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Ritter Jens C JC Department of Vascular Surgery, King's Health Partners, Kings College Hospital, London, UK. - - 2013
Ischaemic stroke represents a major health hazard in the western world, which has a severe impact on society and the health-care system. Roughly, 10% of all first ischaemic strokes can be attributed to significant atherosclerotic disease of the carotid arteries. Correct management of these lesions is essential in the prevention ...
Oishi Sakiko - - 2012
Atrial inflammation is critical to atrial fibrillation initiation and progression. Although left atrial dilatation is a risk factor for atrial fibrillation, the mechanism linking atrial dilatation and inflammation is unclear. We evaluated the mechanisms underlying infiltration of macrophages induced by stretch of atrial myocytes. Murine macrophages were co-cultured with HL-1 ...
Penzkofer T - - 2012
Purpose: To systematically investigate the impact of image acquisition and contrast injection parameters for CO2-enhanced CT angiography (CTA) of the aorto-iliac and peripheral arteries in a pig model using commercially available equipment. The aim was to establish an imaging protocol that is ready for use in human subjects. Materials and ...
Liebenberg C - - 2012
BACKGROUND: Babesiosis in dogs is associated with severe thrombocytopenia; yet infected dogs rarely show clinical signs of hemorrhage. HYPOTHESIS: Dogs with uncomplicated babesiosis have normal hemostatic capacity despite severe thrombocytopenia. ANIMALS: Nineteen client-owned dogs with uncomplicated babesiosis; 10 healthy controls. METHODS: A prospective, cross-sectional, observational study. Thromboelastography (TEG), prothrombin time ...
Kaiser J Phillip - - 2012
Liver disease is a major health issue characterized by several pathological changes, with steatosis (fatty liver) representing a common initial step in its pathogenesis. Steatosis is of critical importance because prevention of fatty liver can obviate downstream pathologies of liver disease (eg, fibrosis). Recent studies have shown a strong correlation ...
Lin Sheng-Hsiang SH Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, - - 2013
Despite the consistent presence of performance deficits on the Wisconsin Card Sorting Test (WCST) in schizophrenia patients, whether poorer performance is also present in their nonpsychotic relatives is not certain. This study aimed to estimate both the recurrence risk ratio (λs) and the heritability of WCST scores in simplex and ...
Ma Donghui - - 2012
Skeleton craft: An efficient synthesis of (±)-(6aβ)-5-demethyl-6a-deoxy-5-(methoxycarbonyl)tazettinone, the common core structure of (±)-tazettine and (±)-6a-epipretazettine, has been accomplished in 6 steps with 54 % overall yield on a gram scale, starting from commercially available p-hydroxybenzaldehyde and piperonyl alcohol. The requisite pentacyclic skeleton is constructed by a tandem intramolecular oxidative Friedel-Crafts/aza-Michael reaction ...
Chan-Park Mary B - - 2012
The large-scale application of semiconducting single walled carbon nanotubes (s-SWCNTs) for printed electronics requires scalable, repeateable, as well as non-contaminating, assembly techniques. Previously explored nanotube deposition methods include serial methods such as inkjet printing and parallel methods such as spin coating with photolithography. The serial methods are usually slow while ...
Holloway Chris - - 2012
Abstract  On March 9, 2012, the New York Academy of Sciences brought together experts representing a variety of perspectives-including academic, industrial, regulatory, as well as those from physicians and consumers-to discuss considerations for the non-biological complex drug (NBCD) regulatory approval pathway, given the emerging regulatory guidelines for biosimilars (follow-on biological ...
Soonthorntantikul Wasura - - 2012
Based on the separation selectivity equation, related to the dimensionless parameters for fully charged achiral analytes using a neutral CD, the separation selectivity can be classified into seven patterns. With respect to CZE without CD, the presence of CD in the buffer may improve, or reduce, the separation selectivity with ...
- - 2012
Older adults with multiple chronic conditions (MCCs) require considerable health services and complex care. Because the persistence and progression of diseases and courses of treatments affect health status in multiple dimensions, well-validated universal outcome measures across diseases are needed for research, clinical care, and administrative purposes. An expert panel meeting ...
Carnovale C - - 2012
WHAT IS KNOWN AND OBJECTIVE: Rheumatoid arthritis is an autoimmune disorder characterized by persistent synovitis and systemic inflammation. Genetic factors account for approximately 50% of cases of rheumatoid arthritis and environmental factors include smoking. Urinary incontinence may occur as a medication adverse effect. We present the first report of a ...
Zeyl Jeffrey N - - 2012
Neural responses to sensory stimuli often differ between sexes, vary seasonally, and can be regulated by endocrine activity, but the ecological and physiological mechanisms driving such patterns are not well understood. The current study examined how auditory function in the round goby (Neogobius melanostomus), a vocal teleost, co-varied with sex, ...
Nakai Asako - - 2012
PURPOSE: To determine the optimal single shot fast spin echo (SSFSE) technique by varying interval between image acquisitions for cine MRI of uterine peristalsis. MATERIALS AND METHODS: MRI was performed in 13 premenopausal women (4 normal and 9 with benign pelvic pathology) in various phases of their menstrual cycle. Midsagittal ...
Taufany Fadlilatul - - 2012
A controlled composition-based method-that is, the microwave-assisted ethylene glycol (MEG) method-was successfully developed to prepare bimetallic Pt(x) Ru(100-x) /C nanoparticles (NPs) with different alloy compositions. This study highlights the impact of the variation in alloy composition of Pt(x) Ru(100-x) /C NPs on their alloying extent (structure) and subsequently their catalytic ...
Le Roy Tiphaine - - 2012
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is prevalent among obese people and is considered the hepatic manifestation of metabolic syndrome. However, not all obese individuals develop NAFLD. Our objective was to demonstrate the role of the gut microbiota in NAFLD development using transplantation experiments in mice. DESIGN: Two donor C57BL/6J ...
Välimäki P - - 2012
The relative roles of genetic differentiation and developmental plasticity in generating latitudinal gradients in life histories remain insufficiently understood. In particular, this applies to determination of voltinism (annual number of generations) in short-lived ectotherms, and the associated trait values. We studied different components of variation in development of Chiasmia clathrata ...
Kaul Christian - - 2012
People perceive and evaluate others on the basis of social categories, such as race, gender and age. Initial processing of targets in terms of visually salient social categories is often characterized as inevitable. In the current experiment, we examine the influence of processing goals on the representation of race in ...
Zhao Huaizhou - - 2012
We present the figure-of-merit (ZT) improvement in nanostructured FeSb(2-x)Ag(x) with Ag(1-y)Sb(y) nanoinclusions through a metal/semiconductor interface engineering approach. Owing to the interfaces between FeSb(2-x)Ag(x) and Ag(1-y)Sb(y) phases, as well as the identical work functions, both thermal conductivity and electrical resistivity of the nanocomposites were significantly reduced in the lower temperature ...
McKee Martin - - 2012
Britain's aged population has, so far, been spared the worst of the government's austerity policies, which have impacted most on young people and those of working age. However, this has not gone unnoticed by a number of political pundits who are sowing inter-generational divisions, marshalling often highly selective facts to ...
Kim Mi Jung - - 2012
We report a completely substrate-controlled approach to the asymmetric total synthesis of representative dioxabicyclic bromoallene marine natural products with either a 2,10-dioxabicyclo[7.3.0]dodecene or 2,9-dioxabicyclo[6.3.0]undecene skeleton from commercially available glycidol as a common starting material. The former include (-)-isolaurallene (1), the enantiomeric form of natural (+)-neolaurallene (2), and (+)-itomanallene A (3c), ...
Zhu Qiuhua - - 2012
A new series of C-6 unsubstituted tetrahydropyrimidines 6 have been directly synthesized via a convenient urea-catalyzed chemoselective five-component reaction (5CR) under mild conditions. Compounds 6 show typical aggregation-induced emission enhancement (AIEE) characteristics because they are practically no emissive in solution but emit blue or green fluorescence in aggregates with fluorescence ...
Hersh Julie K JK - - 2013
This is a response to Dr Charlotte Rosalind Blease's paper 'Electroconvulsive Therapy (ECT), the Placebo Effect and Informed Consent', written by Julie K. Hersh who has had ECT. Hersh argues that placebo effect is impossible to prove without endangering the lives of participants in the study. In addition, informing potential ...
Huang Y - - 2012
Leydig cell tumour (LCT) is an uncommon tumour that typically occurs in the testis. Primary epididymal LCT is extremely rare. To the best of our knowledge, only two cases have been reported in the world literature. Herein, we report a case of primary epididymal LCT in a 41-year-old Chinese male. ...
Weisenbach Sara L - - 2012
This study examined sex differences in categorization of facial emotions and in activation of brain regionssupportive of those classifications. In Experiment 1, performance on the Facial Emotion Perception Test (FEPT) was examined among 75 healthy females and 63 healthy males. Females were more accurate in the categorization of fearful expressions ...
Lawo Vera - - 2012
Objectives.Using a novel task-switching variant of dichotic selective listening, we examined age-related differences in the ability to intentionally switch auditory attention between 2 speakers defined by their sex.Method.In our task, young (M(age) = 23.2 years) and older adults (M(age) = 66.6 years) performed a numerical size categorization on spoken number ...
Robinson Nicola - - 2012
OBJECTIVES: To explore barriers, challenges and best practice within patient and public engagement (PPE) in sexual and reproductive health and HIV (SRHH) services in London. METHODS: Consultation exercise using qualitative interviews with 27 stakeholders including commissioners, managers, voluntary/community organizations (VCOs) clinicians and patients, analysed using Framework Analysis and Atlas.ti software. ...
Hammes Stefan - - 2012
Background: The demand for hair and tattoo removal with laser and IPL technology (intense pulsed light technology) is continually increasing. Nowadays these treatments are often carried out by medical laypersons without medical supervision in franchise companies, wellness facilities, cosmetic institutes and hair or tattoo studios. This is the first survey ...
Cole Martin G - - 2012
OBJECTIVE: To describe Confusion Assessment Method (CAM) core symptoms of delirium occurring before and after incident episodes of delirium in older long-term care (LTC) residents. A secondary objective was to describe the mean number of symptoms before and after episodes by dementia status. DESIGN: Secondary analysis of data collected for ...
Yeman Helen - - 2012
The interactions of different analytes with monomeric and hydride-modified stationary phases have been investigated employing suspended-state NMR spectroscopy. The suspended-state high-resolution/magic-angle-spinning (1) H-NMR spectrum of an analyte in the presence of C(18) SP material shows a splitting into two sets of signals for the analyte molecule. One state reflects a ...
Miki Yuichi - - 2012
Photodynamic therapy (PDT) induces selective cell death of neoplastic tissue and connecting vasculature by combining photosensitizers with light. Here we clarified the types of cell death induced by PDT in combination with the photosensitizer talaporfin sodium (mono-L-aspartyl chlorine e6, NPe6) in order to evaluate the potential of this therapy as ...
Waegeneers Nadia - - 2012
The total selenium content of about 800 food products purchased in Belgium was determined and combined with food records to determine the nutritional selenium status of Belgian people. The largest selenium concentrations (>1 mg kg(-1)) were found in Brazil nuts and offal, of which the consumption is limited. Usually consumed food groups ...
Seow Kok-Min - - 2012
Prolongation of gastrointestinal transit resulting in nausea and vomiting in pregnancy (NVP) is the most common phenomenon during the first trimester of pregnancy. Increased human chorionic gonadotropin (hCG) levels during the first trimester is the most likely cause of NVP. The aim of this study was to investigate the effect ...
Nesrallah Gihad E - - 2012
BackgroundIntradialytic hypotension (IDH) is associated with morbidity and mortality. We conducted a systematic review to determine whether biofeedback hemodialysis (HD) can improve IDH and other outcomes, compared with HD without biofeedback.MethodsData sources included the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and ISI Web of Science. We included randomized ...
Stocker Thomas F - - 2012
The linear relationship between cumulative carbon emissions and global climate warming implies that as mitigation is delayed, climate targets become unachievable.
Humble Margaret M MM Mitochondrial DNA Replication Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, - - 2013
Mammalian mitochondrial DNA (mtDNA) is replicated by the heterotrimeric Pol γ comprised of a single catalytic subunit, encoded by Polg, and a homodimeric accessory subunit encoded by the Polg2 gene. While the catalytic subunit has been shown to be essential for embryo development, genetic data regarding the accessory subunit are ...
Ou Hsiu-Chung - - 2013
Atherosclerosis is a complex inflammatory arterial disease, and oxidized low-density lipoprotein (oxLDL) is directly associated with chronic vascular inflammation. Previous studies have shown that Ginkgo biloba extract (GbE) acts as a therapeutic agent for neurological and cardiovascular disorders. However, the mechanisms mediating the actions of GbE are still largely unknown. ...
Liu Xiao Ming - - 2012
In situ high-pressure Raman spectroscopy, with corroborating density functional calculations, is used to probe C-H chemical bonds formed when dissociated hydrogen diffuses from a platinum nanocatalyst to three distinct graphenic surfaces. At ambient temperature, hydrogenation and dehydrogenation is reversible in the combined presence of an active catalyst and oxygen heteroatoms. ...
Mukherjee Shaunak - - 2012
Heterogeneous catalysis is of paramount importance in chemistry and energy applications. Catalysts that couple light energy into chemical reactions in a directed, orbital-specific manner would greatly reduce the energy input requirements of chemical transformations, revolutionizing catalysis-driven chemistry. Here we report the room temperature dissociation of H2 on gold nanoparticles using ...
Shim Jihyun - - 2012
Amino acid side-chain fluctuations play an essential role in the structure and function of proteins. Accordingly, in theoretical studies of proteins, it is important to have an accurate description of their conformational properties. Recently, new side-chain torsion parameters were introduced into the CHARMM and Amber additive force fields and evaluated ...
Koriem Khaled M M - - 2012
Abstract Cadmium has been classified as an environmental pollutant and human carcinogen. Pectin is a family of complex polysaccharides that function as hydrating agents and cementing materials for the cellulosic network. The aim of this study was to evaluate the protective role of pectin against cadmium induced testicular toxicity and ...
Mowrey Corinne - - 2012
Behavior-based ergonomics therapy (BBET) has been proposed in the past as a viable individualized non-pharmacological intervention to manage challenging behaviors and promote engagement among long-term care residents diagnosed with Alzheimer's/dementia. We evaluate the effect of BBET on quality of life and behavioral medication usage in an 18-bed dementia care unit ...
Barsukova-Stuckart Maria - - 2012
A total of 16 discrete polyoxopalladates(II) [MO(8)Pd(II)(12)L(8)](n-), with a metal ion M encapsulated in a cuboid-shaped {Pd(12)O(8)L(8)} cage, have been synthesized: the phenylarsonate-capped series (1) L = PhAsO(3)(2-), M = Sc(3+) (ScPhAs), Mn(2+) (MnPhAs), Fe(3+) (FePhAs), Co(2+) (CoPhAs), Ni(2+) (NiPhAs), Cu(2+) (CuPhAs), Zn(2+) (ZnPhAs); the phenylphosphonate-capped series: (2) L = ...
Argay Márton - - 2012
Objective: To obtain informationon the main causatives of acute myocardialinfarction (AMI), the background needs to be analyzed. Our aim was to identify those pharmaceutical aspects of this polymorbidity where the pharmacist can contribute. Earlier and recent European and Hungarian studies show similar results: cardiovascular (CV) death is still the leading ...
de Vries Eva E - - 2012
BackgroundAlthough acceptable outcomes have been reported in kidney transplantation from donation after cardiac death (DCD), little is known about kidney transplantation from paediatric DCD. The objective of this study was to compare the outcome of kidney transplantation using paediatric DCD with the outcome of paediatric donation after brain death (DBD).MethodsRecipients ...
Yin Guochuan - - 2012
Multiple transition metal functional groups including metaloxo, hydroxo, and hydroperoxide groups play significant roles in various biological and chemical oxidations such as electron transfer, oxygen transfer, and hydrogen abstraction. Further studies that clarify their oxidative relationships and the relationship between their reactivity and their physicochemical properties will expand our ability ...
Bannas P - - 2012
Imaging studies are essential for both diagnosis and initial staging of multiple myeloma, as well as for differentiation from other monoclonal plasma cell diseases. Apart from conventional radiography, a variety of newer imaging modalities including whole-body low-dose-CT, whole-body MRI and 18F-FDG PET/CT may be used for detection of osseous and ...
Suzuki Takeshi - - 2012
Non-diapausing spider mites (Tetranychus urticae) live on the undersurface of host leaves during summer, but diapausing mites overwinter in dark hibernacula. The light environments of these habitats would differ: visible radiation (VIS) but not ultraviolet radiation (UV) would reach the undersurface, but neither would enter dark hibernacula. Thus, mites of ...
Falcão L F R - - 2012
BACKGROUND: /st>The use of ultrasound (US) in regional anaesthesia enables a reduction in the local anaesthetic volume. The present study aimed to determine the minimum effective volume (MEV(90)) of 0.5% bupivacaine with epinephrine for interscalene brachial plexus block (ISBPB). METHODS: /st>The volume of the anaesthetic was determined using a step-up/step-down ...
Kempf Kerstin - - 2013
Effects of lifestyle change on blood glucose levels can be monitored by self-monitoring of blood glucose (SMBG) in type 2 diabetes mellitus (T2DM) patients. We analyzed whether the SMBG-structured lifestyle intervention program ROSSO-in-praxi-international can improve glucometabolic control in the short and the long term. One hundred twenty-four SMBG-naive ambulatory non-insulin-treated ...
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