Search Results
Results 751 - 800 of 3799
< 11 12 13 14 15 16 17 18 19 20 21 >
Vogelaar Ingrid P - - 2012
Orofacial clefts (OFC) are among the most common birth defects worldwide. The etiology of non-syndromic OFC is still largely unknown. During embryonic development, the cell adhesion molecule E-cadherin, encoded by CDH1, is highly expressed in the median edge epithelium of the palate. Further, in multiple families with CDH1 mutations, OFC ...
Kaiser Nathan Kenneth - - 2012
Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) typically utilizes m/z-independent excitation magnitude to excite all ions to the same cyclotron radius so that detected signal magnitude is directly proportional to relative ion abundance. However, deleterious space charge interaction between ion clouds is maximized for clouds of equal radius. ...
Rahman Md Musfiqur - - 2012
A new method was developed for kresoxim-methyl (parent compound) and its two thermolabile metabolites, BF 490-2 and BF 490-9, in Korean plum, introducing pepper leaf matrix as a natural analyte protectant for GC-amenable metabolites using a GC-electron capture detector. Samples were extracted with a simple and rapid method using a ...
Oramasionwu Christine U CU UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, - - 2013
Therapeutic advances have resulted in an epidemiological shift in the predominant causes of hospitalization for patients with HIV/AIDS. An emerging cause for hospitalization in this patient population is cardiovascular disease (CVD); however, data are limited regarding how this shift affects different racial groups. The objective of this observational, retrospective study ...
Kantaputra Piranit Nik - - 2012
We report on two daughters and a son of a Thai family who were affected with BWS. Their clinical findings consist of cleft palate, omphalocele, anterior ear creases, indented lesions on the posterior rim of the helix, macroglossia, posterior crossbite, and anterior open bite. The younger daughter and son had ...
Li Xiang - - 2012
Abstract In vitro cytotoxicity assays can be used to evaluate potential toxicological effects of tobacco products. Total particulate matter (TPM) from mainstream cigarette smoke trapped by a Cambridge filter is used widely for biological evaluation of smoke. This present study compared neutral red uptake (NRU) assay, lactate dehydrogenase (LDH) activity ...
Zhong X H - - 2012
The performance of carbon nanotube fibers (CNTFs) significantly depends on the packing styles of carbon nanotube (CNT) bundles. Revealing the structures and characterizations of CNT bundles is contributive to understanding the structures, properties and even the formation of CNTFs during chemical vapor deposition (CVD) processing. In this paper, bundles consisting ...
Yu Miao - - 2012
A complete understanding of the potential function of 5-hydroxymethylcytosine (5-hmC), a DNA cytosine modification in mammalian cells, requires an accurate single-base resolution sequencing method. Here we describe a modified bisulfite-sequencing method, Tet-assisted bisulfite sequencing (TAB-seq), which can identify 5-hmC at single-base resolution, as well as determine its abundance at each ...
Okumura-Noji Kuniko - - 2012
Familial cholesteryl ester transfer protein (CETP) deficiency is more common in some East Asian populations than elsewhere, suggesting the possibility of a selective advantage of this genetic defect against regional infectious diseases. Historically, infection with the Asian blood fluke Schistosoma japonicum has been endemic in these regions, including Japan. We ...
Hess Thomas M TM Department of Psychology, North Carolina State University, Raleigh, NC 27695-7801, USA. - - 2013
We investigated how information search strategies used to support decision making were influenced by self-related implications of the task to the individual. Consistent with the notion of selective engagement, we hypothesized that increased self-relevance would result in more adaptive search behaviors and that this effect would be stronger in older ...
Haines Terry P - - 2012
BACKGROUND: The behaviour of hospitalized older adults can contribute to falls, a common adverse event during and after hospitalization. OBJECTIVE: To understand why older adults take risks that may lead to falls in the hospital setting and in the transition period following discharge home. DESIGN: Qualitative research. SETTING AND PARTICIPANTS: ...
Vitkin Edward - - 2012
ABSTRACT: Genome-scale metabolic network reconstructions are considered a key step in quantifying the genotype-phenotype relationship. We present a novel gap-filling approach, MetabolIc Reconstruction via functionAl GEnomics (MIRAGE), which identifies missing network reactions by integrating metabolic flux analysis and functional genomics data. MIRAGE's performance is demonstrated on the reconstruction of metabolic ...
Zhang Lei - - 2012
Autophagy is a highly conserved process; representing the major eukaryotic degradative pathway of cellular components. Autophagy-mediated recycling of cellular materials contributes to cell differentiation, tissue remodeling, and proper development. In fungi, autophagy is required for normal growth and cell differentiation. The entomopathogenic fungus Beauveria bassiana and its invertebrate targets represent ...
Elmayergi Nader - - 2012
BACKGROUND: Although high risk left main PCI populations have been previously described, there is little data describing outcomes and the role of the logistic EuroSCORE in surgical turndown cohorts or patients in extremis due to acute infarction or cardiogenic shock from left main ischemia. METHODS: Consecutive patients with unprotected LM ...
Page Theresa H - - 2012
ABSTRACT: INTRODUCTION: The aim of this study was to examine whether circulating levels of the pro-inflammatory glycoprotein tenascin-C (TNC) are elevated in musculoskeletal disorders including rheumatoid arthritis (RA) and to assess in RA whether levels are related to clinical disease status and / or patient response to treatment. METHODS: TNC ...
Santer Benjamin D - - 2013
We perform a multimodel detection and attribution study with climate model simulation output and satellite-based measurements of tropospheric and stratospheric temperature change. We use simulation output from 20 climate models participating in phase 5 of the Coupled Model Intercomparison Project. This multimodel archive provides estimates of the signal pattern in ...
O'Shaughnessy P J PJ College of Medical, Veterinary and Life Sciences, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK. - - 2013
The human feto-maternal unit produces large amounts of steroid hormones, particularly estrogens, during the second and third trimesters. The fetal adrenal gland and the placenta are considered the principal tissues driving steroid production but the fetal liver is likely to play an essential role in this process. This study was ...
Petit Christopher J - - 2012
Percutaneous implantation of valved stents is now routinely performed to treat pulmonary valve regurgitation and stenosis. In addition, there are isolated reports of implantation of valved stents in the tricuspid position to treat prosthetic tricuspid stenosis or regurgitation when a prosthetic valve ring exists. We present a case in which ...
Spinelli Maria Silvia - - 2012
ABSTRACT: We report the case of a parosteal osteosarcoma of the distal ulna, treated with wide resection without reconstruction. The patient developed lung metastasis and a mass in the interosseus membrane of the forearm proximally to the osteotomy. The lung mass was found to be a metastasis from parosteal osteosarcoma ...
Ruggieri Vito Giovanni - - 2012
Transcatheter aortic valve implantation could represent an alternative option to conventional surgery in high risk patients with degeneration of aortic bioprosthesis. Herein we report the performance of a valve-in-valve procedure in urgent conditions and via the left axillary artery in a patient with patent left internal mammary artery coronary graft. ...
Fan Chuan-Dong CD Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, - - 2013
AKT is a critical effector kinase downstream of the PI3K pathway that regulates a plethora of cellular processes including cell growth, death, differentiation, and migration. Mechanisms underlying activated phospho-AKT (pAKT) translocation to its action sites remain unclear. Here we show that NEDD4-1 is a novel E3 ligase that specifically regulates ...
Napoli Eleonora - - 2012
A number of studies have been conducted that link mitochondrial dysfunction (MD) to Huntington's disease (HD); however, contradicting results had resulted in a lack of a clear mechanism that links expression of mutant Huntingtin protein and MD. Mouse homozygous (HM) and heterozygous (HT) mutant striatal cells with two or one ...
Weber Katharina - - 2012
Two model compounds of the active site of [NiFe]-hydrogenases with an unusual {S(2)Ni(μ-S)(μ-CO)Fe(CO)(2)S} coordination environment around the metals are reported. The neutral compound [Ni(xbsms)(μ-CO)(μ-S)Fe(CO)(2)('S')], (1) (H(2)xbsms = 1,2-bis(4-mercapto-3,3-dimethyl-2-thiabutyl)benzene) is converted to [1H][BF(4)] by reversible protonation using HBF(4)•Et(2)O. The protonation takes place at the terminal thiolate sulfur atom that is coordinated ...
Kim Giyeon - - 2012
This study examined racial and ethnic differences in healthcare use, delayed care, and management of care of older adults with a self-reported diagnosis of diabetes mellitus. Drawing on the 2009 California Health Interview Survey (CHIS), the sample included 3,003 adults (representative of N = 998,795) aged 60 and older from five racial ...
Brenner Jillian M - - 2012
Confronted with articular cartilage's limited capacity for self-repair, joint resurfacing techniques offer an attractive treatment for damaged or diseased tissue. While tissue engineered cartilage constructs can be created, a substantial number of cells are required to generate sufficient quantities of tissue for the repair of large defects. As routine cell ...
Hawcutt Daniel B - - 2012
Pharmacogenomics research is becoming more prevalent in both academia and the pharmaceutical industry. While some discoveries have been integrated into practice and are benefiting patient care, these successes have been limited given the vast amount of research undertaken. However, the advances in high-throughput genomic technologies, better study designs and improved ...
Chen Yi-Hui - - 2012
The o- and p-amino green-fluorescence-protein synthetic chromophores (GFPSCs) were synthesized from the corresponding o- and p-nitro protecting group. Among the four protecting groups of the o-amino group, the o-nitro protecting group is the only choice to synthesize the o-amino GFPSCs. The first singlet excited states of o- and p-amino GFPSCs ...
Prasanna Nagalakshmi - - 2012
Abstract The present study was performed to investigate the ameliorative role of p-coumaric acid against sodium arsenite-induced cardiotoxicity in rats. Sodium arsenite (5 mg/kg/b.wt,) was orally administered once a day for 30 days to the animals to induce cardiotoxicity. After the experimental period, cardiotoxicity was assessed by estimating the levels ...
Hong Jong Wook - - 2012
Alloy allies: Trisoctahedral (TOH) Au-Pd alloy nanocrystals (NCs; see figure) enclosed exclusively by {441} high-index facets have been synthesized. Precise control over the reductant/surfactant concentration and the molar ratio of metal precursors allowed the optimization of growth kinetics of NCs, which is the key to the successful formation of TOH ...
Maria Teresa Mella - - 2012
Abstract Objective: To evaluate for the presence of risk factors (RFs) for preterm birth (PTB) in women without prior PTB having second trimester cervical length (CL) screening, and to estimate the utility of RF screening. Methods: "Low-risk" singletons were prospectively screened with midtrimester transvaginal ultrasound CL. Prior PTB, intrauterine fetal ...
O'Rourke Jamie A - - 2012
Phosphorus, in its orthophosphate form (Pi), is one of the most limiting macronutrients in soils for plant growth and development. However, the whole genome molecular mechanisms contributing to plant acclimation to Pi deficiency remain largely unknown. White lupin (Lupinus albus L.) has evolved unique adaptations for growth in Pi deficient ...
Schier Robert - - 2012
Aim: The inflammatory response following tissue injury after major surgery is known to affect endothelial function and vascular reactivity. In this study we evaluated the utility of bedside Digital Thermal Monitoring (DTM) as a surrogate for evaluating vascular function in the postoperative period.Methods: Ischemia-induced reactive hyperemia variables were measured in ...
Parret Romain - - 2012
We report in situ Raman scattering experiments on single layer graphene (SLG) and Bernal bilayer graphene (BLG) during exposure to rubidium vapor. The G and 2D bands evolutions with doping time are presented and analyzed. On SLG, the extended doping range scanned (up to about 1014 electrons/cm²) allows the observation ...
Smith Sonali M - - 2012
ABSTRACT Relapsed Hodgkin lymphoma remains a clinical challenge, with few non-cytotoxic treatment options. CD80 is a surface antigen that normally functions as a co-stimulatory molecule but is aberrantly and uniformly expressed on Reed Sternberg cells. Galiximab is a primatized monoclonal antibody against CD80, with a favorable toxicity profile demonstrated in ...
Liu Bingkun - - 2012
Vertically aligned TiO(2) nanorod arrays (NRAs) modified with Ag(2)S quantum dots (QDs) have been successfully prepared via a successive ionic layer adsorption and reaction (SILAR) process. Ultraviolet-visible (UV-vis) absorption spectra and surface photovoltage (SPV) measurements reveal that the Ag(2)S sensitization extends the range of the photoresponse of the TiO(2) NRAs ...
Meng Qing-Yuan - - 2012
A cross-dehydrogenative coupling (CDC) reaction between tertiary amines and nitroalkanes has been realized under an oxygen atmosphere in water simply by using graphene-supported RuO(2) as the catalyst, which was made from water-soluble graphene with sulfonic groups and RuCl(3)·nH(2)O to form RuO(2)·nH(2)O nanocomposites in situ. In contrast to RuCl(3)·nH(2)O and RuO(2)·nH(2)O, ...
Tacke Carline E - - 2012
BACKGROUND: -Although histopathological studies suggest persistent myocardial abnormalities after Kawasaki disease (KD), the long-term effects on cardiac function remain to be revealed. We investigated biventricular volumes, function and the presence of myocardial fibrosis by cardiac magnetic resonance imaging (CMRI) during long-term follow-up of KD. METHODS AND RESULTS: -Sixty patients with ...
Challagundla Sudhakar Rao - - 2012
BackgroundFollowing advice from the Scottish Antimicrobial Prescribing Group, we switched our antibiotic prophylaxis for elective hip and knee replacement surgery from cefuroxime to flucloxacillin with single-dose gentamicin in order to reduce the incidence of Clostridium difficile associated diarrhoea (CDAD). A clinical impression that more patients subsequently developed acute kidney injury ...
Zhu Motao M Department of Epidemiology, West Virginia University, Morgantown, West Virginia 26506–9151, USA. - - 2013
Pedestrians account for a third of the 1.2 million traffic fatalities annually worldwide, and men are overrepresented. We examined the factors that contribute to this male-female discrepancy: walking exposure (kilometres walked per person-year), vehicle-pedestrian collision risk (number of collisions per kilometres walked) and vehicle-pedestrian collision case fatality rate (number of ...
Lawrence David J - - 2012
Measurements by the Neutron Spectrometer on the MESSENGER spacecraft show decreases in the flux of epithermal and fast neutrons from Mercury's north polar region that are consistent with the presence of water ice in permanently shadowed regions. The neutron data indicate that Mercury's radar-bright polar deposits contain, on average, a ...
Stansfield Brian K BK Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, IN 46202, - - 2013
Mutations in the NF1 tumor suppressor gene cause Neurofibromatosis type 1 (NF1). Neurofibromin, the protein product of NF1, functions as a negative regulator of Ras activity. Some NF1 patients develop cardiovascular disease, which represents an underrecognized disease complication and contributes to excess morbidity and mortality. Specifically, NF1 patients develop arterial ...
Ogawa Yojiro - - 2013
Diuretic-induced mild hypovolemia with hemoconcentration reportedly improves dynamic cerebral autoregulation, whereas central hypovolemia without hemoconcentration induced by lower body negative pressure (LBNP) has no effect or impairs dynamic cerebral autoregulation. This discrepancy may be explained by different blood properties, by degrees of central hypovolemia, or both. We investigated the effects ...
Mehlman E - - 2012
BACKGROUND: Cardiomyopathy of obesity occurs in humans, but the gross and cellular myocardial response to obesity in dogs is not well defined. OBJECTIVES: To characterize in vivo myocardial morphology and function in normotensive obese dogs, and quantitate collagen, triglyceride and myocyte cross-sectional area (CSA) in postmortem tissues from obese dogs. ...
Ustun Seher - - 2012
Restoration of cartilage defect remains a challenge as the current treatments are ineffective to return tissue to its health. Thus, developing therapies for treatment of cartilage tissue damages caused by common joint diseases including osteoarthritis, rheumatoid arthritis and accidents is crucial. Sulfated glycosaminoglycan molecules are vital constituents of both developing ...
Yan Biao - - 2012
MicroRNAs (miRNAs) are ~22 nt noncoding RNAs that play an important role in regulating muscle development. Our previous study shows that miR-206 is specifically expressed in tilapia skeletal muscle, and exhibits dynamic expression pattern during different developmental stages. Here, we reveal that miR-206 emerges as a crucial regulator of tilapia ...
Whiteside Sandra P - - 2012
This case study describes an investigation into the speaking characteristics of a set of male monozygotic (MZ) twins (T1 and T2) and an age- and sex-matched sibling (S). Measures of speech tempo and fundamental frequency (F0) were analysed in the speech samples of a reading passage. Results showed significant between-sibling ...
Saba Michele - - 2012
Intensity instabilities are a common trademark of the photoluminescence of nanoemitters. This general behavior is commonly attributed to random fluctuations of free charges and activation of charge traps reducing the emission yield intermittently. However, the actual physical origin of this phenomenon is lively debated. Here we devise an experiment, variable ...
Lee Jonathan L C - - 2013
The reconsolidation of memories after their retrieval involves cellular mechanisms that recapitulate much of the initial consolidation process. However, we have previously demonstrated that there are independent cellular mechanisms of consolidation and reconsolidation in the dorsal hippocampus for contextual fear memories. Expression of BDNF was required for consolidation, while Zif268 ...
Mondal Shovan - - 2012
Radically efficient: New and appealing enantioselective cyclizations leading to highly functionalized carbocycles and heterocycles have been reported (see scheme; TMS=trimethylsilyl). These methodologies, based on the cascade combination of radical and polar steps, provide alternatives to conventional methodologies.
Katter Katharina K Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, Vienna, - - 2013
Germline transgenesis is an important procedure for functional investigation of biological pathways, as well as for animal biotechnology. We have established a simple, nonviral protocol in three important biomedical model organisms frequently used in physiological studies. The protocol is based on the hyperactive Sleeping Beauty transposon system, SB100X, which reproducibly ...
< 11 12 13 14 15 16 17 18 19 20 21 >