Search Results
Results 51 - 100 of 5693
1 2 3 4 5 6 7 8 9 10 >
Tirado Alfredo - - 2013
Bedside ultrasound is an extremely valuable and rapidly accessible diagnostic and therapeutic modality in potentially life- and limb-threatening situations in the emergency department. In this report, the authors discuss the role of ultrasound in quick assessment of pathologic conditions and its use to aid in diagnostic and therapeutic interventions.
Lauwerys Bernard R - - 2013
We developed interferon-α-kinoid (IFN-K), a drug composed of inactivated IFNα coupled to a carrier protein, keyhole limpet hemocyanin. In human IFNα-transgenic mice, IFN-K induces polyclonal antibodies that neutralize all 13 subtypes of human IFNα. We also previously demonstrated that IFN-K slows disease progression in a mouse model of systemic lupus ...
Felson David T DT Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, 650 Albany Street, Suite X200, Boston, MA 02118, USA. - - 2013
To study the effect of valgus malalignment on knee osteoarthritis (OA) incidence and progression. We measured the mechanical axis from long limb radiographs from the Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI) to define limbs with valgus malalignment (mechanical axis of ≥1.1° valgus) and examined the effect of ...
Peakman M M Department of Immunobiology, King's College London, School of Medicine and National Institute of Health Research Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust and King's College, London, UK. - - 2013
Following almost 30 years of intensive research, initiated by the observation that Type 1 diabetes development is associated with a characteristic pancreatic immune cell infiltrate, a picture is emerging of which of the diverse effector arms of the immune system are involved in β-cell destruction. Like any chronic pathology, there is considerable ...
Serini G G Institute for Cancer Research at Candiolo (IRCC), University of Torino, Turin, - - 2013
Findings from preclinical and clinical studies show that vascular normalization represents a novel strategy to enhance the efficacy of and overcome the acquired resistance to anti-angiogenic therapies in cancer. Several mechanisms of tumour vessel normalization have been revealed. Amongst them, secreted class 3 semaphorins (Sema3), which regulate axon guidance and ...
Bauer Rita R Department ofPsychiatry and Psychotherapy, Universityof Regensburg, Universitätsstrasse 84, Regensburg, Germany. - - 2013
The study sought to broaden the focus of research on caregivers' burden by examining caregiving rewards and their relation to coping skills. Data from semistructured interviews with 60 family caregivers of patients with mental illness in Germany were examined by content analysis. Information was gathered with the Freiburg Questionnaire on ...
Loane David J DJ Department of Anesthesiology and Center for Shock, Trauma, and Anesthesiology Research (STAR), National Study Center for Trauma and EMS, University of Maryland School of Medicine, Baltimore, MD 21201, - - 2013
Abstract Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial-mediated neurodegeneration in vitro, and is neuroprotective in experimental models of CNS injury. In vitro studies also suggest that the beneficial effects of mGluR5 activation involve nicotinamide ...
Liu Huijuan H Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, - - 2013
Neural stem cells (NSCs) play essential roles in nervous system development and postnatal neuroregeneration and their deregulation underlies the development of neurodegenerative disorders. Yet how NSC proliferation and differentiation are controlled is not fully understood. Here we present evidence that tumor suppressor p53 regulates NSC proliferation and differentiation via the ...
Tao Bei-Bei BB Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai, - - 2013
The potential receptor for hydrogen sulfide (H2S) remains unknown. H2S could directly activate vascular endothelial growth factor receptor 2 (VEGFR2) and that a small interfering RNA (siRNA)-mediated knockdown of VEGFR2 inhibited H2S-induced migration of human vascular endothelial cells. H2S promoted angiogenesis in Matrigel plug assay in mice and this effect ...
Bonaventura Celia C Nicholas School of the Environment, Duke University Marine Laboratory, Beaufort, NC 28516, USA. - - 2013
The broad classes of O(2)-binding proteins known as hemoglobins (Hbs) carry out oxygenation and redox functions that allow organisms with significantly different physiological demands to exist in a wide range of environments. This is aided by allosteric controls that modulate the protein's redox reactions as well as its O(2)-binding functions. ...
Yang Zhen Z Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California, - - 2013
Our previous studies have shown that nitric oxide (NO) plays an important role in increasing the invasion and proliferation of human melanoma cells, suggesting that targeting NO signaling may facilitate therapy and prevention. Neuronal nitric oxide synthase (nNOS) is present in melanocytes, a cell type that originates from the neural ...
Bode Manuela M Division of Cell Biology, University of Kaiserslautern, Kaiserslautern, - - 2013
To identify yeast mutants that show a strong redox dependence of the ability to respire, we systematically screened a yeast deletion library for mutants that require the presence of reductants for growth on nonfermentable carbon sources. Respirative growth of 44 yeast mutants was significantly improved by the addition of dithiothreitol ...
Cho Young-Keol YK Department of Microbiology, University of Ulsan College of Medicine, Seoul, Korea. - - 2013
The Korean subclade of subtype B (KSB) is the most prevalent HIV-1 strain found in Korea. To date, only two near full-length HIV-1 sequences from Korean patients have been reported. Here, we analyzed a total of 24 near full-length genomes of HIV-1 strains that were isolated from 17 antiretroviral therapy ...
Wang Zu-yong ZY Department of Mechanical Engineering, National University of Singapore, Singapore, - - 2013
Anisotropic geometries are critical for eliciting cell alignment to dictate tissue microarchitectures and biological functions. Current fabrication techniques are complex and utilize toxic solvents, hampering their applications for translational research. Here, we present a novel simple, solvent-free, and reproducible method via uniaxial stretching for incorporating anisotropic topographies on bioresorbable films ...
Kim Ju-Hyun - - 2013
The purpose of this study is to explain the effect of participation in productive activities on life satisfaction and its implications for social evaluation of productive aging. This study uses data collected from 1,250 elderly women living in urban areas. The regression model was used to examine the influence of ...
Prasad Sandip M - - 2013
With increasing adoption of minimally invasive surgical techniques in urologic oncology, the efficacy, safety, and adequacy of lymphadenectomy were reviewed for studies about prostate, bladder, kidney, upper tract urothelial, testicular, and penile cancer published in the past 18 months. In prostate cancer, in which robotic prostatectomy has become the predominant ...
Ghossein-Doha Chahinda - - 2013
Introduction: Preeclamptic pregnancies induce concentric left ventricular hypertrophy instead of eccentric left ventricular hypertrophy as seen in healthy pregnancies. Although these differences persist for at least several months postpartum, the long-term fate of these changes is unknown. Objective: To explore the age-related changes in cardiovascular structure and function in formerly ...
Rick Ferenc G - - 2013
We provide new viewpoints of hormonal control of benign prostatic hyperplasia (BPH). The latest treatment findings with 5-alpha reductase inhibitors (5-ARIs) finasteride and dutasteride, refined indications, efficacy, and safety are discussed and compared. We also discuss potential new 5-ARIs and other hormonal treatments. Finasteride and dutasteride have equal efficacy and ...
Bruce Gillian - - 2013
ABSTRACT. Objective: The current study had two key aims: (a) to determine if Type D personality (the synergistic effect of negative affect and social inhibition) is associated with alcohol consumption in social drinkers and (b) to examine if this relationship is mediated by drinking motives. Method: In a cross-sectional study, ...
Geels Lot M - - 2013
ABSTRACT. Objective: Multiple factors predict early alcohol initiation in teenagers. Among these are genetic risk factors, childhood behavioral problems, life events, lifestyle, and family environment. We constructed a developmental prediction model for alcohol initiation below the Dutch legal drinking age (16 years), elaborating on the pathways identified by earlier studies.Method: ...
Liang Lei - - 2013
It is well established that both hematoporphyrin monomethyl ether-sonodynamic therapy (HMME-SDT) and doxorubicin (DOX) can induce cell apoptosis but each alone has its own limitations. To date, the combined effects of HMME-SDT and DOX on inducing cell apoptosis are little known and the mechanism for the combined effects remains poorly ...
Vakil Nimish B - - 2013
Gastroesophageal reflux disease (GERD) symptoms are best assessed using patient-reported outcome (PRO) instruments. Guidance on developing well-defined and reliable instruments that capture optimal information from the patient's perspective was recently published by the US Food and Drug Administration and the European Medicines Agency. The aim of this systematic review was ...
Gross Charles - - 2013
In the long history of the study of the nervous system, there have been a number of major developments that involved radical and permanent changes in fundamental beliefs and assumptions about the nervous system and in tactics and strategies for studying it. These may be termed Revolutions in Neuroscience. This ...
Anderson Kristen G - - 2013
ABSTRACT. Objective: Our goals were to develop a realistic simulation of collegiate drinking contexts and evaluate the predictive validity of this methodology. Method: After methods development, 88 incoming students (61% women) completed measures of alcohol consumption, alcohol expectancies and motives, and the Collegiate-Simulated Intoxication Digital Elicitation (C-SIDE). Eight months later, ...
Espinosa Geovanni - - 2013
Nutrition seems to modify the pathogenesis of benign prostatic hyperplasia (BPH) effect symptomology in men suffering from lower urinary tract symptoms (LUTS). Although there are numerous pharmaceuticals and procedures for these conditions, nutrition may improve outcomes as a primary approach or in tandem with BPH medications or procedures. The purpose ...
Bennett Kellie - - 2013
In order to consider findings about the relationship between spirituality, religiosity and personality disorders, recent research was reviewed and emerging patterns in the latest findings were explored. Within the diagnostic category of personality disorders, recent research into the role of spirituality has focused on schizotypy and borderline personality traits and ...
Moore Christopher I - - 2013
This study examined the cortical representation of vibrotactile detection in humans using event-related fMRI paired with psychophysics. Suprathreshold vibrotactile stimulation activated several areas, including primary (SI) and second somatosensory cortices (SII/PV). For threshold-level stimuli, poststimulus activity in contralateral and ipsilateral SII/PV was the best correlate of detection success. In these ...
Ismail Mohamed Taha - - 2013
Objective: To evaluate the efficacy of 3 progestin treatment regimens in the management of simple endometrial hyperplasia without cytological atypia in premenopausal women. Study Design: Prospective randomized comparative study. The study included 90 premenopausal women with histological diagnosis of simple endometrial hyperplasia (EH) without atypia, during the period from January ...
Mercier Laurence - - 2013
The goal of this study was to find a registration technique to improve the alignment of ultrasound images taken before and after brain tumor resection. Validation was performed on 16 tumor cases in 2 ways: (1) manually selected tags on pre- and postresection ultrasounds were used to compute the mean ...
Synnøve Moan Inger - - 2013
ABSTRACT. Objective: The aim of this study was twofold: (a) to examine how an increase in the frequency of heavy drinking episodes affects the incidence of drunk driving and (b) to examine whether the effect of alcohol use on drunk driving is contingent on impulsivity.Method: Two waves of the Young ...
Lee Hsiu-Hao - - 2013
Primary aldosteronism (PA), an underdiagnosed cause of hypertension, is associated with more significant cardiac remodeling and myocardial fibrosis than is essential hypertension (EH). The aim of this study was to validate myocardial fibrosis and to evaluate factors associated with the degree of myocardial fibrosis in patients with PA. We prospectively ...
Nadel Lynn - - 2013
We discuss the question of differentiation along the anterior-posterior longitudinal axis of the hippocampus. Data from a recent fMRI study are reanalyzed to determine whether activations in these hippocampal regions are affected by the nature of the information being accessed during a scanning session in which participants thought about episodes ...
McCall Holly - - 2013
Ion mobility spectrometry (IMS) is frequently used to gauge the success of remediation in clandestine methamphetamine laboratory sites due to portability of the instrument. In most cases, remediation involves some form of surface cleaning, followed by assaying using IMS to detect residual contaminants. However, the effectiveness of this cleaning approach ...
Byles Julie - - 2013
This quantitative research study uses survey data of women born between 1946 and 1951 in Australia. It follows earlier work that identified the importance of transitions from work for women of the baby boomer generation. We provide important insights into the lives of women who have partially or fully retired ...
Mendola Janine D - - 2013
In monocular pattern rivalry, a composite image is shown to both eyes. The patient experiences perceptual alternations in which the two stimulus components alternate in clarity or salience. We used fMRI at 3T to image brain activity while participants perceived monocular rivalry passively or indicated their percepts with a task. ...
Dasgupta Doyel - - 2013
We examined the attitude of postmenopausal women toward menopause and aging with respect to sociodemographic variables and postmenopausal years. Four hundred and eighty postmenopausal women representing Bengali-speaking Hindu ethnic group of West Bengal, India were interviewed about their attitude toward menopause and aging. Information on sociodemographic and reproductive characteristics and ...
Barbosa Daniel - - 2013
A novel framework to efficiently deal with three-dimensional (3-D) segmentation of challenging inhomogeneous data in real-time has been recently introduced by the authors. However, the existing framework still relied on manual initialization, which prevented taking full advantage of the computational speed of the method. In the present article, an automatic ...
Da Costa Laura A - - 2013
Vitamin E is a lipophilic antioxidant that has been inversely associated with certain chronic diseases; however, the biological processes regulated by this vitamin have not been fully elucidated. The objective of the present study was to examine the association between the most biologically active and abundant form of vitamin E ...
Innocenti Iglis - - 2013
A classic finding of the psychology of memory is the "serial position effect." Immediate free recall of a word list is more efficient for items presented early (primacy effect) or late (recency effect), with respect to those in the middle. In an event-related, randomized block design, we interfered with the ...
Quéniart Anne - - 2013
In social sciences, little attention has been paid to the role and functions of grandmothers in the family, and still less, to their role as legators and transmitters of values. Do older women have the impression they are transmitting or have transmitted something to succeeding generations? If so, what do ...
Poch Michael A - - 2013
To summarize the fundamental principles for technique of robot-assisted radical cystectomy (RARC) based on current peer reviewed literature. Also provide most recent evidence for the efficacy of RARC and Intracorporeal Ileal Conduit (ICIC). Technical tricks have increased the efficiency of RARC and ICIC diversion. Perioperative and short-term outcomes have demonstrated ...
Selzler Katherine - - 2013
Subthalamic nucleus (STN) deep brain stimulation (DBS) has become an accepted treatment for the motor manifestations of Parkinson disease (PD). The beneficial motor effects of STN DBS are likely due to modulation of BG output to frontal cortical regions associated with motor control, but the underlying neurophysiology of STN DBS ...
Montemurro Beth - - 2013
In American society, the sexually desirable woman is young and thin. Changes associated with aging such as wrinkled skin or weight gain often bring women further from societal ideals of attractiveness. As physical appearance is very much related to desirability, we explore sexual body image and the way that it ...
Darragh Teresa M - - 2013
The terminology for human papillomavirus (HPV)-associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend terminology unified across lower anogenital ...
Jeong Su Keun - - 2013
In many everyday activities, we need to attend and encode multiple target objects among distractor objects. For example, when driving a car on a busy street, we need to simultaneously attend objects such as traffic signs, pedestrians, and other cars, while ignoring colorful and flashing objects in display windows. To ...
LaRocque Joshua J - - 2013
For decades it has been assumed that sustained, elevated neural activity--the so-called active trace--is the neural correlate of the short-term retention of information. However, a recent fMRI study has suggested that this activity may be more related to attention than to retention. Specifically, a multivariate pattern analysis failed to find ...
Saroul Nicolas - - 2013
Investigation of long-term satisfaction and correlation with audiometric measurements after osseointegrated bone-conduction device (OBCD) surgery for patients with single-sided deafness (SSD). Thirty-six patients implanted with an OBCD for SSD. Retrospective review in a university medical center. Rehabilitative. The patients were implanted after a test with an OBCD worn on a ...
Simoni Y Y INSERM, U986, Hospital Cochin/St Vincent de Paul, Université Paris Descartes, Paris, - - 2013
T cells reactive to lipids and restricted by major histocompatibility complex (MHC) class I-like molecules represent more than 15% of all lymphocytes in human blood. This heterogeneous population of innate cells includes the invariant natural killer T cells (iNK T), type II NK T cells, CD1a,b,c-restricted T cells and mucosal-associated ...
Marzano A V AV Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, - - 2013
Bullous pemphigoid (BP) is a potentially life-threatening autoimmune blistering disease that is burdened with an increased risk of cardiovascular events. In BP, there is an interplay between inflammation and coagulation both locally, which contributes to skin damage, and systemically, which leads to a prothrombotic state. Fibrinolysis is an important defence ...
Lu M-C MC Division of Allergy, Immunology and Rheumatology, Buddhist Dalin Tzu Chi General Hospital, Chia-Yi, - - 2013
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with abnormal T cell immune responses. We hypothesized that aberrant expression of microRNAs (miRNAs) in T cells may contribute to the pathogenesis of SLE. First, we analysed the expression profiles of 270 human miRNAs in T cells from five SLE patients ...
1 2 3 4 5 6 7 8 9 10 >