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Results 551 - 600 of 4108
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Vera Gabriella - - 2013
Cernunnos is a DNA repair factor of the nonhomologous end-joining machinery. Its deficiency in humans causes radiosensitive severe combined immune deficiency (SCID) with microcephaly, characterized in part by a profound lymphopenia. In contrast to the human condition, the immune system of Cernunnos knockout (KO) mice is not overwhelmingly affected. In ...
Gilman Rich - - 2012
This study validates a new self-report measure, the Ostracism Experience Scale for Adolescents (OES-A). Nineteen items were tested on a sample of 876 high school seniors to assess 2 of the most common ostracism experiences: being actively excluded from the peer group and being largely ignored by others. Exploratory and ...
Payne David E - - 2013
Staphylococcus aureus is a human commensal and pathogen that is capable of forming biofilms on a variety of host tissues and implanted medical devices. Biofilm-associated infections resist antimicrobial chemotherapy and attack from the host immune system, making these infections particularly difficult to treat. In order to gain insight into environmental ...
Lu Xiao-Yan - - 2012
Studying the essence of a syndrome has been a key challenge in the field of Chinese medicine. Until now, due to limitations of the methods available, the progress towards understanding such complicated systems has been slow. Metabonomics encompasses the dynamics, composition and analysis of metabolites, enabling the observation of changes ...
Thomas Kali S KS Center for Gerontology and Healthcare Research, Brown University, Providence, RI, - - 2013
To test the relationship between older Americans Act (OAA) program expenditures and the prevalence of low-care residents in nursing homes (NHs). DATA SOURCES AND COLLECTION: Two secondary data sources: State Program Reports (state expenditure data) and NH facility-level data downloaded from LTCfocUS.org for 16,030 US NHs (2000-2009). Using a two-way ...
Daniel R M - - 2012
Longitudinal studies, where data are repeatedly collected on subjects over a period, are common in medical research. When estimating the effect of a time-varying treatment or exposure on an outcome of interest measured at a later time, standard methods fail to give consistent estimators in the presence of time-varying confounders ...
Gu Yapeng - - 2012
HLA-DO/H2-O is a highly conserved, nonpolymorphic MHC class II-like molecule expressed in association with H2-M in thymic epithelial cells, B lymphocytes, and primary dendritic cells. The physiological function of DO remains unknown. The finding of cell maturation-dependent DO expression in B lymphocytes and dendritic cells suggests the possibility that H2-O ...
Tanaka Toyohito - - 2012
Brilliant blue FCF of food color was given in the diets of mice at levels of 0% (control), 0.08, 0.24, and 0.72% from 5 weeks of age in the F(0) generation and continuing to 11 weeks of age in the F(1) generation and selected reproductive and neurobehavioral parameters were measured. ...
Viswanatha Raghuvir R Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, - - 2012
In this paper, we describe how a dynamic regulatory process is necessary to restrict microvilli to the apical aspect of polarized epithelial cells. We found that local phosphocycling regulation of ezrin, a critical plasma membrane-cytoskeletal linker of microvilli, was required to restrict its function to the apical membrane. Proteomic approaches ...
Ehrlich Hans-Christian - - 2012
A common task in drug development is the selection of compounds fulfilling specific structural features from a large data pool. While several methods that iteratively search through such data sets exist, their application is limited compared to the infinite character of molecular space. The introducing of the concept of fragment ...
Wiberg Kenneth B - - 2012
Bond dissociation enthalpies can exhibit dramatic variations resulting from substituent effects. The remarkable range of experimental OH bond dissociation enthalpies have been reproduced using CBS-APNO calculations with very good accuracy, so we have employed these calculations to extend the available BDE data. The effect on these BDEs of lone pairs ...
Mallory Frank B - - 2012
In recent years we have used the photocyclizations of diarylethylenes to synthesize a number of [n]phenacenes in the hope that they might be useful as the bridging groups for electron transfer processes in donor-bridge-acceptor molecules. Because [n]phenacenes with n > 5 are very insoluble, their synthesis and characterization has required ...
Tammetta Paul P Coffey Geotechnics, Level 18, Citadel Tower, 799 Pacific Highway Chatswood, NSW, 2067, Australia; - - 2013
The height of complete groundwater drainage above subsided longwall panels (referred to as H) at underground mines is determined using a data base of hydraulic head measurements made with multiple devices down the depth profile at each of a number of sites worldwide. H is shown to be relatively independent ...
Pravosudov V V VV Department of Biology, University of Nevada, Reno, NV 89557, USA. - - 2013
There is significant and often heritable variation in cognition and its underlying neural mechanisms, yet specific genetic contributions to such variation are not well characterized. Black-capped chickadees present a good model to investigate the genetic basis of cognition because they exhibit tremendous climate-related variation in memory, hippocampal morphology and neurogenesis ...
Saleem Tariq Z - - 2012
Background:Palliative care is rarely being offered to patients with Parkinson's disease.Aim:To assess symptom prevalence, severity and palliative care needs in advanced stages of Parkinsonism.Design:A cross-sectional survey using a palliative care assessment tool, the Palliative Outcome Scale was administered to patients.Setting/participants:Eight-two patients with a diagnosis of idiopathic Parkinson's disease, multiple systems ...
Magnusson Gunilla - - 2012
AIM: To study which eye-screening protocol prevails in Swedish maternity/neonatal wards, evaluate efficacy in a prospective study, and compare results with earlier Swedish retrospective results. METHODS: Surveys were sent in 2006 to maternity/neonatal and women's health departments regarding screening policy. Response frequency was 96% (122/127). Data were derived from The ...
Hall Randon T - - 2012
BACKGROUND AND OBJECTIVE:Blood culture contamination in the pediatric population remains a significant quality and safety issue because false-positive blood cultures lead to unnecessary use of resources and testing. In addition, few studies describe interventions to reduce peripheral blood culture contamination rates in this population. We hypothesized that the introduction of ...
Rodriguez R A - - 2012
Safety and effectiveness of any medical therapy depends on patients taking their medication as prescribed and the extent of this is defined as medication adherence [1]. Poor medication adherence is frequently found across all types of pharmacological therapy. Estimates indicate that 28% of new prescriptions are unfilled and for patients ...
Zhang Yan - - 2012
Poly(dopamine) PDA coatings have recently attracted considerable interest for a variety of applications. Here, we investigate the film deposition of dopamine mixed with a non-ionic polymer i.e., poly(ethylene glycol) (PEG), poly(vinyl alcohol) (PVA), and poly(N-vinyl pyrrolidone) (PVP) onto silica substrates using X-ray photoelectron spectroscopy and quartz crystal microbalance. Further, we ...
Buchwald M M Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University, Jena, - - 2013
Activated Cdc42-associated kinase 1 (ACK1) is a nonreceptor tyrosine kinase linked to cellular transformation. The aberrant regulation of ACK1 promotes tumor progression and metastasis. Therefore, ACK1 is regarded as a valid target in cancer therapy. Seven in absentia homolog (SIAH) ubiquitin ligases facilitate substrate ubiquitinylation that targets proteins to the ...
Sparks S Andy - - 2012
Abstract The use of portable urine osmometers is widespread, but no studies have assessed the validity of this measurement technique. Furthermore, it is unclear what effect freezing has on osmolality. One-hundred participants of mean (±SD) age 25.1 ± 7.6 years, height 1.77 ± 0.1 m and weight 77.1 ± 10.8 kg provided single urine samples that were analysed ...
Hawinkels L J A C - - 2012
The interaction between epithelial cancer cells and cancer-associated fibroblasts (CAFs) has a major role in cancer progression and eventually in metastasis. In colorectal cancer (CRC), CAFs are present in high abundance, but their origin and functional interaction with epithelial tumor cells has not been elucidated. In this study we observed ...
Gilfedder Benjamin Silas - - 2012
There is little known about the short term dynamics of groundwater - surface water exchange in losing rivers. This is partly due to the paucity of chemical techniques that can autonomously collect high-frequency data in groundwater bores. Here we present two new instruments for continuous in-situ 222Rn measurement in bores ...
Poulter Steven L - - 2012
Studies of spontaneous behavior to assess memory are widespread, but often the relationships of objects to contexts and spatial locations are poorly defined. We examined whether object-location memory was maintained following global, but not local, changes to the geometric shape of an arena. Rats explored two trial-unique objects in a ...
Dhasaiyan Prabhu - - 2012
Just a little bit: The remarkable influence of a small change in the molecular geometry on the self-assembled structures of the acidic form of sophorolipids (SLs) derived from oleic, elaidic, and stearic acid is demonstrated. Most interestingly helical structures were seen only from SLs derived from elaidic acid (the trans ...
Rai Neeraj - - 2012
The explicit--hydrogen version of the transferable potentials for phase equilibria (TraPPE--EH) force field is extended to various substituted benzenes through the parameterization of the exocyclic groups -F, -Cl, -Br, -C≡N, and -OH and to polycyclic aromatic hydrocarbons through the parameterization of the aromatic linker carbon atom for multiple rings. The ...
El Hajj Nady N Institute of Human Genetics, Julius Maximilians University, Würzburg, - - 2013
Epigenetic processes are primary candidates when searching for mechanisms that can stably modulate gene expression and metabolic pathways according to early life conditions. To test the effects of gestational diabetes mellitus (GDM) on the epigenome of the next generation, cord blood and placenta tissue were obtained from 88 newborns of ...
Pal Debjani - - 2012
Proteins destined for the thylakoid lumen of chloroplasts must cross three membranes en route. The chloroplast Twin Arginine Translocation (cpTat) system facilitates transport of about half of all proteins that cross the thylakoid membrane in chloroplasts. Known mechanistic features of the cpTat system are drastically different from other known translocation ...
Tomanov Konstantin - - 2012
Small ubiquitin-like modifier (SUMO) conjugation affects a broad range of processes in plants, including growth, flower initiation, pathogen defense, and responses to abiotic stress. Here, we investigate in vivo and in vitro a SUMO conjugating enzyme with a Cys to Ser change in the active site, and show that it ...
Dussert Y - - 2012
Unravelling the mechanisms involved in adaptation to understand plant morphological evolution is a challenging goal. For crop species, identification of molecular causal polymorphisms involved in domestication traits is central to this issue. Pearl millet, a domesticated grass mostly found in semi-arid areas of Africa and India, is an interesting model ...
Ditta Annie Stanfield - - 2012
This article describes a new approach for studying collaborative memory that examines people's editing processes for naturally occurring memory errors. In this approach, memories of individuals are combined via a chaining method in which each participant indirectly receives information from the previous participant. Participants were asked to individually study word ...
Moura A E - - 2012
Despite the scarcity of geographical barriers in the ocean environment, delphinid cetaceans often exhibit marked patterns of population structure on a regional scale. The European coastline is a prime example, with species exhibiting population structure across well-defined environmental boundaries. Here we undertake a comprehensive population genetic study on the European ...
Kaljee Linda M LM Wayne State University, Pediatric Prevention Research Center, The Carman and Ann Adams Department of Pediatrics, Detroit, Michigan 48201, USA. - - 2013
Salmonella enterica serotype Typhi (S. Typhi) was estimated to cause over 200,000 deaths and more than 21 million illnesses worldwide, including over 400,000 illnesses in Africa. The current study was conducted in four villages on Pemba Island, Zanzibar, in 2010. We present data on policy makers', health administrators', and village ...
Khan Md Gulam - - 2012
ABSTRACT: BACKGROUND: Visceral leishmaniasis (VL) remains as one of the most neglected tropical diseases with over 60% of the world's total VL cases occurring in the Indian subcontinent. Due to the invasive risky procedure and technical expertise required in the classical parasitological diagnosis, the goal of the VL experts has ...
Meegan Jenny - - 2012
Marine-origin Brucella infections and serologic evidence of exposure have been documented in multiple cetacean species. A dolphin-specific indirect enzyme-linked immunosorbent assay (ELISA) was developed to screen bottlenose dolphin sera for anti-Brucella antibodies. A total of 131 serum samples collected over a 2 to 18 yr period from 6 bottlenose dolphins ...
Cornet Stéphane - - 2012
The epidemiology of vector-borne pathogens is largely determined by the host-choice behaviour of their vectors. Here, we investigate whether a Plasmodium infection renders the host more attractive to host-seeking mosquitoes. For this purpose, we work on a novel experimental system: the avian malaria parasite Plasmodium relictum, and its natural vector, ...
Bezsonov Evgeny E EE Department of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, Moscow, - - 2013
The pH-dependence of the ability of Bgl2p to form fibrils was studied using synthetic peptides with potential amyloidogenic determinants (PADs) predicted in the Bgl2p sequence. Three PADs, FTIFVGV, SWNVLVA and NAFS, were selected on the basis of combination of computational algorithms. Peptides AEGFTIFVGV, VDSWNVLVAG and VMANAFSYWQ, containing these PADs, were ...
April Julien - - 2012
Allopatric speciation may be the principal mechanism generating new species. Yet, it remains difficult to judge the generality of this process because few studies have provided evidence that geographic isolation has triggered the development of reproductive isolation over multiple species of a regional fauna. Here, we first combine results from ...
Pesce Mirko - - 2012
Recently, several studies reported a relationship between immune system activation and anger expression. Consequently, the aim of this study was to explore immunitary molecular mechanisms that potentially underlie anger expression. To this end, we applied the Frustration-Aggression Theory in a contact sport model, utilizing the nearing of sporting events to ...
Sciumé Giuseppe G Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, - - 2012
Interleukin (IL)-22-producing innate lymphoid cells (ILCs; ILC22) comprise a heterogeneous population of cells that are dependent on the transcription factor retinoid-related orphan γt (RORγt) and are critical for barrier function of the intestinal mucosa. A distinct ILC22 subset expresses the natural cytotoxicity receptor NKp46 (NKp46+ ILC22); however, the factors that ...
Fromberger Peter - - 2012
Recent theories in sexuality highlight the importance of automatic and controlled attentional processes in viewing sexually relevant stimuli. The model of Spiering and Everaerd (2007) assumes that sexually relevant features of a stimulus are preattentively selected and automatically induce focal attention to these sexually relevant aspects. Whether this assumption proves ...
Karwat Darshan Mukesh Arvinda - - 2012
High-speed gas sampling experiments to measure the intermediate products formed during fuel decomposition remain challenging yet important experimental objectives. This paper presents new speciation data on two important fuel reference compounds-n-heptane and n-butanol-at practical thermodynamic conditions of 700 K and 9 atm, for stoichiometric fuel-to-oxygen ratios and a dilution of ...
Jansen David A W A M - - 2013
All animals are anatomically constrained in the number of discrete call types they can produce. Recent studies suggest that by combining existing calls into meaningful sequences, animals can increase the information content of their vocal repertoire despite these constraints. Additionally, signalers can use vocal signatures or cues correlated to other ...
Lupi Laura - - 2012
The relaxation properties of hydration water around fructose, glucose, sucrose and trehalose molecules have been studied by means of extended frequency range depolarized light scattering and molecular dynamics simulations. Evidence is given of an hydration dynamics retarded by a factor ξ = 5 - 6 for all the analyzed solutes. ...
Yoshida Jun - - 2012
A new series of oxo-centered tricobalt(iii, iii, iii) complexes, containing mixed bridges of acetate and pyrazolate anions, has been synthesized based on a strategy consisting of two stages. In the first stage, the reaction of cobalt(ii) acetate tetrahydrate with pyrazole in the presence of oxidants, followed by purification with silica-gel ...
Kim Sung Kuk - - 2012
On the basis of 1H NMR spectroscopic analyses and single crystal X-ray crystal structural data, the ion pair receptor 1, bearing a calix[4]pyrrole for anion binding and calix[4]arene crown-5 for cation recognition, was found to act as a receptor for both CsF and KF ion pairs. Both substrates are bound ...
Braun Katherine A - - 2013
Adr1 and Cat8 are nutrient-regulated transcription factors in Saccharomyces cerevisiae that coactivate genes necessary for growth in the absence of a fermentable carbon source. Transcriptional activation by Adr1 is dependent on the AMP-activated protein kinase Snf1 and is inhibited by binding of Bmh, yeast 14-3-3 proteins, to the phosphorylated Adr1 ...
Hall Lindsay J - - 2013
Natural killer (NK) cells are traditionally considered in the context of tumor surveillance and viral defense, but their role in bacterial infections, particularly those caused by enteric pathogens, is less clear. C57BL/6 mice were orally gavaged with Citrobacter rodentium, a murine pathogen related to human diarrheagenic Escherichia coli. We used ...
Hu Zuo-Jun - - 2012
ABSTRACT: BACKGROUND: In a previous in vitro study, we confirmed that small-caliber nanofibrous polyurethane (PU) vascular grafts have favorable mechanical properties and biocompatibility. In the present study, we examined the in vivo biocompatibility and stability of these grafts. METHODS: Forty-eight adult male beagle dogs were randomly divided into two groups ...
Juhl Mette - - 2012
OBJECTIVE: The aim of the present study was to examine the association between occupational lifting and the risk of fetal death according to gestational age. METHODS: We used data from the Danish National Birth Cohort (1996-2002). Among 71 500 occupationally active women, 2886 experienced a fetal death. Information on lifting ...
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