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Hall Matthew M Department of Policy Analysis and Management, Cornell University, Ithaca, NY, 14853, USA, - - 2013
This article explores patterns and determinants of immigrant segregation for 10 immigrant groups in established, new, and minor destination areas. Using a group-specific typology of metropolitan destinations, this study finds that without controls for immigrant-group and metropolitan-level characteristics, immigrants in new destinations are more segregated and immigrants in minor destinations ...
Baluom Muhammad M Rigel Pharmaceuticals, Inc., 1180 Veterans Blvd., South San Francisco, CA 94080, USA. - - 2013
Fostamatinib (R788) is an orally dosed prodrug designed to deliver the active metabolite R940406 (R406), a spleen tyrosine kinase (SYK) inhibitor, for the treatment of rheumatoid arthritis. The objectives were to evaluate the human pharmacokinetic properties of fostamatinib and R406. Three clinical studies were conducted in healthy subjects: (A) A ...
Palmer John R B JR Woodrow Wilson School of Public and International Affairs and Office of Population Research, Princeton University, 284 Wallace Hall, Princeton, NJ 08544, USA. - - 2013
This article explores new methods for gathering and analyzing spatially rich demographic data using mobile phones. It describes a pilot study (the Human Mobility Project) in which volunteers around the world were successfully recruited to share GPS and cellular tower information on their trajectories and respond to dynamic, location-based surveys ...
Riosmena Fernando F University of Colorado at Boulder, 483 UCB, Boulder, CO 80309, USA. - - 2013
In this article, we test for four potential explanations of the Hispanic Health Paradox (HHP): the "salmon bias," emigration selection, and sociocultural protection originating in either destination or sending country. To reduce biases related to attrition by return migration typical of most U.S.-based surveys, we combine data from the Mexican ...
Goyal Akash A Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, - - 2013
As an astrocytic protein specific to the central nervous system, S100b is a potentially useful marker in outcome prediction after traumatic brain injury (TBI). Some studies have questioned the validity of S100b, citing the extracerebral origins of the protein as reducing the specificity of the marker. This study evaluated S100b ...
Miranda Daniel L DL Department of Orthopaedics, The Warren Alpert Medical School, Brown University and Rhode Island Hospital, Providence, RI 02903, - - 2013
The purpose of this study was to compare kinetic and knee kinematic measurements from male and female anterior cruciate ligament (ACL)-intact (ACLINT) and ACL-reconstructed (ACLREC) subjects during a jump-cut maneuver using biplanar videoradiography. Twenty subjects were recruited; 10 ACLINT (5 men and 5 women) and 10 ACLREC (4 men and ...
Thornberry Terence P TP Department of Criminology and Criminal Justice, University of Maryland, 2220 LeFrak Hall, College Park, MD 20742, USA. - - 2013
Identification of the causes of child maltreatment perpetration is prerequisite for developing efficacious prevention initiatives to reduce its occurrence. Earlier maltreatment victimization is often suggested as an important cause of subsequent maltreatment perpetration. This study investigates a) whether maltreatment victimization causes subsequent perpetration and b) whether the timing of maltreatment ...
Cahoon Elizabeth K EK Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, NIH, Bethesda, Maryland, USA. - - 2013
Serum thyroglobulin (Tg) has been associated with a number of thyroid disorders and has been proposed as an indicator of iodine deficiency in a population. However, few studies have addressed the epidemiology of Tg in a population-based setting or in the context of exposure to radioactive iodine-131 (I-131). Our objective ...
Dahl-Petersen Inger Katrine IK National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. - - 2013
Information about physical activity (PA) in Greenland is limited, partly because of a lack of validated instruments in countries with non-Western living conditions. We modified the long form of the International Physical Activity Questionnaire (IPAQ-L) to arctic living conditions. The aim of the study was to compare IPAQ-L estimates with ...
Hardesty Christina K CK Division of Pediatric Orthopaedics, Rainbow Babies and Children's Hospital, University Hospitals Case Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, - - 2013
Are obese patients with idiopathic scoliosis undergoing spinal surgery at higher risk for perioperative complications? This is not clearly understood. One previous study showed a greater preoperative thoracic kyphosis but no increase in perioperative complications. We asked whether obese adolescents with idiopathic scoliosis have more perioperative complications and decreased curve ...
Mason Caitlin C Fred Hutchinson Cancer Research Center, Seattle, WA 98109, - - 2013
The objective of this study is to investigate the effects of 12 months of dietary weight loss and/or aerobic exercise on lean mass and the measurements defining sarcopenia in postmenopausal women and to examine the potential moderating effect of serum 25-hydroxyvitamin D (25(OH)D) and age. Four hundred thirty-nine overweight and ...
Trilk Jennifer L JL Department of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USA. - - 2013
Nonalcoholic fatty liver disease (NAFLD) is considered the liver component of the metabolic syndrome and is strongly associated with cardiometabolic diseases. In adults, cardiorespiratory fitness (CRF) is inversely associated with alanine aminotransferase (ALT), a blood biomarker for NAFLD. However, information regarding these associations is scarce for youth. The objective of ...
Priyadharshini Bhavana B Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, - - 2013
Blockade of co-stimulatory signals to T cells is extremely effective for the induction of transplantation tolerance in immunologically naive rodents. However, infections and inflammation compromise the efficacy of co-stimulation blockade regimens for the induction of tolerance, thereby stimulating the rejection of allografts. Previous studies have shown that stimulation of innate ...
Williams Paul T PT Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. - - 2013
This study aimed to test whether equivalent changes in moderate (walking) and vigorous exercise (running) produce equivalent weight loss under free-living, nonexperimental conditions. Regression analyses of changes (Δ) in body mass index (BMI) versus exercise energy expenditure (ΔMET-hours per day, 1 MET = 3.5 mL O2·kg·min) from survey questionnaires completed ...
Patel Manish M MM National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. - - 2013
A substantial number of surveillance studies have documented rotavirus prevalence among children admitted for dehydrating diarrhea. We sought to establish global seasonal patterns of rotavirus disease before the introduction of widespread vaccination. We reviewed studies of rotavirus detection in children with diarrhea published since 1995. We assessed potential relationships between ...
Ke Bowen B Department of Chemistry, Center for Biotechnology and Drug Design, and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30302-4098, - - 2013
A stable and highly selective fluorescent probe has been designed and synthesized for the rapid detection of fluoride ions (F(-)) in aqueous solution and living cells. The design was based on the high reactivity of F(-) toward a silyl group.
de Oliveira Martins Daniel D Laboratory of Functional Neuroanatomy of Pain, Department of Anatomy, University of São Paulo, São Paulo, - - 2013
Nerve-related complications have been frequently reported in dental procedures, and a very frequent type of occurrence involves the inferior alveolar nerve (IAN). The nerve injury in humans often results in persistent pain accompanied by allodynia and hyperalgesia. In this investigation, we used an experimental IAN injury in rats, which was ...
Villa Luigi L Division of Nephrology, RWTH Aachen University Hospital, Germany. - - 2013
Mesangioproliferative glomerulonephritis is the most common nephritis worldwide. We examined the effects of low- and high-dose telmisartan, an angiotensin II receptor blocker, in rats with progressive anti-Thy1.1 mesangioproliferative glomerulonephritis in a clinically relevant situation of established renal damage. Uninephrectomized nephritic rats were randomized on day 28 to remain untreated (control ...
Barker Bethan L - - 2013
COPD (chronic obstructive pulmonary disease) is a heterogeneous disease associated with significant morbidity and mortality. Current diagnostic criteria based on the presence of fixed airflow obstruction and symptoms do not integrate the complex pathological changes occurring within lung, do not define different airway inflammatory patterns, nor do they define different ...
Matkowski Adam - - 2013
Mangiferin is a plant natural polyphenol of C-glycosylxanthone structure and various pharmacological activities. It can be found in many plant species, among which the mango tree (Mangifera indica) is one of the primary sources. Mangiferin is also present in some medicinal herbs, influencing their therapeutic and preventive properties, and in ...
Hale Lorna J LJ Academic and Children's Renal Unit, University of Bristol, Learning and Research, Southmead Hospital, Bristol BS10 5NB, - - 2013
Ninety-one years ago insulin was discovered, which was one of the most important medical discoveries in the past century, transforming the lives of millions of diabetic patients. Initially insulin was considered only important for rapid control of blood glucose by its action on a restricted number of tissues; however, it ...
Boot M M Pediatric, Adolescent and Young Adult Section, Genetics & Epidemiology Section, Joslin Diabetes Center, Boston, MA, - - 2013
To evaluate parents' goals and parents' perceptions of physicians' goals for blood glucose and HbA(1c) in children and adolescents with Type 1 diabetes. In a cross-sectional observational assessment, parents (80% mothers) of 153 children/adolescents (56% female), aged 12.9 ± 2.3 years (range 8-16 years) with Type 1 diabetes for 6.3 ± 3.5 years, completed surveys regarding their ...
Choi Sarah E SE Program in Nursing Science, College of Health Sciences, University of California at Irvine, 100B Berk Hall, Irvine, CA 92697-3959, USA. - - 2013
Patients with diabetes have a higher prevalence of depression than the general population. Korean immigrants with type 2 diabetes are understudied. The aim of this study was to identify the prevalence and correlates of depressive symptoms in Korean immigrants. In this cross-sectional descriptive study, a community sample of 164 Korean ...
Quintana Francisco J FJ Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. - - 2013
Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can influence the immune response and the development of autoimmune diseases. ...
Kim Chihwa C Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Kentucky 40202, - - 2013
Ceramide-1-phosphate (C1P) is a bioactive lipid that, in contrast to ceramide, is an antiapoptotic molecule released from cells that are damaged and "leaky." As reported recently, C1P promotes migration of hematopoietic cells. In this article, we tested the hypothesis that C1P released upon tissue damage may play an underappreciated role ...
Lian Xiaojun X Department of Chemical & Biological Engineering University of Wisconsin, Madison, Wisconsin 53706, - - 2013
The study of the regulatory signaling hierarchies of human heart development is limited by a lack of model systems that can reproduce the precise developmental events that occur during human embryogenesis. The advent of human pluripotent stem cell (hPSC) technology and robust cardiac differentiation methods affords a unique opportunity to ...
Singh Lakshman L Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2013
Age-related osteoporosis is characterized by a decrease in bone-forming capacity mediated by defects in the number and function of osteoblasts. An important cellular mechanism that may in part explain osteoblast dysfunction that occurs with aging is senescence of mesenchymal progenitor cells (MPCs). In the telomere-based Wrn(-/-) Terc(-/-) model of accelerated ...
Wang Bo B State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People's Republic of - - 2013
Bark beetles are among the most destructive of pine forest pests and they form close symbiotic relationships with ophiostomatoid fungi. Although some fungi are considered to be mutualistic symbionts of bark beetles with respect to the supply of nutrients, detrimental effects of fungal symbionts on larval growth have also been ...
Schmelz Martin M Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. - - 2013
The ability to predict how another individual will behave is useful in social competition. Chimpanzees can predict the behaviour of another based on what they observe her to see, hear, know and infer. Here we show that chimpanzees act on the assumption that others have preferences that match their own. ...
Murienne Jérôme J Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, - - 2013
The refugial speciation model, or 'species pump', is widely accepted in the context of tropical biogeography and has been advocated as an explanation for present species distributions in tropical Western and Central Africa. In order to test this hypothesis, a phylogeny of the cryptic arachnid order Ricinulei, based on four ...
Jimoh S A SA School of Anatomical Sciences, University of the Witwatersrand, Johannesburg, South - - 2013
The terminal respiratory units of the gas exchange tissue of the avian lung, the air capillaries (ACs) and the blood capillaries (BCs), are small and rigid: the basis of this mechanical feature has been highly contentious. Because the strength of the blood-gas barrier (BGB) of the mammalian lung has been ...
Limbourg Tobias T Netherlands Institute of Ecology (NIOO-KNAW), Wageningen, The - - 2013
Differential allocation (DA)-the adjustment of an individual's parental investment in relation to its mate's attractiveness-is increasingly recognized as an important component of sexual selection. However, although DA is expected by both sexes of parents in species with biparental care, DA by males has rarely been investigated. We have previously demonstrated ...
Binning Sandra A SA Division of Evolution, Ecology and Genetics, Research School of Biology, Australian Research Council Centre of Excellence for Coral Reef Studies, The Australian National University, Canberra, Australian Capital Territory 0200, Australia. - - 2013
Ectoparasites can reduce individual fitness by negatively affecting behavioural, morphological and physiological traits. In fishes, there are potential costs if ectoparasites decrease streamlining, thereby directly compromising swimming performance. Few studies have examined the effects of ectoparasites on fish swimming performance and none distinguish between energetic costs imposed by changes in ...
Rypstra Ann L AL Department of Zoology, Miami University, Hamilton, OH 45011, USA. - - 2013
The role of predators in food webs extends beyond their ability to kill and consume prey. Such trait-mediated effects occur when signals of the predator influence the behaviour of other animals. Because all spiders are silk-producing carnivores, we hypothesized that silk alone would signal other arthropods and enhance non-lethal effects ...
Goldbogen Jeremy A JA Cascadia Research Collective, Olympia, WA 98501, USA. - - 2013
The extreme body size of blue whales requires a high energy intake and therefore demands efficient foraging strategies. As an obligate lunge feeder on aggregations of small zooplankton, blue whales engulf a large volume of prey-laden water in a single, rapid gulp. The efficiency of this feeding mechanism is strongly ...
Lam Carl W CW Department of Chemical Engineering and Materials Science, University of California, Davis, California 95616, - - 2013
Using RIO Tronics utility meter products as an industrial case study, the numeric Fraunhofer Toxic Potential Indicator (TPI) assessment tool is used to determine high impact materials with the aim of reducing the content of inherently toxic substances in these products. However, because product redesign with alternative materials affects entire ...
Gong Deshun - - 2013
Human RBM25 (RNA-binding motif protein 25) is a novel splicing factor that contains a PWI domain, a newly identified RNA/DNA-binding domain, and regulates Bcl-x pre-mRNA alternative splicing. The flanking basic region has been suggested to serve as a co-operative partner of the PWI domain in the binding of nucleic acids, ...
Tsipis Athanassios C AC Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece. - - 2013
The molecular and electronic structures, stabilities, bonding features, magnetotropic and spectroscopic properties of the triangular Pt(3)(μ(2)-L)(3)(L')(3) clusters and their [(μ(3)-Tl)Pt(3)(μ(2)-L)(3)(L')(3)](+) (L = CO, SnR(2), SnH(2), SiR(2), SiH(2), CH(3)CN, PH(2), C(6)F(5), SO(2) or HCN and L' = CO, PH(3), CH(3)CN, C(6)F(5), HCN) half-sandwiches have been studied by means of density functional ...
Garg Scot - - 2013
Coronary artery disease remains one of the major causes of morbidity and mortality worldwide. Percutaneous coronary intervention has been shown to be an effective treatment for angina pectoris, although it does not provide any prognostic benefit in stable patients. Drug-eluting stents (DES) have revolutionised the practice of interventional cardiology by ...
El Khoury C - - 2013
Fibrinolysis had long been the reference treatment in patients with ST-Elevation Myocardial Infarction (STEMI). It was associated with a large reduction in mortality as compared with delayed or no reperfusion in patients managed early, within the first 2 hours from the onset of symptoms. Fibrinolysis also had well-known potential complications: cerebral ...
Mulvaney J F JF Division of Otolaryngology, Department of Surgery, School of Medicine, University of California, San Diego, La Jolla, CA, USA. - - 2013
In the cochlea, patterning of the organ of Corti is tightly regulated to produce a single row of sound-detecting inner hair cells and three rows of outer hair cells, which amplify and refine the signal. The recently identified R-Spondin family of signaling molecules usually act as co-activators of Wnt signaling; ...
Kopecky Benjamin J BJ University of Iowa, Department of Biology, Iowa City, IA 52242, USA. - - 2013
Hearing restoration through hair cell regeneration will require revealing the dynamic interactions between proliferation and differentiation during development to avoid the limited viability of regenerated hair cells. Pax2-Cre N-Myc conditional knockout (CKO) mice highlighted the need of N-Myc for proper neurosensory development and possible redundancy with L-Myc. The late-onset hair ...
Toda Noboru N Toyama Institute for Cardiovascular Pharmacology Research, Osaka, Japan. - - 2013
Aldosterone, in doses inappropriate to the salt status, plays an important role in the development of cardiovascular injury, including endothelial dysfunction, independent of its hypertensive effects. Acute non-genomic effects of aldosterone acting on mineralocorticoid receptors are inconsistent in healthy humans: vasoconstriction or forearm blood flow decrease via endothelial dysfunction, vasodilatation ...
Matsuo Yuichi Y Departments of Environmental and Preventive Medicine, Oita University, Yufu-City, Oita, - - 2013
Helicobacter pylori cagA can be classified into mainly two types (East-Asian-type and Western-type cagA) according to the repeat regions located in the 3' region. Recent studies showed that the Western-type cagA in strains from Okinawa, Japan formed a different cluster (J-Western-type cagA subtype). It has also been reported that J-Western-type ...
Andrews Daniel A DA Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, - - 2013
The bacterial flagellar motor is an intricate nanomachine powered by a transmembrane electrochemical gradient. Rotation is driven by the cumulative action of several peptidoglycan-anchored stator complexes on the rotor. In proton-motive force-driven motors, the stator complex is composed of a motility protein B (MotB) dimer surrounded by four copies of ...
Meikle S T ST Brighton Studies in Tissue-mimicry and Aided Regeneration, School of Pharmacy and Biomolecular Sciences, University of Brighton, , Huxley Building, Lewes Road, Brighton, - - 2013
The lack of direct bonding between the surface of an implant and the mineralized bony tissue is among the main causes of aseptic loosening in titanium-based implants. Surface etching and ceramic coatings have led to improved osteointegration, but their clinical performance is still limited either by partial bonding or by ...
de Back Walter W Center for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, - - 2013
The cell fate decision of multi-potent pancreatic progenitor cells between the exocrine and endocrine lineages is regulated by Notch signalling, mediated by cell-cell interactions. However, canonical models of Notch-mediated lateral inhibition cannot explain the scattered spatial distribution of endocrine cells and the cell-type ratio in the developing pancreas. Based on ...
Suvakov Milovan M Department of Theoretical Physics, Jo┼Żef Stefan Institute, Ljubljana, - - 2013
Quantitative study of collective dynamics in online social networks is a new challenge based on the abundance of empirical data. Conclusions, however, may depend on factors such as user's psychology profiles and their reasons to use the online contacts. In this study, we have compiled and analysed two datasets from ...
Williamson Kate A KA Cardiovascular Research Group, University of Manchester, 3rd Floor Core Technology Facility, 46 Grafton St., Manchester, M13 9NT, - - 2013
Aging poses one of the largest risk factors for the development of cardiovascular disease. The increased propensity toward vascular pathology with advancing age maybe explained, in part, by a reduction in the ability of circulating endothelial progenitor cells to contribute to vascular repair and regeneration. Although there is evidence to ...
Rogers Alan R - - 2013
Males of many species help in the care and provisioning of offspring, and these investments often correlate with genetic relatedness. For example, many human males invest in the children of sisters, and this is especially so where men are less likely to share genes with children of wives. Although this ...
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