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Raveau Bernard - - 2012
Transition-metal oxides have been widely studied for understanding the physics of strongly electron-correlated systems. The crucial role of crystal chemistry for the discovery of three families: the high T(c) superconducting cuprates, the colossal magnetoresistance manganates, the thermoelectric, and multiferroic cobaltates, is explored.
Rabinovitch Marlene M Stanford University School of Medicine, Stanford, California 94305-5162, USA. - - 2012
Recent clinical and experimental studies are redefining the cellular and molecular bases of pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in association with the idiopathic form of PAH--together with a vast increase in our understanding of cell signaling, cell transformation, and cell-cell interactions; gene expression; microRNA processing; and ...
Kleinstäuber Maria - - 2012
The current study investigated the role of fear-avoidance-a concept from chronic pain research-in chronic tinnitus. A self-report measure the "Tinnitus Fear-Avoidance Cognitions and Behaviors Scale (T-FAS)" was developed and validated. Furthermore, the role of fear-avoidance behavior as mediator of the relationship between anxiety sensitivity and tinnitus handicap was investigated. From ...
Yang Ya - - 2012
We report the first flexible hybrid energy cell that is capable of simultaneously or individually harvesting thermal, mechanical, and solar energies to power some electronic devices. For having both the pyroelectric and piezoelectric properties, a polarized poly(vinylidene fluoride) (PVDF) film-based nanogenerator (NG) was used to harvest thermal and mechanical energies. ...
Fassnacht W - - 2013
To report a rare case of delayed endovascular coil extrusion following embolisation of a lingual artery pseudoaneurysm. A 23-year-old woman presented with dysphagia and odynophagia 11 months after having experienced massive post-tonsillectomy haemorrhage. At that time, the bleeding had been stopped by embolisation of a lingual artery pseudoaneurysm and the ...
Brondolin Mirco - - 2012
BACKGROUND: Sphingolipids represent a major class of lipids which both serve as structural components of membranes and as bioactive molecules involved in lipid signaling. Ceramide synthases (cers) reside in the center of sphingolipid metabolism by producing ceramide through de novo synthesis or degradative pathways. While the six mammalian cers family ...
Alibrahim Ammar A Departments of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, - - 2013
To evaluate the role of swelling-induced activation of volume-regulated anion channels (VRACs) in a neonatal hypoxic-ischemic injury model using the selective VRAC blocker 4-(2-butyl-6,7-dichloro-2-cyclopentyl-indan-1-on5-yl) oxobutyric acid (DCPIB). Cerebral hypoxic-ischemic injury was induced in 7-day-old mouse pups with Rice-Vannucci method. Prior to the onset of ischemia, the animals were ip administered ...
González-Terán Bárbara B Department of Vascular Biology and Inflammation, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, - - 2013
Bacterial LPS (endotoxin) has been implicated in the pathogenesis of acute liver disease through its induction of the proinflammatory cytokine TNF-α. TNF-α is a key determinant of the outcome in a well-established mouse model of acute liver failure during septic shock. One possible mechanism for regulating TNF-α expression is through ...
Noyori Ryoji - - 2012
As Louis Pasteur said, "Chance favors only a prepared mind." Serendipitous events reorienting the pathway of science often occur through the actions of dedicated individuals with unique cultural and educational backgrounds, an original sense of values, and firm principles. Science is the fountainhead of human knowledge and possesses an indispensable ...
Ogoshi Tomoki - - 2012
We report a new route for the selective synthesis of di- and tetra-functionalized pillararenes via oxidation and reduction of the pillararene units. Hypervalent-iodine oxidation of perethylated pillar[5]arene afforded pillar[5]arene derivatives containing one benzoquinone unit and two benzoquinones at the A,B- and A,C-units. A pillar[6]arene derivative containing one benzoquinone unit was ...
Haugen Thomas A - - 2012
Abstract We examined the effect of different false start rules and starters' holding time on athletics sprinters' reaction times. Reaction times from 210 female (25.2 ± 3.8 years) and 361 male (24.8 ± 3.8 years) 100 m sprinters, participating in international championships for seniors from 1997 to 2011, were analysed. Holding time calculations were based ...
Cognard Emmanuelle - - 2012
Pancreatic β-cells are highly responsive to changes in glucose but the mechanisms involved are only partially understood. There is increasing evidence that the β-catenin signalling pathway plays an important role in regulating β-cell function but the mechanisms regulating β-catenin signalling in these cells is not well understood. Here we show ...
Griffis Joshua W - - 2012
Genome Sequence Scanning (GSS) is a bacterial identification technology that detects sparse sequence-specific fluorescent tags on long DNA molecules linearized in a continuous-flow microfunnel. The efficiency and sensitivity of GSS depends on the detection throughput of well-stretched molecules. Previous studies have investigated the fundamental roles of elongational and shear flow ...
Bautista-Castaño I - - 2012
The effects of bread consumption change over time on anthropometric measures have been scarcely studied. We analysed 2213 participants at high risk for CVD from the PREvención con DIeta MEDiterránea (PREDIMED) trial to assess the association between changes in the consumption of bread and weight and waist circumference gain over ...
Wang Chundong - - 2012
Due to its unique electronic properties and wide spectrum of promising applications, graphene has attracted much attention from scientists in various fields. Control and engineering of graphene's semiconducting properties is considered to be key to its applications in electronic devices. Here, we report a novel method to prepare in situ ...
Jin Zhao - - 2012
Barley malt is essential for beer production. In the present study, the non-prolamin fractions, including proteins with metabolic activities or structural functions were extracted from barley malts of the widely used cultivars Gannpi and Baudin in China. The metabolic proteomes (pI 4~7) were constructed and compared using two-dimensional electrophoresis (2DE) ...
Xiao Bo - - 2012
Galactosylated chitosan-hydroxypropyltrimethylammonium (gal-HTCC) was synthesized by galactosylating and quaternizing chitosan to endue chitosan with targeting specificity for potential applications as gene vectors. The composition and physicochemical properties of gal-HTCC were characterized by FT-IR, (1) H NMR, elemental analysis, X-ray diffraction, and turbidity measurement. It was found that water-soluble gal-HTCC showed ...
Khan Umar - - 2012
We have exfoliated hexagonal boron nitride by ultrasonication in solutions of polyvinylalcohol in water. The resultant nanosheets are sterically stabilised by adsorbed polymer chains. Centrifugation-based size-selection was used to give dispersions of nanosheets with aspect ratio (length/thickness) of ∼1400. Such dispersions can be used to produce polyvinylalcohol-BN composite films. Helium ...
Jang Kwang-Suk - - 2012
The surface property of a polyimide gate insulator was successfully modified with an n-octadecyl side-chain. Alkyl chain-grafted poly(amic acid), the polyimide precursor, was synthesized using the diamine comonomer with an alkyl side-chain. By adding a base catalyst to the poly(amic acid) coating solution, the imidization temperature of the spin-coated film ...
Ernst Richard R - - 2012
Science, music, art, life: Nobel Laureate Richard Ernst discusses the influence of music and art on his life and how advanced Raman spectroscopy comes to his aid as a "hobby chemist" and art restorer.
Rasheed Zafar - - 2012
Zafar Sheikh, Rizwan Ahmad, Naila Sheikh, & Rashd Ali. Enhanced recognition of reactive oxygen species damaged human serum albumin by circulating systemic lupus erythematosus autoantibodies. Autoimmunity, 2007; 40(7): 512-520. Following publication of this article, an error has been identified in the format of the authors' names. The correct format is ...
van Gunsteren Wilfred F - - 2012
"Seven deadly sins" in modern academic research and publishing can be condensed into a list ranging from poorly described experimental or computational setups to falsification of data. This Essay describes these sins and their ramifications, and serves as a code of best practice for researchers in their quest for scientific ...
He Jing-kang JK Department of Cardiothoracic Surgery, the First Affiliated Hospital of Soochow University, Suzhou, - - 2013
To investigate the antitumor actions of the Crotalus durissus neurotoxin (crotoxin) on human esophageal carcinoma (Eca-109) cells in vitro and transplanted esophageal Eca-109 tumors in nude mice. The growth-inhibitory effect was analyzed in Eca-109 cells using MTT assay. Cell morphology changes in nuclei were observed using Hoechst 33342 staining, while ...
Sukhai Mahadeo A - - 2013
Despite efforts to understand and treat acute myeloid leukemia (AML), there remains a need for more comprehensive therapies to prevent AML-associated relapses. To identify new therapeutic strategies for AML, we screened a library of on- and off-patent drugs and identified the antimalarial agent mefloquine as a compound that selectively kills ...
Schmidbaur Hubert - - 2012
The revitalized concept of "coordination at carbon" allows relationships between seemingly unrelated families of carbon-centered compounds to be discovered generating fascinating patchwork families of compounds. It is shown how olefins and cyclopropanes can be regarded as donors for carbon acceptors C(1) , C(2) , and C(3) . Through this approach, ...
Geng Weizhi - - 2012
An efficient Pd-catalyzed cleavage of C(sp3)-N bonds in secondary amines and consequent C(sp2)-N and C(sp3)-N coupling process was developed. Various secondary amines could be used to react with alkenyl or aryl dibromides affording pyrroles and indoles in high yields. Cyclopentadiene-phosphine ligands, a new type of P-olefin ligands, were found to ...
Liu Shengsheng - - 2012
ABSTRACT: BACKGROUND: Diabetes has become a major public health problem in China. Support of patient self-management is a key component of effective diabetes care and improved patient outcomes. A series of peer-led community-based disease-specific self-management programs including diabetes have been widely disseminated in urban communities of Shanghai since 1999. However, ...
Sun Kai K Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China. - - 2013
To construct a lentivirus-based inhibitor with specific secondary structure that could exert long-term suppression on microRNA-338-3p (miR-338-3p), thus elucidating its molecular function in colorectal carcinoma cells. The miR-338-3p inhibitor sequence was synthesized and inserted into pLV-THM plasmid. HEK-293T cells were co-transfected with the lentiviral vectors pLV-THM-miR-338-3p-inhibitor, psPAX2, and pMD2.G. The ...
Ly Philip T T - - 2013
Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological hallmark of Alzheimer's disease (AD). Aβ is generated from sequential cleavages of the β-amyloid precursor protein (APP) by the β- and γ-secretases, and β-site APP-cleaving enzyme 1 (BACE1) is the β-secretase essential for Aβ ...
Cech Thomas R - - 2012
RNA, just another starting material? Nobel Laureate Tom Cech shows that with an education steeped in kinetics, thermodynamics, and molecular structure, and armed with the ability to synthesize molecules, the chemist is ideally suited to investigate RNA.
Karasek Pavel - - 2012
The prospects of near- and supercritical water for treatment of the inner surfaces of fused silica capillaries have been tested employing an in-lab-assembled apparatus. Unlike all other agents used for the purpose, water cannot introduce any undesirable heteroatoms to the treated surface. Theoretical background for this work comes from the ...
Nurchi Valeria M - - 2012
Triethylenetetramine (TETA) dihydrochloride, or trientine, is a therapeutic molecule that has long been used as a copper-chelating agent for the second-line treatment of patients with Wilson's disease. More recently, it has also been employed as an experimental therapeutic molecule in diabetes where it improves cardiac structure in patients with diabetic ...
Elkins C A - - 2012
Modern risk control and food safety practices involving food-borne bacterial pathogens are benefiting from new genomic technologies for rapid, yet highly specific, strain characterisations. Within the United States Food and Drug Administration (USFDA) Center for Food Safety and Applied Nutrition (CFSAN), optical genome mapping and DNA microarray genotyping have been ...
Zhao Junmei - - 2012
Monodisperse orthorhombic-phase BiF(3) nanocrystals with various shapes were prepared easily by a novel solvent extraction approach using an acid-base-coupled extractant. More importantly, the extractant used in this route can be recycled after synthesis. Our results show great promise for further extending the method to the preparation of other metal-fluoride nanoparticles.
Taylor Nicole D - - 2012
AIM: The study aims to review the contemporary presentation, diagnosis and treatment of children with infantile hypertrophic pyloric stenosis (IHPS) at an Australian paediatric tertiary centre. METHODS: A retrospective case review of patients with IHPS presenting to our institution between January 2004 and December 2010 was performed. Results were compared ...
Neuhaus John M - - 2012
Generalized linear mixed models with random intercepts and slopes provide useful analyses of clustered and longitudinal data and typically require the specification of the distribution of the random effects. Previous work for models with only random intercepts has shown that misspecifying the shape of this distribution may bias estimates of ...
Knobloch Marlen M Brain Research Institute, Faculty of Medicine, University of Zurich, 8057 Zurich, - - 2013
Mechanisms controlling the proliferative activity of neural stem and progenitor cells (NSPCs) have a pivotal role to ensure life-long neurogenesis in the mammalian brain. How metabolic programs are coupled with NSPC activity remains unknown. Here we show that fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is ...
Hoelting Lisa - - 2012
Nanoparticles (NPs) have been shown to accumulate in organs, cross the blood-brain barrier and placenta, and have the potential to elicit developmental neurotoxicity (DNT). Here, we developed a human embryonic stem cell (hESC)-derived 3-dimensional (3-D) in vitro model that allows for testing of potential developmental neurotoxicants. Early central nervous system ...
Rollauer Sarah E SE Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, - - 2012
The twin-arginine translocation (Tat) pathway is one of two general protein transport systems found in the prokaryotic cytoplasmic membrane and is conserved in the thylakoid membrane of plant chloroplasts. The defining, and highly unusual, property of the Tat pathway is that it transports folded proteins, a task that must be ...
Ospinal-Jiménez Monica - - 2012
The denaturation of three model proteins, bovine serum albumin (BSA), ovalbumin and lysozyme, with fully fluorinated potassium sulfonate surfactants was studied using small angle x-ray scattering (SAXS), dynamic light scattering (DLS), polyacrylamide gel electrophoresis (PAGE) and circular dichroism (CD). Scattering analysis revealed that protein-surfactant complexes of fluorinated molecules could also ...
Ye Yu Y Division of Protein and Nucleic Acids Chemistry, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, - - 2012
Mechanisms of protein recognition have been extensively studied for single-domain proteins, but are less well characterized for dynamic multidomain systems. Ubiquitin chains represent a biologically important multidomain system that requires recognition by structurally diverse ubiquitin-interacting proteins. Ubiquitin chain conformations in isolation are often different from conformations observed in ubiquitin-interacting protein ...
Sausen Mark - - 2013
Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. To determine the genetic basis for neuroblastoma, we performed whole-genome sequencing (6 cases), exome sequencing (16 cases), genome-wide rearrangement analyses (32 cases) and targeted analyses of specific genomic loci (40 cases) using massively parallel ...
Kretz Markus M The Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, - - 2013
Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epidermal differentiation by a post-transcriptional mechanism. TINCR is required for high ...
Otomo Chinatsu - - 2013
The autophagy factor ATG12~ATG5 conjugate exhibits E3 ligase-like activity which facilitates the lipidation of members of the LC3 family. The crystal structure of the human ATG12~ATG5 conjugate bound to the N-terminal region of ATG16L1, the factor that recruits the conjugate to autophagosomal membranes, reveals an integrated architecture in which ATG12 ...
Kim Kook Hwan - - 2012
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle-specific deletion of Atg7 (encoding autophagy-related 7). Unexpectedly, these mice showed decreased fat mass and were protected from diet-induced obesity and insulin resistance; this phenotype ...
Cock-Rada Alicia - - 2012
The metastatic cascade which leads to the death of cancer patients results from a multi-step process of tumor progression caused by genetic and epigenetic alterations in key regulatory molecules. It is, therefore, crucial to improve our understanding of the regulation of genes controlling the metastatic process in order to identify ...
Kidoh Masafumi - - 2013
We hypothesized that 3D time-of-flight (TOF) and true fast imaging with steady-state precession (true-FISP) fusion imaging could provide more information regarding the arterial vessel wall. The purpose of this study was to compare the accuracy of lesion detection and the diagnostic confidence of VAD between TOF images alone and fused ...
McDonald Jenny L - - 2012
AIM: The study aims to describe the developmental and behavioural difficulties in pre-school children who have experienced maltreatment and/or neglect METHODS: A retrospective medical file audit of all children assessed at the Cottage Family Care Centre, a child protection pre-school, between April 2004 and June 2010. Demographic characteristics, parent and ...
d'Emden Helen - - 2012
AIM: To describe the presence and type of disturbed eating behaviours and thoughts in a combined male/female Australian sample of adolescents with type 1 diabetes, and examine the association of eating behaviours and thoughts with glycaemic control as evidenced by high glycosylated haemoglobin levels (HbA1c). METHODS: In this cross-sectional descriptive ...
Kabra Mayank - - 2012
We present a machine learning-based system for automatically computing interpretable, quantitative measures of animal behavior. Through our interactive system, users encode their intuition about behavior by annotating a small set of video frames. These manual labels are converted into classifiers that can automatically annotate behaviors in screen-scale data sets. Our ...
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