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Ozlü Ferda - - 2012
Exposure to parenteral nutrition (PN) is one major factor in the development of cholestasis. The aim of this retrospective study was to compare the effect of these two different PN regimens on PN associated cholestasis. The files of the patients who have received different PN regimens for > 14 days ...
Montaudouin Caroline C Unité de Biologie des Populations Lymphocytaires, Départment d'Immunologie, Institut Pasteur, Paris 75015, - - 2013
Maintenance of plasma IgM levels is critical for immune system function and homeostasis in humans and mice. However, the mechanisms that control homeostasis of the activated IgM-secreting B cells are unknown. After adoptive transfer into immune-deficient hosts, B lymphocytes expand poorly, but fully reconstitute the pool of natural IgM-secreting cells ...
Taylor Mark - - 2012
BackgroundThe relapse rate after a first episode of schizophrenia is high, often due to non-adherence with medication. Long-acting injections of antipsychotics (LAI) are used to promote adherence to medication.ObjectiveTo review the literature on the use of LAIs in first-episode and early schizophrenia.MethodA systematic electronic search of all original data containing ...
Cheadle Lucas L Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, - - 2012
Synaptic adhesion organizes synapses, yet the signaling pathways that drive and integrate synapse development remain incompletely understood. We screened for regulators of these processes by proteomically analyzing synaptic membranes lacking the synaptogenic adhesion molecule SynCAM 1. This identified FERM, Rho/ArhGEF, and Pleckstrin domain protein 1 (Farp1) as strongly reduced in ...
Mukhopadhyay Kanya - - 2012
AIMS: To study growth of very low birth weight neonates (VLBW) during first year and identify risk factors of malnutrition METHODS: Neonates ≤34 weeks and ≤1500g enrolled in a human milk fortification trial were prospectively followed till one year corrected age. Anthropometry was plotted on WHO charts. Risk factors were ...
May-Concha I - - 2012
In this study, we evaluated the responses of Triatoma dimidiata Latreille (Hemiptera: Reduviidae) to volatiles emitted by conspecific females, males, mating pairs and metasternal gland (MG) extracts with a Y-tube olfactometer. The volatile compounds released by mating pairs and MGs of T. dimidiata were identified using solid-phase microextraction and coupled ...
Gomez-Mendoza Miguel - - 2012
Bile acids (BAs) are a family of natural steroids biosynthesized from cholesterol in the liver that tend to form aggregates in solution. A fluorescent derivative of cholic acid, namely 3-Dns-ChA, was employed as a reporter to establish the speciation diagrams of the most abundant BAs that can be found mainly ...
Roche Michael J - - 2012
The cognitive-affective processing system (CAPS) has been proposed as a useful metaframework for integrating contextual differences in situations with individual differences in personality pathology. In this article, we evaluated the potential of combining the CAPS metaframework and contemporary interpersonal theory to investigate how individual differences in pathological narcissism influenced interpersonal ...
Bobadilla Alfredo D - - 2012
Polyethylene glycol (PEG) functionalization of carbon nanotubes (CNTs) is widely used to render CNTs suitable as vectors for targeted drug delivery. One recently described PEGylated version uses an oxidized single-walled carbon nanotube called a hydrophilic carbon cluster (HCC). The resulting geometric dimension of the hybrid PEG-CNT or PEG-HCC is an ...
Deblois G - - 2012
Proliferating cells need to produce a large amount of energy and, at the same time, need to maintain a constant supply of biosynthetic precursors of macromolecules that are used as building blocks for generating new cells. Indeed, many cancer cells undergo a switch from mitochondrial to glycolytic metabolism and display ...
Lock F E - - 2012
The sub-population of tumor cells termed 'cancer stem cells' (CSCs) possess the capability to generate tumors, undergo epithelial-mesenchymal transition (EMT) and are implicated in metastasis, making treatments to specifically target CSCs an attractive therapeutic strategy. Tumor hypoxia plays a key role in regulating EMT and cancer stem cell function. Carbonic ...
Lai Jonathan - - 2012
Abstract Objective: To investigate the potential value of maternal serum concentration of activin-A at 30-33 weeks' gestation in the prediction of preeclampsia (PE) developing at or after 34 weeks. Methods: Serum concentrations of activin-A were measured at 11-13 and at 30-33 weeks' gestation in a case-control study of 50 cases ...
Pagonabarraga Javier - - 2012
Frontal subcortical cognitive defects are predominant in Parkinson's disease (PD). Temporal lobe dysfunction seems more relevant for progression to dementia. We aimed to study the relative importance of temporal lobe defects versus executive impairment in the progression to dementia in PD by using proton magnetic resonance spectroscopy ((1)H-MRS). The (1)H-MRS ...
Li Liming - - 2012
HMGB3 (high-mobility group box 3) is an X-linked member of a family of sequence-independent chromatin-binding proteins and functions as a universal sentinel for nucleic acid-mediated innate immune responses. The splice variant expression, promoter characterization and targeted microRNAs of the bovine HMGB3 gene were investigated to explore its expression pattern and ...
Li Yijing - - 2012
Many compounds containing a five-membered heterocyclic ring display exceptional chemical properties and versatile biological activities. In this Minireview, thiadiazoles are summarized according to their therapeutic potential, highlighting the versatility of this scaffold in medicinal chemistry. The unique properties of thiadiazoles are also discussed in relation to their potential effect on ...
Lindsten Rune - - 2012
summary Orthodontics as health care is sometimes at odds with modern marketing with its strong focus on esthetics. In this commentary, I highlight how important it is that research of orthodontic treatment as a value for the entire community is performed and published.
Szpila K - - 2012
First instars of Lucilia ampullacea Villeneuve, Lucilia caesar Linnaeus, Lucilia cuprina Weidemann, Lucilia richardsi Collin, Lucilia sericata Meigen and Lucilia silvarum Meigen (Diptera: Calliphoridae) are thoroughly documented with scanning electron microscopy images, light microscopy photographs and line drawings. The following morphological structures are documented: pseudocephalon, antennal complex, maxillary palpus, facial ...
Otoda Toshiki T Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Sciences, Ishikawa, - - 2013
Chronic endoplasmic reticulum (ER) stress is a major contributor to obesity-induced insulin resistance in the liver. However, the molecular link between obesity and ER stress remains to be identified. Proteasomes are important multicatalytic enzyme complexes that degrade misfolded and oxidized proteins. Here, we report that both mouse models of obesity ...
de Vos M - - 2013
Rifampin resistance in clinical isolates of Mycobacterium tuberculosis arises primarily through the selection of bacterial variants harboring mutations in the 81-bp rifampin resistance-determining region of the rpoB gene. While these mutations were shown to infer a fitness cost in the absence of antibiotic pressure, compensatory mutations in rpoA and rpoC ...
Bagutski Viktor - - 2012
Direct electrophilic borylation using Y(2)BCl (Y(2) = Cl(2) or o-catecholato) with equimolar AlCl(3) and a tertiary amine has been applied to a wide range of arenes and heteroarenes. In situ functionalization of the sensitive ArBCl(2) products is possible with TMS(2)MIDA, to afford bench-stable and easily isolable MIDA-boronates in moderate to ...
Ma Minglin M David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, - - 2013
Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step ...
Gogolin Lars - - 2012
Analysis of multiple protein-protein interactions using microarray technology remains challenging, and site-specific immobilization of functional proteins is a key step in these approaches. Here we establish the efficient synthesis of protein-DNA conjugates for several members of a small family of GTPases. The family of Rab/Ypt GTPases is intimately involved in ...
Lakschevitz Flavia S - - 2012
*Background: Neutrophils, key cells of the innate immune system, were previously thought to be terminally differentiated cells, incapable of altering their gene expression following differentiation and maturation in the bone marrow. Only recently it has been shown that neutrophils carry out rapid and complex changes in gene expression during inflammatory ...
Pasricha Janet M JM Victorian Infectious Diseases Service, and Diagnostic Haematology Department, Royal Melbourne Hospital, Melbourne, Victoria, Australia. - - 2013
Exclusion of malaria traditionally requires three negative serial thick and thin blood films. However, many clinical laboratories now routinely perform rapid diagnostic tests (RDTs) in addition to blood films when malaria is suspected. We sought to determine whether serial testing is necessary in this setting. We examined 388 cases of ...
Kang Yoona - - 2012
The ability to adaptively exert control over negative emotions is associated with beneficial mental health outcomes. Less is known about the associated emotional sequelae surrounding controllable versus uncontrollable positive emotional experiences. The ability to harness positive emotions is of particular importance in populations involving disrupted positive emotion functioning. In the ...
Park Seung-Keun - - 2012
We introduce a simple process to synthesize few-layered MoS(2) nanosheets supported on coaxial carbon nanotubes through an l-cysteine-assisted hydrothermal route, in which l-cysteine, a cheap and ordinary amino acid, plays a fundamental role in controlling the morphology of the hybrid material and the binder to help the growth of MoS(2) ...
Otsuka Yasunari - - 2012
A direct catalytic asymmetric γ-addition of allyl cyanide to aldehydes promoted by soft Lewis acid/hard Brønsted base cooperative catalysis is described. The resulting homoallylic alcohols bearing a Z-configured α,β-unsaturated nitrile allow rapid access to enantioenriched δ-valerolactones.
Garbers Christoph C Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine University, 40225 Düsseldorf, - - 2013
IL-27 consists of the cytokine subunit p28 and the non-signaling α-receptor EBI3. p28 was shown to additionally act via the non-signaling membrane-bound IL-6 α-receptor (IL-6R) as an agonistic cytokine but also as a gp130 β-receptor antagonist, leading to inhibition of IL-6 signaling. Here, we developed a strategy for bacterial expression, ...
Lu Lu - - 2012
The Shrew Gymnure Neotetracus sinensis belongs to family Erinaceidae, and distributes in China, Myanmar, and northern Vietnam. In this study, the whole mitochondrial genome of N. sinensis was first sequenced and characterized. The genome is 16,982 bases in length. Bayesian inference and maximum likelihood methods were used to construct phylogenetic ...
Reichle Erik D ED Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA. - - 2013
The question of why readers sometimes skip words has important theoretical implications for our understanding of perception, cognition, and oculomotor control during reading (Drieghe, Rayner, & Pollatsek, 2005). In this article, the E-Z Reader model of eye-movement control in reading (Reichle, 2011) was used to examine the behavioral consequences of ...
Zhang Qingbo Q CAS Key Laboratory of Marine Bio-resources Sustainable Utilization , RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, - - 2012
The P450 enzyme XiaM was identified as a candidate to form the C-24 carboxyl group in xiamycin A (1). Alteration of medium composition led to the discovery of four new compounds from the ΔxiaM and the ΔxiaK (encoding an aromatic ring hydroxylase) mutants. Biotransformation experiments revealed that XiaM was capable ...
Mironov S L SL Department of Neuro- and Sensory Physiology, Georg-August-University, Humboldtallee 23, 37073 Göttingen, Germany. - - 2013
Emergence of persistent activity in networks can be controlled by intracellular signalling pathways but the mechanisms involved and their role are not yet fully explored. Using calcium imaging and patch-clamp we examined the rhythmic activity in the preBötzinger complex (preBötC) in the lower brainstem that generates the respiratory motor output. ...
Liu Lianqi L Department of Psychiatry, University of California, San Diego, - - 2013
This study examined the longitudinal relation between health-related quality of life (HR-QOL) and subjective and objective sleep quality in 166 women with newly diagnosed Stage-1 through Stage-3 breast cancer, who were scheduled to receive ≥ 4 cycles of adjuvant/neoadjuvant chemotherapy. HR-QOL was assessed with the Medical Outcomes Study 36-item Short ...
Sweetman Deirdre U - - 2012
Acute kidney injury frequently develops following term perinatal hypoxia-ischaemia. Quantifying the degree of acute kidney injury is difficult however, as methods currently in use are suboptimal. Acute kidney injury management is largely supportive with little evidence basis for many interventions. This review discusses management strategies and novel biomarkers that may ...
Zeng Zhiping - - 2012
Tandem composites made by integrating random sponge and aligned array layers show wider energy absorption range than individual layers. These composites have potential applications in energy absorption and cushioning under mechanical compression.
Miró Elisenda - - 2012
A total of 788 clinical Enterobacteriaceae were collected to describe the aminoglycoside-modifying genes (AME genes) and to characterize the plasmids that carry these genes. Among the 788 strains collected, 330 (41.8%) were aminoglycoside-resistant: 264 Escherichia coli (80%), 33 Proteus mirabilis (10%), 10 Klebsiella pneumoniae (3%), six K. oxytoca (1.8%), five ...
Zhou Zhun - - 2012
Aqueous-soluble melamine polymer was condensed into nanoparticles by specific heterocycle binding interactions with 5-fluorouracil (5-FU) or cyanuric acid (CA). Small-molecule/polymer recognition of this type exhibited a clear exothermic binding signature and is sufficiently robust to induce macromolecular assembly in water. Polymer amphiphiles with melamine sites in the hydrophobic block could ...
Vernacchio Louis - - 2012
OBJECTIVE:We sought to define processes of pediatric asthma care identifiable through administrative data that correlate with asthma exacerbations for use in quality improvement.METHODS:Commercially insured children aged 5 to 17 years from the Pediatric Physicians' Organization at Children's, an independent practice association affiliated with Boston Children's Hospital, with persistent asthma in ...
Myers Frank B FB Department of Bioengineering, University of California, Berkeley, CA 94720, - - 2013
Stem cell therapies hold great promise for repairing tissues damaged due to disease or injury. However, a major obstacle facing this field is the difficulty in identifying cells of a desired phenotype from the heterogeneous population that arises during stem cell differentiation. Conventional fluorescence flow cytometry and magnetic cell purification ...
Park Hyesung - - 2012
Growth of semiconducting nanostructures on graphene would open up opportunities for the development of flexible optoelectronic devices, but challenges remain in preserving the structural and electrical properties of graphene during this process. We demonstrate growth of highly uniform and well-aligned ZnO nanowire arrays on graphene by modifying the graphene surface ...
Yasunaga Shin'ichiro - - 2013
Polycomb-group (PcG) complex 1 acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. Scmh1 is a substoichiometric component of PcG complex 1 that provides the complex with an interaction domain for geminin. Scmh1 is unstable and regulated through the ...
Santarelli Stefano S Department of Nephrology, Ospedale Carlo Urbani, Jesi, - - 2013
Videolaparoscopy is considered the reference method for peritoneal catheter placement in patients with previous abdominal surgery. The placement procedure is usually performed with at least two access sites: one for the catheter and the second for the laparoscope. Here, we describe a new one-port laparoscopic procedure that uses only one ...
Wu Gang - - 2012
Previous studies have demonstrated that statin can reduce the risk of acute coronary syndrome. In order to explore the mechanism, we observed the effects of pravastatin on plaque stability in atherosclerotic rabbits. Sixteen male rabbits were fed with a high fat diet following their damaged abdominal aortic endothelium by using ...
Nielsen Alan K S - - 2012
Wolfgang Köhler (1929, Gestalt psychology, New York, NY: Liveright) famously reported a bias in people's choice of nonsense words as labels for novel objects, pointing to possible naïve expectations about language structure. Two accounts have been offered to explain this bias, one focusing on the visuomotor effects of different vowel ...
Lüchtenberg M - - 2012
Background: The results of endonasal dacryocystorhinostomies (DCR) with transillumination and intubation are presented.Materials and Methods: In the period from 1999 to 2009 follow-up examinations of 50 endonasal DCRs were carried out. All patients over 18 were included. The files were systematically evaluated. The follow-up examinations were performed after a minimum ...
Pfeffer John M JM Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, - - 2013
O-Acetylpeptidoglycan esterase from Neisseria gonorrhoeae functions to release O-acetyl groups from the C-6 position of muramoyl residues in O-acetylated peptidoglycan, thereby permitting the continued metabolism of this essential cell wall heteropolymer. It has been demonstrated to be a serine esterase with sequence similarity to the family CE-3 carbohydrate esterases of ...
Santosa Sylvia S Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, - - 2013
Increases in weight have been associated with corresponding increases in insulin resistance in postmenopausal women. Although estrogen has significant impact on body fat and body fat distribution, the cellular mechanisms that influence this process are not yet known. We measured adipose tissue fatty acid (FA) storage and FA storage factors ...
Leang Rithea - - 2013
We describe here the results of antimalarial therapeutic efficacy studies conducted in Cambodia from 2008 to 2010. A total of 15 studies in four sentinel sites were conducted using dihydroartemisinin-piperaquine (DP) for the treatment of Plasmodium falciparum infection and chloroquine (CQ) and DP for the treatment of P. vivax infection. ...
Stobaugh Jordan T - - 2012
The need for multidimensional separations for bottom-up proteomic analyses has been well demonstrated by many over the past decade. The vast majority of reported approaches have focused primarily on improving the separation once the sample has already been digested. The work presented in this study shows an improvement in multidimensional ...
Parisod C - - 2012
Introgression of sequences from crop species in wild relatives is of fundamental and practical concern. Here, we address gene flow between cultivated wheat and its widespread polyploid relative, Aegilops triuncialis, using 12 EST-SSR markers mapped on wheat chromosomes. The presence of wheat diagnostic alleles in natural populations of the barbed ...
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