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Pellicer-Porres J - - 2012
We describe the results of x-ray absorption experiments carried out to deduce structural and chemical information in Eu(3+) doped, transparent, oxyfluoride glass and nanostructured glass-ceramic samples. The spectra were measured at the Pb and Eu-L(III) edges. The Eu environment in the glass samples is observed to be similar to that ...
Hojan Katarzyna - - 2012
Endocrine therapy (ET) is a common method of treatment in breast cancer patients; however, its negative impact on body composition, body physique (physical body shape/measurements), and quality of life (QoL) remains controversial. Previous studies have shown physical exercise can have a positive effect on QoL in breast cancer patients, especially ...
Blankenstein Thomas - - 2012
Mutant cancer-driving oncogenes are the best therapeutic targets, both with drugs like small molecule inhibitors (SMI) and adoptive T cell therapy (ATT), the most effective form of immunotherapy. Cancer cell survival often depends on oncogenes, which implies that they are homogenously expressed by all cancer cells and are difficult to ...
Baskin Jacquelyn L JL Children’s Center for Cancer and Blood Diseases, Children’s Hospital of Los Angeles, Los Angeles, California, USA. - - 2013
Cure rates among children with brain tumors differ between low-income and high-income countries. To evaluate causes of these differences, we analyzed aspects of care provided to pediatric neuro-oncology patients in a low middle-income South American country. Three methods were used to evaluate treatment of children with brain tumors in Paraguay: ...
Williamson Owen D - - 2012
BACKGROUND: Pre-injury disability must be determined when assessing whether treatment programs return people to pre-injury status, however there is little empirical evidence to support recommendations that this be done as soon as possible after injury to prevent recall bias. OBJECTIVES: To determine disagreement between recall of pre-injury disability at different ...
Flowers R M - - 2012
The Grand Canyon is one of the most dramatic features on Earth, yet when and why it was carved have been controversial topics for more than 150 years. Here, we present apatite (4)He/(3)He thermochronometry data from the Grand Canyon basement that tightly constrain the near-surface cooling history associated with canyon ...
Kato Takafumi - - 2012
Sleep-related movement disorders are characterized by the specific phenotypes of muscle activities and movements during sleep. However, the state-specific characteristics of muscle bursts and movement during sleep are poorly understood. In this study, jaw-closing and -opening muscle electromyographic (EMG) activities and jaw movements were quantified to characterize phenotypes of motor ...
Grubisic Andrej - - 2012
Electron emission from individual Au nanorods deposited on indium-tin-oxide (ITO) following excitation with femtosecond laser pulses near the rod longitudinal plasmon resonance is studied via scanning photoionization microscopy. The measured electron signal is observed to strongly depend on the excitation laser polarization and wavelength. Correlated secondary electron microscopy (SEM) and ...
Gauci Charles C University of Melbourne; Faculty of Veterinary Science; Werribee, Australia; Australian Institute for Bioengineering and Nanotechnology; University of Queensland; Queensland, - - 2013
Taenia solium is a zoonotic parasite that causes cysticercosis. The parasite is a major cause of human disease in impoverished communities where it is transmitted to humans from pigs which act as intermediate hosts. Vaccination of pigs to prevent transmission of T. solium to humans is an approach that has ...
Salerno Michael - - 2012
PURPOSE: To develop and validate modified Look-Locker (MOLLI) protocols to generate myocardial T(1) maps within clinically acceptable breath-hold durations and to compare partition coefficients (λ) of gadolinium (Gd)-DTPA determined from either bolus injection (BI) or continuous infusion (CI) techniques. MATERIALS AND METHODS: T(1) mapping was performed in phantoms and in ...
Rollstin A D - - 2012
Background. There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia. The kinetics, risk of hepatotoxicity, and the possible dose adjustments to N-acetylcysteine (NAC) therapy are not known in this setting. Case report. A 37-year-old female was found unconscious outside in December and ...
Hurtgen Marie - - 2012
Water-soluble star-like poly(vinyl alcohol)/C(60) and poly{[poly(ethylene glycol) acrylate]-co-(vinyl acetate)}/C(60) nanohybrids are prepared by grafting macroradicals onto C(60) and are assessed as photosensitizers for photodynamic therapy. The photophysical and biological properties of both nanohybrids highlight key characteristics influencing their overall efficiency. The macromolecular structure (linear/graft) and nature (presence/absence of hydroxyl groups) ...
Pechanova Olga - - 2012
Zea mays L. is the most grown cereal crop in the world (839 million tons in 2012). Accordingly to its agro-economical importance, maize has received tremendous attention from research communities of academic, state, and industry origin. In this manuscript, we aspire to provide readers with the first comprehensive review of ...
Naka Toyoko - - 2012
It has been suggested that copper ion is involved in the pathogenesis of various diseases. The aim of this study is to examine the association of serum copper levels and glycemic control in patients with type 2 diabetes. We recruited a total of 132 patients with type 2 diabetes, and ...
Fang Yaping Y Applied Bioinformatics Laboratory, University of Kansas, Lawrence, KS 66047, USA. - - 2013
Nuclear receptors (NRs) are a class of transcription factors playing important roles in various biological processes. An NR often impacts numerous genes and different NRs share overlapped target networks. To fulfil the need for a database incorporating binding sites of different NRs at various conditions for easy comparison and visualization ...
Dominguez Wilfredo - - 2012
Bifidobacteria are widely used as probiotics and have attracted increasing research interest worldwide. However, molecular techniques are still very scarce mainly due to the low efficiencies and strain-specific electroporation protocols that have been developed. Bacterial conjugation enables the transfer of genetic material among a relatively wide range of organisms and ...
Borio Stefano - - 2012
Proliferative and necrotising otitis externa is a rare and recently described disease affecting the ear canals and concave pinnae of kittens. This article describes a case of proliferative and necrotising otits externa in a young adult cat. In this case, the lesions did not affected the pinnae, but both ear ...
Coraux Johann - - 2012
The properties of sp(2) carbon allotropes can be tuned and enriched by their interaction with other materials. The large interface to the outside world in these forms of carbon is ideally suited for combining in an optimal manner several functionalities thanks to this interaction. A wide range of novel materials ...
Young Karen M - - 2012
Preservation of muscle morphology depends on a continuing regulatory balance between molecules that protect, and molecules that damage, muscle structural integrity. Excessive disruption of the biochemical balance that favours reactive oxygen species (ROS) in disused muscles may lead to oxidative stress; which in turn is associated with increased atrophic or ...
Broell Franziska - - 2012
Monitoring and measuring the behaviour and movement of aquatic animals in the wild is typically challenging, though micro-accelerometer (archival or telemetry) tags now provide the means to remotely identify and quantify behavioural states and rates such as resting, swimming, and migrating, and to estimate activity and energy budgets. Most studies ...
Watson Scott M D - - 2012
The thermodynamics of the templating of materials on one-dimensional templates, such as DNA, is modeled by considering two terms: the surface tension of the material (γ) and a line energy (σ = 2πr(T)γ(T)) that represents the adhesion of the material to the template (radius r(T)). We show that as long as the ...
Smith Caroline - - 2012
OBJECTIVE: To determine the feasibility and acceptability of acupuncture in managing fatigue and well-being in breast cancer survivors. METHODS: A randomised controlled trial compared acupuncture was with sham acupuncture and wait list controls was performed in Sydney, Australia. A total of 30 women with fatigue following breast cancer treatment participated ...
Liu Qiongming Q State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, 100850, - - 2013
Nuclear receptors (NRs) are a superfamily of transcription factors that, upon binding to ligands, bind specific DNA sequences and regulate a transcriptional program governing cell proliferation, differentiation, and metabolism. In the liver, by sensing lipid-soluble hormones and dietary lipids and governing the expression of key liver metabolic genes, NR proteins ...
Karli Rifat - - 2012
OBJECTIVE: The objective of this study was to investigate the correlation of symptoms in patients with presumed allergic rhinitis on the basis of their medical history and physical examination with the levels of total immunoglobulin E (IgE) and specific IgE, and to question the necessity of these tests in diagnosis. ...
Ng Yee-Yung - - 2012
BackgroundMost studies investigate the association between the baseline Romano-Charlson comorbidity index (CCI) and survival on hemodialysis (HD). Few consider the effect of progression in the CCI score (CCIp) on patient survival before HD initiation. That is CCIp = CCI(-)(1) - CCI(-3), where CCI(-1) is the CCI score in the first ...
Chang Cuilan - - 2012
The online coupling of capillary electrophoresis with ambient direct analysis in real time mass spectrometry (DART-MS) was realized by a coaxial tip interface. The analytes eluted from CE were directly ionized by the metastable helium flux produced by DART and transferred into MS for the detection, with which the online ...
Schwaebel Thimon - - 2012
We developed a new conjugated cruciform flourophore (XF) featuring imine groups. The condensation of an XF containing aldehyde functionalities and selected primary amines leads to several XF- imine derivatives. Upon addition of Cu2+ or Zn2+ ions to solutions of the imine XFs in different solvents a red shifted emission is ...
Nudds R L - - 2012
The relative length proportions of the three bony elements of the pelvic (femur, tibiotarsus and tarsometatarsus) and pectoral (humerus, ulna and manus) limbs of the early Cretaceous bird Gansus yumenensis, a well-represented basal ornithuromorph from China, are investigated and compared to those of extant taxa. Ternary plots show that the ...
Liu Juan - - 2012
Brown adipose tissue (BAT) increases energy expenditure and is an attractive therapeutic target for obesity. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an amplifier of local glucocorticoid activity, has been shown to modulate white adipose tissue (WAT) metabolism and function. In the present study, we investigated the roles of 11β-HSD1 in regulating ...
Imaizumi Takaki - - 2012
We developed 1,3-dipolar cycloaddition reactions of azomethine imines with terminal alkynes catalyzed by group 11 metal amides to provide N,N-bicyclic pyrazolidinone derivatives. This reaction afforded the cycloadducts in a unique 5,7-disubstituted manner. Furthermore, we succeeded in applying this catalysis to asymmetric reactions, and the desired heterocycles were produced in high ...
Fujinaga Masayuki - - 2012
Three novel 4-substituted benzamides have been synthesized as potential ligands for the positron emission tomography (PET) imaging of metabotropic glutamate 1 (mGlu1) receptors in the brain. Of these compounds, N-(4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-N,4-dimethylbenzamide (4) exhibited the highest binding affinity (Ki = 13.6 nM) for mGlu1 receptors and was subsequently labeled with carbon-11. In ...
Evans Simon R - - 2012
Within-population colour variation is widespread in animals, yet the determinants of variable coloration have been relatively neglected by ecologists. Age-dependent expression of conspicuous coloration is prevalent, particularly in birds. Such patterns can be generated by multiple combinations of demographic heterogeneity or within-individual change; longitudinal analyses are necessary to establish the ...
Midtgaard Julie - - 2012
Background. Sedentary behaviour and reduced exercise capacity are potential persisting effects of anti-cancer therapy that may predispose to serious health conditions. It is well-established that physical exercise may prevent some of these problems. However, the extent to which cancer survivors are able to adopt long-term physical activity habits depends largely ...
Han Miao - - 2012
The genetic diversity of 85 isolates of Phytophthora infestans collected in 2007 from Gansu province in China was determined and compared with 21 isolates collected before 2004. Among them, 70 belonged to the A1 mating type and 15 were self-fertile (SF). The mitochondrial DNA haplotypes revealed both Ia (25%) and ...
Obuchi Wataru - - 2012
Membrane transporter proteins may influence the sensitivity of cancer cells to anti-cancer drugs that can be recognized as substrates. The purpose of this study was to identify proteins that play a key role in the drug sensitivity of stomach and breast cancer cell lines by measuring the absolute protein expression ...
Yamada Tatsuya - - 2013
The mechanisms underlying subcellular oxygen transport mediated by myoglobin (Mb) remain unclear. Recent evidence suggests that, in the myocardium, transverse diffusion of Mb is too slow to effectively supply oxygen to meet the immediate mitochondrial oxygen demands at the onset of muscle contractions. The cell may accommodate the demand by ...
Grieser C - - 2012
Purpose: To evaluate morphologic characteristics and establish a standardized diagnostic algorithm to differentiate benign cystic pancreatic tumors (CPTs) in non-pancreatitis patients using multidetector computed tomography (CT) and magnetic resonance imaging (MRI).Materials and Methods: Patients with histopathologically proven CPTs who had undergone MRI and/or CT and subsequent tumor resection in our ...
Apfelbaum Evgeniy Mikhailovich - - 2012
The critical point coordinates of Beryllium have been calculated by means of recently found similarity relations between the Zeno-line and the critical point parameters. We have used the NVT MC simulations and pseudopotential theory to calculate the Zeno-line parameters together with the data of isobaric measurements to construct the liquid ...
Cheviron Zachary A ZA School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA. - - 2013
Small mammals face especially severe thermoregulatory challenges at high altitude because the reduced O2 availability constrains the capacity for aerobic thermogenesis. Adaptive enhancement of thermogenic performance under hypoxic conditions may be achieved via physiological adjustments that occur within the lifetime of individuals (phenotypic plasticity) and/or genetically based changes that occur ...
Fujino Noboru - - 2012
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a disease of the sarcomere, and approximately 5% of cases of HCM show systolic dysfunction with poor prognosis. Few data exist regarding the systolic dysfunction in a large population of genotyped HCM subjects. HYPOTHESIS: The aim of this study was to assess the systolic dysfunction ...
Devi Thangjam Ranjita - - 2012
Sex comb is a recently evolved male specific character confined to the Sophophoran group of Drosophila. Such innovations in phenotypes as Waddington proposed, are, outcome of 'canalization' in developmental pathways which occur due to mutations creating 'choice points' in genetic regulatory pathways. Our interest in the present study is to ...
Kaur Parminder P Biodesign Institute, Arizona State University, Tempe, AZ 85287, - - 2012
AFM images show that chromatin reconstituted on methylated DNA (meDNA) is compacted when imaged under water. Chromatin reconstituted on unmethylated DNA is less compacted and less sensitive to hydration. These differences must reflect changes in the physical properties of DNA on methylation, but prior studies have not revealed large differences ...
Huang Feihu - - 2012
Introducing hydrogen bond donors to a receptor was found to be an effective approach to improve both its selectivity and binding affinity for pyrophosphate in water. The crystal structure of Zn3-ADP complex showed the improvements come from the combination of H-bonding and metal coordination in a manner similar to many ...
Dunavin Neil C - - 2012
ABSTRACT Autologous stem cell transplant (ASCT) is an effective treatment for multiple myeloma (MM). However the timing of ASCT in the era of novel agents (lenalidomide, thalidomide, bortezomib) is unknown. We retrospectively reviewed the outcome of MM patients who received novel agent based induction treatment and received first ASCT within ...
Blankenship James C - - 2012
Percutaneous coronary interventions (PCI) may be performed during the same session as diagnostic catheterization (ad hoc PCI) or at a later session (delayed PCI). Randomized trials comparing these strategies have not been performed; cohort studies have not identified consistent differences in safety or efficacy between the two strategies. Ad hoc ...
Dai Chongshan - - 2012
Abstract: The study investigated the effect of colistin exposure on calcium homeostasis and mitochondria functions in neurons. We used an in vitro drug model to induce neurotoxicity that closely mimic the in vivo condition by exposing primary cultures of chick cortex neurons to different concentrations of 0, 0.83, 4.15 and ...
Bekenstein Yehonadav - - 2012
Hybrid inorganic nanoparticles, comprising a semiconducting Cu(2)S quantum-dot (QD) core encapsulated by a metallic Ru cage-like shell, and each of their individual components, are studied via scanning tunneling spectroscopy. Bare Cu(2)S QDs show nearly identical semiconducting-like I-V characteristics while the empty Ru cages exhibit single electron tunneling effects-the Coulomb blockade ...
Gennaco Michael A - - 2012
Absolute rate constant measurements for the reactions of OH with cyclopentane and cycloheptane in the gas phase in 6-8 Torr of nitrogen from 233 to 351 K in the Harvard University High-Pressure Flow System (HPFS) are reported. Hydroxyl concentrations were measured using laser-induced fluorescence, and alkane concentrations were measured using ...
Wood T J - - 2012
Non-equilibrium plasmachemical deposition using platinum(II) hexafluoroacetylacetonate precursor leads to the single-step formation of nanocomposite layers comprising an organic host matrix embedded with metal particles of size less than 5 nm. These multifunctional nanocomposite films are found to display both ionic and electronic conductivities.
Modeo Letizia - - 2012
We combined morphological (i.e. live, stained, scanning, and transmission electron microscopy) with morphometric and molecular analysis to describe a ciliate species collected from shallow reefs in Guam, grown, and maintained in our laboratory. The species was recognized as a member of Euplotidium, and compared with established species of the genus: ...
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