Search Results
Results 51 - 100 of 5706
1 2 3 4 5 6 7 8 9 10 >
Meyer Colette - - 2013
GNRH significantly inhibits proliferation of a proportion of cancer cell lines by activating GNRH receptor (GNRHR)-G protein signaling. Therefore, manipulation of GNRHR signaling may have an under-utilized role in treating certain breast and ovarian cancers. However, the precise signaling pathways necessary for the effect and the features of cellular responses ...
Tirado Alfredo - - 2013
Bedside ultrasound is an extremely valuable and rapidly accessible diagnostic and therapeutic modality in potentially life- and limb-threatening situations in the emergency department. In this report, the authors discuss the role of ultrasound in quick assessment of pathologic conditions and its use to aid in diagnostic and therapeutic interventions.
Aiken Ashley H - - 2013
Oral cavity cancer comprises nearly 30% of all malignant tumors of the head and neck. After a definitive diagnosis has been made, imaging is essential for staging the primary tumor by evaluating submucosal spread and invasion of adjacent structures, and to identify nodal or distant metastasis. Oral cavity anatomy is ...
Saindane Amit M - - 2013
Thyroid cancer includes several neoplasms originating from the thyroid gland-from indolent and curable histologies of differentiated thyroid carcinoma to aggressive anaplastic thyroid carcinoma. Differentiation of thyroid nodules is problematic on CT and MR imaging unless there is evidence of extrathyroidal extension. Evaluation of regional lymph nodes is often performed clinically ...
Corey Amanda - - 2013
The face of oropharyngeal squamous cell carcinoma (OPSCC) is changing. It has a dichotomous nature, with 1 subset of the disease associated with tobacco and alcohol use and the other having proven association with human papilloma virus infection. Imaging plays an important role in the staging and surveillance of OPSCC, ...
L'italien Anita J - - 2013
The management of cardiovascular emergencies is a fundamental component of the practice of an emergency practitioner. Delays in the evaluations and management can lead to significant morbidity or mortality. It is of vital importance to be familiar with procedures such as pericardiocentesis, cardioversion, defibrillation, temporary pacing, and options for the ...
Boss Stuart E - - 2013
Musculoskeletal injury and diseases are common presentations in the Emergency Department. Emergency physicians must be versed in the critical procedural skills necessary to diagnose joint infection, manage fractures and dislocations, and assess for compartment syndrome. Arthrocentesis, splinting, dislocation reduction, and the evaluation of limb compartment syndrome are reviewed.
Felson David T DT Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany Street, Suite X200, Boston, MA 02118, USA. - - 2013
To study the effect of valgus malalignment on knee osteoarthritis (OA) incidence and progression. We measured the mechanical axis from long limb radiographs from the Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI) to define limbs with valgus malalignment (mechanical axis of ≥1.1° valgus) and examined the effect of ...
Liu Huijuan H Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, - - 2013
Neural stem cells (NSCs) play essential roles in nervous system development and postnatal neuroregeneration and their deregulation underlies the development of neurodegenerative disorders. Yet how NSC proliferation and differentiation are controlled is not fully understood. Here we present evidence that tumor suppressor p53 regulates NSC proliferation and differentiation via the ...
Loane David J DJ Department of Anesthesiology and Center for Shock, Trauma, and Anesthesiology Research (STAR), National Study Center for Trauma and EMS, University of Maryland School of Medicine, Baltimore, MD 21201, - - 2013
Abstract Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial-mediated neurodegeneration in vitro, and is neuroprotective in experimental models of CNS injury. In vitro studies also suggest that the beneficial effects of mGluR5 activation involve nicotinamide ...
Tao Bei-Bei BB Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai, - - 2013
The potential receptor for hydrogen sulfide (H2S) remains unknown. H2S could directly activate vascular endothelial growth factor receptor 2 (VEGFR2) and that a small interfering RNA (siRNA)-mediated knockdown of VEGFR2 inhibited H2S-induced migration of human vascular endothelial cells. H2S promoted angiogenesis in Matrigel plug assay in mice and this effect ...
Alili Lirija L Medical Faculty, Institute of Biochemistry & Molecular Biology I, Heinrich-Heine-University, 40225 Duesseldorf, Germany. - - 2013
Melanoma is the most aggressive type of malignant skin cancer derived from uncontrolled proliferation of melanocytes. Melanoma cells possess a high potential to metastasize, and the prognosis for advanced melanoma is rather poor due to its strong resistance to conventional chemotherapeutics. Nanomaterials are at the cutting edge of the rapidly ...
Ravet Karl K Biology Department, Colorado State University, Fort Collins, CO 80523, USA. - - 2013
Photosynthesis, the process that drives life on earth, relies on transition metal (e.g., Fe and Cu) containing proteins that participate in electron transfer in the chloroplast. However, the light reactions also generate high levels of reactive oxygen species (ROS), which makes metal use in plants a challenge. Sophisticated regulatory networks ...
Kim Hwa-Young HY Department of Biochemistry and Molecular Biology, Yeungnam University College of Medicine, Daegu, Republic of Korea. - - 2013
Selenium is utilized in the methionine sulfoxide reduction system that occurs in most organisms. Methionine sulfoxide reductases (Msrs), MsrA and MsrB, are the enzymes responsible for this system. Msrs repair oxidatively damaged proteins, protect against oxidative stress, and regulate protein function, and have also been implicated in the aging process. ...
Bonaventura Celia C Nicholas School of the Environment, Duke University Marine Laboratory, Beaufort, NC 28516, USA. - - 2013
The broad classes of O(2)-binding proteins known as hemoglobins (Hbs) carry out oxygenation and redox functions that allow organisms with significantly different physiological demands to exist in a wide range of environments. This is aided by allosteric controls that modulate the protein's redox reactions as well as its O(2)-binding functions. ...
Yang Zhen Z Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California, - - 2013
Our previous studies have shown that nitric oxide (NO) plays an important role in increasing the invasion and proliferation of human melanoma cells, suggesting that targeting NO signaling may facilitate therapy and prevention. Neuronal nitric oxide synthase (nNOS) is present in melanocytes, a cell type that originates from the neural ...
Bode Manuela M Division of Cell Biology, University of Kaiserslautern, Kaiserslautern, - - 2013
To identify yeast mutants that show a strong redox dependence of the ability to respire, we systematically screened a yeast deletion library for mutants that require the presence of reductants for growth on nonfermentable carbon sources. Respirative growth of 44 yeast mutants was significantly improved by the addition of dithiothreitol ...
Cho Young-Keol YK Department of Microbiology, University of Ulsan College of Medicine, Seoul, Korea. - - 2013
The Korean subclade of subtype B (KSB) is the most prevalent HIV-1 strain found in Korea. To date, only two near full-length HIV-1 sequences from Korean patients have been reported. Here, we analyzed a total of 24 near full-length genomes of HIV-1 strains that were isolated from 17 antiretroviral therapy ...
Wang Zu-yong ZY Department of Mechanical Engineering, National University of Singapore, Singapore, - - 2013
Anisotropic geometries are critical for eliciting cell alignment to dictate tissue microarchitectures and biological functions. Current fabrication techniques are complex and utilize toxic solvents, hampering their applications for translational research. Here, we present a novel simple, solvent-free, and reproducible method via uniaxial stretching for incorporating anisotropic topographies on bioresorbable films ...
Vakil Nimish B - - 2013
Gastroesophageal reflux disease (GERD) symptoms are best assessed using patient-reported outcome (PRO) instruments. Guidance on developing well-defined and reliable instruments that capture optimal information from the patient's perspective was recently published by the US Food and Drug Administration and the European Medicines Agency. The aim of this systematic review was ...
Gross Charles - - 2013
In the long history of the study of the nervous system, there have been a number of major developments that involved radical and permanent changes in fundamental beliefs and assumptions about the nervous system and in tactics and strategies for studying it. These may be termed Revolutions in Neuroscience. This ...
Zieschang Tania T Agaplesion Bethanien Hospital, Center for Geriatric Medicine at the University of Heidelberg, Rohrbacher Street 149, Heidelberg, Germany. - - 2013
Evidence for sustainability of motor training effects in people with dementia is lacking. To examine whether the substantial improvements in motor performance achieved through a three-month specialized, standardized motor training were sustained, the participants of the randomized controlled trial were re-evaluated nine months after training had ceased. As part of ...
Whiteman Shawn D SD Department of Human Development and Family Studies, Purdue University, West Lafayette, IN 47907, USA. - - 2013
An accumulating body of work indicates that siblings uniquely influence each other's alcohol and substance use behaviors during adolescence. The mechanisms underlying these associations, however, are unknown because most studies have not measured sibling influence processes. The present study addressed this gap by exploring the links between multiple influence processes ...
Syed Emdadul H EH Department of Community and Global Health, Graduate School of Medicine, University of Tokyo, Tokyo, - - 2013
To evaluate the relationship between arsenic exposure and oral cavity lesions among an arsenic-exposed population in Bangladesh. We carried out an analysis utilizing the baseline data of the Health Effects of Arsenic Exposure Longitudinal Study, which is an ongoing population-based cohort study to investigate health outcomes associated with arsenic exposure ...
Bennett Kellie - - 2013
In order to consider findings about the relationship between spirituality, religiosity and personality disorders, recent research was reviewed and emerging patterns in the latest findings were explored. Within the diagnostic category of personality disorders, recent research into the role of spirituality has focused on schizotypy and borderline personality traits and ...
Moore Christopher I - - 2013
This study examined the cortical representation of vibrotactile detection in humans using event-related fMRI paired with psychophysics. Suprathreshold vibrotactile stimulation activated several areas, including primary (SI) and second somatosensory cortices (SII/PV). For threshold-level stimuli, poststimulus activity in contralateral and ipsilateral SII/PV was the best correlate of detection success. In these ...
Jackson Kristina M KM Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, - - 2013
Although hangover results from excessive alcohol consumption, the specific pathways through which hangover symptoms arise have not been elucidated. Research on predictors of hangover sensitivity may provide clues about such mechanisms. The present study investigated whether tobacco smoking on days of heavy drinking affects next-day hangover incidence and severity. The ...
Ghossein-Doha Chahinda - - 2013
Introduction: Preeclamptic pregnancies induce concentric left ventricular hypertrophy instead of eccentric left ventricular hypertrophy as seen in healthy pregnancies. Although these differences persist for at least several months postpartum, the long-term fate of these changes is unknown. Objective: To explore the age-related changes in cardiovascular structure and function in formerly ...
Litt Dana M DM Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA. - - 2013
Alcohol use disorders and anxiety disorders often co-occur; moreover, lesbian and bisexual women appear at higher risk for both alcohol and anxiety disorders. Although research among college student samples has found direct effects of increased use of protective behavioral strategies on decreasing alcohol use and alcohol-related negative consequences, this has ...
Zhang Y Y Department of Physiology, Fourth Military Medical University, Xi'an, - - 2013
Glucose-insulin-potassium (GIK) is a useful adjunct to myocarditis. Besides its essential action in energy metabolism, insulin also exerts an anti-inflammatory effect. This study investigated the effect of insulin on myocardial inflammation in experimental autoimmune myocarditis (EAM) in mice and its potential role in T cell regulation. Mice were divided randomly ...
Kim Ju-Hyun - - 2013
The purpose of this study is to explain the effect of participation in productive activities on life satisfaction and its implications for social evaluation of productive aging. This study uses data collected from 1,250 elderly women living in urban areas. The regression model was used to examine the influence of ...
Cadigan Jennifer M JM Department of Educational, School, and Counseling Psychology, University of Missouri, Columbia, MO 65211, USA. - - 2013
Cross-sectional data show that college athletes consume more alcohol and experience more general alcohol-related problems than those not participating in athletics. To our knowledge, the current study is the first to use a longitudinal design to examine the extent to which the course of drinking and alcohol-related problems relates to ...
Duncan Daniel L DL Department of Pathology and Laboratory Medicine, University of North Carolina Women's and Children's Hospitals, Chapel Hill, NC, - - 2013
A 44-yr-old woman underwent a total hysterectomy and bilateral salpingectomy secondary to uterine leiomyomas. Gross examination of the fallopian tubes revealed no masses or lesions; however, 2 small foci of granulosa cells were identified microscopically within one of the fallopian tubes. These foci were suspicious for granulosa cell tumor metastases. ...
Jia M M State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, - - 2013
This study evaluates the correlation between natural killer (NK) cell function and human immunodeficiency virus (HIV)-1 disease progression in 133 untreated HIV-1 positive Chinese subjects, including 41 former plasma donors (FPDs) and 92 men who have sex with men, and 35 HIV-negative controls. Flow cytometry was used to determine the ...
Rick Ferenc G - - 2013
We provide new viewpoints of hormonal control of benign prostatic hyperplasia (BPH). The latest treatment findings with 5-alpha reductase inhibitors (5-ARIs) finasteride and dutasteride, refined indications, efficacy, and safety are discussed and compared. We also discuss potential new 5-ARIs and other hormonal treatments. Finasteride and dutasteride have equal efficacy and ...
Bruce Gillian - - 2013
ABSTRACT. Objective: The current study had two key aims: (a) to determine if Type D personality (the synergistic effect of negative affect and social inhibition) is associated with alcohol consumption in social drinkers and (b) to examine if this relationship is mediated by drinking motives. Method: In a cross-sectional study, ...
Rogalski Emily J EJ Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, 320 E Superior Street, 11th Floor Searle Building, Chicago, IL 60611, USA. - - 2013
The Northwestern University SuperAging Project recruits community dwellers over the age of 80 who have unusually high performance on tests of episodic memory. In a previous report, a small cohort of SuperAgers was found to have higher cortical thickness on structural MRI than a group of age-matched but cognitively average ...
Mendola Janine D - - 2013
In monocular pattern rivalry, a composite image is shown to both eyes. The patient experiences perceptual alternations in which the two stimulus components alternate in clarity or salience. We used fMRI at 3T to image brain activity while participants perceived monocular rivalry passively or indicated their percepts with a task. ...
Cleveland Michael J MJ The Prevention Research Center, The College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA. - - 2013
Among emerging adults, those who do not attain postsecondary education are at highest risk for experiencing longterm problems related to alcohol use, including alcohol dependence. The purpose of the current study was to identify latent classes of alcohol users among non-college-attending youth and examine correlates of class membership. Screening criteria ...
Tosco A A Department of Pediatrics, University Federico II, Naples, - - 2013
Anti-tissue transglutaminase 2 (anti-TG2) antibodies are present in the serum of the great majority of untreated coeliac disease (CD) patients. They are produced and deposited in the small intestinal mucosa. Potential CD patients present serum anti-TG2 antibodies higher than cut-off, but a normal duodenal mucosa where mucosal deposits of anti-TG2 ...
Mahboubi Hossein H Division of Neurotology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California 92868, - - 2013
Whether a prototype direct-drive hearing device (DHD) is effective in driving the tympanic membrane (TM) in a temporal bone specimen to enable it to potentially treat moderate-to-severe hearing loss. Patient satisfaction with air conduction hearing aids has been low because of sound distortion, occlusion effect, and feedback issues. Implantable hearing ...
Anderson Kristen G - - 2013
ABSTRACT. Objective: Our goals were to develop a realistic simulation of collegiate drinking contexts and evaluate the predictive validity of this methodology. Method: After methods development, 88 incoming students (61% women) completed measures of alcohol consumption, alcohol expectancies and motives, and the Collegiate-Simulated Intoxication Digital Elicitation (C-SIDE). Eight months later, ...
Geels Lot M - - 2013
ABSTRACT. Objective: Multiple factors predict early alcohol initiation in teenagers. Among these are genetic risk factors, childhood behavioral problems, life events, lifestyle, and family environment. We constructed a developmental prediction model for alcohol initiation below the Dutch legal drinking age (16 years), elaborating on the pathways identified by earlier studies.Method: ...
Jeong Su Keun - - 2013
In many everyday activities, we need to attend and encode multiple target objects among distractor objects. For example, when driving a car on a busy street, we need to simultaneously attend objects such as traffic signs, pedestrians, and other cars, while ignoring colorful and flashing objects in display windows. To ...
Liang Lei - - 2013
It is well established that both hematoporphyrin monomethyl ether-sonodynamic therapy (HMME-SDT) and doxorubicin (DOX) can induce cell apoptosis but each alone has its own limitations. To date, the combined effects of HMME-SDT and DOX on inducing cell apoptosis are little known and the mechanism for the combined effects remains poorly ...
Quéniart Anne - - 2013
In social sciences, little attention has been paid to the role and functions of grandmothers in the family, and still less, to their role as legators and transmitters of values. Do older women have the impression they are transmitting or have transmitted something to succeeding generations? If so, what do ...
Darragh Teresa M - - 2013
The terminology for human papillomavirus (HPV)-associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend terminology unified across lower anogenital ...
Oleinika K K Chemokine Research Group, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, - - 2013
Regulatory T cells (T(regs) ) are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral tolerance. However, in the context of cancer their role is more complex, and they are thought to contribute to the progress of many tumours. As cancer cells express both self- and ...
Tych Rowen E RE Department of Neurological Surgery, University of Washington, Seattle, WA, - - 2013
We tested the hypothesis that neuropathic tissue is more sensitive to stimulation by intense focused ultrasound (iFU) than control tissue. We created a diffusely neuropathic paw in rats via partial ligation of the sciatic nerve, whose sensitivity to iFU stimulation we compared with sham-surgery and normal control paws. We then ...
Szigeti Kinga K Department of Neurology, University at Buffalo SUNY, Buffalo, NY 14203, USA. - - 2013
Alzheimer's disease (AD) is a progressive neurodegenerative disease with high prevalence, which imposes a substantial public health problem. The heritability of AD is estimated at 60-80% forecasting the potential use of genetic biomarkers for risk stratification in the future. Several large scale genome-wide association studies using high frequency variants identified ...
1 2 3 4 5 6 7 8 9 10 >