Search Results
Results 251 - 300 of 5693
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Clark Daniel P A - - 2012
There is growing literature exploring the possibility of parallel retrieval of location memories, although this literature focuses primarily on the speed of retrieval with little attention to the accuracy of location memory recall. Baguley, Lansdale, Lines, and Parkin (2006) found that when a person has two or more memories for ...
Zhang Zhenyi - - 2012
Well-designed hierarchical nanostructures with one dimensional (1D) TiO(2) nanofibers (120-350 nm in diameter and several micrometers in length) and ultrathin hexagonal SnS(2) nanosheets (40-70 nm in lateral size and 4-8 nm in thickness) were successfully synthesized by combining the electrospinning technique (for TiO(2) nanofibers) and a hydrothermal growth method (for ...
Mittoux Aurélia - - 2012
PURPOSE: To explore whether the presence of specific health services impact the time to death in schizophrenia. METHODS: Cox's proportional hazard model was used to assess the effect of country-specific health care variables (total health care expenditure, public health care expenditure, number of hospital beds, number of physicians, and World ...
Cheng Shasha - - 2012
Ion mobility spectrometry (IMS) is a key trace detection technique for explosives and the development of simple, stable and efficient nonradioactive ionization source is highly demanded. A dopant-assisted negative photoionization (DANP) source has been developed for IMS, which uses a commercial VUV krypton lamp to ionize acetone as the source ...
Interian Alejandro - - 2012
OBJECTIVE: Unequal mental health among U.S. underserved racial-ethnic populations has become a prominent national concern. Contributing to this inequity is our limited ability to engage individuals from underserved populations into treatment. To help address this, a systematic literature review was conducted to examine the evidence base for interventions that can ...
Hoffmann Reinhard W - - 2012
For almost 200 years, the synthesis of natural products has been practiced. In this time span, not only the target structures have become increasingly more complex (see two examples from the 1970s), the objectives of natural product synthesis have also changed. Likewise, the standards and criteria for the conduction of ...
Nastase Anthony F - - 2012
Beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) is a target of interest for treating patients with Alzheimer's disease (AD). Inhibition of BACE1 may prevent amyloid-ß (Aß) plaque formation and the development or progression of Alzheimer's disease. Known BACE1 inhibitors were analyzed using computational chemistry and cheminformatics techniques to search for ...
Lebkowska-Wieruszewska B - - 2012
The residue depletion profile of sulfachlorpyrazine was studied in healthy broilers after oral administration of Sulfatyf®, given at a dose of 50 mg sulfachlorpyrazine (SCP) per kg body weight once daily for 3 consecutive days. Twenty-five medicated broilers were slaughtered on the 5th, 10th, 14th and 16th day of post-medication, and ...
Maia José António Ribeiro - - 2012
A very brief history of Portuguese twin research in sport and human movement sciences is presented. Recruitment procedures, zygosity determination, and phenotypes are given for twins and their parents from the mainland, and Azores and Madeira archipelagos. Preliminary findings are mostly related to physical activity, health-related physical fitness, gross motor ...
Griffis Joshua W - - 2012
Genome Sequence Scanning (GSS) is a bacterial identification technology that detects sparse sequence-specific fluorescent tags on long DNA molecules linearized in a continuous-flow microfunnel. The efficiency and sensitivity of GSS depends on the detection throughput of well-stretched molecules. Previous studies have investigated the fundamental roles of elongational and shear flow ...
Bautista-Castaño I - - 2012
The effects of bread consumption change over time on anthropometric measures have been scarcely studied. We analysed 2213 participants at high risk for CVD from the PREvención con DIeta MEDiterránea (PREDIMED) trial to assess the association between changes in the consumption of bread and weight and waist circumference gain over ...
Khoufache Khaled - - 2013
Influenza causes substantial morbidity and mortality, and highly pathogenic and drug-resistant strains are likely to emerge in the future. Protease-activated receptor 1 (PAR1) is a thrombin-activated receptor that contributes to inflammatory responses at mucosal surfaces. The role of PAR1 in pathogenesis of virus infections is unknown. Here, we demonstrate that ...
Contestabile Andrea - - 2013
Down syndrome (DS) patients exhibit abnormalities of hippocampal-dependent explicit memory, a feature that is replicated in relevant mouse models of the disease. Adult hippocampal neurogenesis, which is impaired in DS and other neuropsychiatric diseases, plays a key role in hippocampal circuit plasticity and has been implicated in learning and memory. ...
Ly Philip T T - - 2013
Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological hallmark of Alzheimer's disease (AD). Aβ is generated from sequential cleavages of the β-amyloid precursor protein (APP) by the β- and γ-secretases, and β-site APP-cleaving enzyme 1 (BACE1) is the β-secretase essential for Aβ ...
Sukhai Mahadeo A - - 2013
Despite efforts to understand and treat acute myeloid leukemia (AML), there remains a need for more comprehensive therapies to prevent AML-associated relapses. To identify new therapeutic strategies for AML, we screened a library of on- and off-patent drugs and identified the antimalarial agent mefloquine as a compound that selectively kills ...
El-Shehaby Amal M - - 2013
Left ventricular hypertrophy (LVH) is a common manifestation of cardiovascular disease and has an important prognostic value in patients with end-stage renal disease (ESRD). Vitamin D receptor (VDR) has been intensively investigated, and one of these (BsmI) already has been associated with survival in the dialysis population. The aim of ...
Hayashi Takuya - - 2013
A cell-based therapy for the replacement of dopaminergic neurons has been a long-term goal in Parkinson's disease research. Here, we show that autologous engraftment of A9 dopaminergic neuron-like cells induced from mesenchymal stem cells (MSCs) leads to long-term survival of the cells and restoration of motor function in hemiparkinsonian macaques. ...
Mossman Jim A - - 2013
Recent studies investigating possible causes of male subfertility have largely focused on how lifestyle or environmental factors impact on the process of spermatogenesis. Markedly, fewer studies have investigated those risk factors that result in reduced sperm quality, such as poor sperm motility. The speed at which sperm swim is a ...
Lee Dominic - - 2013
Erectile dysfunction (ED) and stress urinary incontinence (SUI) from urethral sphincteric deficiency is not an uncommon problem. The commonest etiology is intervention for localized prostate cancer and/or radical cystoprostatectomy for muscle invasive bladder cancer. Despite advances in surgical technology with robotic assisted laparoscopic prostatectomy and nerve sparing techniques, the rates ...
Kovac Jason R - - 2013
Priapism is a rare condition that involves persistent penile erection for greater than 4 h. Distinct variants exist, each with unique characteristics. Ischemic priapism is a painful medical emergency that may occur as a result of veno-occlusion leading to hypoxia and tissue death. Recurrent bouts of ischemic priapism, or stuttering ...
Fassnacht W - - 2013
To report a rare case of delayed endovascular coil extrusion following embolisation of a lingual artery pseudoaneurysm. A 23-year-old woman presented with dysphagia and odynophagia 11 months after having experienced massive post-tonsillectomy haemorrhage. At that time, the bleeding had been stopped by embolisation of a lingual artery pseudoaneurysm and the ...
Jensen DE López Kristine - - 2012
ABSTRACT This study examines the comprehension and production of subject and object relative clauses (SRCs, ORCs) by children with Specific Language Impairment (SLI) and their typically developing (TD) peers. The purpose is to investigate whether relative clauses are problematic for Danish children with SLI and to compare errors with those ...
Proto William R WR Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, - - 2013
Apoptosis and other types of regulated cell death have been defined as fundamental processes in plant and animal development, but the occurrence of, and possible roles for, regulated cell death in parasitic protozoa remain controversial. A key problem has been the difficulty in reconciling the presence of apparent morphological markers ...
Gumiero Andrea - - 2013
We have previously demonstrated (Badyal et al., J. Biol. Chem., 2006, 281, 24512) that removal of the active site tryptophan (Trp41) in ascorbate peroxidase increases the conformational mobility of the distal histidine residue (His42) and that His42 coordinates to the iron in the oxidised W41A enzyme to give a 6-coordinate, ...
Bagni Claudia C Katholieke Universiteit Leuven, Center for Human Genetics, Leuven, Belgium. - - 2012
Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and is also linked to other neurologic and psychiatric disorders. FXS is caused by a triplet expansion that inhibits expression of the FMR1 gene; the gene product, FMRP, regulates mRNA metabolism in the brain and thus controls ...
Wigley Dale B DB Division of Structural Biology, Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK. - - 2013
In bacteria, the processing of double-strand DNA breaks is mediated by the RecBCD, AddAB and AdnAB complexes. These multisubunit helicase-nuclease machines resect the DNA ends and load RecA protein to initiate homologous recombination. Recent studies have revealed fascinating insights into the molecular mechanisms of this process and the evolution of ...
Rabinovitch Marlene M Stanford University School of Medicine, Stanford, California 94305-5162, USA. - - 2012
Recent clinical and experimental studies are redefining the cellular and molecular bases of pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in association with the idiopathic form of PAH--together with a vast increase in our understanding of cell signaling, cell transformation, and cell-cell interactions; gene expression; microRNA processing; and ...
Barr G A GA Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. - - 2013
Stimulation of a variety of brain sites electrically or by opiates activates descending inhibitory pathways to attenuate noxious input to the spinal cord dorsal horn and produce analgesia. Analgesia induced by electrical stimulation of the periaqueductal grey (PAG) of the midbrain or medial rostral ventral medulla (RVM) matures late, towards ...
González-Terán Bárbara B Department of Vascular Biology and Inflammation, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, - - 2013
Bacterial LPS (endotoxin) has been implicated in the pathogenesis of acute liver disease through its induction of the proinflammatory cytokine TNF-α. TNF-α is a key determinant of the outcome in a well-established mouse model of acute liver failure during septic shock. One possible mechanism for regulating TNF-α expression is through ...
Faber Katrin K Department of Internal Medicine III, Ulm University, Ulm, - - 2013
Aberrant expression of the homeodomain transcription factor CDX2 occurs in most cases of acute myeloid leukemia (AML) and promotes leukemogenesis, making CDX2, in principle, an attractive therapeutic target. Conversely, CDX2 acts as a tumor suppressor in colonic epithelium. The effectors mediating the leukemogenic activity of CDX2 and the mechanism underlying ...
Easley Regina A - - 2012
Measurements of ocean pH and carbonate ion concentrations in the North Pacific and Arctic Oceans were used to determine calcium carbonate saturation states (Ω(CaCO3)) from spectrophotometric methods alone. Total carbonate ion concentrations, [CO(3)(2-)](T) were, for the first time at sea, directly measured using Pb(II) UV absorbance spectra. The basis of ...
Rossy Jérémie - - 2012
Phosphorylation of the T cell antigen receptor (TCR) by the tyrosine kinase Lck is an essential step in the activation of T cells. Because Lck is constitutively active, spatial organization may regulate TCR signaling. Here we found that Lck distributions on the molecular level were controlled by the conformational states ...
Mak Donna B - - 2012
AIM: Adolescence is the final opportunity for a large-scale immunisation programme before adulthood. The Western Australian (WA) school-based vaccination programme provides Year 7 students with free vaccination against hepatitis B virus (HBV); diphtheria, tetanus and pertussis (dTpa); varicella zoster virus (VZV); and human papilloma virus (HPV). We aimed to identify ...
Tudehope David - - 2012
AIM: To describe decisions made for babies who died in the delivery room as a result of clinical practice of non-resuscitation or unsuccessful resuscitation. METHODS: A retrospective study was conducted of neonatal deaths (NNDs) ≥ 400 g and/or ≥20 weeks' gestation born at Mater Mothers' Hospitals 1998-2009 who were not admitted ...
Rush Elaine - - 2012
AIM: School-based interventions to tackle the rise in childhood overweight and obesity remain inconclusive and are often limited in their application to diverse populations. To inform and measure the effect of the implementation of a primary school-based longitudinal randomised controlled nutrition and activity intervention, Project Energize, baseline measures of body ...
Cock-Rada Alicia - - 2012
The metastatic cascade which leads to the death of cancer patients results from a multi-step process of tumor progression caused by genetic and epigenetic alterations in key regulatory molecules. It is, therefore, crucial to improve our understanding of the regulation of genes controlling the metastatic process in order to identify ...
Longhini Renata - - 2012
It has been demonstrated that histamine interferes with the recruitment, formation and activity of osteoclasts via H(1) - and H(2) -receptors. Cimetidine is a H(2) -receptor antagonist used for treatment of gastric ulcers that seems to prevent bone resorption. In this study, a possible cimetidine interference was investigated in the ...
McKay Heather - - 2012
AIM: To evaluate the impact of newly designed Paediatric Early Warning Scores and an accompanying education package, COMPASS, on the frequency of documentation of vital signs and communication between health professionals and associated medical review in deteriorating paediatric patients. METHODS: One thousand fifty-nine patients in the pre-intervention phase and 899 ...
Bradman Kate - - 2012
AIM: The aim of this study is to directly compare published prediction tools with triage nurse (TN) predictions within a defined paediatric population. METHOD: A prospective observational study carried out over a week in May 2010 in the Emergency Department (ED) at Princess Margaret Hospital for Children in Perth, Western ...
Shim Ju Hyun - - 2012
OBJECTIVES: We retrospectively investigated the prognostic value of hepatocyte nuclear factor-1 (HNF1) proteins in 159 liver transplant patients with hepatocellular carcinomas (HCC), including 36 (22.6%) exceeding the Milan criteria. METHODS: Expression of alpha-fetoprotein (AFP), HNF1α, and HNF1β was examined by immunohistochemistry on duplicate tissue microarray slides containing the HCC tumor ...
Ospinal-Jiménez Monica - - 2012
The denaturation of three model proteins, bovine serum albumin (BSA), ovalbumin and lysozyme, with fully fluorinated potassium sulfonate surfactants was studied using small angle x-ray scattering (SAXS), dynamic light scattering (DLS), polyacrylamide gel electrophoresis (PAGE) and circular dichroism (CD). Scattering analysis revealed that protein-surfactant complexes of fluorinated molecules could also ...
McDonald Jenny L - - 2012
AIM: The study aims to describe the developmental and behavioural difficulties in pre-school children who have experienced maltreatment and/or neglect METHODS: A retrospective medical file audit of all children assessed at the Cottage Family Care Centre, a child protection pre-school, between April 2004 and June 2010. Demographic characteristics, parent and ...
d'Emden Helen - - 2012
AIM: To describe the presence and type of disturbed eating behaviours and thoughts in a combined male/female Australian sample of adolescents with type 1 diabetes, and examine the association of eating behaviours and thoughts with glycaemic control as evidenced by high glycosylated haemoglobin levels (HbA1c). METHODS: In this cross-sectional descriptive ...
Kabra Mayank - - 2012
We present a machine learning-based system for automatically computing interpretable, quantitative measures of animal behavior. Through our interactive system, users encode their intuition about behavior by annotating a small set of video frames. These manual labels are converted into classifiers that can automatically annotate behaviors in screen-scale data sets. Our ...
Liu Wenyong - - 2012
We report the colloidal synthesis of monodisperse nanocrystals (NCs) of InSb, which is an important member of III-V semiconductor family. Colloidal InSb NC quantum dots showed well-resolved excitonic transitions in the near-infrared spectral range, with the optical band gaps tunable from ~1.03 eV (1200 nm) to ~0.71 eV (1750 nm) ...
Qian Huidong - - 2012
Ultrathin films of organic networks on various substrates were fabricated through solution-based molecular layer deposition (MLD) technique. The rigid tetrahedral geometries of polyfunctional amine and acyl chloride involved in the reaction ensure the continuity of the polymerization process. A linear increase in film thickness with respect to cycle number was ...
Euterpio Maria Anna - - 2012
A molecularly imprinted polymer was prepared using E-resveratrol as template and was evaluated for multi-component multi-class analysis of polyphenolic compounds in complex matrices such as natural and alcoholic beverages. Chromatographic evaluation of the polymer exhibited high selectivity for E-resveratrol and its structural analogues as quercetin and other flavonoids. An analytical ...
Taylor Nicole D - - 2012
AIM: The study aims to review the contemporary presentation, diagnosis and treatment of children with infantile hypertrophic pyloric stenosis (IHPS) at an Australian paediatric tertiary centre. METHODS: A retrospective case review of patients with IHPS presenting to our institution between January 2004 and December 2010 was performed. Results were compared ...
Neuhaus John M - - 2012
Generalized linear mixed models with random intercepts and slopes provide useful analyses of clustered and longitudinal data and typically require the specification of the distribution of the random effects. Previous work for models with only random intercepts has shown that misspecifying the shape of this distribution may bias estimates of ...
Hoelting Lisa - - 2012
Nanoparticles (NPs) have been shown to accumulate in organs, cross the blood-brain barrier and placenta, and have the potential to elicit developmental neurotoxicity (DNT). Here, we developed a human embryonic stem cell (hESC)-derived 3-dimensional (3-D) in vitro model that allows for testing of potential developmental neurotoxicants. Early central nervous system ...
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