013
Cover: Cover: Model of oscillatory motion of chromatin domains (ChrD) and replication timing. See article on page 609-616 by Pliss et al, in this issue. Cover design by Priscilla Vazquez.
Akin S - - 2013
It is generally believed that there is a beneficial effect of collaterals on death and re-infarction statistics in patients with coronary artery disease (CAD) but studies to date are small and inconsistent. To meta-analyse the studies published in this field in order to obtain more powerful information. We searched Medline ...
Muroi Carl - - 2013
The role and impact of systemic inflammatory response after aneurysmal subarachnoid hemorrhage remain to be elucidated. To assess the time course and correlation of systemic inflammatory parameters with outcome and the occurrence of delayed ischemic neurological deficits (DINDs) after subarachnoid hemorrhage. Besides the baseline characteristics, daily interleukin-6 (IL-6), procalcitonin, C-reactive ...
Lu Liwen L Lungs for Living Research Centre, UCL Respiratory, University College London, 5 University Street, London, WC1E 6JF, - - 2013
Epidermal growth factor receptor (EGFR) pathway activation is a frequent event in human carcinomas. Mutations in EGFR itself are, however, rare, and the mechanisms regulating EGFR activation remain elusive. Leucine-rich immunoglobulin repeats-1 (LRIG1), an inhibitor of EGFR activity, is one of four genes identified that predict patient survival across solid ...
Quinn Tam - - 2013
Pleural effusions can be catagorised in to transudative effusions or exudative effusions. Causes include cardiovascular disease, infection and neoplasm. Diagnosis is the key to determining what management is required. History and examination can elicit the cause of the effusion and radiological investigations can be a useful adjunct. Thoracocentesis and laboratory ...
Yanagawa Jane - - 2013
The uniquely diffuse nature of malignant pleural mesothelioma (MPM) makes it difficult to diagnose, stage, and treat. In addition, it is a relatively uncommon disease, making adequate prospective trials difficult to perform and leading to several controversies regarding the best management of MPM. Perhaps the greatest area of dispute is ...
Yalcin Nilay Gamze - - 2013
Pleural effusions are most often secondary to an underlying condition and may be the first sign of the underlying pathologic condition. The balance between the hydrostatic and oncotic forces dictates pleural fluid homeostasis. The parietal pleura has a more significant role in pleural fluid homeostasis. Its vessels are closer to ...
Gillen Jacob - - 2013
The treatment of chronic recurrent pleural effusions continues to evolve with the recent emergence of tunneled indwelling pleural catheters (IPCs). Talc pleurodesis has been the standard of care for treatment of recurrent pleural effusions, but IPCs have gained more favor in recent years. IPCs offer several advantages, including a less ...
Murthy Sudish C - - 2013
The two reasonable options for surgical management of malignant pleural effusions are tunneled pleural catheters and video-assisted thoracic surgery with talc pleurodesis. Successful palliation demands balancing the patient's wishes, performance status, and prognosis with the ability to obtain full lung expansion and control fluid production. There is no ideal procedure; ...
Thomas Rajesh - - 2013
Benign pleural effusions are twice as common as malignant effusions and have diverse causes and manifestations, which often makes them a diagnostic challenge. Differentiating effusions as a transudate or exudate is the first, and often helpful, step in directing investigations for diagnosis and management. Congestive heart failure and hepatic hydrothorax ...
Cooke David T - - 2013
Chest tubes are placed in the pleural space, either surgically or percutaneously to evacuate abnormal fluid and air. Indications for chest tubes include therapeutic drainage of pleural conditions such as pneumothorax, hemothorax, empyema, chylothorax, and malignant effusions, as well as prophylaxis drainage of air, blood, and other fluids after chest ...
Rathinam Sridhar - - 2013
Trapped lung is defined by the inability of the lung to expand and fill the thoracic cavity because of a restricting "peel." This restriction may be secondary to a benign inflammatory or fibrotic cortex or to a malignant visceral pleural tumor. This condition has a significant impact on the patient's ...
Tawadros Thomas - - 2013
The acquisition of neuroendocrine (NE) characteristics by prostate cancer (PCa) cells is closely related to tumour progression and hormone resistance. The mechanisms by which NE cells influence PCa growth and progression are not fully understood. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in oncogenic processes, and MIF ...
Kim Hee Yeon HY Division of Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, - - 2013
There is limited clinical research regarding the changes in peripheral lymphocyte subsets during the early post-operative period of liver transplantation. Serial changes of T cells and B cells in living donor liver transplantation (LDLT) recipients during the early post-transplantion period were prospectively investigated. From June 2010 to February 2011, 27 ...
Solomon A A Platelet Biology Group, Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, London, - - 2013
There is a proven link between exposure to traffic-derived particulate air pollution and the incidence of platelet-driven cardiovascular diseases. It is suggested that inhalation of small, nanosized particles increases cardiovascular risk via toxicological and inflammatory processes and translocation of nanoparticles into the bloodstream has been shown in experimental models. We ...
Georgiev Peter P New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, MA, - - 2013
Hypoxia-adenosinergic suppression and redirection of the immune response has been implicated in the regulation of antipathogen and antitumor immunity, with hypoxia-inducible factor 1α (HIF-1α) playing a major role. In this study, we investigated the role of isoform I.1, a quantitatively minor alternative isoform of HIF-1α, in antibacterial immunity and sepsis ...
Chen Haihan H Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, Iowa 52242, - - 2013
Airborne fly ash from coal combustion may represent a source of bioavailable iron (Fe) in the open ocean. However, few studies have focused on Fe speciation and distribution in coal fly ash. In this study, chemical imaging of fly ash has been performed using a dual-beam focused ion beam/scanning electron ...
Gonzalez Andrew - - 2013
There is concern that the rate of environmental change is now exceeding the capacity of many populations to adapt. Mitigation of biodiversity loss requires science that integrates both ecological and evolutionary responses of populations and communities to rapid environmental change, and can identify the conditions that allow the recovery of ...
Schiffers Katja - - 2013
Dispersal is a key determinant of a population's evolutionary potential. It facilitates the propagation of beneficial alleles throughout the distributional range of spatially outspread populations and increases the speed of adaptation. However, when habitat is heterogeneous and individuals are locally adapted, dispersal may, at the same time, reduce fitness through ...
Gonzalez Andrew A Biology Department, McGill University, 1205 Avenue Docteur Penfield, Montreal, Quebec, Canada. - - 2013
Whether evolution will be rapid enough to rescue declining populations will depend upon population size, the supply of genetic variation, the degree of maladaptation and the historical direction of selection. We examined whether the level of environmental stress experienced by a population prior to abrupt environmental change affects the probability ...
Bell Graham G Biology Department, McGill University, 1205 Avenue Docteur Penfield, Montreal, Quebec, Canada. - - 2013
Populations subject to severe stress may be rescued by natural selection, but its operation is restricted by ecological and genetic constraints. The cost of natural selection expresses the limited capacity of a population to sustain the load of mortality or sterility required for effective selection. Genostasis expresses the lack of ...
Ferriere Regis R Ecole Normale Supérieure, Laboratoire Ecologie-Evolution, UMR 7625 UPMC-ENS-CNRS, 46 rue d'Ulm, 75005 Paris, France. - - 2013
Adaptive dynamics theory has been devised to account for feedbacks between ecological and evolutionary processes. Doing so opens new dimensions to and raises new challenges about evolutionary rescue. Adaptive dynamics theory predicts that successive trait substitutions driven by eco-evolutionary feedbacks can gradually erode population size or growth rate, thus potentially ...
Kirkpatrick Mark M Section of Integrative Biology, University of Texas, Austin, TX 78712, USA. - - 2013
A factor that may limit the ability of many populations to adapt to changing conditions is the rate at which beneficial mutations can become established. We study the probability that mutations become established in changing environments by extending the classic theory for branching processes. When environments change in time, under ...
Osmond Matthew Miles MM Redpath Museum, McGill University, 859 Sherbrooke Street West, Montreal, Quebec, Canada. - - 2013
Populations facing novel environments can persist by adapting. In nature, the ability to adapt and persist will depend on interactions between coexisting individuals. Here we use an adaptive dynamic model to assess how the potential for evolutionary rescue is affected by intra- and interspecific competition. Intraspecific competition (negative density-dependence) lowers ...
Lavergne Sébastien S Laboratoire d'Ecologie Alpine, Université Joseph Fourier-CNRS, UMR 5553, 38041 Grenoble Cedex 9, France. - - 2013
Predicting how and when adaptive evolution might rescue species from global change, and integrating this process into tools of biodiversity forecasting, has now become an urgent task. Here, we explored whether recent population trends of species can be explained by their past rate of niche evolution, which can be inferred ...
Kovach-Orr Caolan C Department of Biology, McGill University, 1205 Avenue Docteur-Penfield, Montreal, Quebec, Canada. - - 2013
Under changing environmental conditions, intraspecific variation can potentially rescue populations from extinction. There are two principal sources of variation that may ultimately lead to population rescue: genetic diversity and phenotypic plasticity. We compared the potential for evolutionary rescue (through genetic diversity) and plastic rescue (through phenotypic plasticity) by analysing their ...
Chevin Luis-Miguel LM Centre d'Ecologie Fonctionnelle et Evolutive (UMR 5175), 1919 route de Mende, 34293 Montpellier Cedex 5, France. - - 2013
Population persistence in a new and stressful environment can be influenced by the plastic phenotypic responses of individuals to this environment, and by the genetic evolution of plasticity itself. This process has recently been investigated theoretically, but testing the quantitative predictions in the wild is challenging because (i) there are ...
Vander Wal E E Département de biologie, Université de Sherbrooke, 2500 boul. de l'Université, Sherbrooke, Québec, Canada. - - 2013
The current rapid rate of human-driven environmental change presents wild populations with novel conditions and stresses. Theory and experimental evidence for evolutionary rescue present a promising case for species facing environmental change persisting via adaptation. Here, we assess the potential for evolutionary rescue in wild vertebrates. Available information on evolutionary ...
Gomulkiewicz Richard R School of Biological Sciences, Washington State University, Pullman, WA 99164, USA. - - 2013
Laboratory model systems and mathematical models have shed considerable light on the fundamental properties and processes of evolutionary rescue. But it remains to determine the extent to which these model-based findings can help biologists predict when evolution will fail or succeed in rescuing natural populations that are facing novel conditions ...
Gienapp Phillip P Department of Animal Ecology, Netherlands Institute of Ecology (NIOO-KNAW), PO Box 50, 6700 AB Wageningen, The - - 2013
Populations need to adapt to sustained climate change, which requires micro-evolutionary change in the long term. A key question is how the rate of this micro-evolutionary change compares with the rate of environmental change, given that theoretically there is a 'critical rate of environmental change' beyond which increased maladaptation leads ...
Gandon S S CEFE, CNRS, 1919 route de Mende, Montpellier 34293, France. - - 2013
The ability of a pathogen to cause an epidemic when introduced in a new host population often relies on its ability to adapt to this new environment. Here, we give a brief overview of recent theoretical and empirical studies of such evolutionary emergence of pathogens. We discuss the effects of ...
Martin Guillaume G Université Montpellier 2, CC 065, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France. - - 2013
Evolutionary rescue occurs when a population genetically adapts to a new stressful environment that would otherwise cause its extinction. Forecasting the probability of persistence under stress, including emergence of drug resistance as a special case of interest, requires experimentally validated quantitative predictions. Here, we propose general analytical predictions, based on ...
Moroz Yurii S YS Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, - - 2013
We demonstrated that β-(1-azulenyl)-L-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein-protein interactions while not perturbing them.
- - 2013
The cover image shows the structure of methane hydrate, a form of water ice containing a large amount of methane within a crystal structure of water. Accurate description of hydrogen-bonding energies between water molecules and van der Waals interactions between guest molecules and host water cages is crucial for study ...
- - 2013
As presented on page 149 by Kenta Yamada and Nobuaki Koga, a method to analyze intramolecular interaction energy is applied to an analysis of the P-O bonding in phosphine oxide in conjunction with a newly developed technique to interpret change in electronic structure upon the interaction. The inside cover picture ...
Fortin Audrey A Centre de recherche du CHU Ste-Justine, Université de Montréal, Montréal, Québec, - - 2013
The relative ineffectiveness of hematopoietic stem cells in reaching the bone marrow upon transplantation combined with the limited number of these cells available is a major reason for graft failure and delayed hematopoietic recovery. Hence, the development of strategies that could enhance homing is of high interest. Here, we provide ...
Olney K E KE Department of Radiation Oncology, University of Iowa , Iowa City, IA 52242, - - 2013
Pharmacological ascorbate, via its oxidation, has been proposed as a pro-drug for the delivery of H(2)O(2) to tumors. Pharmacological ascorbate decreases clonogenic survival of pancreatic cancer cells, which can be reversed by treatment with scavengers of H(2)O(2). The goal of this study was to determine if inhibitors of intracellular hydroperoxide ...
Angoa-Pérez Mariana M Research & Development Service, John D. Dingell VA Medical Center, Detroit, MI 48201, - - 2013
Mephedrone (4-methylmethcathinone) is a β-ketoamphetamine stimulant drug of abuse with close structural and mechanistic similarities to methamphetamine. One of the most powerful actions associated with mephedrone is the ability to stimulate dopamine (DA) release and block its re-uptake through its interaction with the dopamine transporter (DAT). Although mephedrone does not ...
Manabe Yasuko Y Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA 02215, - - 2013
Chronic exercise training results in numerous skeletal muscle adaptations, including increases in insulin sensitivity and glycogen content. To understand the mechanism leading to increased muscle glycogen, we studied the effects of exercise training on glycogen regulatory proteins in rat skeletal muscle. Female Sprague Dawley rats performed voluntary wheel running for ...
Goitia Belén B Instituto de Fisiología, Biología Molecular y Neurociencias-IFIBYNE- CONICET-UBA, Intendente Guiraldes 2670, Pabellón 2, Piso 2, Ciudad Universitaria, C1428BGA-Buenos Aires, - - 2013
Methylphenidate (MPH) is widely used to treat children and adolescents diagnosed with attention deficit/hyperactivity disorder. Although MPH shares mechanistic similarities to cocaine, its effects on GABAergic transmission in sensory thalamic nuclei are unknown. Our objective was to compare cocaine and MPH effects on GABAergic projections between thalamic reticular and ventrobasal ...
Ahn Kwang H KH Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, - - 2013
Allosteric modulation of G-protein coupled receptors (GPCRs) represents a novel approach for fine-tuning GPCR functions. The cannabinoid CB1 receptor, a GPCR associated with the CNS, has been implicated in the treatment of drug addiction, pain, and appetite disorders. We report here the synthesis and pharmacological characterization of two indole-2-carboxamides:5-chloro-3-ethyl-1-methyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (ICAM-a) ...
Müller Lars L Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 25-29, D-07743 Jena, - - 2013
The health benefits of tomato seed oil (TSO) have been suggested to be related to its antioxidant activity, although at the moment not much information is available on the antioxidant effects of TSO in biological systems. In this paper, we evaluated the antioxidant capacity of TSO using different spectrophotometrical antioxidant ...
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