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Castano Brunilde - - 2012
The synthesis and characterisation of copper(i) complexes of chiral pyridine-containing macrocyclic ligands () and their use as catalysts in asymmetric cyclopropanation reactions are reported. All ligands and metal complexes were fully characterised, including crystal structures of some species determined by X-ray diffraction on single crystals. This allowed characterising the very ...
Karasek Pavel - - 2012
The prospects of near- and supercritical water for treatment of the inner surfaces of fused silica capillaries have been tested employing an in-lab-assembled apparatus. Unlike all other agents used for the purpose, water cannot introduce any undesirable heteroatoms to the treated surface. Theoretical background for this work comes from the ...
Nurchi Valeria M - - 2012
Triethylenetetramine (TETA) dihydrochloride, or trientine, is a therapeutic molecule that has long been used as a copper-chelating agent for the second-line treatment of patients with Wilson's disease. More recently, it has also been employed as an experimental therapeutic molecule in diabetes where it improves cardiac structure in patients with diabetic ...
Elkins C A - - 2012
Modern risk control and food safety practices involving food-borne bacterial pathogens are benefiting from new genomic technologies for rapid, yet highly specific, strain characterisations. Within the United States Food and Drug Administration (USFDA) Center for Food Safety and Applied Nutrition (CFSAN), optical genome mapping and DNA microarray genotyping have been ...
Zhao Junmei - - 2012
Monodisperse orthorhombic-phase BiF(3) nanocrystals with various shapes were prepared easily by a novel solvent extraction approach using an acid-base-coupled extractant. More importantly, the extractant used in this route can be recycled after synthesis. Our results show great promise for further extending the method to the preparation of other metal-fluoride nanoparticles.
Wang Wei - - 2012
Conventionally, rechargeable batteries with a fast charge-discharge rate, while being able to be implemented in large-scale applications with low prices, are critical for new energy storage systems. In this work, first-principles simulations were employed to theoretically investigate the insertion of sodium into the Na(2)Ti(3)O(7) structure. The result discovered that the ...
Peng Qiuming - - 2012
The objective of this study was to prepare a new biodegradable Mg-based biomaterial, which provides good mechanical integrity in combination with anti-inflammatory function during the degradation process. The silver element was used, because it improved the mechanical properties as an effective grain refiner and it is also treated as a ...
Wang Chundong - - 2012
Due to its unique electronic properties and wide spectrum of promising applications, graphene has attracted much attention from scientists in various fields. Control and engineering of graphene's semiconducting properties is considered to be key to its applications in electronic devices. Here, we report a novel method to prepare in situ ...
Jin Zhao - - 2012
Barley malt is essential for beer production. In the present study, the non-prolamin fractions, including proteins with metabolic activities or structural functions were extracted from barley malts of the widely used cultivars Gannpi and Baudin in China. The metabolic proteomes (pI 4~7) were constructed and compared using two-dimensional electrophoresis (2DE) ...
Xiao Bo - - 2012
Galactosylated chitosan-hydroxypropyltrimethylammonium (gal-HTCC) was synthesized by galactosylating and quaternizing chitosan to endue chitosan with targeting specificity for potential applications as gene vectors. The composition and physicochemical properties of gal-HTCC were characterized by FT-IR, (1) H NMR, elemental analysis, X-ray diffraction, and turbidity measurement. It was found that water-soluble gal-HTCC showed ...
Alibrahim Ammar - - 2012
Aim:To evaluate the role of swelling-induced activation of volume-regulated anion channels (VRACs) in a neonatal hypoxic-ischemic injury model using the selective VRAC blocker 4-(2-butyl-6,7-dichloro-2-cyclopentyl-indan-1-on5-yl) oxobutyric acid (DCPIB).Methods:Cerebral hypoxic-ischemic injury was induced in 7-day-old mouse pups with Rice-Vannucci method. Prior to the onset of ischemia, the animals were ip administered DCPIB ...
Noyori Ryoji - - 2012
As Louis Pasteur said, "Chance favors only a prepared mind." Serendipitous events reorienting the pathway of science often occur through the actions of dedicated individuals with unique cultural and educational backgrounds, an original sense of values, and firm principles. Science is the fountainhead of human knowledge and possesses an indispensable ...
Yamamoto A Y - - 2012
SUMMARY Congenital cytomegalovirus (CMV) infection rates increase with maternal seroprevalence due to transmission from maternal non-primary infection. CMV seroprevalence estimates of pregnant women are needed for planning strategies against congenital CMV transmission. We aimed to determine the age-specific prevalence of serum antibodies for CMV in a representative age-stratified sample of ...
Akarolo-Anthony Sally N - - 2012
As the nutrition transition continues in Africa, it is crucial to identify population-specific dietary patterns. Healthy diets may then be promoted for prevention and alleviation of the chronic disease burden associated with nutrition. Using a semi-quantitate food frequency questionnaire, we conducted a cross-sectional study and computed the proportions of foods ...
Vaikkinen Anu - - 2012
A heat-assisted laser ablation electrospray ionization (HA-LAESI) method for the simultaneous mass spectrometric analysis of nonpolar and polar analytes was developed. The sample was introduced using mid-infrared laser ablation of a water-rich target. The ablated analytes were ionized with an electrospray plume, which was intercepted by a heated nitrogen gas ...
Philipp Patrick - - 2012
The performance of organic optoelectronic devices depends a lot on interface structure and width. Dynamic secondary ion mass spectrometry (SIMS) has been widely used to investigate interfaces in classical semiconductor devices and limitations are quite well understood. For low-energy dynamic SIMS on organic optoelectronic devices, sputter-induced diffusion processes and roughness ...
van Gastel W A - - 2012
BACKGROUND: Although the association between cannabis use and a wide range of psychiatric symptoms is fairly well established, it is not clear whether cannabis use is also a risk factor for general mental health problems at secondary school. Method A total of 10 324 secondary school children aged 11-16 years, ...
Kehr Nermin Seda - - 2012
Dye-loaded periodic mesoporous organosilica particles functionalized with bioactive molecules were used for the generation of a nanocomposite alginate hydrogel. The affinity of cells was up to four times higher with the embedded particles than with simple alginate hydrogel, caused by both the nanometer-scale particle itself and its bioactive functionalization.
Kim Hun Young - - 2012
The elimination pathway of stereochemically defined β-halovinyl ketones has been investigated using a mild base NEt3, leading to the formation of allenyl ketones and propargyl ketones. A preferential α-vinyl enolization of (E)-β-chlorovinyl ketones has been observed where a non-planar s-cis conformation is proposed as a dominant conformation as opposed to ...
Niu Yi - - 2012
We consider a marginal model for the regression analysis of clustered failure time data with a cure fraction. We propose to use novel generalized estimating equations in an expectation-maximization algorithm to estimate regression parameters in a semiparametric proportional hazards mixture cure model. The dependence among the cure statuses and among ...
Rawson Kenneth G - - 2012
AIM: The purpose of this study was to evaluate the concentrations of fluoride in community water at the point of source, compared to the concentration delivered to various locations within the Las Vegas Valley, to determine if the levels of fluoride change over distance. METHODS: Ten samples per week over ...
Mickes Laura - - 2012
We investigated the nature of motor symptoms in the preclinical stage of Huntington's disease. Individuals with the CAG expanded repeat of Huntington's disease (prHD) and two control groups were tested on a task requiring a releasing movement (releasing a depressed button) followed by a ballistic movement (pressing a different button). ...
Boivin Michel - - 2012
The Quebec Newborn Twin Study (QNTS) is an ongoing prospective longitudinal follow-up of a birth cohort of twins born between 1995 and 1998 in the greater Montreal area, Québec, Canada. The goal of QNTS is to document individual differences in the cognitive, behavioral, and social-emotional aspects of developmental health across ...
Chan George C - - 2012
A statistical protocol was developed and verified for automated signaling of matrix interferences in inductively coupled plasma-atomic emission spectrometry (ICP-AES). Spatial emission profiles in ICP-AES are versatile indicators for flagging matrix interference. A family of calibration curves is first generated by measurements of standard solutions at different spatial locations in ...
Nicolaou K C - - 2012
At the core of chemistry lie the structure of the molecule, the art of its synthesis, and the design of function within it. This Essay traces the understanding of the structure of the molecule, the emergence of organic synthesis, and the art of total synthesis from the 19th century to ...
Jardim Denis Leonardo Fontes - - 2012
Objectives: Bevacizumab has been approved by the US Food and Drug Administration as a first-line therapy for metastatic non-small-cell lung cancer (NSCLC), in combination with carboplatin and paclitaxel. A single Latin American center experience was reviewed to determine the safety and efficacy of adding bevacizumab to first-line chemotherapy in a ...
Wilson Robert L - - 2012
The uneven cholesterol distribution among organelles and within the plasma membrane is postulated to be critical for proper cellular function. To study how interactions between cholesterol and specific lipid species contribute to the uneven cholesterol distribution between and within cellular membranes, model lipid membranes are frequently employed. Although the cholesterol ...
McLernon D J - - 2012
SUMMARY We estimated prevalence and incidence of liver condition outcomes, and costs to the health service of diagnosed hepatitis B virus (HBV) in Tayside, UK. HBV patients were identified from electronic virology data between 1989 and 2003. The health resource costs of HBV for surface antigen-positive (HBsAg+) patients and HBV ...
Lin Po-Chiao - - 2012
We have developed a target-molecule-functionalized magnetic nanoparticle (MNP)-based method to facilitate the study of bio-molecular recognition and separation. The superparamagnetic property of MNPs allows the corresponding biomolecules to be rapidly separated from crude biofluids with a significant improvement in recovery yield and specificity. Various MNPs functionalized with tag molecules (chitin, ...
McKenney Peter T - - 2012
Sporulation in Bacillus subtilis involves an asymmetric cell division followed by differentiation into two cell types, the endospore and the mother cell. The endospore coat is a multilayered shell that protects the bacterial genome during stress conditions and is composed of dozens of proteins. Recently, fluorescence microscopy coupled with high-resolution ...
Kroneisen Meike - - 2012
Nairne and collaborators showed that assessing the relevance of words in the context of an imagined survival scenario boosts memory for these words. Although this survival-processing advantage has attracted a considerable amount of research, little is known about the proximate memory mechanism mediating this effect. Recently, Kroneisen and Erdfelder (2011) ...
Albrecht B - - 2012
BACKGROUND: Patients with attention deficit-hyperactivity disorder (ADHD) exhibit difficulties in multiple attentional functions. Although high heritability rates suggest a strong genetic impact, aetiological pathways from genes and environmental factors to the ADHD phenotype are not well understood. Tracking the time course of deviant task processing using event-related electrophysiological brain activity ...
Roche Ann M - - 2012
ISSUE: The rationale and potential impact of Australia's recent legislative changes regulating secondary supply of alcohol to minors, particularly on private premises. APPROACH: An examination of similarities and differences between state and territory liquor licensing legislation regulating secondary supply of alcohol to minors was undertaken. KEY FINDINGS: The Northern Territory, ...
Sun Jing - - 2012
Aim:To explore whether the synthetic cannabinoid receptor agonist WIN55,212-2 could protect oligodendrocyte precursor cells (OPCs) in stroke penumbra, thereby providing neuroprotection following permanent focal cerebral ischemia in rats.Methods:Adult male SD rats were subjected to permanent middle cerebral artery occlusion (p-MCAO). The animals were administered WIN55,212-2 at 2 h, and sacrificed ...
Graf Heiko - - 2012
While antidepressants are supposed to exert similar effects on mood and drive via various mechanisms of action, diverging effects are observed regarding side-effects and accordingly on neural correlates of motivation, emotion, reward and salient stimuli processing as a function of the drugs impact on neurotransmission. In the context of erotic ...
Lin Lin - - 2012
Shell@core-nanostructured TiO(2)@ZnO n-p-n heterojunction nanorods with diameter of 30 nm were successfully fabricated via a hydrothermal method. The photodegradation rate of the TiO(2)@ZnO n-p-n nanorods evaluated by photodegrading methyl orange has been demonstrated to increase three times compared to that of wurtzite hexagonal ZnO. Anatase TiO(2) and Ti(2)O(3) grow along ...
Lampard Amy M - - 2012
OBJECTIVE: To determine if the relationships between additional maintaining factors and core eating disorder maintaining mechanisms outlined in the cognitive-behavioural model of eating disorders are transdiagnostic. METHOD: Patients (n = 1451) diagnosed with anorexia nervosa, bulimia nervosa (BN) or eating disorder not otherwise specified completed the Eating Disorder Examination Questionnaire, Eating Disorder ...
Mabbott Samuel - - 2012
A new optimisation strategy for the SERS detection of mephedrone using a portable Raman system has been developed. A fractional factorial design was employed and the number of statistically significant experiments (288) was greatly reduced from the actual total number of experiments (1722), which minimised the workload whilst maintaining the ...
Rusten Espen - - 2012
Purpose. To study soft tissue sarcomas using dynamic positron emission tomography (PET) with the glucose analog tracer [(18)F]fluoro-2-deoxy-D-glucose ((18)FDG), to investigate correlations between derived PET image parameters and clinical characteristics, and to discuss implications of dynamic PET acquisition (D-PET). Material and methods. D-PET images of 11 patients with soft tissue ...
Mames Iwona - - 2012
A new type of hetero- and homo-polynuclear complexes of copper(ii) and nickel(ii) containing 1,2,3-triazole groups in polymethylene chains have been synthesized and characterized using NMR and electrochemical methods. The triazole link facilitates the synthesis of hetero-dinuclear macrocyclic complexes. Introducing the triazole unit into the complex structure can lead to increased ...
Shi Jing - - 2012
Aim:To investigate the pharmacokinetics and dopamine/acetylcholine-releasing effects of ginsenoside Re (Re) in brain regions related to learning and memory, and to clarify the neurochemical mechanisms underlying its anti-dementia activity.Methods:Microdialysis was conducted on awake, freely moving adult male SD rats with dialysis probes implanted into the hippocampus, medial prefrontal cortex (mPFC) ...
Kantarevic Jasmin - - 2012
Pay for performance (P4P) incentives for physicians are generally designed as additional payments that can be paired with any existing payment mechanism such as a salary, fee-for-services and capitation. However, the link between the physician response to performance incentives and the existing payment mechanisms is still not well understood. In ...
Hara-Kudo Y - - 2012
The National Food Surveillance System in Japan was formed in 1998 to monitor the contamination of retail foods with bacterial pathogens. Approximately 2000-3000 samples were tested annually, and the data from food categories that had more than 400 samples collected during 1998-2008 were analysed. With regard to meat, the frequency ...
Cervantes Sara - - 2012
The gastrointestinal tract carries out essential functions for the organism, including the digestion and absorption of nutrients. The cells lining the lumen of the gut tube derive from the endoderm, one of the three germ layers formed during gastrulation. The length of the intestinal tract determines its digestive and absorptive ...
Lanteri G - - 2012
Male cross-breed lamb conjoined twins were sent for examination. The twins came from a farm located in the outskirts of Palermo. The twins were spontaneously delivered and found dead by the farmer. X-ray examination and necropsy were performed. The deformity was identified as deradelphus cephalo-thoracoomphalopagus. This condition has never been ...
Li Jing - - 2012
Aim:To investigate the molecular mechanisms underlying the influence of DNA polymerase from different genotypes of hepatitis B virus (HBV) on the binding affinity of adefovir (ADV).Methods:Computational approaches, including homology modeling, docking, MD simulation and MM/PBSA free energy analyses were used.Results:Sequence analyses revealed that residue 238 near the binding pocket was ...
Karbalaei Narges - - 2012
Objective. Since thyroid hormones play fundamental roles in somatic growth and metabolism, disturbances of thyroid function affect many organs and systems. Both fetal hypothyroidism and aging can affect carbohydrate metabolism during adult life. This study aims to assess the glucose tolerance and insulin secretion capacity of islets in young and ...
Dang Jun - - 2012
Grade ≥ 3 radiation pneumonitis (RP) is generally severe and life-threatening. Predictors of grade ≥ 2 are usually used for grade ≥ 3 RP prediction, but it is unclear whether these predictors are appropriate. In this study, predictors of grade ≥ 2 and grade ≥ 3 RP were investigated separately. ...
Chang Yu-Ching - - 2012
A simple pretreatment procedure was developed for the analysis of dioxins in soil samples using gas chromatography/multiphoton ionization/time-of-flight mass spectrometry. The sample was subjected to a pressurized liquid extraction procedure, followed by separation using a pair of Sulfoxide and Ag-ION columns for clean-up. Due to the high selectivity of laser ...
Hynds Robert E - - 2012
Epithelial organ remodeling is a major contributing factor to worldwide death and disease, costing healthcare systems billions of dollars every year. Despite this, most fundamental epithelial organ research fails to produce new therapies and mortality rates for epithelial organ diseases remain unacceptably high. In large part, this failure in translating ...
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