Search Results
Results 101 - 150 of 4108
1 2 3 4 5 6 7 8 9 10 >
Kleinberg Lawrence - - 2013
Adenocarcinoma of the distal esophagus and gastroesophageal junction has been rapidly increasing in incidence in Western nations over the past several decades. Although in the past, a similar management strategy has been used for adenocarcinoma and squamous cell carcinoma, without distinguishing by location or pathology, there is now greater motivation ...
Svalheim S - - 2013
The aim of the study was to investigate immunoglobulin levels in patients with epilepsy using the antiepileptic drugs (AED) levetiracetam (LEV), carbamazepine (CBZ), or lamotrigine (LTG). A total of 211 patients and 80 controls (age: 18-45 years) of both genders were included. The patients had been treated with either LEV ...
Pacheco Susan M - - 2013
Clostridium difficile remains an important cause of infectious colitis, particularly in healthcare facilities. This review summarizes recent advances in the epidemiology, diagnosis, and treatment of this endemic pathogen. C. difficile infection (CDI) hospitalizations and mortality rates have increased over the last decade. The BI/NAP1/027 strain has been responsible for epidemics ...
Flesch Hannah - - 2013
Although insufficiently studied, schools of complementary and alternative medicine (CAM) provide substantial insight into the transformation of medicine in the United States. Scholars have suggested that the increasing acceptance of CAM is due to its alignment with biomedical models of professionalization, education, research, and practice. At West Coast University, students ...
Vedeler C A - - 2013
Chronic immune-mediated demyelinating polyneuropathies can often lead to severe neurologic disability. Literature review and personal experience with these types of neuropathies. It is important to recognize these immune-mediated neuropathies as they respond to treatment.
Vijayan Vinaya - - 2013
Several methods have been reported for identifying periodically varying genes from gene expression datasets. We compare the performance of five existing methods and a combination of G-statistic and autocovariance (called GVAR) using simulated sine-function-based and cell-cycle-based datasets. Based on this analysis we recommend appropriate methods for different experimental situations (length ...
Strobel Sebastian - - 2013
This article summarizes the latest developments for three types of idiopathic colitis: ulcerative colitis, Crohn's disease, and microscopic colitis. Crohn's disease and ulcerative colitis are highly related genetically. Colonoscopy remains the gold standard for making a diagnosis. The addition of chromoendoscopy can aid in identification and removal of colonic dysplasia ...
Saxena Sangeeta - - 2013
Geminiviruses are single-stranded circular DNA viruses causing leaf curl disease in papaya crop. Post-Transcriptional Gene Silencing (PTGS), also known as RNAi, acts as a natural antiviral defence mechanism and plays a role in genome maintenance and development in plants. PTGS suppression by viruses makes the plant RNA silencing machinery inefficient. ...
Sand K M - - 2013
Approximately 30% of all stroke patients suffer from post-stroke visual impairment. Hemianopia is the most common symptom, but also neglect, diplopia, reduced visual acuity, ptosis, anisocoria, and nystagmus are frequent. Partial or complete recovery of visual disorders can occur, but many patients suffer permanent disability. This disability is often less ...
Anzalone Charles L - - 2013
To highlight the recent observations regarding not only research but also the clinical features and management of Sweet's syndrome. Some of the new insights concerning Sweet's syndrome include: (1) bortezomib-induced Sweet's syndrome (some of which are the histiocytoid variant), (2) a rare extracutaneous manifestation of Sweet's syndrome with cardiovascular involvement ...
McLaughlin Maureen Kirkpatrick - - 2013
The aim of this study was to describe program requirements and scholarly outcomes for registered nurse (RN)-led research in US hospitals. Magnet recognition emphasis on evidence-based practice and research has stimulated the growth of hospital-based nursing research programs. Hospital policies stipulating whether RNs can lead studies as principal investigators (PIs) ...
Monjazeb Arta Monir - - 2013
The benefit of multimodality therapy is clearly established for adenocarcinomas of the distal esophagus and gastroesophageal junction, but its impact on toxicity is not well defined. We reviewed data from prospective randomized trials to better define the risks of multimodality therapy. The rates of surgical mortality and complications range from ...
Rivasseau Jonveaux Therese T CMRR de Lorraine Hôpital de Brabois CHU Nancy, Vandoeuvre les Nancy, France. - - 2013
The French Alzheimer Plan 2008-2012 anticipates the implementation of new Units specialized in cognitive rehabilitation and psycho-behavioral therapy of Alzheimer's disease (AD) patients. Conceived for AD and other dementia patients of all ages, their objectives are to propose a cognitive rehabilitation program, to prevent or treat psycho-behavioral crises, and to ...
Cotton Calvin U CU Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4970, - - 2013
Proliferation of epithelial tissues is controlled by polarized distribution of signaling receptors including the EGF receptor (EGFR). In kidney, EGFRs are segregated from soluble ligands present in apical fluid of nephrons by selective targeting to basolateral membranes. We have shown previously that the epithelial-specific clathrin adaptor AP1B mediates basolateral EGFR ...
Fan Yongliang Y Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, - - 2013
Many insect groups have coevolved with bacterial endosymbionts that live within specialized host cells. As a salient example, ants in the tribe Camponotini rely on Blochmannia, an intracellular bacterial mutualist that synthesizes amino acids and recycles nitrogen for the host. We performed a shotgun, label-free, LC/MS/MS quantitative proteomic analysis to ...
Patti Gary J GJ Washington University, Department of Chemistry, Saint Louis, Missouri 63110, USA. - - 2013
Global metabolomics describes the comprehensive analysis of small molecules in a biological system without bias. With mass spectrometry-based methods, global metabolomic data sets typically comprise thousands of peaks, each of which is associated with a mass-to-charge ratio, retention time, fold change, p-value, and relative intensity. Although several visualization schemes have ...
Jo Sunhwan S Department of Molecular Biosciences and Center for Bioinformatics, The University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, - - 2013
Advanced free energy perturbation molecular dynamics (FEP/MD) simulation methods are available to accurately calculate absolute binding free energies of protein-ligand complexes. However, these methods rely on several sophisticated command scripts implementing various biasing energy restraints to enhance the convergence of the FEP/MD calculations, which must all be handled properly to ...
Dadiboyena Sureshbabu - - 2012
A solid-phase methodology to construct aminobenzimidazole tethered sultams and benzothiazepinones from commercial amino acids, amines, carboxylic acids and sulfonyl chlorides is described. Coupling of Fmoc-Cys(Trt)-OH to resin-bound aminobenzimidazole scaffold provided an essential precursor for the construction of a variety of seven membered benzofused cyclic sulfonamides and thiazepinones via palladium catalyzed ...
Cembran Alessandro A Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, - - 2012
The catalytic subunit of protein kinase A (PKA-C) is subject to several post- or cotranslational modifications that regulate its activity both spatially and temporally. Among those, N-myristoylation increases the kinase affinity for membranes and might also be implicated in substrate recognition and allosteric regulation. Here, we investigated the effects of ...
Yan Liang-Jun LJ Department of Pharmacology and Neuroscience and Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA. - - 2013
Under oxidative stress conditions, mitochondria are the major site for cellular production of reactive oxygen species (ROS) such as superoxide anion and H2O2 that can attack numerous mitochondrial proteins including dihydrolipoamide dehydrogenase (DLDH). While DLDH is known to be vulnerable to oxidative inactivation, the mechanisms have not been clearly elucidated. ...
Swift Robert V RV Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, - - 2012
The mRNA guanylyltransferase, or mRNA capping enzyme, cotranscriptionally caps the 5'-end of nascent mRNA with GMP during the second reaction in a set of three enzymatic reactions that result in the formation of an N7-methylguanosine cap during mRNA maturation. The mRNA capping enzyme is characterized, in part, by a conserved ...
Glueck Charles J CJ Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH, USA. - - 2013
Prospectively assess whether metformin/diet pre-conception and throughout pregnancy would safely reduce first trimester miscarriage and improve pregnancy outcomes in women with polycystic ovary syndrome (PCOS). In 76 PCOS women, first pregnancy miscarriage and live birth were compared before and on metformin/diet, started 6.8 months (median) before conception, continued throughout pregnancy. ...
Rivera-Cancel Giomar G Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-8816, - - 2012
Light-oxygen-voltage (LOV) domains serve as the photosensory modules for a wide range of plant and bacterial proteins, conferring blue light-dependent regulation to effector activities as diverse as enzymes and DNA binding. LOV domains can also be engineered into a variety of exogenous targets, allowing similar regulation for new protein-based reagents. ...
Yu Miao M Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, - - 2012
The high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), binds HDL and mediates selective cholesteryl ester uptake. SR-BI's structure and mechanism are poorly understood. We used mass spectrometry to assign the two disulfide bonds in SR-BI that connect cysteines within the conserved Cys(321)-Pro(322)-Cys(323) (CPC) motif and connect ...
Li Guodong - - 2012
Background/Aims: Over the past decade, heat shock protein 90 (Hsp90) has emerged as a potential therapeutic target for cancer. However, the molecular mechanisms of down-regulation Hsp90 expression in osteosarcoma are incompletely understood. To develop potential therapy targeting Heat shock protein 90B1 (Hsp90B1), we studied the roles of miR- 223 in ...
Liu Kewei - - 2012
Single β-Ga(2) O(3) /amorphous SnO(2) core/shell microribbon-based sensors are fabricated on page 3599 on a flexible substrate. In future life and health science fields, this sensor array can be used to detect the relative humidity of air at room temperature. Sensitivity increases linearly with strain, and can therefore be enhanced ...
Zhou Xuechang - - 2012
Large-area, serial fabrication of 3D polymer structures via parallel dippen nanodisplacement lithography (p-DNL) is demonstrated by Z. Zheng and co-workers on page 3568. p-DNL is a scanning probe-based lithography method that utilizes an array of atomic force microscopy tips to simultaneously displace the inert self-assembled monolayer (SAM) on the surface ...
Zeinstra J S F - - 2012
In this study, we present the rare case of a patient with a multifocal giant cell tumor of the tendon sheath occurring at three different localizations along the same tendon. We review radiographic, ultrasonographic, and magnetic resonance imaging findings, and discuss previously reported cases.
Cece Hasan - - 2012
PURPOSE: The aim of the study is to evaluate neonatal bilirubin encephalopathy in the acute period by the DWI. MATERIALS AND METHODS: Thirty newborn babies with hyperbilirubinemia at the gestational age of 38-40 weeks, diagnosed with acute neonatal bilirubin encephalopathy as a result of clinical findings were included in the study, ...
Allahverdi Mahmoud - - 2012
PURPOSE: This study was performed to evaluate the role of in vivo dosimetry with semiconductor detectors in gynaecological medium dose rate brachytherapy, and to compare the actual doses delivered to organs at risk (as measured using in vivo dosimetry) with those calculated during treatment planning. MATERIALS AND METHODS: Doses to ...
Bulavina Larisa - - 2012
Purinergic signaling plays a major role in the regulation of phagocytosis in microglia. Interplay between P2 and P1 receptor activation is controlled by a cascade of extracellular enzymes which dephosphorylate purines resulting in the formation of adenosine. The ATP- and ADP-degrading capacity of cultured microglia depends on the expression of ...
López-Saca José Mario - - 2012
Within an oncology setting, certain chemotherapy drugs, such as cisplatin, may lead to magnesium loss causing nephropathy. Neurological and cardiovascular symptoms caused by hypomagnesaemia are well known. The relationship between serious hypomagnesemia and severe pain is not well documented but nevertheless, when faced with unexplained episodes of pain which do ...
Choi Hyeyoung - - 2012
A rapid and simple gas chromatography-mass spectrometry (GC-MS) method was developed and validated to identify and quantify synthetic cannabinoids in the materials seized during drug trafficking. Accuracy and reproducibility of the method were improved by using deuterated JWH-018 and JWH-073 as internal standards. Validation results of the GC-MS method showed ...
de Rijk Theo C - - 2012
Bacterial products based on Bacillus thuringiensis are registered in many countries as plant protection products (PPPs) and are widely used as insecticides and nematocides. However, certain B. thuringiensis strains produce harmful toxins and are therefore not allowed to be used as PPPs. The serotype B. thuringiensis thuringiensis produces the beta-exotoxin ...
Yoshizako Takeshi - - 2012
PURPOSE: The aim of this study was to determine to what extent we could identify the metabolism product peak using 3-T proton magnetic resonance spectroscopic imaging (MRSI) of the prostate gland in healthy volunteers by combining an external array coil with Malcolm Levitt composite-pulse decoupling sequence (MLEV)-point-resolved spatially localized spectroscopy ...
Liang Yu - - 2012
Capillary liquid chromatography (cLC) has great potential for protein and peptide separation, with advantages of high efficiency, high resolution, low sample consumption, and high sensitivity when coupled with mass spectrometry. In recent years, monoliths have been widely used as the stationary phases for capillary columns, owing to easy preparation, high ...
Choi Sung Sik - - 2012
Soluble-NSF attachment protein receptor (SNARE) proteins play a role in vesicle fusion, exocytosis, and intracellular trafficking in neuronal cells as well as in fertilization and embryogenesis. We investigated the expression patterns of two SNARE proteins, SNAP-25 and synaptotagmin VII (SytVII), and their regulation by pregnant mare serum gonadotropin (PMSG) during ...
Bianco Giuliana - - 2012
Two synthetic precursor peptides, H(2)N-CVGIW and H(2)N-LVMCCVGIW, involved in the quorum sensing of Lactobacillus plantarum WCFS1, were characterized by mass spectrometry (MS) with electrospray ionization and 7-T Fourier transform ion cyclotron resonance (ESI-FTICR) instrument. Cell-free bacterial supernatant solutions were analyzed by reversed-phase liquid chromatography with ESI-FTICR MS to verify the ...
Snekhalatha U - - 2012
OBJECTIVE: The aim of this study was to evaluate the progression of arthritis in a complete Freund's adjuvant (CFA)-induced Wistar rat model and to monitor inflammatory arthritis activity using thermal imaging compared with histopathology. METHODOLOGY: Fifteen adult male Wistar rats were studied in an adjuvant-induced arthritis model by the injection ...
Xiang Yu - - 2013
We report herein a general methodology for metal ion detection using low-cost, simple, and widely accessible personal glucose meters through an invasive DNA approach.
Patterson J M - - 2012
OBJECTIVES: A diagnosis of head and neck cancer (HNC) is a profound event for patients and family members who play a crucial role in their care. Eating and drinking difficulties affect patients' quality of life (QOL), but the impact on the carers' QOL has not been explored. This preliminary mixed ...
Gómez García Ignacio - - 2012
Abstract Objective. The aims of this study were to investigate retroperitoneal fibrosis in a Spanish hospital and present a review of the international literature to attempt to elucidate a diagnostic and therapeutic approach to this unusual pathology. Material and methods. A database search was performed in the pathology department and ...
Brilhante R S N - - 2012
This study evaluated the in vitro interaction between ciprofloxacin (CIP) and classical antifungals against Histoplasma capsulatum var. capsulatum in mycelial (n = 16) and yeast-like forms (n = 9) and Coccidioides posadasii in mycelial form (n = 16). This research was conducted through broth microdilution and macrodilution, according to Clinical Laboratory Standards Institute. Inocula were prepared ...
Kubo Eri E Department of Ophthalmology, Kanazawa Medical University, Kahoku, Ishikawa, Japan. - - 2013
Injury to lens epithelial cells (LECs) leads to epithelial-mesenchymal transition (EMT) with resultant fibrosis. The tropomyosin (Tpm) family of cytoskeleton proteins is involved in regulating and stabilizing actin microfilaments. Aberrant expression of Tpms leads to abnormal morphological changes with disintegration of epithelial integrity. The EMT of LECs has been proposed ...
Procacci N M - - 2012
Bimanual coordination is governed by constraints that permit congruent movements to be performed more easily than incongruent movements. Theories concerning the origin of these constraints range from low level motor-muscle explanations to high level perceptual-cognitive ones. To elucidate the processes underlying coordinative constraints, we asked subjects to use a pair ...
David Tomáš - - 2012
Three symmetrical methylene-bis[(aminomethyl)phosphinic acids] bearing different substituents on the central carbon atom, (NH(2)CH(2))PO(2)H-C(R(1))(R(2))-PO(2)H(CH(2)NH(2)) where R(1) = OH, R(2) = Me (H(2)), R(1) = OH, R(2) = Ph (H(2)) and R(1),R(2) = H (H(2)), were synthesized. Acid-base and complexing properties of the ligands were studied in solution as well as in ...
Tassin Alexandra A Laboratory of Molecular Biology, Research Institute for Health Sciences and Technology, University of Mons, Mons, - - 2013
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most frequent hereditary muscle disorders. It is linked to contractions of the D4Z4 repeat array in 4q35. We have characterized the double homeobox 4 (DUX4) gene in D4Z4 and its mRNA transcribed from the distal D4Z4 unit to a polyadenylation signal in ...
D'Adamo Ebe - - 2012
Abstract In obese adults with non alcoholic fatty liver disease (NAFLD), treatment with vitamin E has resulted in an improvement in liver histology, whereas variable and limited results are available in children. Our aim was to assess whether lifestyle combined with supplementation with Vitamin E might reduce oxidative stress and ...
Liao Xiao-Ling - - 2012
BACKGROUND AND PURPOSE: The European Cooperative Acute Stroke Study (ECASS) III showed that intravenous recombinant tissue plasminogen activator (rtPA) administered in the 3 to 4.5 h after symptom onset significantly improved clinical outcomes in patients with acute ischemic stroke (AIS). But little is known regarding the safety and efficacy of intravenous ...
Scriba M F - - 2012
Insight into the function of sleep may be gained by studying animals in the ecological context in which sleep evolved. Until recently, technological constraints prevented electroencephalogram (EEG) studies of animals sleeping in the wild. However, the recent development of a small recorder (Neurologger 2) that animals can carry on their ...
1 2 3 4 5 6 7 8 9 10 >