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Results 601 - 650 of 4108
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Matsuda Atsunori - - 2012
Anionic hydrated titanate (HnTiOm: HTO) nanosheets and cationic magnesium-aluminum layered double hydroxide (Mg-Al LDH) nanosheets were electrophoretically deposited on positively and negatively charged indium tin oxide (ITO)-coated glass substrates, respectively. The HTO nanosheets and Mg-Al LDH nanosheets obtained were identified in neutral water as H2Ti4O9•nH2O with a -potential of -23mV ...
Kortum Robert L RL Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, - - 2013
Mice expressing a germline mutation in the phospholipase C-γ1-binding site of linker for activation of T cells (LAT) show progressive lymphoproliferation and ultimately die at 4-6 mo age. The hyperactivated T cells in these mice show defective TCR-induced calcium flux but enhanced Ras/ERK activation, which is critical for disease progression. ...
Boulon Marie-Emmanuelle - - 2012
Spotting trends: Upon going from Tb(III) to Yb(III) centers in the complexes of the DOTA(4-) ligand a reorientation of the easy axis of magnetization from perpendicular to parallel to the LnO bond of the apical water molecule is experimentally observed and theoretically predicted. Only ions with an odd number of ...
Melchardt Thomas - - 2012
Abstract Over the past decade, the treatment of patients with CLL has been improved by several new cytostatic agents and monoclonal antibodies. This development has resulted in higher response rates and more profound levels of immunosuppression than with previously used treatments. With the intrinsic immune defect of CLL, the degree ...
Lim Soo - - 2012
BACKGROUND:Metabolic syndrome (MetSyn) in children and adolescence is increasing worldwide; however, its pattern may be different between Asians and Americans. We compare the prevalence and patterns of MetSyn between American and Korean children and adolescents between roughly 1998 and 2007.METHODS:Data from the American and Korean versions of the NHANES (NHANES ...
Vohra Nasreen A - - 2012
This paper reports a single-institution experience with the use of isolated limb infusion for limb salvage in locally advanced, unresectable, recurrent limb threatening soft tissue sarcomas. Background: Locally advanced, limb threatening soft tissue sarcomas (STS) pose a significant treatment challenge. We report our experience using isolated limb infusion (ILI) in ...
Wu Judy I-Chia - - 2012
Like the larger non-planar Möbius rings, porphyrinoid aromaticity is not due primarily to the macrocyclic π conjugation of the corresponding annulene perimeters. The block-localized wavefunction (BLW) derived aromatic stabilization energies (ASE) of several porphyrinoids reveal that, on a per atom basis, the appended 6π electron heterocycles of porphyrinoids confers aromaticity ...
Laukkanen L - - 2012
Several ecological and genetic factors affect the diet specialization of insect herbivores. The evolution of specialization may be constrained by lack of genetic variation in herbivore performance on different food-plant species. By traditional view, trade-offs, that is, negative genetic correlations between the performance of the herbivores on different food-plant species ...
Pandey P R - - 2012
Upregulation of lipogenesis is a hallmark of cancer and blocking the lipogenic pathway is known to cause tumor cell death by apoptosis. However, the exact role of lipogenesis in tumor initiation is as yet poorly understood. We examined the expression profile of key lipogenic genes in clinical samples of ductal ...
Kelly Matthew A - - 2012
Vector Symbolic Architectures (VSAs) such as Holographic Reduced Representations (HRRs) are computational associative memories used by cognitive psychologists to model behavioural and neurological aspects of human memory. We present a novel analysis of the mathematics of VSAs and a novel technique for representing data in HRRs. Encoding and decoding in ...
Gambichler T - - 2012
In a recent issue of this journal, Speeckaert and co-workers (2011) reported on melanoma-specific T cell reactions and dysregulation of regulatory T cells (Tregs) in malignant melanoma (MM). CD4(+) CD25(high) cells are defined to express forkhead box protein 3 (FOXP3) transcription factor and form a distinct thymus-derived lineage in mice ...
Kamihira-Ishijima Miya - - 2012
Islet amyloid polypeptide (IAPP) is a major component of pancreatic amyloid deposits associated with type 2 diabetes. Polyphenols contained in plant foods have been found to inhibit amyloid fibril formation of proteins/peptides. However, the inhibition mechanism is not clear for a variety of systems. Here the inhibition mechanism of green ...
Keshava Hari B - - 2012
Background Heparin is routinely administered to brain-dead donors before cardiac arrest, although it is not universally allowed for donation after cardiac death (DCD) donors due to concerns that death may be hastened. The lack of heparin may lead to thrombosis and compromised graft function. We evaluated the impact of timing of ...
Palmer Brent E BE Division of Allergy and Clinical Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. - - 2013
The programmed death-1 (PD-1) pathway limits the function of virus-specific T cells during chronic infection. We previously showed that blockade of the PD-1 pathway increases HIV-1-associated T cell function in vitro. However, the effect of PD-1 blockade on HIV-1 disease progression in vivo has not been examined. As in humans, ...
Ashe Karen H - - 2012
Like patients with prion disease, Alzheimer patients suffer from a fatal, progressive form of dementia. There is growing evidence that amyloid-β (Aβ) aggregates may be transmissible similar to prions, at least under extreme experimental conditions. However, unlike mice infected with prion protein (PrP) prions, those inoculated with Aβ do not ...
Ma Xiqing - - 2012
Plant architecture is an important agronomic trait and is useful for identification of plant species. The molecular basis of plant architecture, however, is largely unknown. Forward genetics was used to identify an Arabidopsis mutant with altered plant architecture. Using genetic and molecular approaches, we analyzed the roles of a mutated ...
Sakabe Masayo - - 2012
We have synthesized and evaluated a series of hydroxymethyl rhodamine derivatives and found an intriguing difference of intramolecular spirocyclization behavior: the acetylated derivative of hydroxymethyl rhodamine green (Ac-HMRG) exists as a closed spirocyclic structure in aqueous solution at physiological pH, whereas HMRG itself takes an open non-spirocyclic structure. Ac-HMRG is ...
McGill Alison - - 2012
Since January 2011, videoconference fracture clinics have been held between the rural Mt Isa Hospital (MIH) and the tertiary referral centre, the Princess Alexandra Hospital in Brisbane, approximately 900 km away. We have examined the activity and costs of the videoconferencing clinics over a 17-month period. During the study period, ...
Boahene Kofi D O - - 2012
Muscle tendon unit (MTU) transfer is a common procedure performed to restore hand function after peripheral nerve or spinal cord injury. The principles of MTU transfer established for hand surgery can be adopted to optimize the dynamic excursion of the temporalis tendon transfer procedure for facial reanimation. Additionally, the force ...
D'Antonio Francesco - - 2012
Objectives: Monochorionic (MC) twins are at increased risk of early fetal loss secondary to vascular complications such as twin-twin transfusion syndrome (TTTS). The aim of this study is to compare the early perinatal loss rates between MC and dichorionic (DC) twins in an era of invasive treatment for TTTS. Methods: ...
Recordon-Pinson P P Laboratoire de Virologie, CHU de Bordeaux and MFP-UMR5234, Universite Bordeaux 2, Bordeaux, - - 2013
There is evidence that HIV-1 evolution under maraviroc (MVC) pressure can lead to the selection of either X4-tropic variants and/or R5-tropic, MVC-resistant isolates. However, the viral dynamics of HIV-1 variants in patients with virological failure (VF) on MVC-containing regimens remain poorly studied. Here, we investigated the V3 loop evolution of ...
Makovski Tal - - 2012
How does responding to an object affect explicit memory for visual information? The close theoretical relationship between action and perception suggests that items that require a response should be better remembered than items that require no response. However, conclusive evidence for this claim is lacking, as semantic coherence, category size, ...
Gerdes Christian A CA The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, - - 2013
Anti-EGF receptor (EGFR) antibodies and small-molecule tyrosine kinase inhibitors have shown activity in epithelial tumors; however, agents that work by blocking the EGFR growth signal are ineffective when the oncogenic stimulus arises downstream, such as in tumors with KRAS mutations. Antibodies of the IgG1 subclass can also kill tumor cells ...
Velilla N Martínez - - 2012
Background: Subsyndromal delirium has an increasing relevance in the medical literature. There are only three studies in hospitalized elderly patients. Our goal is to demonstrate the importance of this syndrome in a population with more complexity and cognitive impairment than in previous studies. Methods: Prospective multicentre study in three tertiary ...
Bourgault-Fagnou Michelle D - - 2012
Seniors have been consistently under-represented in the health anxiety treatment literature. The aim of this study was to test the efficacy of a six-session enhanced cognitive behaviour therapy (ECBT) programme for subclinical health anxiety in seniors, and to examine whether the programme fostered therapeutic alliance and motivation for psychotherapy as ...
Ozcan Fırat - - 2012
Abstract Objective: Red cell distribution width (RDW) is a strong prognostic marker for systolic left heart failure regardless of the anemia status, and heart rate variability (HRV) is negatively associated with mortality and sudden cardiac death in patients with systolic left heart failure. Their relationship has not been investigated in ...
Liu Z - - 2012
The transcription factor GLI2 has an important role in the transduction of Hedgehog signaling and thereby regulates tumorigenesis in a wide variety of human tumors. However, the mechanisms controlling GLI2 protein expression and stabilization are incompletely understood. In this study, we show that the mitogen-activated protein kinase MEK1 modulates GLI2 ...
Cho Kyung-Bin - - 2012
The hydroxylation of alkanes by heme FeIVO species occurs via the hydrogen abstraction-oxygen rebound mechanism. It has been assumed that nonheme FeIVO species follow the heme FeIVO paradigm in the C-H bond activation reactions. Herein, we report theoretical and experimental evidence that C-H bond activation of alkanes by synthetic nonheme ...
Buyze Jozefien - - 2012
Dynamic treatment strategies are designed to change treatments over time in response to intermediate outcomes. They can be deployed for primary treatment as well as for the introduction of adjuvant treatment or other treatment-enhancing interventions. When treatment interventions are delayed until needed, more cost-efficient strategies will result. Sequential multiple assignment ...
Bainbridge Roxanne - - 2012
Researchers working with Aboriginal Australian partners are confronted with an array of historical, social, and political complexities which make it difficult to come to theoretical and methodological decisions. In this article, we describe a culturally safe and respectful framework that maintains the intellectual and theoretical rigor expected of academic research. ...
Viviani Vadim R - - 2012
Beetle luciferases emit different bioluminescence colors from green to red, however, the structural determinants and mechanisms of spectral modulation are not fully understood. Nno clear relationship between the physical-chemical identity of the luciferin binding site residues and bioluminescence colors was found in different luciferases, and it is unclear whether critical ...
Avci Ceren - - 2012
The dynamics of serum adsorption on bare and monoethylene glycol adlayer-modified gold surfaces is investigated using acoustic wave physics. Hydration experiments support the pivotal role ascribed to water in the antifouling of surfaces. Behavioural discrepancy is interpreted in terms of difference in water structuring properties (surface kosmotropicity).
Wolf Timothy J TJ Programme in Occupational Therapy, Washington University School of Medicine, Saint Louis, MO, - - 2013
The objective of the study was to determine how performance on cognitive assessments administered in the subacute phase of mild stroke change or remain stable over time. A prospective longitudinal cohort pilot study was used to assess the cognitive status of participants with mild stroke (n = 20) at two ...
Oppong Gertrude O - - 2013
Curli fibrils, the best-characterized functional bacterial amyloids, are an important component of enterobacterial biofilms. We have previously shown that curli fibrils are recognized by the Toll-like receptor 2 (TLR2)/TLR1 heterodimer complex. Utilizing polarized T-84 cells, an intestinal epithelial cell line derived from colon carcinoma grown on semipermeable tissue culture inserts, ...
Newton Philip - - 2012
Infection with human rhinovirus (HRV) is thought to result in acute respiratory exacerbations of chronic obstructive pulmonary disorder (COPD). Consequently, prevention of HRV infection may provide therapeutic benefit to these patients. As all major group HRV serotypes infect cells via an interaction between viral coat proteins and intercellular adhesion molecule-1 ...
Erten Mujde Z - - 2012
OBJECTIVE: To compare the use of guideline-recommended prescription medications for diabetes among Medicare beneficiaries enrolled in stand-alone prescription drug plans (PDPs) with Medicare Advantage prescription drug plans (MAPDs) in the presence of potential selection bias. DATA SOURCES/STUDY SETTING: Centers for Medicare and Medicaid Services' Chronic Condition Data Warehouse (2006, 2007). ...
Zhang Zhonghai - - 2012
In the present study, a visible-light responsive plasmonic photocatalytic composite material is designed by rationally selecting Au nanocrystals and assembling them with the TiO2 based photonic crystal substrate. The selection of the Au nanocrystals is so that their surface plasmonic resonance (SPR) wavelength matches the photonic band gap of the ...
Algahtani F H - - 2012
Pulmonary embolism (PE) is a common condition in the Emergency Department and its incidence increases exponentially with age [1]. PE remains largely underdiagnosed and inappropriately treated, resulting in suboptimal outcomes. This is partly due to the fact that clinical symptoms and signs are nonspecific [2]. © 2012 International Society on ...
Ivanovskaya Anna - - 2012
Mixed metal sulfides containing combinations of W, Fe, Mo, Ni, and Ru were synthesized and screened for activity and stability for the hydrogen evolution reaction (HER) in aqueous hydrobromic acid (HBr). Co- and Ni-substituted RuS2 were identified as potentially active HER electrocatalysts by high-throughput screening (HTS), and the specific compositions ...
Ehrentraut Stefan F SF Mucosal Inflammation Program, Department of Medicine and Immunology, University of Colorado School of Medicine, Aurora, CO 80045, - - 2013
A deeper understanding of the mechanisms that control responses to inflammation is critical to the development of effective therapies. We sought to define the most proximal regulators of the Cullin (Cul)-RING ligases, which play a central role in the stabilization of NF-κB and hypoxia-inducible factor (HIF). In these studies, we ...
Flynn Traci - - 2012
OBJECTIVES/HYPOTHESIS: To study longitudinal prevalence of otitis media with effusion (OME) in children between 7 and 16 years of age by cleft group, and hearing sensitivity across time and across frequencies. STUDY DESIGN: Retrospective and longitudinal. METHODS: All children with cleft palate born from 1991 to 1993 were included in ...
Ahmed Syed M - - 2012
The small GTPase Rap1 regulates inside-out integrin activation and thereby influences cell adhesion, migration, and polarity. Several Rap1 effectors have been described to mediate the cellular effects of Rap1 in a context-dependent manner. Radil is emerging as an important Rap effector implicated in cell spreading and migration, but the molecular ...
Salz Helen K HK Department of Genetics and Genome Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH, USA. - - 2013
The Drosophila Sex-lethal (Sxl) gene encodes a female-specific RNA binding protein that in somatic cells globally regulates all aspects of female-specific development and behavior. Sxl also has a critical, but less well understood, role in female germ cells. Germ cells without Sxl protein can adopt a stem cell fate when ...
Kuehl A-R - - 2012
The induction of angiogenesis is essential for successful engraftment of freely transplanted cells or cellular composites. How to augment angiogenesis to ensure an appropriate viability of the grafts is still under investigation. This study evaluated the proangiogenic capability of different syngeneic free liver transplants and elucidated the origin of the ...
Van Marter Linda J LJ Boston Children's Hospital, Boston, Massachusetts 02115, USA. - - 2013
Persistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome of late-preterm and full-term infants associated with failure of the normal fetal-to-neonatal circulatory transition. This study was designed to test the hypothesis that risk for PPHN is increased after antenatal exposure to nonsteroidal antiinflammatory drugs (NSAIDs), with particular emphasis ...
Telbisz Agnes - - 2012
The human ABCG2 multidrug transporter actively extrudes a wide range of hydrophobic drugs and xenobiotics recognized by the transporter in the membrane phase. In order to examine the molecular nature of the transporter and the effects of the lipid environment, we have established an efficient protocol for the purification and ...
Paula Bonancia - - 2012
The two enantiomers of 2-(2-hydroxybiphenyl-4-yl)propanoic acid ((S)- and (R)-BPOH) have been selected as probes for human serum albumin (HSA). Photophysical characterization in the absence of protein led to emission maxima, singlet energies, quantum yields and fluorescence lifetimes values of 332 nm, 91 kcal mol-1, 0.28 and 1.8 ns for BPOH ...
Monaghan-Benson E E 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA [2] Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, - - 2013
The ability of cells to invade into the dermis is a critical event in the development of cutaneous melanoma and ultimately an indicator of poor prognosis. However, the molecular events surrounding the acquisition of this invasive phenotype remain incompletely understood. Mutations in B-RAF are frequent in melanoma and are known ...
Li Longyu - - 2012
Influence of Hofmeister ions has been investigated on the size and guest encapsulation stability of a polymeric nanogel. While variations in macroscopic phase transitions have been observed in response to the presence of salts, changes in the size and host-guest behavior of polymeric aggregates in the presence of salts have ...
Landsman V - - 2012
We propose to estimate average exposure (or treatment) effects from observational data for multiple exposure groups by fitting an approximation of the marginal sample distribution of the response variable in each exposure group to the data. The marginal sample distribution is a function of the true distribution of the response ...
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