Search Results
Results 51 - 100 of 4108
1 2 3 4 5 6 7 8 9 10 >
Ahn Kwang H KH Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, - - 2013
Allosteric modulation of G-protein coupled receptors (GPCRs) represents a novel approach for fine-tuning GPCR functions. The cannabinoid CB1 receptor, a GPCR associated with the CNS, has been implicated in the treatment of drug addiction, pain, and appetite disorders. We report here the synthesis and pharmacological characterization of two indole-2-carboxamides:5-chloro-3-ethyl-1-methyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (ICAM-a) ...
Müller Lars L Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 25-29, D-07743 Jena, - - 2013
The health benefits of tomato seed oil (TSO) have been suggested to be related to its antioxidant activity, although at the moment not much information is available on the antioxidant effects of TSO in biological systems. In this paper, we evaluated the antioxidant capacity of TSO using different spectrophotometrical antioxidant ...
Valenti Maria Teresa MT Department of Medicine, Clinic of Internal Medicine, Section D, University of Verona, Verona, - - 2013
N-truncated and N-modified forms of amyloid-β (Aβ) peptide are found in diffused and dense core plaques in Alzheimer's disease (AD) brain. Among them, the most abundant N-truncated peptide starts with pyroglutamyl at residue 3 (AβpE3). AβpE3 has increased aggregation potential and toxicity and its abundance has been reported to correlate ...
Zhan Liang L Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-7334, - - 2013
The quest to map brain connectivity is being pursued worldwide using diffusion imaging, among other techniques. Even so, we know little about how brain connectivity measures depend on the magnetic field strength of the scanner. To investigate this, we scanned 10 healthy subjects at 7 and 3 tesla-using 128-gradient high-angular ...
Amenabar Alfredo - - 2013
Surgical resection remains the mainstay of potentially curative therapy for gastroesophageal junction (GEJ) tumors. However, because of the location of the tumor at the boundary between the esophagus and stomach, GEJ tumors have been a source of controversy in regard to their definition, classification, staging and surgical management. The definition ...
Rønning O M - - 2013
The purpose of this article is to find possible predictors associated with long-term mortality and long-term cardiovascular death after stroke. A cohort of 550 patients with acute stroke admitted to a single hospital within 24 h of a stroke were recruited consecutively. Patients were followed for 12 years or until death. Information ...
Buas Matthew F MF Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, - - 2013
Gastroesophageal (GE) junction carcinoma is a rare but often lethal condition with increasing importance as a public health problem in recent decades. Whereas diagnosis of this disease has been complicated historically by the lack of uniform classification standards, available data from the Surveillance, Epidemiology, and End Results cancer registry program ...
Cagnin Annachiara A On leave at IRCCS, San Camillo Hospital Foundation, Venezia, Italy Department of Neurosciences: SNPSRR, University of Padova, Padova, Italy. - - 2013
Cholesterol metabolism alteration is a hot topic in the field of Alzheimer's disease (AD). However, data on plasma lipoproteins cholesterol distribution and oxidation in AD and their possible genetic determinants are lacking. The paraoxonase-1 (PON1) gene -107C/T promoter polymorphisms have been found associated with AD. One of the fundamental functions ...
Sarasohn-Kahn Jane - - 2013
This article discusses the role of patients and self-care enabled through the use of technology. Patients have shown interest in healthcare tools that are artfully designed and based on their wants and personal habits. The expectation is that, as these tools evolve, patients will find sufficient motivation and capability to ...
Ananthapadmanabhan K P - - 2013
A symposium was held in October 2011 on skin cleansing and its role in basic skin care. The meeting was attended by an international group of leading dermatologists.
Wu Jingli - - 2013
Haplotyping problem has been the subject of extensive research in recent years, and is one of the hottest areas of Computational Biology today. In this paper, we study the single individual Single Nucleotide Polymorphism (SNP) haplotype reconstruction problem. A heuristic algorithm is proposed for assembling a pair of haplotypes from ...
Thilakarathne Pushpike J - - 2013
In microarray data analysis, the comparison of gene expression levels in different conditions and selection of biologically relevant genes are essential tasks. In this study, we propose a novel statistical procedure based on standardised conditional residuals from a linear mixed-effects model which allows comparison of conditions, even if only one ...
Ljøstad U - - 2013
In this review, we aim to discuss the definition, clinical and laboratory features, diagnostics, and management of chronic Lyme. Chronic Lyme is a rare condition caused by long-lasting and ongoing infection with the spirochete Borrelia burgdorferi (Bb). The most common manifestations are progressive encephalitis, myelitis, acrodermatitis chronica atrophicans with or ...
Hong Theodore S - - 2013
Targeted therapies have been studied in combination with chemoradiation therapy for esophageal and gastroesophageal junction cancers. To date, the Human Epidermal Growth Factor Receptor 2 (HER2) HER2, epidermal growth factor receptor, and vascular endothelial growth factor pathways have been most extensively studied in esophagogastric cancers. However, despite strong preclinical rationale ...
Femminella Grazia Daniela GD Department of Medical Translational Sciences, Federico II University of Naples, Naples, - - 2013
Alzheimer's disease (AD) is a devastating form of dementia that imposes a severe burden on health systems and society. Although several aspects of AD pathogenesis have been elucidated over the last few decades, many questions still need to be addressed. In fact, currently available medications only provide symptomatic improvement in ...
Gjerstad L - - 2013
There is a strong tradition of neuroscience in Norway, and Norwegian neurologists have been actively involved in developing partnerships between all those who recognize the importance of the brain and of brain diseases. It was therefore unsurprising that Norwegian neurologists took the initiative in establishing the Norwegian Brain Council (NBC). ...
Fromm A - - 2013
Mild cognitive impairment (MCI) is a subtle memory disorder not matching criteria for dementia. There is evidence for vascular comorbidity in several types of dementia. We hypothesized that neurovascular workup would detect a high degree of vascular disease in patients with MCI. In cooperation with our memory clinic, patients with ...
Tagliapietra Matteo M Department of Neurosciences, SNPSRR, University of Padova, Via Giustiniani 5, Padua, - - 2013
Rapidly progressive dementia (RPD) is a rare presentation of different neurological disorders characterized by cognitive impairment leading to loss of functional independence within 24 months or less. The increasing recognition of treatable non-prion causes of RPD has made the differential diagnosis with sporadic Creutzfeldt-Jakob disease (sCJD) of crucial importance. We ...
Wu Abraham J - - 2013
Positron emission tomography (PET) is now widely used in the initial evaluation of esophageal and gastroesophageal junction tumors. It can detect otherwise occult metastases, affecting staging and treatment in a significant proportion of patients. The intensity of PET uptake before treatment has been correlated with outcomes, but it remains uncertain ...
Lulu Sabeen S UCSF Multiple Sclerosis Center, San Francisco, CA 94158, USA. - - 2013
The continuous improvements of our understanding of the pathophysiological changes that occur in multiple sclerosis (MS) have translated into many novel therapeutic agents at different stages of development. These agents target more specifically the innate or the adaptive immune response. We will review agents available or under development that target ...
Pepek Joseph M - - 2013
Contemporary randomized trials have demonstrated that radiation therapy combined with chemotherapy and surgery improves survival in both the neoadjuvant and adjuvant treatment of gastroesophageal cancers. Consequently, radiation treatment planning and administration have taken on an added importance to ensure optimal outcomes as well as minimize treatment-related morbidity. This article highlights ...
Brosius Frank C FC - - 2013
There has been an advance in our understanding of the mechanisms of diabetic nephropathy over the past few years and much of that has occurred because of studies in animal models of diabetic nephropathy. Studies in animal models of diabetic nephropathy, especially in mice, have underlined the multifactorial nature of ...
Olchanski Natalia - - 2013
The Patient Protection and Affordable Care Act of 2010 (ACA) added preventive services for women, recommended by the IOM, to healthcare coverage requirements beginning in August 2011. The current review provides evidence on the economic impact of services that will be covered under the ACA, focusing on IOM-recommended measures that ...
Meier Carlos - - 2013
This article discusses the role of data in the reform of the U.S. healthcare system by focusing on electronic health records (EHRs) and the role of stakeholders. Review of research published between 2005 and 2012 was conducted in 2012. Published literature supports the benefit of information technology in the healthcare ...
Lund C G - - 2013
In acute ischemic stroke, rapid revascularization of the cerebral 'penumbra volume' is the key to better patient outcome. The largest and most proximal cerebral thrombotic artery occlusions can in most cases only be opened by intra-arterial intervention. The use of intra-arterial revascularization is rapidly expanding throughout Europe and North America, ...
Laske Christoph C Section for Dementia Research, Hertie-Institute of Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Germany. - - 2013
Alzheimer's disease (AD) has been linked to a state of cerebral and systemic inflammation. The objective of the present study was to determine whether singular markers or a set of inflammatory biomarkers in peripheral blood allow discrimination between AD patients and healthy controls at the individual level. Using bead based ...
Di Biase Luigi - - 2013
Long-standing persistent (LSP) atrial fibrillation is the most challenging arrhythmia to treat. Catheter ablation of atrial fibrillation has reached satisfactory results for the long-term treatment of paroxysmal atrial fibrillation, but not for the treatment of LSP atrial fibrillation. Several approaches with various outcomes have been described in the literature. The ...
Cario Elke - - 2013
This review focuses on recent advances and novel insights into the mechanistic events that may link commensal microbiota and host innate immunity in the pathophysiology of intestinal inflammation and neoplasia. Unanswered questions are discussed and future perspectives in the field are highlighted. Commensal microbiota, host innate immunity, and genetics form ...
Zhang Guangya - - 2013
In this study, the amino acid composition of thermophilic and mesophilic protein sequences was systematically analysed to obtain the thermostable factors. We found that the residues, Ala, Val, Leu, Ile, Thr, Gln, Glu, Lys and Arg showed a significant difference between these two kinds of proteins. On the basis of ...
Nissen Nina - - 2013
Health practices designated, over time, as complementary and alternative to normative biomedicine represent one of the earliest manifestations of the growing significance, especially for women, of holistic health care in many Western English-speaking societies. In this article, I interrogate ideas and practices around the body and self in Western herbal ...
Ku Geoffrey Y - - 2013
A doublet of a fluoropyrimidine and a platinum compound remains the reference regimen in palliative chemotherapy for esophagogastric cancers. Newer regimens involve the substitution of infusional 5-fluorouracil (FU) for a shorter infusional schedule or oral 5-FU prodrugs and the replacement of cisplatin with oxaliplatin. Although the addition of epirubicin to ...
Lunde H M B - - 2013
The major sleep disorders are common in multiple sclerosis (MS) and are associated with significant morbidity. Despite this, the rate of recognition and management of these conditions are low. All types of sleep disorders are seen in patients with MS: insomnia, circadian rhythm sleep disorders, sleep-related movement disorders, sleep-related breathing ...
Gras Beatriz - - 2013
Symptoms associated with disorders of the motility of colon and rectum are common problems in clinical practice. Advances in this field continue to expand our understanding of these disorders and provide new and different treatments with promising results. This article reviews new advances in the past year on the measurement ...
Raineau Clémentine - - 2013
The descriptions of fire charmers' practice, its context, and physicians' stances toward these healing practices demonstrate the resistance of French biomedical institutions toward the full acceptance of the logic of care. I draw on data from observations conducted in a rural area of the Auvergne, France (1996-1999), semistructured interviews with ...
Pan Ende - - 2013
Ammosamides E-F (1-2), are amidine analogs of the ammosamide family of alkaloids isolated from a marine-derived Streptomyces variabilis. Further studies with S. variabilis revealed a variety of aryl and alkyl amines added into the fermentation media could be efficiently incorporated into the ammosamide framework to generate a library of precursor-directed ...
Torkildsen O - - 2013
Fat-soluble vitamins (A, D, E and K) have properties that could be relevant as modulators of disease activity in multiple sclerosis (MS). We performed a systematic search on PubMed and Medline up to May 2012, using the search strings 'vitamin A', 'retinol', 'retinal', 'carotenoids', 'vitamin D', 'vitamin E', 'alpha-tocopherol', 'vitamin ...
Lang Claudia - - 2013
The appropriation of biopsychiatric concepts such as depression, and their reframing in clinical and academic discussions, are important parts of the revitalization of bhūt vidyā as Ayurvedic psychiatry. Drawing on ethnographic fieldwork conducted in Kerala from 2009 to 2011, in this article we explore the process and the controversies of ...
Xie Minzhu - - 2013
The individual haplotyping problem is the computational problem of constructing two haplotypes from one's DNA fragments. We proposed parameterised algorithms for computational models Minimum SNP Removal (MSR) and Minimum Fragment Removal (MFR) of the problem. For m DNA fragments and n SNPs, our algorithms solve MSR and MFR in O(2<SUP ...
Brodtkorb E - - 2013
Many episodic phenomena involving motor, sensory, autonomic, and behavioral functions may imitate epilepsy. The aim of this article is to focus on the various manifestations and the diagnostic and therapeutic challenges of the most common of these disorders, as well as their relationship to emotional aspects. Syncope is caused by ...
Schulle Krystal L KL University of Houston, College of Optometry, Houston, Texas 77204-2020, - - 2013
To determine the repeatability of eye length measurements made centrally and off-axis using a low-coherence interferometer. Eye length was measured (left eye) in 29 adults using the Haag-Streit Lenstar LS 900. Five measurements were made centrally, 10 degrees temporally, and 10 degrees nasally on the retina by the same examiner ...
Kurz M W - - 2013
The understanding of stroke has changed in the recent years from rehabilitation to an emergency approach. We review existing data from symptom recognition to thrombolysis and identify challenges in the different phases of patient treatment. Implementation of treatment in dedicated stroke units with a multidisciplinary team exclusively treating stroke patients ...
Wuethrich Patrick Y - - 2013
In a previous observational study, thoracic epidural analgesia (TEA) after open renal surgery resulted in clinically relevant postvoid residuals (PVRs). This study aimed to investigate the individual contribution of epidurally administrated drugs and surgery in bladder dysfunction. In this single-center, parallel-group, randomized (computer-generated list), double-blind superiority trial, 40 patients undergoing ...
Katsumata Yuriko Y Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA. - - 2013
We cross-sectionally examined which lipid profiles are associated with better cognitive function among those aged 80 and older, free of dementia (Clinical Dementia Rating ≤0.5), functionally independent, and community-dwelling. Our cohort consisted of 193 participants from the "Keys to Optimal Cognitive Aging (KOCOA) Project", a prospective cohort study in Okinawa, ...
Kelly Katherine Patterson - - 2013
The aim of this study was to describe the facilitators and hindrances associated with the conduct of registered nurse-led research in US hospitals. Hospital-based nursing research programs are growing in response to increasing emphasis on evidence-based practice. Concerns existed about institutional regulations prohibiting staff nurses' ability to be principal investigators ...
Harris Estelle S ES Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, - - 2013
The leukocyte adhesion deficiency (LAD) syndromes are rare genetically determined conditions with challenging clinical features. These immunodeficiencies also provide insights that are broadly relevant to the biology of leukocytes, platelets, intercellular interactions, and intracellular signaling. Recent discoveries merit their review in the context of existing knowledge. New activities of β(2) ...
Cappendijk Susanne L T - - 2013
The zebra finch is a superb natural animal model to study cognition and as such could contribute to the further understanding of nicotinic intervention therapies for patients suffering from cognitive impairment as observed in neurodegenerative disorders. Manual analysis of data produced by this model is extremely labour intensive, error-prone, and ...
Knudsen-Baas K M - - 2013
Pseudoprogression is a treatment-related effect seen on imaging in high-grade glioma. Enhancement of gadolinium contrast on control MRI can be misinterpreted as tumor recurrence and is also difficult to distinguish from radiation necrosis. Pseudoprogression is seen in up to 30% after standard treatment for glioblastoma multiforme (GBM), which is radiotherapy ...
Mathis Kellie L - - 2013
The field of colorectal surgery continues to move forward as technical innovations emerge and as surgeons ask critical questions. The results of subsequent investigations often lead to changes in practice. This review examines recent publications that describe these practice changes. We identified and reviewed recent publications in the areas of ...
McClean Stuart - - 2013
In the arena of biomedical sciences, technical skills and expert judgment are at a premium, and the standardization and repeatability of an intervention is crucial to help determine, for example, the effectiveness of a new drug in a clinical trial. Crystal and spiritual healers are less rule-bound, and their playfulness ...
Hamlyn John M - - 2013
Endogenous cardiotonic steroids (CTS) exert long-term effects on salt and blood pressure homeostasis. Here we discuss recent observations on mechanisms of salt sensitivity that involve endogenous ouabain and novel pathways in the brain and discuss their possible relationship to arterial and renal function in hypertension. Chronic elevation of brain sodium ...
1 2 3 4 5 6 7 8 9 10 >