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Buas Matthew F MF Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, - - 2013
Gastroesophageal (GE) junction carcinoma is a rare but often lethal condition with increasing importance as a public health problem in recent decades. Whereas diagnosis of this disease has been complicated historically by the lack of uniform classification standards, available data from the Surveillance, Epidemiology, and End Results cancer registry program ...
Zhan Liang L Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-7334, - - 2013
The quest to map brain connectivity is being pursued worldwide using diffusion imaging, among other techniques. Even so, we know little about how brain connectivity measures depend on the magnetic field strength of the scanner. To investigate this, we scanned 10 healthy subjects at 7 and 3 tesla-using 128-gradient high-angular ...
Harris Estelle S ES Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, - - 2013
The leukocyte adhesion deficiency (LAD) syndromes are rare genetically determined conditions with challenging clinical features. These immunodeficiencies also provide insights that are broadly relevant to the biology of leukocytes, platelets, intercellular interactions, and intracellular signaling. Recent discoveries merit their review in the context of existing knowledge. New activities of β(2) ...
Schulle Krystal L KL University of Houston, College of Optometry, Houston, Texas 77204-2020, - - 2013
To determine the repeatability of eye length measurements made centrally and off-axis using a low-coherence interferometer. Eye length was measured (left eye) in 29 adults using the Haag-Streit Lenstar LS 900. Five measurements were made centrally, 10 degrees temporally, and 10 degrees nasally on the retina by the same examiner ...
Katsumata Yuriko Y Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA. - - 2013
We cross-sectionally examined which lipid profiles are associated with better cognitive function among those aged 80 and older, free of dementia (Clinical Dementia Rating ≤0.5), functionally independent, and community-dwelling. Our cohort consisted of 193 participants from the "Keys to Optimal Cognitive Aging (KOCOA) Project", a prospective cohort study in Okinawa, ...
Rivasseau Jonveaux Therese T CMRR de Lorraine Hôpital de Brabois CHU Nancy, Vandoeuvre les Nancy, France. - - 2013
The French Alzheimer Plan 2008-2012 anticipates the implementation of new Units specialized in cognitive rehabilitation and psycho-behavioral therapy of Alzheimer's disease (AD) patients. Conceived for AD and other dementia patients of all ages, their objectives are to propose a cognitive rehabilitation program, to prevent or treat psycho-behavioral crises, and to ...
Femminella Grazia Daniela GD Department of Medical Translational Sciences, Federico II University of Naples, Naples, - - 2013
Alzheimer's disease (AD) is a devastating form of dementia that imposes a severe burden on health systems and society. Although several aspects of AD pathogenesis have been elucidated over the last few decades, many questions still need to be addressed. In fact, currently available medications only provide symptomatic improvement in ...
Cagnin Annachiara A On leave at IRCCS, San Camillo Hospital Foundation, Venezia, Italy Department of Neurosciences: SNPSRR, University of Padova, Padova, Italy. - - 2013
Cholesterol metabolism alteration is a hot topic in the field of Alzheimer's disease (AD). However, data on plasma lipoproteins cholesterol distribution and oxidation in AD and their possible genetic determinants are lacking. The paraoxonase-1 (PON1) gene -107C/T promoter polymorphisms have been found associated with AD. One of the fundamental functions ...
Valenti Maria Teresa MT Department of Medicine, Clinic of Internal Medicine, Section D, University of Verona, Verona, - - 2013
N-truncated and N-modified forms of amyloid-β (Aβ) peptide are found in diffused and dense core plaques in Alzheimer's disease (AD) brain. Among them, the most abundant N-truncated peptide starts with pyroglutamyl at residue 3 (AβpE3). AβpE3 has increased aggregation potential and toxicity and its abundance has been reported to correlate ...
Tagliapietra Matteo M Department of Neurosciences, SNPSRR, University of Padova, Via Giustiniani 5, Padua, - - 2013
Rapidly progressive dementia (RPD) is a rare presentation of different neurological disorders characterized by cognitive impairment leading to loss of functional independence within 24 months or less. The increasing recognition of treatable non-prion causes of RPD has made the differential diagnosis with sporadic Creutzfeldt-Jakob disease (sCJD) of crucial importance. We ...
Laske Christoph C Section for Dementia Research, Hertie-Institute of Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Germany. - - 2013
Alzheimer's disease (AD) has been linked to a state of cerebral and systemic inflammation. The objective of the present study was to determine whether singular markers or a set of inflammatory biomarkers in peripheral blood allow discrimination between AD patients and healthy controls at the individual level. Using bead based ...
Cotton Calvin U CU Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4970, - - 2013
Proliferation of epithelial tissues is controlled by polarized distribution of signaling receptors including the EGF receptor (EGFR). In kidney, EGFRs are segregated from soluble ligands present in apical fluid of nephrons by selective targeting to basolateral membranes. We have shown previously that the epithelial-specific clathrin adaptor AP1B mediates basolateral EGFR ...
Fan Yongliang Y Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, - - 2013
Many insect groups have coevolved with bacterial endosymbionts that live within specialized host cells. As a salient example, ants in the tribe Camponotini rely on Blochmannia, an intracellular bacterial mutualist that synthesizes amino acids and recycles nitrogen for the host. We performed a shotgun, label-free, LC/MS/MS quantitative proteomic analysis to ...
Patti Gary J GJ Washington University, Department of Chemistry, Saint Louis, Missouri 63110, USA. - - 2013
Global metabolomics describes the comprehensive analysis of small molecules in a biological system without bias. With mass spectrometry-based methods, global metabolomic data sets typically comprise thousands of peaks, each of which is associated with a mass-to-charge ratio, retention time, fold change, p-value, and relative intensity. Although several visualization schemes have ...
Jo Sunhwan S Department of Molecular Biosciences and Center for Bioinformatics, The University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, - - 2013
Advanced free energy perturbation molecular dynamics (FEP/MD) simulation methods are available to accurately calculate absolute binding free energies of protein-ligand complexes. However, these methods rely on several sophisticated command scripts implementing various biasing energy restraints to enhance the convergence of the FEP/MD calculations, which must all be handled properly to ...
Dadiboyena Sureshbabu - - 2012
A solid-phase methodology to construct aminobenzimidazole tethered sultams and benzothiazepinones from commercial amino acids, amines, carboxylic acids and sulfonyl chlorides is described. Coupling of Fmoc-Cys(Trt)-OH to resin-bound aminobenzimidazole scaffold provided an essential precursor for the construction of a variety of seven membered benzofused cyclic sulfonamides and thiazepinones via palladium catalyzed ...
Cembran Alessandro A Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, - - 2012
The catalytic subunit of protein kinase A (PKA-C) is subject to several post- or cotranslational modifications that regulate its activity both spatially and temporally. Among those, N-myristoylation increases the kinase affinity for membranes and might also be implicated in substrate recognition and allosteric regulation. Here, we investigated the effects of ...
Swift Robert V RV Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, - - 2012
The mRNA guanylyltransferase, or mRNA capping enzyme, cotranscriptionally caps the 5'-end of nascent mRNA with GMP during the second reaction in a set of three enzymatic reactions that result in the formation of an N7-methylguanosine cap during mRNA maturation. The mRNA capping enzyme is characterized, in part, by a conserved ...
Yan Liang-Jun LJ Department of Pharmacology and Neuroscience and Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA. - - 2013
Under oxidative stress conditions, mitochondria are the major site for cellular production of reactive oxygen species (ROS) such as superoxide anion and H2O2 that can attack numerous mitochondrial proteins including dihydrolipoamide dehydrogenase (DLDH). While DLDH is known to be vulnerable to oxidative inactivation, the mechanisms have not been clearly elucidated. ...
Rivera-Cancel Giomar G Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-8816, - - 2012
Light-oxygen-voltage (LOV) domains serve as the photosensory modules for a wide range of plant and bacterial proteins, conferring blue light-dependent regulation to effector activities as diverse as enzymes and DNA binding. LOV domains can also be engineered into a variety of exogenous targets, allowing similar regulation for new protein-based reagents. ...
Yu Miao M Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, - - 2012
The high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), binds HDL and mediates selective cholesteryl ester uptake. SR-BI's structure and mechanism are poorly understood. We used mass spectrometry to assign the two disulfide bonds in SR-BI that connect cysteines within the conserved Cys(321)-Pro(322)-Cys(323) (CPC) motif and connect ...
Li Guodong - - 2012
Background/Aims: Over the past decade, heat shock protein 90 (Hsp90) has emerged as a potential therapeutic target for cancer. However, the molecular mechanisms of down-regulation Hsp90 expression in osteosarcoma are incompletely understood. To develop potential therapy targeting Heat shock protein 90B1 (Hsp90B1), we studied the roles of miR- 223 in ...
Bianco Giuliana - - 2012
Two synthetic precursor peptides, H(2)N-CVGIW and H(2)N-LVMCCVGIW, involved in the quorum sensing of Lactobacillus plantarum WCFS1, were characterized by mass spectrometry (MS) with electrospray ionization and 7-T Fourier transform ion cyclotron resonance (ESI-FTICR) instrument. Cell-free bacterial supernatant solutions were analyzed by reversed-phase liquid chromatography with ESI-FTICR MS to verify the ...
Cece Hasan - - 2012
PURPOSE: The aim of the study is to evaluate neonatal bilirubin encephalopathy in the acute period by the DWI. MATERIALS AND METHODS: Thirty newborn babies with hyperbilirubinemia at the gestational age of 38-40 weeks, diagnosed with acute neonatal bilirubin encephalopathy as a result of clinical findings were included in the study, ...
Zeinstra J S F - - 2012
In this study, we present the rare case of a patient with a multifocal giant cell tumor of the tendon sheath occurring at three different localizations along the same tendon. We review radiographic, ultrasonographic, and magnetic resonance imaging findings, and discuss previously reported cases.
Yoshizako Takeshi - - 2012
PURPOSE: The aim of this study was to determine to what extent we could identify the metabolism product peak using 3-T proton magnetic resonance spectroscopic imaging (MRSI) of the prostate gland in healthy volunteers by combining an external array coil with Malcolm Levitt composite-pulse decoupling sequence (MLEV)-point-resolved spatially localized spectroscopy ...
de Rijk Theo C - - 2012
Bacterial products based on Bacillus thuringiensis are registered in many countries as plant protection products (PPPs) and are widely used as insecticides and nematocides. However, certain B. thuringiensis strains produce harmful toxins and are therefore not allowed to be used as PPPs. The serotype B. thuringiensis thuringiensis produces the beta-exotoxin ...
Allahverdi Mahmoud - - 2012
PURPOSE: This study was performed to evaluate the role of in vivo dosimetry with semiconductor detectors in gynaecological medium dose rate brachytherapy, and to compare the actual doses delivered to organs at risk (as measured using in vivo dosimetry) with those calculated during treatment planning. MATERIALS AND METHODS: Doses to ...
Choi Sung Sik - - 2012
Soluble-NSF attachment protein receptor (SNARE) proteins play a role in vesicle fusion, exocytosis, and intracellular trafficking in neuronal cells as well as in fertilization and embryogenesis. We investigated the expression patterns of two SNARE proteins, SNAP-25 and synaptotagmin VII (SytVII), and their regulation by pregnant mare serum gonadotropin (PMSG) during ...
Liang Yu - - 2012
Capillary liquid chromatography (cLC) has great potential for protein and peptide separation, with advantages of high efficiency, high resolution, low sample consumption, and high sensitivity when coupled with mass spectrometry. In recent years, monoliths have been widely used as the stationary phases for capillary columns, owing to easy preparation, high ...
Snekhalatha U - - 2012
OBJECTIVE: The aim of this study was to evaluate the progression of arthritis in a complete Freund's adjuvant (CFA)-induced Wistar rat model and to monitor inflammatory arthritis activity using thermal imaging compared with histopathology. METHODOLOGY: Fifteen adult male Wistar rats were studied in an adjuvant-induced arthritis model by the injection ...
Bulavina Larisa - - 2012
Purinergic signaling plays a major role in the regulation of phagocytosis in microglia. Interplay between P2 and P1 receptor activation is controlled by a cascade of extracellular enzymes which dephosphorylate purines resulting in the formation of adenosine. The ATP- and ADP-degrading capacity of cultured microglia depends on the expression of ...
López-Saca José Mario - - 2012
Within an oncology setting, certain chemotherapy drugs, such as cisplatin, may lead to magnesium loss causing nephropathy. Neurological and cardiovascular symptoms caused by hypomagnesaemia are well known. The relationship between serious hypomagnesemia and severe pain is not well documented but nevertheless, when faced with unexplained episodes of pain which do ...
Choi Hyeyoung - - 2012
A rapid and simple gas chromatography-mass spectrometry (GC-MS) method was developed and validated to identify and quantify synthetic cannabinoids in the materials seized during drug trafficking. Accuracy and reproducibility of the method were improved by using deuterated JWH-018 and JWH-073 as internal standards. Validation results of the GC-MS method showed ...
Akerstedt Torbjörn - - 2012
Sleepiness is linked to accidents and reduced performance, and is usually attributed to short/poor prior sleep and sleepiness. However, while the link between reduced sleep and subsequent sleepiness is well established in laboratory experiments of sleep reduction, very little is known about the day-to-day variation of sleepiness in everyday life ...
Cippà Pietro E - - 2012
Survival of lymphocytes and melanocyte stem cells critically depends on B cell lymphoma 2 (Bcl-2). In T lymphocytes, a basal calcineurin activity maintains Bcl-2 expression in naïve cells, and the activation of the calcineurin pathway orchestrates the regulation of the intrinsic apoptosis pathway after antigen recognition. Therefore, calcineurin inhibitors might ...
Shizuka Daizaburo - - 2012
Parental food allocation in birds has long been a focal point for life history and parent-offspring conflict theories. In asynchronously hatching species, parents are thought to either adjust brood size through death of marginal offspring (brood reduction), or feed the disadvantaged chicks to reduce the competitive hierarchy (parental compensation). Here, ...
Mashima Ryuichi - - 2012
Asthma is a chronic inflammatory disease of the lung with airflow obstruction and bronchospasm, characterized by pulmonary eosinophilia, airway remodeling, increased airway hyperresponsiveness to environmental stimuli, and excessive Th2-type cytokine production. Recent studies indicate that crosstalk between the innate and adaptive immune systems is crucial for this disease. We and ...
Oliveira Jefferson Xavier de - - 2012
The aim of the present study was to investigate the relationship between degenerative bone changes of the head of the mandible and the presence of joint effusion (JE). This study was based on sagittal magnetic resonance imaging (MRI) reports of 148 temporomandibular joints (TMJs) of 74 patients complaining of pain ...
Plainchont Bertrand - - 2012
The validation of a molecular organic structure on the basis of 1D and 2D HSQC, COSY and HMBC NMR spectra is proposed as an alternative to the methods that are mainly based on chemical shift prediction. The CCASA software was written for this purpose. It provides an updated and improved ...
Shynlova Oksana - - 2012
This study aimed to determine the mechanism of uterine activation during labour, both term (TL) and preterm (PTL). We hypothesized that the peripheral leucocytes are recruited to uterine tissues by locally produced cytokines where they contribute to the initiation of parturition. Mouse uteri were collected (i) during gestation, TL and ...
Majumder M - - 2012
We report resistivity, magnetization and (19)F NMR results in a polycrystalline sample of SmFeAsO(0.86)F(0.14). The resistivity and magnetization data show a sharp drop at 48 K indicating a superconducting transition. The nuclear spin-lattice rate (1/T(1)) and spin-spin relaxation rate (1/T(2)) clearly show the existence of a structural phase transition near 163 K ...
Guan Ji-Lin - - 2012
BACKGROUND: The prognostic and predictive value of KRAS mutations in patients with lung cancer is controversial. Biases in disease stage, treatment regimen, small-scale patient studies, and biomarker status have led to inconsistent results in previous reports. METHODS: The KRAS and EGFR genes were examined in 1935 consecutive patients with non-small ...
Lee Tsair-Fwu - - 2012
ABSTRACT: BACKGROUND: With advances in modern radiotherapy (RT), many patients with head and neck (HN) cancer can be effectively cured. However, xerostomia is a common complication in patients after RT for HN cancer. The purpose of this study was to use the Lyman--Kutcher--Burman (LKB) model to derive parameters for the ...
Lee Jong Hoon - - 2012
PURPOSE: This study was conducted to evaluate the significance of carcinoembryonic antigen (CEA) level as a predictor for tumor response to chemoradiotherapy (CRT) and a prognosticator for survival in Asian patients with advanced rectal cancer. MATERIALS AND METHODS: We enrolled 345 patients with primary rectal cancer who had undergone preoperative ...
Chou Wan-Ting - - 2012
Background: It is unclear whether weight change since young adulthood affects the risk of mortality due to cardiovascular disease (CVD). The aim of this study was to investigate weight change since age 20 in relation to the risk of CVD mortality. Methods and Results: A total of 41,364 eligible Japanese men and ...
Silva Neto M B - - 2012
We investigate the unusual magnetic, thermodynamic and transport properties of nearly-critical, weakly-itinerant ferromagnets with the general formula UTX, where T=Rh, Co and X=Ge, Si. As a unique feature of these systems, we show how changes in the V(df) hybridization, which controls their proximity to a ferromagnetic instability, determine the evolution ...
Fearon Kenneth - - 2012
Cancer cachexia is a metabolic syndrome that can be present even in the absence of weight loss ('precachexia'). Cachexia is often compounded by pre-existing muscle loss, and is exacerbated by cancer therapy. Furthermore, cachexia is frequently obscured by obesity, leading to under-diagnosis and excess mortality. Muscle wasting (the signal event ...
Saha Adrija - - 2012
Murraya koenigii (Mk) leaves possess a hypoglycemic effect. Activity of paraoxonase 1 (PON1), a HDL-associated antioxidant enzyme, was found to be decreased during hyperglycemia. The present study explored the effect of Murraya koenigii leaves (MkL) on paraoxonase 1 activity in order to control the oxidative stress in diabetes. Hyperglycemia was ...
Striedner G - - 2012
 : Bioprocess engineering is an application-oriented science in an interdisciplinary environment, and a meaningful combination of different scientific disciplines is the only way to meet the challenges of bioprocess complexity. Setting up a reasoned process monitoring platform is the first step in an iterative procedure aiming at process and systems ...
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