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Labouta Hagar I - - 2013
ABSTRACT. Owing to the limited source of human skin (HS) and the ethical restrictions of using animals in experiments, in vitro skin equivalents are a possible alternative for conducting particle penetration experiments. The conditions for conducting penetration experiments with model particles, 15-nm gold nanoparticles (AuNP), through nonsealed skin equivalents are ...
Hu Y - - 2013
The purpose of this study was to explore the relationship between left ventricular (LV) dysfunction and arterial wall stiffening. A total of 218 patients over the age of 45 diagnosed with hypertension in Jinan City and hospitalised between 2010 and 2011 were included in this study. LV function was evaluated ...
Marie I - - 2013
To assess the outcome of interstitial lung disease (ILD) in anti-Jo-1 patients with antisynthetase syndrome, determine predictive variables of ILD deterioration in these patients, and compare features of anti-Jo-1 patients with and without ILD. Ninety-one anti-Jo-1 patients were identified by medical records search in 4 medical centers. All of these ...
Losina Elena E Brigham and Women's Hospital, Harvard University, and Boston University School of Public Health, Boston, MA 02115, USA. - - 2013
To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population. We estimated the incidence of diagnosed symptomatic knee OA in the US by combining data on age-, sex-, and obesity-specific prevalence from ...
Vincent Ann A Mayo Clinic, Rochester, MN 55905, USA. - - 2013
To estimate and compare the prevalence of fibromyalgia by 2 different methods in Olmsted County, Minnesota. The first method was a retrospective review of medical records of potential cases of fibromyalgia in Olmsted County using the Rochester Epidemiology Project (from January 1, 2005, to December 31, 2009) to estimate the ...
Razykov Ilya I McGill University and Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, - - 2013
Item 9 of the Patient Health Questionnaire-9 (PHQ-9), which inquires about both passive thoughts of death and active ideas of self-harm, has been used to assess suicide risk in arthritis. The objectives of this study were 1) to determine the proportion of systemic sclerosis (SSc; scleroderma) patients who responded "yes" ...
Pembroke Thomas P I TP Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK. - - 2013
Natural killer (NK) cells provide an immediate first line of defence against viral infections. Memory responses, maintained by CD4(+) T cells, require exposure to viral antigen and provide long-term protection against future infections. It is known that NK cells can promote the development of the adaptive response through cytokine production ...
Martin Erika G EG *Rockefeller College of Public Affairs & Policy and †Nelson A. Rockefeller Institute of Government, University at Albany-State University of New York, Albany, NY ‡Robert Wood Johnson Foundation Clinical Scholars Program, Department of Internal Medicine, Yale University School of Medicine, New Haven, - - 2013
Untreated substance use disorders (SUD) among HIV patients contribute to worse HIV care outcomes and increased HIV transmission. Although there are clinical and policy recommendations for integrated SUD and HIV treatment, payment issues including complex funding streams are a barrier. We assessed the availability of guideline-concordant medication-assisted therapies to treat ...
Bonelli M - - 2013
The binding of abatacept (CTLA-4Ig) to the B7 ligands CD80 and CD86 prevents the engagement of CD28 on T cells and thereby prevents effector T cell activation. In addition, a direct effect of CTLA-4Ig on antigen-presenting cells (APCs) could contribute to the therapeutic effect. To further elucidate the mechanism of ...
Feldman Candace H CH Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. - - 2013
Systemic lupus erythematosus (SLE) and lupus nephritis (LN) disproportionately affect individuals who are members of racial/ethnic minority groups and individuals of lower socioeconomic status (SES). This study was undertaken to investigate the epidemiology and sociodemographics of SLE and LN in the low-income US Medicaid population. We utilized Medicaid Analytic eXtract ...
van den Brand B T BT Radboud University Nijmegen Medical Centre, Nijmegen, The - - 2013
Hyperactivation of innate immunity by Toll-like receptors (TLRs) can contribute to the development of autoinflammatory or autoimmune diseases. This study evaluated the activation of Tyro3, Axl, Mer (TAM) receptors, physiologic negative regulators of TLRs, by their agonists, growth arrest-specific protein 6 (GAS-6) and protein S, in the prevention of collagen-induced ...
Semrau Katherine K Center for Global Health and Development, Boston University School of Public Health, Boston, MA 02118, USA. - - 2013
Mastitis and abscess in HIV-infected women increase the risk of breastfeeding transmission of HIV. Guidelines encourage women to stop breastfeeding on the affected breast and feed on the contralateral breast. However, impact of breast pathology on breast milk HIV dynamics is unknown. HIV RNA was quantified in 211 breast milk ...
Lewis John S JS Jr Duke University Medical Center, Durham, North Carolina 27710, - - 2013
To examine the relationship between inflammation and posttraumatic arthritis (PTA) in a murine intraarticular fracture model. Male C57BL/6 and MRL/MpJ "superhealer" mice received tibial plateau fractures using a previously established method. Mice were killed on day 0 (within 4 hours of fracture) and days 1, 3, 5, 7, 28, and ...
Gerber Scott A SA University of Rochester School of Medicine and Dentistry, Department of Microbiology and Immunology, Rochester, NY, USA. - - 2013
The tumour microenvironment is complex containing not only neoplastic cells but also a variety of host cells. The heterogeneous infiltrating immune cells include subsets of cells with opposing functions, whose activities are mediated either directly or through the cytokines they produce. Systemic delivery of cytokines such as interleukin-2 ( IL-2) ...
Andrade Adriana S A AS Department of Medicine, Division of Infectious Diseases, Johns Hopkins University, Baltimore, MD, USA. - - 2013
Optimal antiretroviral therapy (ART) effectiveness depends on medication adherence, which is a complex behavior with many contributing factors, including neurocognitive function. Pharmacy refill records offer a promising and practical tool to assess adherence. A substudy of the CHARTER (CNS HIV Anti-Retroviral Therapy Effects Research) study was conducted at the Johns ...
Ichinose Kunihiro K Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, - - 2013
CTLA-4 is a negative regulator of the immune response expressed by regulatory T (Treg) cells and activated T cells. Polymorphisms in the CTLA4 gene have been associated with autoimmune diseases, including systemic lupus erythematosus. Disease-associated polymorphisms have been shown to affect the production of the different CTLA-4 variants through an ...
Toledano Michel B - - 2013
The thioredoxin (TRX) and glutathione (GSH) pathways are universally conserved thiol-reductase systems that drive an array of cellular functions involving reversible disulfide formation. Here we consider these pathways in Saccharomyces cerevisiae, focusing on their cell compartment-specific functions, as well as the mechanisms that explain extreme differences of redox states between ...
Hawkins Eric - - 2013
Airway management is a critical procedure and essential skill necessary for all physicians working in the emergency department. Optimal resuscitative treatment of medical and trauma patients often revolves around timely and effective airway interventions that can be challenging in the acute setting, especially in critical patients. Time-honored airway techniques and ...
Aiken Ashley H - - 2013
Oral cavity cancer comprises nearly 30% of all malignant tumors of the head and neck. After a definitive diagnosis has been made, imaging is essential for staging the primary tumor by evaluating submucosal spread and invasion of adjacent structures, and to identify nodal or distant metastasis. Oral cavity anatomy is ...
Lorenzo Gamaliel - - 2013
Image-guided tissue sampling is becoming increasingly important for management of head and neck cancers. Ultrasound-guided fine-needle aspiration (UG-FNA) is safe, effective, and has many advantages compared with palpation-guided FNA and computed tomography-guided FNA. The technique of UG-FNA is highly operator and experience dependent; however, understanding the complex anatomy, disease processes, ...
Chen Amy Y - - 2013
To accurately interpret pretreatment and posttreatment imaging in patients with hypopharyngeal squamous cell carcinoma (SCC), one must understand the complex anatomy of this part of the aerodigestive system. Common patterns of spread must be recognized, andpitfalls in imaging must be understood. This article reviews the epidemiology, anatomy, staging, treatment, and pitfalls ...
Lewis Gemma C - - 2013
The venous and/or arterial vasculature may be accessed for fluid resuscitation, testing and monitoring, administration of blood product or medication, or procedural reasons, such as the implantation of cardiac pacemaker wires. Accessing the vascular system is a common and often critically important step in emergency patient care. This article reviews ...
Hudgins Patricia A - - 2013
Cancer staging is how clinicians describe the state of the disease, predict prognosis, help determine best treatment, and interpret outcomes. Although several staging systems are available, the most widely used is the tumor node metastasis (TNM) system developed by the American Joint Committee on Cancer. Knowledge of normal anatomy and ...
Friedman Elliott R - - 2013
The major salivary glands consist of the parotid, submandibular, and sublingual glands. Most neoplasms in other subsites in the head and neck are squamous cell carcinoma, but tumors of the salivary glands may be benign or malignant. Surgical treatment differs if the lesion is benign, and therefore preoperative fine needle ...
Falcon-Chevere Jorge L - - 2013
Injuries and illness associated with major trauma that require lifesaving procedures, such as surgical airway, chest tube thoracotomy, emergency department thoracotomy, early recognition and treatment of compartment syndrome, and venous cutdown, are seen in the emergency department. The emergency medicine physician must be proficient in recognizing these injuries and their ...
Tirado Alfredo - - 2013
Ultrasound has rapidly become an essential tool in the emergency department, specifically in procedural guidance. Its use has been demonstrated to improve the success rate of procedures, while decreasing complications. In this article, we explore some of these specific procedures involving needle guidance and structure localization with ultrasound.
Glastonbury Christine M - - 2013
Although nasopharyngeal carcinoma (NPC) is the most common primary malignancy of the nasopharynx, it is an uncommon malignancy in much of the Western world. Over the last several years, there have been important changes in the terminology used for histologic classification of NPC and important changes to the American Joint ...
Baugnon Kristen L - - 2013
Laryngeal carcinoma is a devastating malignancy that severely affects patients' quality of life, with compromise of ability to talk, breathe, and swallow. Accurate tumor staging is imperative, because treatment plans focus on laryngeal conservation therapy whenever possible. Although the mucosal extent of tumor and vocal cord mobility is best assessed ...
Falcon-Chevere Jorge L - - 2013
Injuries and illness to the ears, nose, and throat are frequently seen in the emergency department. The emergency medicine physician must be proficient in recognizing these injuries and their associated complications and be able to provide appropriate management. This article discusses the most common otorrhinolaringologic procedures in which emergency physicians ...
Saindane Amit M - - 2013
Thyroid cancer includes several neoplasms originating from the thyroid gland-from indolent and curable histologies of differentiated thyroid carcinoma to aggressive anaplastic thyroid carcinoma. Differentiation of thyroid nodules is problematic on CT and MR imaging unless there is evidence of extrathyroidal extension. Evaluation of regional lymph nodes is often performed clinically ...
Mercado Joanna - - 2013
Obstetric and gynecologic emergencies are common reasons for emergency department visits. Therefore, emergency physicians must be proficient in the management and treatment of these emergencies. This article reviews critical procedures and provides an overview of each procedure and the indications, contraindications, technique, and potential complications.
Boss Stuart E - - 2013
Musculoskeletal injury and diseases are common presentations in the Emergency Department. Emergency physicians must be versed in the critical procedural skills necessary to diagnose joint infection, manage fractures and dislocations, and assess for compartment syndrome. Arthrocentesis, splinting, dislocation reduction, and the evaluation of limb compartment syndrome are reviewed.
Soto Fernando - - 2013
Children comprise approximately one-quarter of all visits to most emergency departments. Children are generally healthier than adults, yet there are similar priorities in assessment and management of pediatric patients. The initial approach to airway, breathing, and circulation still applies and is first and foremost in the evaluation of young infants ...
L'italien Anita J - - 2013
The management of cardiovascular emergencies is a fundamental component of the practice of an emergency practitioner. Delays in the evaluations and management can lead to significant morbidity or mortality. It is of vital importance to be familiar with procedures such as pericardiocentesis, cardioversion, defibrillation, temporary pacing, and options for the ...
Corey Amanda - - 2013
The face of oropharyngeal squamous cell carcinoma (OPSCC) is changing. It has a dichotomous nature, with 1 subset of the disease associated with tobacco and alcohol use and the other having proven association with human papilloma virus infection. Imaging plays an important role in the staging and surveillance of OPSCC, ...
Ramos-Fernandez Maria R - - 2013
The evaluation and management of genitourinary emergencies is a fundamental component of the training and practice of emergency physicians. Urologic procedures are common in the emergency room. Emergency physicians play a vital role in the initial evaluation and treatment because delays in management can lead to permanent damage. This article ...
Saindane Amit M - - 2013
Lymph nodes status is an important predictor of prognosis in head and neck squamous cell carcinoma, making accurate staging critical. The physical examination of the neck is highly inaccurate. CT, MR imaging, ultrasound (US), and positron emission tomography-CT (PET-CT) improve accuracy but have limitations. Size criteria, nodal shape and clustering, ...
Essand M - - 2013
T-cell immunotherapy is a promising approach to treat disseminated cancer. However, it has been limited by the ability to isolate and expand T cells restricted to tumour-associated antigens. Using ex vivo gene transfer, T cells from patients can be genetically engineered to express a novel T cell receptor or chimeric ...
Meyer Colette - - 2013
GNRH significantly inhibits proliferation of a proportion of cancer cell lines by activating GNRH receptor (GNRHR)-G protein signaling. Therefore, manipulation of GNRHR signaling may have an under-utilized role in treating certain breast and ovarian cancers. However, the precise signaling pathways necessary for the effect and the features of cellular responses ...
Kunrath Julie - - 2013
Essential hypertension is associated with chronic exposure to high levels of inorganic arsenic in drinking water. However, early signs of risk for developing hypertension remain unclear in people exposed to chronic low-to-moderate inorganic arsenic. We evaluated cardiovascular stress reactivity and recovery in healthy, normotensive, middle-aged men living in an arsenic-endemic ...
Pelzer Nadine - - 2013
Hemiplegic migraine (HM) is a rare subtype of migraine with aura, characterized by transient hemiparesis during attacks. Diagnosis is based on the International Classification of Headache Disorders criteria (ICHD-II). Two types of HM are recognized: familial (FHM) and sporadic hemiplegic migraine (SHM). HM is genetically heterogeneous. Three genes have been ...
Tirado Alfredo - - 2013
Bedside ultrasound is an extremely valuable and rapidly accessible diagnostic and therapeutic modality in potentially life- and limb-threatening situations in the emergency department. In this report, the authors discuss the role of ultrasound in quick assessment of pathologic conditions and its use to aid in diagnostic and therapeutic interventions.
Lauwerys Bernard R - - 2013
We developed interferon-α-kinoid (IFN-K), a drug composed of inactivated IFNα coupled to a carrier protein, keyhole limpet hemocyanin. In human IFNα-transgenic mice, IFN-K induces polyclonal antibodies that neutralize all 13 subtypes of human IFNα. We also previously demonstrated that IFN-K slows disease progression in a mouse model of systemic lupus ...
Felson David T DT Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany Street, Suite X200, Boston, MA 02118, USA. - - 2013
To study the effect of valgus malalignment on knee osteoarthritis (OA) incidence and progression. We measured the mechanical axis from long limb radiographs from the Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI) to define limbs with valgus malalignment (mechanical axis of ≥1.1° valgus) and examined the effect of ...
Peakman M M Department of Immunobiology, King's College London, School of Medicine and National Institute of Health Research Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust and King's College, London, UK. - - 2013
Following almost 30 years of intensive research, initiated by the observation that Type 1 diabetes development is associated with a characteristic pancreatic immune cell infiltrate, a picture is emerging of which of the diverse effector arms of the immune system are involved in β-cell destruction. Like any chronic pathology, there is considerable ...
Serini G G Institute for Cancer Research at Candiolo (IRCC), University of Torino, Turin, - - 2013
Findings from preclinical and clinical studies show that vascular normalization represents a novel strategy to enhance the efficacy of and overcome the acquired resistance to anti-angiogenic therapies in cancer. Several mechanisms of tumour vessel normalization have been revealed. Amongst them, secreted class 3 semaphorins (Sema3), which regulate axon guidance and ...
Bauer Rita R Department ofPsychiatry and Psychotherapy, Universityof Regensburg, Universitätsstrasse 84, Regensburg, Germany. - - 2013
The study sought to broaden the focus of research on caregivers' burden by examining caregiving rewards and their relation to coping skills. Data from semistructured interviews with 60 family caregivers of patients with mental illness in Germany were examined by content analysis. Information was gathered with the Freiburg Questionnaire on ...
Loane David J DJ Department of Anesthesiology and Center for Shock, Trauma, and Anesthesiology Research (STAR), National Study Center for Trauma and EMS, University of Maryland School of Medicine, Baltimore, MD 21201, - - 2013
Abstract Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial-mediated neurodegeneration in vitro, and is neuroprotective in experimental models of CNS injury. In vitro studies also suggest that the beneficial effects of mGluR5 activation involve nicotinamide ...
Liu Huijuan H Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, - - 2013
Neural stem cells (NSCs) play essential roles in nervous system development and postnatal neuroregeneration and their deregulation underlies the development of neurodegenerative disorders. Yet how NSC proliferation and differentiation are controlled is not fully understood. Here we present evidence that tumor suppressor p53 regulates NSC proliferation and differentiation via the ...
Bonaventura Celia - - 2013
The broad classes of O(2)-binding proteins known as hemoglobins (Hbs) carry out oxygenation and redox functions that allow organisms with significantly different physiological demands to exist in a wide range of environments. This is aided by allosteric controls that modulate the protein's redox reactions as well as its O(2)-binding functions. ...
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