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Jatzek Anna A Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, - - 2013
CD8 T cells exhibit dynamic alterations in proliferation and apoptosis during various phases of the CD8 T-cell response, but the mechanisms that regulate cellular proliferation from the standpoint of CD8 T-cell memory are not well defined. The cyclin-dependent kinase inhibitor p27(Kip1) functions as a negative regulator of the cell cycle ...
Cho Kyung-Bin - - 2012
The hydroxylation of alkanes by heme FeIVO species occurs via the hydrogen abstraction-oxygen rebound mechanism. It has been assumed that nonheme FeIVO species follow the heme FeIVO paradigm in the C-H bond activation reactions. Herein, we report theoretical and experimental evidence that C-H bond activation of alkanes by synthetic nonheme ...
Buyze Jozefien - - 2012
Dynamic treatment strategies are designed to change treatments over time in response to intermediate outcomes. They can be deployed for primary treatment as well as for the introduction of adjuvant treatment or other treatment-enhancing interventions. When treatment interventions are delayed until needed, more cost-efficient strategies will result. Sequential multiple assignment ...
Bainbridge Roxanne - - 2012
Researchers working with Aboriginal Australian partners are confronted with an array of historical, social, and political complexities which make it difficult to come to theoretical and methodological decisions. In this article, we describe a culturally safe and respectful framework that maintains the intellectual and theoretical rigor expected of academic research. ...
Viviani Vadim R - - 2012
Beetle luciferases emit different bioluminescence colors from green to red, however, the structural determinants and mechanisms of spectral modulation are not fully understood. Nno clear relationship between the physical-chemical identity of the luciferin binding site residues and bioluminescence colors was found in different luciferases, and it is unclear whether critical ...
Avci Ceren - - 2012
The dynamics of serum adsorption on bare and monoethylene glycol adlayer-modified gold surfaces is investigated using acoustic wave physics. Hydration experiments support the pivotal role ascribed to water in the antifouling of surfaces. Behavioural discrepancy is interpreted in terms of difference in water structuring properties (surface kosmotropicity).
Newton Philip - - 2012
Infection with human rhinovirus (HRV) is thought to result in acute respiratory exacerbations of chronic obstructive pulmonary disorder (COPD). Consequently, prevention of HRV infection may provide therapeutic benefit to these patients. As all major group HRV serotypes infect cells via an interaction between viral coat proteins and intercellular adhesion molecule-1 ...
Erten Mujde Z - - 2012
OBJECTIVE: To compare the use of guideline-recommended prescription medications for diabetes among Medicare beneficiaries enrolled in stand-alone prescription drug plans (PDPs) with Medicare Advantage prescription drug plans (MAPDs) in the presence of potential selection bias. DATA SOURCES/STUDY SETTING: Centers for Medicare and Medicaid Services' Chronic Condition Data Warehouse (2006, 2007). ...
Zhang Zhonghai - - 2012
In the present study, a visible-light responsive plasmonic photocatalytic composite material is designed by rationally selecting Au nanocrystals and assembling them with the TiO2 based photonic crystal substrate. The selection of the Au nanocrystals is so that their surface plasmonic resonance (SPR) wavelength matches the photonic band gap of the ...
Algahtani F H - - 2012
Pulmonary embolism (PE) is a common condition in the Emergency Department and its incidence increases exponentially with age [1]. PE remains largely underdiagnosed and inappropriately treated, resulting in suboptimal outcomes. This is partly due to the fact that clinical symptoms and signs are nonspecific [2]. © 2012 International Society on ...
Femminella Grazia Daniela - - 2012
Alzheimer's disease (AD) is a devastating form of dementia that imposes a severe burden on health systems and society. Although several aspects of AD pathogenesis have been elucidated over the last few decades, many questions still need to be addressed. In fact, currently available medications only provide symptomatic improvement in ...
Ivanovskaya Anna - - 2012
Mixed metal sulfides containing combinations of W, Fe, Mo, Ni, and Ru were synthesized and screened for activity and stability for the hydrogen evolution reaction (HER) in aqueous hydrobromic acid (HBr). Co- and Ni-substituted RuS2 were identified as potentially active HER electrocatalysts by high-throughput screening (HTS), and the specific compositions ...
Flynn Traci - - 2012
OBJECTIVES/HYPOTHESIS: To study longitudinal prevalence of otitis media with effusion (OME) in children between 7 and 16 years of age by cleft group, and hearing sensitivity across time and across frequencies. STUDY DESIGN: Retrospective and longitudinal. METHODS: All children with cleft palate born from 1991 to 1993 were included in ...
Kuehl A-R - - 2012
The induction of angiogenesis is essential for successful engraftment of freely transplanted cells or cellular composites. How to augment angiogenesis to ensure an appropriate viability of the grafts is still under investigation. This study evaluated the proangiogenic capability of different syngeneic free liver transplants and elucidated the origin of the ...
Telbisz Agnes - - 2012
The human ABCG2 multidrug transporter actively extrudes a wide range of hydrophobic drugs and xenobiotics recognized by the transporter in the membrane phase. In order to examine the molecular nature of the transporter and the effects of the lipid environment, we have established an efficient protocol for the purification and ...
Paula Bonancia - - 2012
The two enantiomers of 2-(2-hydroxybiphenyl-4-yl)propanoic acid ((S)- and (R)-BPOH) have been selected as probes for human serum albumin (HSA). Photophysical characterization in the absence of protein led to emission maxima, singlet energies, quantum yields and fluorescence lifetimes values of 332 nm, 91 kcal mol-1, 0.28 and 1.8 ns for BPOH ...
Li Longyu - - 2012
Influence of Hofmeister ions has been investigated on the size and guest encapsulation stability of a polymeric nanogel. While variations in macroscopic phase transitions have been observed in response to the presence of salts, changes in the size and host-guest behavior of polymeric aggregates in the presence of salts have ...
Landsman V - - 2012
We propose to estimate average exposure (or treatment) effects from observational data for multiple exposure groups by fitting an approximation of the marginal sample distribution of the response variable in each exposure group to the data. The marginal sample distribution is a function of the true distribution of the response ...
Jonveaux Therese Rivasseau - - 2012
The French Alzheimer Plan 2008-2012 anticipates the implementation of new Units specialized in cognitive rehabilitation and psycho-behavioral therapy of Alzheimer's disease (AD) patients. Conceived for AD and other dementia patients of all ages, their objectives are to propose a cognitive rehabilitation program, to prevent or treat psycho-behavioral crises, and to ...
Csáky-Szunyogh Melinda - - 2012
Abstract Objective. In general the analytical epidemiological studies evaluated cases with congenital heart defects together. However, different congenital heart defect entities have different etiology, and in the vast majority of patients the underlying causes are unclear. Thus the objective of the study was to evaluate the possible etiological factors in ...
Lai Yuekun - - 2012
Herein is described a facile, in situ, ink-regulating approach to rapidly achieve reversible water wettability and adhesion transition, with a large degree of contrast, on the superhydrophobic TiO(2) nanotube array film. The ink printing and removal process allows the wettability and reversible adhesion transitions to be realized. Experimental results demonstrate ...
Jamshidi Zahra - - 2012
Binding of noble metal clusters (Mn, M = Cu, Ag, and Au; n=2-4) with rare gas atoms (Rg = Kr, Xe, and Rn) has been investigated at the density functional (CAM-B3LYP) and ab-initio (MP2) levels of theory. The calculation shows significant affinity of neutral metal clusters for interaction with rare ...
Semsarilar Mona - - 2012
We report the synthesis of cationic sterically-stabilized diblock copolymer nanoparticles via polymerization-induced self-assembly (PISA) using a RAFT aqueous dispersion polymerization formulation. The cationic steric stabilizer is a macromolecular chain transfer agent (macro-CTA) based on quaternized poly(2-(dimethylamino)ethyl methacrylate) (PQDMA), while the hydrophobic core-forming block is based on poly(2-hydroxypropyl methacrylate) (PHPMA). The ...
Nair Chandrika Goh - - 2012
Approximately 80% of adult Cystic Fibrosis (CF) patients become chronically infected with Pseudomonas aeruginosa and consequently require antibiotic therapy at intervals throughout their lives. Achieving lethal concentrations of antibiotics in the lung remains a challenge. Recent evidence from Escherichia coli and Staphylococcus aureus suggests that the generation of hydroxyl radicals ...
Rojas-Triana Mónica - - 2012
Throughout evolution, plants have evolved sophisticated adaptive responses that allow them to grow with a limited supply of phosphate, the preferential form in which the essential macronutrient phosphorus is absorbed by plants. Most of these responses are aimed to increase phosphate availability and acquisition through the roots, to optimize its ...
Gilmore Brian L - - 2012
We present a novel microfluidic platform to examine biological assemblies at high-resolution. We have engineered a functionalized chamber that serves as a "nanoscale biosphere" to capture and maintain rotavirus double-layered particles (DLPs) in a liquid environment. The chamber can be inserted into the column of a transmission electron microscope while ...
Zaramella Patrizia - - 2012
This case report describes a preterm newborn infant who was treated with a single dose of rasburicase for an increase in uric acid level. He died on the third day as a result of complications of hemolysis, which appeared to be precipitated by rasburicase. The patient's death was preceded by ...
Montgomery Robert A - - 2012
Habitat use is widely known to be influenced by abiotic and biotic factors, such as climate, population density, foraging opportunity and predation risk. The influence of the life-history state of an individual organism on habitat use is less well understood, especially for terrestrial mammals. There is good reason to expect ...
Zopf David A - - 2012
OBJECTIVE To evaluate the aesthetic and functional outcomes of a full-thickness skin graft and a separately harvested auricular cartilage graft for nasal alar defects created by Mohs micrographic surgery. DESIGN Twenty patients with deep Mohs micrographic surgery defects of the nasal ala who underwent reconstruction with a full-thickness skin graft ...
Poulter Steven L - - 2012
Studies of spontaneous behavior to assess memory are widespread, but often the relationships of objects to contexts and spatial locations are poorly defined. We examined whether object-location memory was maintained following global, but not local, changes to the geometric shape of an arena. Rats explored two trial-unique objects in a ...
Dhasaiyan Prabhu - - 2012
Just a little bit: The remarkable influence of a small change in the molecular geometry on the self-assembled structures of the acidic form of sophorolipids (SLs) derived from oleic, elaidic, and stearic acid is demonstrated. Most interestingly helical structures were seen only from SLs derived from elaidic acid (the trans ...
Rai Neeraj - - 2012
The explicit--hydrogen version of the transferable potentials for phase equilibria (TraPPE--EH) force field is extended to various substituted benzenes through the parameterization of the exocyclic groups -F, -Cl, -Br, -C≡N, and -OH and to polycyclic aromatic hydrocarbons through the parameterization of the aromatic linker carbon atom for multiple rings. The ...
Vasilyev Stanislav A - - 2012
Abstract Purpose: Human hematopoietic stem cells (HSC) are thought to be a major target of radiation-induced leukemogenesis and also provide a relevant cellular model for assessing cancer risk. Cluster of designation 133+ (CD133+) is a marker found in human progenitor and hematopoietic stem cells. Our study examined repair of radiation-induced ...
Pal Debjani - - 2012
Proteins destined for the thylakoid lumen of chloroplasts must cross three membranes en route. The chloroplast Twin Arginine Translocation (cpTat) system facilitates transport of about half of all proteins that cross the thylakoid membrane in chloroplasts. Known mechanistic features of the cpTat system are drastically different from other known translocation ...
Tomanov Konstantin - - 2012
Small ubiquitin-like modifier (SUMO) conjugation affects a broad range of processes in plants, including growth, flower initiation, pathogen defense, and responses to abiotic stress. Here, we investigate in vivo and in vitro a SUMO conjugating enzyme with a Cys to Ser change in the active site, and show that it ...
Dussert Y - - 2012
Unravelling the mechanisms involved in adaptation to understand plant morphological evolution is a challenging goal. For crop species, identification of molecular causal polymorphisms involved in domestication traits is central to this issue. Pearl millet, a domesticated grass mostly found in semi-arid areas of Africa and India, is an interesting model ...
Ditta Annie Stanfield - - 2012
This article describes a new approach for studying collaborative memory that examines people's editing processes for naturally occurring memory errors. In this approach, memories of individuals are combined via a chaining method in which each participant indirectly receives information from the previous participant. Participants were asked to individually study word ...
Moura A E - - 2012
Despite the scarcity of geographical barriers in the ocean environment, delphinid cetaceans often exhibit marked patterns of population structure on a regional scale. The European coastline is a prime example, with species exhibiting population structure across well-defined environmental boundaries. Here we undertake a comprehensive population genetic study on the European ...
Khan Md Gulam - - 2012
ABSTRACT: BACKGROUND: Visceral leishmaniasis (VL) remains as one of the most neglected tropical diseases with over 60% of the world's total VL cases occurring in the Indian subcontinent. Due to the invasive risky procedure and technical expertise required in the classical parasitological diagnosis, the goal of the VL experts has ...
Meregalli M - - 2012
Muscular dystrophies are heritable and heterogeneous neuromuscular disorders characterized by the primary wasting of skeletal muscle, usually caused by mutations in the proteins forming the link between the cytoskeleton and the basal lamina. Due to mutations in the dystrophin gene, DMD patients suffer for progressive muscle atrophy and exhaustion of ...
Mitchell Perry - - 2012
Reported correlations between organic contaminant sorption affinity and soil organic matter (OM) structure vary widely, suggesting the importance of OM physical conformation and accessibility. Batch equilibration was used to examine the sorption affinity of bisphenol A, atrazine, and diuron to five soils of varying OM composition. 13C Cross-Polarization Magic Angle ...
Mehanna Raja - - 2012
BACKGROUND: Respiratory difficulties are sometimes reported by patients with cranial-cervical and other forms of dystonia, but the nature or mechanisms of the breathing problems have not been well characterized. CASE REPORT: We review 13 dystonic patients with various respiratory complaints and describe their symptoms and response to treatment, including botulinum ...
Li Yingzhi - - 2012
Oriented arrays of polyaniline (PANI) nanorods grown on expanded graphite (EG) nanosheets are fabricated by in situ polymerization to achieve excellent electrochemical properties for applications as supercapacitor electrodes. EG serves as an excellent three-dimensional (3D) conductive skeleton that supports a highly electrolytic accessible surface area of redox active PANI and ...
Meier V - - 2012
BACKGROUND: The epothilones are microtubule-stabilizing agents with promising antitumor effect in refractory and metastatic tumors in humans. The toxicity profile is considered more favorable than in taxanes. The safety of epothilone B (patupilone) has not been evaluated in tumor-bearing dogs. OBJECTIVES: To evaluate the inhibition of proliferation in canine tumor ...
Chiappe Daniele - - 2012
A self-organised approach for the synthesis of transparent metal nanowire arrays is based on defocused ion beam sputtering. The nanowire arrays, supported on low-cost dielectric substrates (glass slides), feature a dual functionality: they exhibit anisotropic conductivity, with sheet resistances which are reduced in comparison to those of transparent conductive oxides, ...
Zaccheria Federica - - 2012
There is a renewed interest in designing solid acid catalysts particularly due to the significance of Lewis acid catalyzed processes such as Friedel-Crafts acylation and alkylation and cellulose hydrolysis for the development of sustainable chemistry. This paper reports a new focus point on the properties of supported CuO on silica, ...
O'Neil Elizabeth - - 2012
BACKGROUND: Therapeutic decisions regarding urinalysis are commonly based on the presence of white and red blood cells. Traditionally, numbers per high-power field are estimated using wet-mount microscopic examination. This technique is not standardized and counts are likely prone to inaccuracy. In addition, differentiation of leukocyte types is not possible. OBJECTIVES: ...
Zewail Ahmed - - 2012
For centuries, the wisdom of the West of investing in basic science and technology led to its dominance in world politics and economics. Today, this wisdom is being put aside: fundamental research is losing its appeal to funding agencies and as a professional asset for job hunters. This state of ...
Akar Ay┼čegül - - 2012
Abstract Purpose: To investigate the effects of low level Electromagnetic Field (low level-EMF) exposure, as frequently encountered in daily life, on the yesmal rat cornea using histological and stereological method. Methods: Twenty-two adult male Wistar rats were randomly divided into two groups: study group (n=11) and control group (n=11). Rats ...
Bláhová Markéta - - 2012
Regioselective alkylation of gamma-cyclodextrin with allyl or propargyl bromide, using optimized reaction conditions, followed by peracetylation of remaining hydroxyl groups and separation of isomers resulted in the set of peracetylated 2(I)-O-, 3(I)-O- and 6(I)-O-alkylated cyclodextrins in up to 19% yields. Ozonolyzis or oxidative cleaveage of peracetylated allyl derivatives resulted in ...
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