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Kotzé Sanet Henriët - - 2012
Many studies have reported on the perceptions of medical students toward dissection. It is important to understand the feelings and symptoms experienced during dissection so that they can be adequately handled. Prior to dissection, first year students are given lectures on aspects of dissection, death and dying, and death rituals ...
Donovan Jeff - - 2012
BACKGROUND: Lichen planopilaris (LPP) is a type of primary scarring alopecia. The pathogenesis is poorly understood, although traumatic skin injury has been implicated in some cases. OBJECTIVE: To present 17 patients diagnosed with LPP after hair transplant surgery. MATERIALS AND METHODS: A retrospective review of the records of patients referred ...
You Liang - - 2012
An efficient and environment friendly surface-protected etching method by using mesoporous silica as a template and alkaline polyelectrolyte as both the protecting and etching agent was developed to prepare a SiO(2) nanotube with a porous shell. The polyelectrolytes attached to the template not only create a localized alkaline environment, but ...
Knapp D W - - 2012
BACKGROUND: Cisplatin combined with a nonselective cyclooxygenase (cox) inhibitor has potent antitumor activity against transitional cell carcinoma (TCC) in dogs, but this treatment is limited by renal toxicosis. Cox-2 is expressed in TCC, but only in limited sites within the kidney. A cox-2 inhibitor could enhance the antitumor activity of ...
Rosanò L - - 2012
Despite the fundamental pathophysiological importance of β-catenin in tumor progression, the mechanism underlying its final transcriptional output has been partially elucidated. Here, we report that β-arrestin-1 (β-arr1) is an epigenetic regulator of endothelin (ET)-1-induced β-catenin signaling in epithelial ovarian cancer (EOC). In response to ET A receptor (ET(A)R) activation by ...
Xue Leigang - - 2012
Si has the highest theoretical capacity among all known anode materials, but it suffers from the dramatic volume change upon repeated lithiation and delithiation processes. In order to overcome the severe volume change, Si nanoparticles were first coated with a polymer-driven carbon layer, and then dispersed in a CNT network. ...
Hamburger Joseph J Kuvin Center, Hebrew University, Hadassah Medical School, Jerusalem, Israel. - - 2013
We previously described loop-mediated isothermal amplification (LAMP) for detection of Schistosoma haematobium and S. mansoni DNA in infected snails. In the present study, we adapted the LAMP assay for application in field laboratories in schistosomiasis-endemic areas. Isolation of DNA was simplified by blotting snail tissue (extracted in NaOH/sodium dodecyl sulfate) ...
Sumioka Takayoshi - - 2012
We investigated the effects of loss of tenascin C on the healing of the stroma using incision-injured mice corneas. Tenascin C was upregulated in the stroma following incision injury to the cornea. Wild-type (WT) and tenascin C-null (knockout (KO)) mice on a C57BL/6 background were used. Cell culture experiments were ...
Cui Xin X Department of Chemistry, University of South Florida, Tampa, Florida 33620-5250, United - - 2012
Co(III)-carbene radicals generated from activation of α-diazocarbonyls by Co(II)-porphyrin complexes have been shown to undergo a new type of tandem radical addition reaction with alkynes that affords five-membered furan structures. The Co(II) complex of 3,5-Di(t)Bu-IbuPhyrin, [Co(P1)], is effective in catalyzing the metalloradical cyclization reaction under neutral and mild conditions. The ...
Abrams Charles K CK Department of Neurology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA. - - 2013
Charcot Marie Tooth disease (CMT) is a group of inherited disorders characterized clinically by exclusively or predominantly peripheral nerve dysfunction. CMT1X, the most common form of X-linked CMT is caused by mutations in connexin 32 (Cx32). In this work, we used dual whole cell patch clamp recording to examine the ...
Smith Anthony C - - 2012
A mobile ear-screening service was established in an Aboriginal community in central Queensland. Telemedicine allowed ear nose and throat (ENT) specialists at the tertiary children's hospital in Brisbane to assess children at a distance using pre-recorded information comprising video-otoscopic images and the results of tympanometry and audiometry. During the first ...
Wang Yanbing - - 2012
Anaphase-promoting complex/cyclosome (APC/C), a multisubunit E3 ligase, plays a critical role in cell cycle control, but the functional characterization of each subunit has not yet been completed. To investigate the function of APC1 in Arabidopsis, we analyzed four mutant alleles of APC1, and found that mutation in APC1 resulted in ...
Cusimano Michael D - - 2013
The increasing incidence of injuries related to playing ice hockey is an important public health issue. We conducted a systematic review to evaluate the effectiveness of interventions designed to reduce injuries related to aggressive acts in ice hockey. We identified relevant articles by searching electronic databases from their inception through ...
Tang Wen - - 2012
ABSTRACT: BACKGROUND: The aim of this study was to investigate the characteristics and outcomes of patients receiving renal replacement therapy for end-stage kidney disease (ESKD) secondary to haemolytic uraemic syndrome (HUS). METHODS: The study included all patients with ESKD who commenced renal replacement therapy in Australia and New Zealand between ...
Zheng Yongsheng - - 2012
By employing a chiral Lewis base as the catalyst, enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines was realized. The reactions proceeded smoothly to afford various chiral 1,2-diarylethanamines with good yields (up to 99%) in good enantioselectivities (up to 98%). Furthermore, one of the products was employed in the synthesis of a pharmaceutical substance.
Kesler Cristina T CT E. L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, - - 2013
The lymphatic vasculature plays vital roles in tissue fluid balance, immune defense, metabolism, and cancer metastasis. In adults, lymphatic vessel formation and remodeling occur primarily during inflammation, development of the corpus luteum, wound healing, and tumor growth. Unlike the blood circulation, where unidirectional flow is sustained by the pumping actions ...
Barding Gregory A - - 2012
Natural disasters such as drought, extreme temperatures, and flooding can severely impact crop production. Understanding the metabolic response of crops threatened with these disasters provides insights into biological response mechanisms that can influence survival. In this study, a comparative analysis of GC-MS and (1)H NMR results was conducted for wild-type ...
Kemi Ole Johan - - 2012
ABSTRACT Objectives: To investigate the mechanisms of losartan- and exercise training-induced improvements on endothelial dysfunction in heart failure. Design: Sprague-Dawley rats subjected to left coronary artery ligation inducing myocardial infarction and heart failure were randomized to losartan treatment, high-intensity exercise training, or both. Results: Losartan, but not exercise training, reduced ...
Lee J M - - 2012
The Met receptor tyrosine kinase, found to be constitutively activated in many tumors, has become a leading target for cancer therapy. Disruptions in Met downregulation have been associated with aggressive tumor progression with several therapeutic strategies addressing this aspect of Met biology. Castias B-lineage lymphoma (Cbl) E3 ligase-mediated degradation, which ...
Chen Wei - - 2012
An efficient tandem elimination-cyclization-desulfitative arylation of 2-(gem-dibromovinyl)phenols(thiophenols) with sodium arylsulfinates has been developed. In the presence of TBAF-PdCl(2)-Cu(OAc)(2)-NEt(3), the reactions generated 2-arylbenzofurans(thiophenes) with good yields in one-pot under ligand-free conditions.
Whalley Matthew G - - 2013
Flashbacks are a defining feature of posttraumatic stress disorder (PTSD), but there have been few studies of their neural basis. We tested predictions from a dual representation model of PTSD that, compared with ordinary episodic memories of the same traumatic event, flashbacks would be associated with activity in dorsal visual ...
Payne Jeffrey B JB Department of Surgical Specialties, University of Nebraska Medical Center College of Dentistry, Lincoln, - - 2013
The purpose of the present study is to examine the association between clinical and radiographic periodontitis measurements during 2 years of periodontal maintenance. Secondary analyses were performed from a 2-year, double-masked, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of subantimicrobial dose doxycycline (SDD) in 128 postmenopausal osteopenic females ...
Mueller Melanie M Department of Neurology, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, - - 2013
The neurotoxicity of (±)-3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") is influenced by temperature and varies according to species. The mechanisms underlying these two features of MDMA neurotoxicity are unknown, but differences in MDMA metabolism have recently been implicated in both. The present study was designed to 1) assess the effect of hypothermia on ...
Jiang Chenyan - - 2012
OBJECTIVES/HYPOTHESIS: Patients with empty nose syndrome experience considerable discomfort in their daily lives and treatment is difficult for their physicians. The purpose of this study was to evaluate the outcome of an empty nose syndrome treatment via reconstruction of the inferior turbinate with porous polyethylene (Medpor). DESIGN AND METHOD: A ...
Mainous Arch G AG - - 2012
OBJECTIVES: To evaluate in a large, nationally representative cohort the association between high serum transferrin saturation (TS) and hospital length of stay and mortality in older adults. DESIGN: Prospective cohort. SETTING: Longitudinal analyses of the Third National Health and Nutrition Examination Survey linked to Medicare claims from 1991 through 2006. ...
Zdarska Marketa - - 2012
The plant hormones cytokinins (CKs) regulate multiple developmental and physiological processes in Arabidopsis thaliana. Responses to CKs vary in different organs and tissues, e.g., the response to CKs has been shown to be opposite in shoot and root samples. However, the tissue-specific targets of CKs and the mechanisms underlying such ...
Ohno Michiya M Division of Nephrology, Murakami Memorial Hospital, Asahi University, Gifu 500-8523 Japan. - - 2013
The efficacy of the phosphate binder lanthanum carbonate has been demonstrated for hemodialysis patients, but no studies have focused on patients undergoing continuous ambulatory peritoneal dialysis (CAPD). We evaluated whether lanthanum carbonate could control phosphate levels in patients on CAPD. ♢ In this 48-week open-label prospective study, 28 patients on ...
Goodman Geoff - - 2012
OBJECTIVES: To identify interaction structures (i.e., patterns of reciprocal interaction) that characterize the treatments of patients with borderline personality disorder (BPD) in crisis. DESIGN: A 6-month naturalistic psychotherapy process and outcome study in which interaction structures were correlated with outcome data. METHODS: Five BPD patients in crisis participated in 6 months ...
Centko Ryan M - - 2012
Four butenolides, ramariolides A-D (1-4), have been isolated from the fruiting bodies of the coral mushroom Ramaria cystidiophora. Their structures were elucidated by analysis of 1D and 2D NMR data and a single-crystal X-ray diffraction analysis of 1, and their absolute configurations were established using Mosher's method. The major metabolite, ...
Akinyede Akinwumi A Department of Pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria. - - 2013
Malaria parasitemia enhances replication of human immunodeficiency virus. Antiretroviral drugs that possess antiplasmodial activity may reverse such an effect. Activity of the antiretroviral drugs lamivudine (L), zidovudine (Z), nevirapine (N), and stavudine (S) against Plasmodium berghei inoculated into 70 adult albino mice was investigated. Eight groups of five animals each ...
Wu Jennifer N JN Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, - - 2013
Although disordered chromatin organization has long been recognized as a feature of cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their relationships to transcription are only beginning to be understood. Cancer genome sequencing studies have revealed a novel theme: frequent mutation of epigenetic regulators. Among these, the ARID1A/BAF250A ...
Vintzileos Anthony M - - 2012
Abstract OBJECTIVE: To assess the role of the referees in assisting with the peer review process of systematic reviews and meta-analyses. STUDY DESIGN: A one-page questionnaire was mailed to 1,391 referees of two journals, the American Journal of Obstetrics and Gynecology and Obstetrics and Gynecology. The referees were asked how ...
Ganesan Muthupandian - - 2012
A novel protecting group directed diversity leading to the synthesis of bridged bicyclic and six-membered iminocyclitols from a common carbohydrate derived diamino triol under Mitsunobu conditions is reported. When the intramolecular cyclization of benzoyl derivative was carried out under Mitsunobu conditions, an unprecedented one-pot domino intramolecular "cyclization-N → O benzoyl ...
Grammatico-Guillon L - - 2012
AIM: Little is known about bone and joint infections (BJIs) in children, despite the risk of growth disturbance. This study examined BJIs epidemiology using the French National Hospital Discharge Database (HD). METHODS: Any child <15 years hospitalised with an HD diagnosis of BJI, alone or in combination with sepsis or ...
Thakran Shalini S Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, - - 2013
Sirtuin 1 (SIRT1) is a nuclear deacetylase that modulates lipid metabolism and enhances mitochondrial activity. SIRT1 targets multiple transcription factors and coactivators. Thyroid hormone (T(3)) stimulates the expression of hepatic genes involved in mitochondrial fatty acid oxidation and gluconeogenesis. We reported that T(3) induces genes for carnitine palmitoyltransferase (cpt1a), pyruvate ...
Hess Jon E - - 2012
Unlike most anadromous fishes that have evolved strict homing behaviour, Pacific lamprey (Entosphenus tridentatus) seem to lack philopatry as evidenced by minimal population structure across the species range. Yet unexplained findings of within-region population genetic heterogeneity coupled with the morphological and behavioural diversity described for the species suggest that adaptive ...
Smedes Foppe - - 2012
The freely dissolved concentration (Cw,0) in the pore water and the accessible (releasable) concentration in the sediment (Cas,0) are important parameters for risk assessment. These parameters were determined by equilibrating contaminated sediments and passive sampler using largely differing sampler-sediment ratios. This method is based on the principle that incubations at ...
Verdicchio Marco - - 2012
The electronic structure of the Beryllium-Hydride anion, BeH(-), was investigated at valence Full-Configuration-Interaction (FCI) level, using large cc-pV6Z basis sets. It appears that there is a deep change of the wavefunction nature as a function of the internuclear distance:the ion structure goes from a weakly bonded Be...H(-) complex, at long ...
Bird Steven T - - 2013
There is an increased risk of venous thromboembolism among women taking oral contraceptives. However, whether there is an additional risk among women with polycystic ovary syndrome (PCOS) is unknown. We developed a population-based cohort from the IMS LifeLink Health Plan Claims Database, which includes managed care organizations in the United ...
Tompane Trevor - - 2012
BACKGROUND AND OBJECTIVE:Diagnostic imaging procedures (DIPs) producing radiation exposure in children have been associated with increased cancer risk. To develop effective clinical practice interventions that reduce pediatric radiation exposure, a longitudinal assessment of DIP ordering practices in the current clinical climate was performed. Our objective was to determine the prevalence ...
Li Ai-Li - - 2012
The present study was planned to explore the effect of L.acidophilus on the Th17 immune response in a mouse model of β-lactoglobulin (β-lg) allergy.Bovine β-lg sensitised BALB/c mice were orally administered with different doses of heat-killed L. acidophilus (low, 5×10(7) CFU; medium, 5×10(8)CFU; high, 5×10(9)CFU) in 200 μL of PBS ...
Okudaira N - - 2012
A single human cell contains more than 5.0 × 10(5) copies of long interspersed element-1 (L1), 80-100 of which are competent for retrotransposition (L1-RTP). Recent observations have revealed the presence of de novo L1 insertions in various tumors, but little is known about its mechanism. Here, we found that 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine ...
Chaparro Eduardo - - 2012
Caspase inhibitors are usually administered intracranially. There's very limited evidence showing that they can be used intraperitoneally, and still have a beneficial effect. We tested the hypothesis that, during focal cerebral ischemia, caspase inhibitors when used in combination with an anesthetic agent results in a significantly reduction in the neuronal ...
Pett Marjorie A - - 2012
OBJECTIVE: To examine the reliability and validity and to decrease the battery of items in the Pain Care Quality (PainCQ(©) ) Surveys. DATA SOURCES/STUDY SETTING: Patient-reported data were collected prospectively from 337 hospitalized adult patients with pain on medical/surgical oncology units in four hospitals in three states. STUDY DESIGN: This ...
Rai Vivek V Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA. - - 2012
The endogenous phospholipid lysophosphatidic acid (LPA) regulates fundamental cellular processes such as proliferation, survival, motility, and invasion implicated in homeostatic and pathological conditions. Hence, delineation of the full range of molecular mechanisms by which LPA exerts its broad effects is essential. We report avid binding of LPA to the receptor ...
Meregalli M - - 2012
Muscular dystrophies are heritable and heterogeneous neuromuscular disorders characterized by the primary wasting of skeletal muscle, usually caused by mutations in the proteins forming the link between the cytoskeleton and the basal lamina. Due to mutations in the dystrophin gene, DMD patients suffer for progressive muscle atrophy and exhaustion of ...
Quy Pham Nguyen PN Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, - - 2013
Drastic protein degradation occurs during muscle atrophy induced by denervation, fasting, immobility, and various systemic diseases. Although the ubiquitin-proteasome system is highly up-regulated in denervated muscles, the involvement of autophagy and protein synthesis has been controversial. Here, we report that autophagy is rather suppressed in denervated muscles even under autophagy-inducible ...
Tahvanainen Johanna - - 2013
The differentiation of human primary T helper 1 (Th1) cells from naïve precursor cells is regulated by a complex, interrelated signaling network. The identification of factors regulating the early steps of Th1 cell polarization can provide important insight in the development of therapeutics for many inflammatory and autoimmune diseases. The ...
Mitchell Perry - - 2012
Reported correlations between organic contaminant sorption affinity and soil organic matter (OM) structure vary widely, suggesting the importance of OM physical conformation and accessibility. Batch equilibration was used to examine the sorption affinity of bisphenol A, atrazine, and diuron to five soils of varying OM composition. 13C Cross-Polarization Magic Angle ...
Mehanna Raja - - 2012
BACKGROUND: Respiratory difficulties are sometimes reported by patients with cranial-cervical and other forms of dystonia, but the nature or mechanisms of the breathing problems have not been well characterized. CASE REPORT: We review 13 dystonic patients with various respiratory complaints and describe their symptoms and response to treatment, including botulinum ...
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