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Groenewald C C Ocular Oncology Service, St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, - - 2013
Most uveal melanomas are treated with radiotherapy. An adequate understanding of the effects of radiation on the tumour and the healthy ocular tissues is necessary. Ionizing radiation damages cell membranes, organelles, and DNA. Irradiated cells are lysed or undergo apoptosis, necrosis, and senescence. These effects occur in tumour cells and ...
Davis J L JL Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. - - 2013
Primary vitreoretinal lymphoma (PVRL) is a rare malignancy that is speculated to arise extraocularly, and preferentially invade and flourish in the ocular and CNS microenvironments. The eye is involved in about 20% of primary central nervous system lymphomas, but the brain is eventually involved in about 80% of PVRL. Most ...
Rene C C Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. - - 2013
It is estimated that 5-10% of all cutaneous malignancies involve the periocular region and management of periocular skin cancers account for a significant proportion of the oculoplastic surgeon's workload. Epithelial tumours are most frequently encountered, including basal cell carcinoma, squamous cell carcinoma, and sebaceous gland carcinoma, in decreasing order of ...
Imao T T Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, - - 2013
Two major apoptosis pathways, the mitochondrial and death receptor pathways, are well recognized. Here we established cell lines from the fetal thymus of Apaf-1-, Caspase-9-, or Bax/Bak-deficient mice. These cell lines were resistant to apoptosis induced by DNA-damaging agents, RNA or protein synthesis inhibitors, or stress in the endoplasmic reticulum. ...
Cavicchia Philip P PP South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, - - 2013
Type 2 diabetes mellitus (T2DM) prevalence has increased dramatically in the United States since the early 1970s. Though T2DM is known to be associated with colorectal cancer (CRC), information on racial differences in the relationship between T2DM and CRC is limited. Using a retrospective cohort design, we compared the association ...
Heimann H H Ocular Oncology Unit, Royal Liverpool University Hospital, Liverpool, UK. - - 2013
The most common intraocular vascular tumours are choroidal haemangiomas, vasoproliferative tumours, and retinal haemangioblastomas. Rarer conditions include cavernous retinal angioma and arteriovenous malformations. Options for ablating the tumour include photodynamic therapy, argon laser photocoagulation, trans-scleral diathermy, cryotherapy, anti-angiogenic agents, plaque radiotherapy, and proton beam radiotherapy. Secondary effects are common and ...
Mancini Massimiliano M Department of Radiology, Oncology and Pathology, Sapienza University of Rome, Rome, - - 2013
The mechanisms underlying coronary microvascular remodeling and dysfunction, which are critical determinants of abnormal myocardial blood flow regulation in human hypertension, are poorly understood. The spontaneously hypertensive rat (SHR) exhibits many features of human hypertensive cardiomyopathy. We demonstrate that remodeling of intramural coronary arterioles is apparent in the SHR already ...
Buckley Christopher D CD Rheumatology Research Group at the Centre for Translational Inflammation Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham, B15 2WD, UK. - - 2013
In 2012, Nature Reviews Immunology organized a conference that brought together scientists and clinicians from both academia and industry to discuss one of the most pressing questions in medicine--how do we turn off rampant, undesirable inflammation? There is a growing appreciation that, similarly to the initiation of inflammation, the resolution ...
Vyas R R Center for the Biology of Disease, Laboratory for Molecular Cancer Biology, VIB, Leuven, - - 2013
Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signaling and repair proteins to the sites of DNA lesions. Coordinated protein SUMOylation and ubiquitylation have crucial roles in regulating the dynamic assembly of protein ...
Ooi Y L YL Department of Ophthalmology, University of Malaya, Kuala Lumpur, - - 2013
To compare the potential retinal toxicity of two commercially Brilliant blue G dyes (Brilliant Peel and Ocublue Plus) and Indocyanine green (ICG) at usual clinical concentration. Brilliant Peel 0.025% (n=9), Ocublue Plus 0.025% (n=9), and ICG 0.05% (n=9) were injected intravitreally into Sprague-Dawley rat left eyes with balanced salt solution ...
Lassen U U Department of Oncology 5072, The Finsen Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. - - 2013
To investigate any effect of a CYP3A4 inhibitor (ketoconazole) or inducer (rifampicin) on cediranib steady-state pharmacokinetics in patients with advanced solid tumours. In two Phase I, open-label trials, patients received once-daily oral doses of cediranib alone [20 mg (ketoconazole study); 45 mg (rifampicin study)] for 7 days followed by cediranib ...
Rekhtman Natasha N Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. - - 2013
Pulmonary large-cell carcinoma-a diagnostically and clinically controversial entity-is defined as a non-small-cell carcinoma lacking morphologic differentiation of either adenocarcinoma or squamous cell carcinoma, but suspected to represent an end stage of poor differentiation of these tumor types. Given the recent advances in immunohistochemistry to distinguish adenocarcinoma and squamous cell carcinoma, ...
Andrews Samantha N SN Wallace Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, 30332, - - 2013
Most methods to increase transdermal drug delivery focus on increasing stratum corneum permeability, without addressing the need to increase permeability of viable epidermis. Here, we assess the hypothesis that viable epidermis offers a significant permeability barrier that becomes rate limiting upon sufficient permeabilization of stratum corneum. We tested this hypothesis ...
Hellerstedt W L WL Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA. - - 2013
To examine the associations of maternal and infant complications with postpartum hospitalisation for psychosis in women with a pre-conception history of psychiatric hospitalisation. Population-based study. Swedish medical birth register. Primiparous women who gave birth between 1 January 1987 and 31 December 2001, and who had a pre-conception history of psychiatric hospitalisation but who were ...
Paley Michael A MA Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, - - 2012
Chronic infections strain the regenerative capacity of antiviral T lymphocyte populations, leading to failure in long-term immunity. The cellular and molecular events controlling this regenerative capacity, however, are unknown. We found that two distinct states of virus-specific CD8(+) T cells exist in chronically infected mice and humans. Differential expression of ...
Williams Christopher C Department of Organic and Biological Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, - - 2012
Placental development and genomic imprinting coevolved with parental conflict over resource distribution to mammalian offspring. The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respectively. M6P/IGF2R of birds and fish do not recognize IGF2. In ...
Tei-Tominaga Maki M Department of Nursing, Hyogo University of Health Sciences, 1-3-6 Minatojima, Chuo-ku, Kobe 650-8530, Japan. - - 2013
This study examined factors related to the intention to leave and the decision to resign, including individual and psychosocial factors in the work environment, among newly graduated nurses (NGNs). We distributed an anonymous self-administered questionnaire to all NGNs (n = 1,477) in a selected prefecture in Japan. The response rate was 41 %. ...
Limaye Alpna R AR Section of Hepatobiliary Diseases, Department of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida, - - 2013
The goal of this study is to evaluate whether an elevated neutrophil-lymphocyte ratio (NLR) at the time of diagnosis predicts survival of patients with hepatocellular carcinoma (HCC) after liver transplantation (LT). We hypothesize that the NLR is predictive of overall survival (OS) and recurrence-free survival (RFS) in patients with HCC ...
Poelma Justin E - - 2012
Block copolymer lithography holds promise as a next-generation technique to achieve the sub-20 nm feature sizes demanded by semiconductor roadmaps. While molecular weight and block immiscibility have traditionally been used to control feature size, this study demonstrates that macromolecular architecture is also a powerful tool for tuning domain spacing. To ...
Hirohata Toshio - - 2012
Adult growth hormone (GH) deficiency (AGHD) in Japan is diagnosed based on peak GH concentrations during GH provocative tests such as GHRP-2 stimulation test. In this study, we aimed to evaluate the ability of serum insulin-like growth factor-1 (sIGF-1) and urinary GH (uGH) at the time of awakening to diagnose ...
Francis Jawad - - 2012
Abstract Aberrant expression of the B lymphoid marker, CD19, in acute myeloid leukemia (AML) has frequently been associated with t(8;21)(q22;q22). However, AML cases lacking t(8;21) may occasionally express CD19. We asked if CD19 expression is restricted to the karyotypically abnormal leukemic cells in primary leukemia samples. We compared, by fluorescence ...
Tsurumi Arihito - - 2012
BACKGROUND: Virtual Histology intravascular ultrasound (VH IVUS) volumetric analysis (analysis of the entire plaque responsible for stenosis) has been used for carotid plaque diagnosis. Knowing the carotid plaque characteristics by analyzing the plaque composition only at the minimum lumen site will facilitate plaque diagnosis using VH IVUS. PURPOSE: To detect ...
Kershaw Cook Laurence J - - 2012
The syntheses of 2,6-di(pyrid-2-yl)pyrazine (L(1)), 2,6-di(pyrazinyl)pyridine (L(2)), 2,2':6',2''-terpyrazine (L(3)), 2,6-di(pyrimidin-4-yl)pyridine (L(4)), 2,6-di(1,2,4-triazin-3-yl)pyridine (L(5)), 4-hydroxy-2,6-di(pyrazinyl)pyridine (L(6)) and 4-hydroxy-2,6-di(pyrimidin-2-yl)pyridine (L(7)) are described. Homoleptic iron(ii) and cobalt(ii) complexes of these ligands have been prepared and, in four cases, structurally characterised. The iron complexes are all low-spin. However, while the cobalt complexes of the ...
Hanna Fikry Younan - - 2012
Conditions affecting the brachial plexus and its branches can cause lameness and/or neurological deficits. There are few reports of schwannomas in cats. In reported cases, the tumours arose from the dermis or subcutis of the limbs, head and neck and thorax, but there are no reports of primary tumours that ...
Yan Zheng - - 2012
Graphene was grown directly on porous nickel films, followed by the growth of controlled lengths of vertical carbon nanotube (CNT) forests that seamlessly emanate from the graphene surface. The metal-graphene-CNT structure is used to directly fabricate field-emitter devices and double-layer capacitors. The three dimensional nanostructured hybrid materials, with better interfacial ...
Romero Melissa R - - 2012
In many marine animals, adult habitat is selected by lecithotrophic (non-feeding) larvae with a limited lifespan. In generalist species, larvae may increasingly accept sub-optimal habitat over time as energy stores are depleted ('desperate larva' hypothesis). If the fitness cost of suboptimal habitat is too high, larvae of specialists may prolong ...
Liu Qiang - - 2012
Electrothermal injuries in monopolar laparoscopy may derive indirectly, but rarely, from capacitive coupling releasing stray currents into neighboring non-targeted tissues, with intact instrument insulation. Since 2007, seven episodes of indirect electrosurgical damage to non-targeted tissues have been observed in our gynecological practice, including incidental coagulative necrosis of appendix, Fallopian tube, ...
Cook Richard - - 2012
Imitation of facial gestures requires the cognitive system to equate the seen-but-unfelt with the felt-but-unseen. Rival accounts propose that this "correspondence problem" is solved either by an innate supramodal mechanism (the active intermodal-mapping, or AIM, model) or by learned, direct links between the corresponding visual and proprioceptive representations of actions ...
Zhou Qing - - 2012
Efficient multiple-electron redox reactions are performed by galactoase oxidase, cysteine dioxygenase, sulfite reductase, and cytochrome c nitrite reductase. A post-translationally modified tyrosine-cysteine cross-link (Tyr-Cys) in their active sites is essential for their functions.
Rodgers Christopher T - - 2012
At clinical MRI field strengths (1.5 and 3 T), quantitative maps of the longitudinal relaxation time T(1) of the myocardium reveal diseased tissue without requiring contrast agents. Cardiac T(1) maps can be measured by Look-Locker inversion recovery sequences such as ShMOLLI at 1.5 and 3 T. Cardiovascular MRI at a ...
Xifre-Perez Elisabet - - 2012
Reflection in a mirror changes the handedness of the real world and right-handed objects turn left-handed and vice versa (M. Gardner, The ambidextrous Universe, Penguin Books, 1964). Also, we learn from electromagnetism textbooks that a flat metallic mirror transforms an electric charge into a virtual opposite charge. Consequently, the mirror ...
Burst Volker - - 2012
BackgroundEndogenous bone marrow-derived cells are known to incorporate into renal epithelium at a low rate. Haematopoietic stem cells (HSCs) rather than mesenchymal stem cells (MSC) are responsible for this phenomenon. MSCs have the potential to ameliorate kidney function after acute kidney injury (AKI) without directly repopulating the tubules. However, little ...
Nestor Jeremie - - 2012
A new simple one-step method has been developed to obtain SiO2 monolithic materials with a bimodal meso- and macroporous pore-size distribution. Sol-gel reactions were carried out in the continuous phase of highly concentrated emulsions with a cubic liquid crystal in this external phase, using a polyoxyethylene alkyl ether surfactant and ...
Yang Yufei - - 2012
The disposal of soil contaminated with polybrominated diphenyl ether (PBDE) was studied using an industrial co-processing cement kiln. Two tests, Test 1 and Test 2, studied the destruction, removal and emissions of PBDE in soils with PBDE concentrations of 4,160 and 25,000 mg/kg, respectively. Emissions of polybrominated dibenzo-p-dioxins and dibenzofurans ...
Keebler Daniel - - 2012
Population-type models, accounting for phenomena such as population lifetimes, mixing patterns, recruitment patterns, genetic evolution and environmental conditions, can be usefully applied to the biology of HIV infection and viral replication. A simple dynamic model can explore the effect of a vaccine-like stimulus on the mortality and infectiousness, which formally ...
Leroux Lionel - - 2012
Severe anaphylactoid reaction after the use of iodinated contrast media are rare but can contraindicate the use of contrast agent. It was the case of a 53-year-old woman suffering from symptomatic severe aortic stenosis, recused for cardiac surgery because of deleterious effects of chest-wall irradiation, with porcelain aorta. We decided ...
Chhibber Aditya - - 2012
Abstract Objective: To compare the dentoskeletal effects and treatment efficiency of the Twin Force Bite Corrector (TFBC) appliance in Class II correction of patients treated before or after the pubertal growth spurt. Materials and Methods: Forty-one normodivergent Class II patients treated with the TFBC appliance were divided into two groups ...
Fonvielle Matthieu - - 2012
Peptidyl-RNA conjugates have various applications in studying the ribosome and enzymes participating in tRNA-dependent pathways such as Fem transferases in peptidoglycan synthesis. Herein a convergent synthesis of peptidyl-RNAs based on Huisgen-Sharpless cycloaddition for the final ligation step is developed. Azides and alkynes are introduced into tRNA and UDP-MurNAc-pentapeptide, respectively. Synthesis ...
Kondakova Anna N - - 2012
A novel constituent of bacterial polysaccharides, 2,3,4-triacetamido-2,3,4-trideoxy-l-arabinose, was found in the O-specific polysaccharide from the lipopolysaccharide of Psychrobacter cryohalolentis K5(T) and identified by 1D and 2D (1)H and (13)C NMR studies of the polysaccharide and a disaccharide obtained by solvolysis of the polysaccharide with triflic acid. The following structure of ...
Fifi J T - - 2012
BACKGROUND AND PURPOSE:Antiplatelet drug resistance has been associated with thromboembolic complications in patients after coronary stent placement. It has not been well-studied in patients who have neurovascular stent-placement procedures. This study aimed to analyze the relationship between antiplatelet drug resistance and neurovascular stent-placement complications.MATERIALS AND METHODS:A prospective data base of ...
Arnold Melina - - 2012
Background. Migrant populations usually experience a health transition with respect to their cancer risk as a result from environmental changes and acculturation processes. We investigated potentially contrasting experiences with breast and stomach cancer risk and survival in migrants to the Netherlands in a retrospective cohort study. Methods. Invasive breast (n ...
Abdul-Ridha Alaa - - 2012
DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) are chemogenetically modified muscarinic acetylcholine receptors (mAChRs) that have minimal responsiveness to acetylcholine (ACh), but are potently and efficaciously activated by an otherwise inert synthetic ligand, clozapine-N-oxide (CNO). DREADDs have been used as tools for selectively modulating signal transduction pathways in vitro ...
Lei Ting - - 2012
Ambipolar transport behavior in isoindigo-based conjugated polymers is observed for the first time. Fluorination on the isoindigo unit effectively lowers the LUMO level of the polymer and significantly increases the electron mobility from 10-2 to 0.43 cm2 V-1 s-1 while maintaining high hole mobility to 1.85 cm2 V-1 s-1 for ...
Jeon Ju-Hyun - - 2012
The acaricidal activities of an active constituent derived from Ostericum koreanum roots and its derivatives were determined using fumigant and direct-contact toxicity bioassays against Dermatophagoides farinae and D. pteronyssinus. This was compared with that of commercial acaricide (benzyl benzoate). In the fumigant toxicity bioassay, 4-chloro-6-isopropyl-3-methylphenol (0.29 μg/cm2) was 37.17 times ...
Zang Yashu - - 2012
Periodic Ag nanoball (NB) arrays on ZnO hollow nanosphere (HNS) supporting structures were fabricated in a large area by a laser irradiation method. The optimized laser power and spherical supporting structure of ZnO with a certain size and separation were employed to aggregate a sputtering-deposited Ag nano-film into an ordered, ...
Burdisso Paula - - 2012
Dicer-like Ribonuclease III enzymes are involved in different paths related to RNA silencing in plants. Little is known about the structural aspects of these processes. Here we present a structural characterization of the second double-stranded-RNA-binding domain (dsRBD) of DCL1, which is presumed to participate in pri-miRNA recognition and subcellular localization ...
Chuang Kai-Jen - - 2012
Background: Aromatherapy is widely used around the world for stress relief. Whether exposure to essential oil increases the risk of cardiovascular events is still unknown. The purpose of this study was to investigate the effect of essential oil on heart rate and blood pressure among solus por aqua (spa) workers.Methods: ...
Zhao Huaizhou - - 2012
We present the figure-of-merit (ZT) improvement in nanostructured FeSb(2-x)Ag(x) with Ag(1-y)Sb(y) nanoinclusions through a metal/semiconductor interface engineering approach. Owing to the interfaces between FeSb(2-x)Ag(x) and Ag(1-y)Sb(y) phases, as well as the identical work functions, both thermal conductivity and electrical resistivity of the nanocomposites were significantly reduced in the lower temperature ...
McKee Martin - - 2012
Britain's aged population has, so far, been spared the worst of the government's austerity policies, which have impacted most on young people and those of working age. However, this has not gone unnoticed by a number of political pundits who are sowing inter-generational divisions, marshalling often highly selective facts to ...
Kim Mi Jung - - 2012
We report a completely substrate-controlled approach to the asymmetric total synthesis of representative dioxabicyclic bromoallene marine natural products with either a 2,10-dioxabicyclo[7.3.0]dodecene or 2,9-dioxabicyclo[6.3.0]undecene skeleton from commercially available glycidol as a common starting material. The former include (-)-isolaurallene (1), the enantiomeric form of natural (+)-neolaurallene (2), and (+)-itomanallene A (3c), ...
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