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Bryant Richard A - - 2013
DSM-5 and ICD-11 have proposed new psychiatric diagnoses to describe persistent and severe grief reactions. These initiatives have sparked much controversy because of concerns that diagnosing grief responses may overpathologize normative distress following bereavement. This review outlines the evidence for diagnosing grief. Multiple studies indicate that, more than 6 months ...
Lommatzsch Steven E - - 2013
This review summarizes the phenotyping of refractory asthma with an emphasis on how direct bronchoscopic observation and analysis of bronchoalveolar lavage (BAL), biopsy, and brushings of the airways helps direct specific personalized therapy. Additional testing used in phenotyping asthmatic patients is reviewed. Several studies and publications over the past decade ...
de Almeida Engler Janice - - 2013
Plant-parasitic root-knot and cyst nematodes have acquired the ability to induce remarkable changes in host cells during the formation of feeding sites. Root-knot nematodes induce several multinucleate giant cells inside a gall whereas cyst nematodes provoke the formation of a multinucleate syncytium. Both strategies impinge on the deregulation of the ...
Bhogal Sanjit K - - 2013
The aim of this article is to examine the evidence for the effectiveness of systemic corticosteroids in managing acute asthma in children as it relates to the timing of its administration. Three themes relevant to the timing of systemic corticosteroid administration as it relates to managing acute asthma in children ...
Blake Kathryn - - 2013
Gastroesophageal reflux disease (GERD) is common in children with asthma and may be present with or without symptoms. Clinicians, influenced by position statements in national guidelines, have routinely treated children with poorly controlled asthma with various anti-GERD medications. This practice is based on the pervasive but unproven belief that GERD ...
Mak Arthur D P - - 2013
This review summarizes recent neurocognitive research to better delineate the nosology, prognostication and cause underlying borderline personality disorder (BPD). BPD had marked clinical heterogeneity with high comorbidity. Executive dysfunction in this disorder was linked to suicidality and treatment adherence, and may serve as an endophenotype. BPD was also characterized by ...
Bruschke A V G - - 2013
The clinical significance of myocardial bridging has been a subject of discussion and controversy since the introduction of coronary arteriography (CAG) in the early 1960s. More recently computed tomography coronary angiography (CTCA) has made it possible to visualise the overlying muscular bands and appears to have a higher sensitivity for ...
Atlar M - - 2013
The hydrodynamic performance of two, recently developed, nanostructured and fluorinated polymer coatings was explored in a systematic experimental study using the Newcastle University Cavitation Tunnel. The experiments consisted of testing the two coatings on an axisymmetric body apparatus to measure their boundary layer flow and frictional drag simultaneously. The tests ...
Watters Ashlie - - 2013
Quagga mussels (Dreissena rostriformis bugensis) have created economic and ecological impacts in the western United States since their discovery in 2007. This study focuses on chemical control for preventing the spread of these mussels. The effectiveness of EarthTec® in killing quagga mussels (adults, juveniles, and veligers) in Lake Mead, Nevada-Arizona, ...
Chindasub Panida - - 2013
Thy-1 is a marker of retinal ganglion cell (RGC) differentiation. Optic nerve injury triggers reduction of Thy-1 promoter activation followed by retinal ganglion cell (RGC) death. This study determined whether MS-275, an inhibitor of the histone deacetylases 1 and 3, can inhibit these changes. Mice expressing cyan fluorescent protein (CFP) ...
Zloto Ofira - - 2013
We examined the clinical differences in manifestation and prognosis of uveal melanoma (UM) between men and women. We evaluated 723 UM patients (325 males) who were treated between 1988 and 2010 at a national referral center. Men and women were compared regarding differences in annual distribution, age at diagnosis, size ...
Conklin Chris M J - - 2013
Fluorescence in situ hybridization (FISH) is the standard procedure for the detection of anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangement in non-small-cell lung carcinoma (NSCLC) but is expensive and time consuming. We tested three antibodies to ALK, using various detection systems, and hypothesized that ALK immunohistochemistry (IHC) may represent a ...
Felder Robin A - - 2013
One-third of the world's population has hypertension and it is responsible for almost 50% of deaths from stroke or coronary heart disease. These statistics do not distinguish salt-sensitive from salt-resistant hypertension or include normotensives who are salt-sensitive even though salt sensitivity, independent of blood pressure, is a risk factor for ...
Coppe Alessandro - - 2013
Antarctic notothenioids radiated over millions of years in subzero waters, evolving peculiar features, such as antifreeze glycoproteins and absence of heat shock response. Icefish, family Channichthyidae, also lack oxygen-binding proteins and display extreme modifications, including high mitochondrial densities in aerobic tissues. A genomic expansion accompanying the evolution of these fish ...
Kefaloyianni Eirini E Pediatrics, NYU School of Medicine, New York, NY 10016, - - 2013
ATP-sensitive K(+) (K(ATP)) channels are expressed ubiquitously, but have diverse roles in various organs and cells. Their diversity can partly be explained by distinct tissue-specific compositions of four copies of the pore-forming inward rectifier potassium channel subunits (Kir6.1 and/or Kir6.2) and four regulatory sulfonylurea receptor subunits (SUR1 and/or SUR2). Channel ...
Kelley Michael J MJ Medical Service, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA. - - 2013
We sought to determine the efficacy of using both irinotecan- and etoposide-containing regimens sequentially for patients with untreated limited-stage small-cell lung cancer. Patients with untreated, measurable, limited-stage small-cell lung cancer with performance status 0 to 2, and adequate organ function were eligible. Treatment consisted of induction with cisplatin 30 mg/m ...
Garg Gunjal G Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA. - - 2013
To determine the correlation between positive peritoneal cytology (PPC) and lymph node metastasis in patients with endometrial cancer grossly confined to the uterus. Data were extracted from the Surveillance, Epidemiology, and End Results database between 1988 and 2005. Only patients with endometrial cancer grossly confined to the uterus who had ...
Poncet Nadège N Division of Cell Signalling & Immunology, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, - - 2013
We consider recent advances in epithelial amino acid transport physiology and our understanding of the functioning of amino acid transporters as sensors, as well as carriers, of tissue nutrient supplies. Gut hormones (e.g. leptin) may regulate intestinal amino acid transporter activity by a variety of mechanisms, although the overall functional ...
Robinson Jo J Orygen Youth Health Research Centre, University of Melbourne, Australia. - - 2013
Suicide, in particular among young people, is a major public health problem, although little is known regarding effective interventions for managing and preventing suicide-related behavior. To review the empirical literature pertaining to suicide postvention, prevention, and early intervention, specifically in school settings. MEDLINE, PsycINFO, and the Cochrane Central Register of ...
Vornhagen Jay J Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, - - 2013
Showerheads support the development of multi-species biofilms that can be unsightly, produce malodor, and may harbor pathogens. The outer-surface spray-plates of many showerheads support visible biofilms that likely contain a mixture of bacteria from freshwater and potentially from human users. Coaggregation, a mechanism by which genetically distinct bacteria specifically recognize ...
Hitzemann R - - 2013
Advances in next-generation sequencing suggest that RNA-Seq is poised to supplant microarray-based approaches for transcriptome analysis. This article briefly reviews the use of microarrays in the brain-behavior context and then illustrates why RNA-Seq is a superior strategy. Compared with microarrays, RNA-Seq has a greater dynamic range, detects both coding and ...
Kuwahara Yasumichi Y UNC-Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA. - - 2013
Malignant rhabdoid tumors (MRTs) are rare, aggressive cancers occuring in young children primarily through inactivation of the SNF5(INI1, SMARCB1) tumor suppressor gene. We and others have demonstrated that mice heterozygous for a Snf5 null allele develop MRTs with partial penetrance. We have also shown that Snf5(+/-) mice that lack expression ...
McCarty Reid M RM Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, - - 2013
7-Carboxy-7-deazaguanine (CDG) synthase (QueE) catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH(4)) to CDG in the third step of the biosynthetic pathway to all 7-deazapurines. Here we present a detailed characterization of QueE from Bacillus subtilis to delineate the mechanism of conversion of CPH(4) to CDG. QueE is a ...
von Wolff Michael - - 2013
Follicle flushing has been proved to be ineffective in polyfollicular in vitro fertilization. To analyze the effect of flushing in monofollicular in vitro fertilization we aspirated and then flushed the follicles in 164 cycles. Total oocyte yield/aspiration was 44.5% in the aspirate, 20.7% in the 1(st) flush, 10.4% in the ...
Schartup Amina T AT Department of Marine Sciences, University of Connecticut, Groton, Connecticut 06340, USA. - - 2013
Methylmercury (MeHg) affects wildlife and human health mainly through marine fish consumption. In marine systems, MeHg is formed from inorganic mercury (Hg(II)) species primarily in sediments, then accumulates and biomagnifies in the food web. Most of the fish consumed in the United States are from estuarine and marine systems, highlighting ...
Peng Hwei-Ming HM Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, - - 2013
The capacity of cytochrome b(5) (b(5)) to influence cytochrome P450 activities has been extensively studied and physiologically validated. Apo-b(5) enhances the activities of CYP3A4, CYP2A6, CYP2C19, and CYP17A1 but not that of CYP2E1 or CYP2D6, suggesting that the b(5) interaction varies among P450s. We previously showed that b(5) residues E48 ...
Pichler Verena V Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A-1090 Vienna, - - 2012
Eight novel mononuclear and two dinuclear platinum(IV) complexes were synthesized and characterized by elemental analysis, one- and two-dimensional NMR spectroscopy, mass spectrometry, and reversed-phase HPLC (log k(w)) and in one case by X-ray diffraction. Cytotoxicity of the compounds was studied in three human cancer cell lines (CH1, SW480, and A549) ...
Yuan Hsiangkuo H Fitzpatrick Institute of Photonics, Departments of Biomedical Engineering and Chemistry, Duke University, Durham, North Carolina 27708, United - - 2013
Surface-enhanced Raman scattering (SERS)-active plasmonic nanomaterials have become a promising agent for molecular imaging and multiplex detection. To produce strong SERS intensity while retaining the nonaggregated state and biocompatibility needed for bioapplications, we integrated near-infrared (NIR) responsive plasmonic gold nanostars with resonant dyes for resonant SERS (SERRS). The SERRS on ...
Han Da D Department of Chemistry, Center for Research at the Bio/Nano Interface, Shands Cancer Center and UF Genetics Institute, University of Florida, Gainesville, Florida 32611-7200, - - 2012
Researchers increasingly envision an important role for artificial biochemical circuits in biological engineering, much like electrical circuits in electrical engineering. Similar to electrical circuits, which control electromechanical devices, biochemical circuits could be utilized as a type of servomechanism to control nanodevices in vitro, monitor chemical reactions in situ, or regulate ...
Cassou Catherine A CA Department of Chemistry, University of California, Berkeley, 94720-1460, United - - 2013
Electrothermal supercharging of protein ions formed by electrospray ionization from buffered aqueous solutions results in significant increases to both the maximum and average charge states compared to native mass spectrometry in which ions are formed from the same solutions but with lower spray potentials. For eight of the nine proteins ...
Planté-Bordeneuve Violaine V Department of Neurology, CHU Henri Mondor, Créteil, France. - - 2013
Abstract Background: Transthyretin (TTR) amyloidosis - the most common type of hereditary amyloidosis - also has an acquired form and is observed in geographically dispersed populations. TTR amyloidosis is marked by considerable clinical heterogeneity, and the main phenotypes are neurologic and cardiovascular. THAOS is an international, noninterventional, longitudinal, observational registry ...
Vandenberg Andrew D AD Department of Physics and Astronomy, California State University at Northridge, Northridge, California 91330, United - - 2012
Electron paramagnetic resonance (EPR) spectra of the nitroxide spin probe 3β-doxyl-5α-cholestane (CSL) are studied as functions of the molar concentration, c, and the temperature, T, in a series of n-alkanes. The results are compared with a similar study of a much smaller spin probe, perdeuterated 2,2,6,6-tetramethyl-4-oxopiperidine-1-oxyl (pDT). The Heisenberg spin ...
Darwiche Ali - - 2012
Pure micrometric antimony can be successfully used as negative electrode material in Na-ion batteries, sustaining a capacity close to 600 mAh g(-1) at a high rate with a Coulombic efficiency of 99 over 160 cycles, an extremely high capacity compared to any other compound tested against both Li and Na. ...
Seki Miharu - - 2013
Laccase oxidizes iodide to molecular iodine or hypoiodous acid, both of which are easily incorporated into natural soil organic matter. In this study, iodide sorption and laccase activity in 2 types of Japanese soil were determined under various experimental conditions to evaluate possible involvement of this enzyme in the sorption ...
Sandiford Lydia L Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, SE1 7EH, - - 2013
The efficient delivery of nanomaterials to specific targets for in vivo biomedical imaging is hindered by rapid sequestration by the reticuloendothelial system (RES) and consequent short circulation times. To overcome these two problems, we have prepared a new stealth PEG polymer conjugate containing a terminal 1,1-bisphosphonate (BP) group for strong ...
García Tonatiuh - - 2012
Methacrylic monomers containing a (phenylene)azobenzene unit substituted with a lateral cyano group and alkyl chains of different length are synthesized and characterized by NMR techniques. Their liquid-crystalline properties are studied by differential scanning calorimetry, polarizing optical microscopy, and X-ray diffraction. All monomers exhibit a mesomorphic behavior that extends over wide ...
Nowak-Król Agnieszka A Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, - - 2012
We show that peripheral nitro groups enhance the maximum two-photon absorption cross-section of trans-A(2)B(2)-porphyrins bearing two phenylethynyl substituents by more than one order of magnitude. Maximum values as high as 1000 GM result from realization of suitable conditions for effective resonance enhancement along with a lowering of the energy and ...
Chen Weiqiang W Integrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, Michigan 48109, - - 2013
Circulating tumor cells (CTCs) detached from both primary and metastatic lesions represent a potential alternative to invasive biopsies as a source of tumor tissue for the detection, characterization and monitoring of cancers. Here we report a simple yet effective strategy for capturing CTCs without using capture antibodies. Our method uniquely ...
Scheinert Dierk - - 2012
The study investigated the efficacy and safety of a balloon expandable, sirolimus-eluting stent (SES) in patients with symptomatic infrapopliteal arterial disease. Results of infrapopliteal interventions using balloon angioplasty and/or bare stents are limited by a relatively high restenosis rate, which could be potentially improved by stabilizing the lesion with a ...
Guo Yutao - - 2012
Atrial fibrillation (AF) is associated with increased risk for stroke and systemic embolism. There is plausible evidence linking inflammation to the initiation and perpetuation of AF and AF-related thrombosis. Various inflammatory markers (C-reactive protein, tumor necrosis factor-α, interleukin-2, interleukin-6, and interleukin-8) have been associated with AF. Proposed mechanisms linking inflammation ...
Hillegass William B - - 2012
The purpose of this study was to characterize long-term outcomes of percutaneous coronary intervention (PCI) in elderly diabetic patients in routine practice. Although drug-eluting stent (DES) implantation in diabetic patients is common practice, pivotal randomized trials enrolled <2,500 diabetic patients, most of whom were <65 years of age. Data from ...
Halkin Amir - - 2012
This study sought to estimate the costs of a national electrocardiographic (ECG) screening of athletes in the United States and the number of lives that would be saved by that program. A single study from Italy suggests that mandatory ECG screening of athletes reduces their risk of sudden cardiac death. ...
Ye Wenjie W Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United - - 2012
Aminophenols can redox cycle through the corresponding quinone imines to generate ROS. The electrophilic quinone imine intermediate can react with protein thiols as a mechanism of immobilization in vivo. Here, we describe the previously unkown transimination of a quinone imine by lysine as an alternative anchoring mechanism. The redox properties ...
Munthe-Kaas Monica Cheng - - 2012
Several CD14 gene-environment interactions in relation to the development of allergic diseases have been reported, but the underlying biological mechanisms are unclear. We recently showed that CD14 methylation increased during childhood, parallelling a decreased impact of CD14 polymorphisms on soluble CD14 levels. Here, we aim to explore whether environmental stimuli ...
El-Rayis Osman A - - 2012
Alamein Marina Lagoon is one of six lagoons, lying on the Egyptian Mediterranean Coast. Between 1988 and 1995, a large-scale recreational compound called Alamein Marina Touristic Village was established to contain most of these lakes. The study aims to assess the quality of Alamein Marina Lagoon water in an attempt ...
Tzvetanov I - - 2012
Antibody-mediated rejection (AMR) typically occurs early after transplantation in approximately 5%-7% of recipients. The literature reports suggest that 12%-37% of kidney transplant recipients with acute AMR do not respond to treatment and eventually lose their grafts. The proteasome inhibitor bortezomib is currently approved by the Food and Drug Administration for ...
Alessandri Bonetti Giulio - - 2012
This clinical report describes the diagnosis and the management of isolated-type recession defects of complex etiology in 2 healthy postorthodontic patients. The lesions were confined to 1 mandibular incisor and were associated with an abnormal buccolingual inclination of the affected tooth despite a lingual retainer made with a round stainless ...
Kim Eun Young - - 2012
Abstract Bovine embryonic stem cells (ESCs) are a powerful tool for agricultural and biomedical applications. The purpose of this study was to introduce a new method for generating bovine ESCs. Mechanically isolated bovine inner cell masses (ICMs) from in vitro-produced blastocysts were cultured individually on a 10-μL mouse embryonic fibroblast ...
Ortega Adam J Aj - - 2012
Orthodontists have used various compliance-dependent physical means such as headgears and intraoral appliances to prevent anchorage loss. The aim of this study was to determine whether 1 local application of the bisphosphonate zoledronate could be used to prevent anchorage loss during extraction space closure in rats. Thirty rats had their ...
Hadimioglu N - - 2012
Choice of the anesthestic technique can reduce or even eliminate stress responses to surgery and decrease the incidence of complications. Our aim was to compare a combination of epidural anesthesia+general anesthesia with general anesthesia alone as regards perioperative insulin resistance and inflammatory activation among renal transplant recipients. Forty-six nondiabetic patients ...
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