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Results 351 - 400 of 2475
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Levic K - - 2012
BACKGROUND: Transanal endoscopic microsurgery (TEM) allows locally complete resection of early rectal cancer as an alternative to conventional radical surgery. In case of unfavourable histology after TEM, or positive resection margins, salvage surgery can be performed. However, it is unclear if the results are equivalent to primary treatment with total ...
O'Mahony Aoife M - - 2012
PURPOSE: Development of RNA interference based therapeutics for neurological and neurodegenerative diseases is hindered by a lack of non-viral vectors with suitable properties for systemic administration. Amphiphilic and cationic cyclodextrins (CD) offer potential for neuronal siRNA delivery. We aimed to improve our CD-based siRNA formulation through incorporation of a polyethyleneglycol ...
Ricci Zaccaria - - 2012
ABSTRACT: Diagnosis and classification of acute kidney injury was addressed systematically only 8 years ago when the classification called RIFLE (acronym of Risk, Injury, Failure, Loss of function and End stage Kidney disease describing progressive severity of renal damage) was created. Since then, several studies have tried to apply, validate, ...
Wiggett Alison J AJ School of Psychology, Adeilad Brigantia, Bangor University, Bangor, LL57 2AS, Wales, UK. - - 2013
The observation of someone else's action facilitates similar actions in the observer. Such priming effects can be driven by alignment between the observer and the observed in body-centred or spatial coordinates (or both). The separate and joint contributions of these sources of priming remain to be fully characterised. Here, we ...
Navia Denise - - 2012
The coconut mite (CM), Aceria guerreronis Keifer, has spread to most coconut production areas worldwide and it has been considered one of the most notorious and important pests of coconut fruits in many countries. Although CM has been reported to damage coconuts for over 40 years in the Americas and Africa ...
Velez Edwards Digna R - - 2013
Genome-wide association studies (GWAS) of obesity measures have identified associations with single nucleotide polymorphisms (SNPs). However, no large-scale evaluation of gene-environment interactions has been performed. We conducted a search of gene-environment (G × E) interactions in post-menopausal African-American and Hispanic women from the Women's Health Initiative SNP Health Association Resource ...
Tyrell Ede - - 2012
OBJECTIVE: To assess the socioeconomic impact of lymphatic filariasis (LF) in Guyana. METHODS: Observational, cross-sectional study of 50 persons with chronic LF attending the Filariasis Clinic who were selected as the cases; and 50 persons with chronic skin conditions but no chronic LF, attending the Skin Clinic who were selected ...
Pondé Robério A A - - 2012
During hepatitis B virus (HBV) infection, at least four antigen-antibody systems are observed: HBsAg and anti-HBs; preS antigen and anti-preS antibody; HBcAg and anti-HBc; and HBeAg and anti-HBe. Through the examination of these antigen-antibody systems, hepatitis B infection is diagnosed and the course of the disorder may be observed. Although ...
Blutstein Tamara - - 2012
In utero exposure to cigarette smoke has severe consequences for the developing fetus, including increased risk of birth complications and behavioral and learning disabilities later in life. Evidence from animal models suggests that the cognitive deficits may be a consequence of in utero nicotine exposure in the brain during critical ...
Schwartz Billie - - 2012
The earthquake in Haiti led to an outpouring of outreach from groups of the Haitian international community as well as to residents of the island. Thus, an understanding of the help-seeking behavior patterns of this group is necessary to make meaning of their receptivity of assistance in a time of ...
Eskandari Mehrzad - - 2012
Soybean seed is a major source of oil for human consumption worldwide and the main renewable feedstock for biodiesel production in North America. Increasing seed oil concentration in soybean [Glycine max (L.) Merrill] with no or minimal impact on protein concentration could be accelerated by exploiting quantitative trait loci (QTL) ...
Stein T P - - 2012
Space flight is a new experience for humans. Humans adapt if not perfectly, rather well to life without gravity. There is a reductive remodeling of the musculo-skeletal system. Protein is lost from muscles and calcium from bones with anti-gravity functions. The observed biochemical and physiological changes reflect this accommodative process. ...
Garcia A - - 2012
This work studies the morphological changes taking place in the goat omasum during prenatal development, using scanning electron microscope, light microscopy and immunohistochemical analysis. A total of 140 goat embryos and fetuses were used, from the first stages of prenatal life until birth. Differentiation of the omasum as a separate ...
Meek Heather - - 2012
This paper explores evolving treatments for hysteria in the eighteenth century by examining a selection of works by both physician-writers and educated literary women. The treatments I identify-which range from aggressive bloodlettings, diets, and beatings, to exercise, fresh air, and writing cures-reveal a unique culture of therapy in which female ...
Panizza Paola - - 2012
AIMS: Identification, cloning, expression and characterization of a novel lipase -Lip I.3- from strain Pseudomonas CR-611. METHODS AND RESULTS: The corresponding gene was identified and isolated by PCR-amplification, cloned and expressed in E. coli, and purified by refolding from inclusion bodies. Analysis of the deduced amino acid sequence revealed high ...
Fletcher Paul J - - 2012
RATIONALE: Depletion of brain serotonin (5-HT) results in impulsive behaviour as measured by increased premature responding in the five-choice serial reaction time (5-CSRT) test. Acute selective blockade of 5-HT(2C) receptors also increases this form of impulsive action, whereas 5-HT(2C) receptor stimulation reduces premature responding. OBJECTIVES: These experiments determined the impact ...
Ootes S T C - - 2012
Deinstitutionalisation has not only made the social inclusion of clients a key objective in long-term mental healthcare, it may also affect the role of the care professional. This article investigates whether the social inclusion objective clashes with other long-standing professional values, specifically when clients give gifts to care professionals. In ...
Georgiades Katholiki - - 2012
As levels of immigration and ethnic diversity continue to rise in most Western societies, the social demography of schools is changing rapidly. Although schools represent a prominent developmental context, relatively little is known about the extent to which the racial/ethnic composition of schools influences mental health outcomes in students. The ...
Lin Hsiao-Che - - 2012
The oscillation angle (OsA), which is the sum of the impingement angles on the two sides when the prosthetic neck sways from the neutral axis of the acetabular cup to the liner rim, is one of the most important factors that can affect the range of motion of an artificial ...
Gross Bradley A - - 2012
As a result of their presumed benign natural history, cerebral capillary telangiectasias (CCTs) are infrequently addressed in the neurosurgical literature. We performed a comprehensive review of CCTs via the PubMed database to synthesize overall epidemiological, radiographic, natural history, and treatment results. Across ten series with 203 patients, mean age was ...
Severin Paul Nicholas - - 2012
The use of medications plays a pivotal role in the management of children with heart diseases. Most children with increased pulmonary blood flow require chronic use of anticongestive heart failure medications until more definitive interventional or surgical procedures are performed. The use of such medications, particularly inotropic agents and diuretics, ...
Frank Laura K - - 2012
OBJECTIVE: The epidemic of obesity and type 2 diabetes is evident in sub-Saharan Africa (SSA). However, their associations have hardly been examined in this region. METHODS: A hospital-based case-control study in urban Ghana consisting of 1221 adults (542 cases and 679 controls) investigated the role of anthropometric parameters for diabetes. ...
Bertrand Dominique - - 2012
The side-effects associated with the immunosuppressive drug sirolimus are numerous and constitute a major limitation for its use in renal transplantation. In this study, we describe two cases of renal transplant recipients treated with sirolimus who developed pericardial tamponade associated with interstitial pneumonia, proteinuria, microcytic anemia and, in one case, ...
Vasko Radovan - - 2012
BACKGROUND: The assessment of hydration status remains a challenging task in hemodialysis (HD) management. There are only limited data available on the relevance of clinical decisions in the estimation of dialysis overhydration (OH). The objective of this study was to examine the significance of clinical judgment in the assessment of ...
Huesmann Mario - - 2012
Background: Chronic cholestatic pruritus (ChP) is caused by various hepatobiliary disorders. This retrospective study describes the distribution of underlying diseases, clinical characteristics and treatment efficacy in a consecutive collective of patients with ChP. Patients and methods: Extensive data from 60 patients with ChP (30 women, 30 men; mean age: 58.0 ...
Schwarz Markus J - - 2012
Increased degradation of tryptophan (TRP) through the kynurenine (KYN) pathway (KP) is known to be involved in the molecular mechanisms resulting in the neuropathogenesis of Alzheimer's disease (AD). Activation of the KP leads to the production of neurotoxic metabolites 3-hydroxykynurenine (3-HK) and quinolinic acid (QUIN) by immune cells and neuroprotective ...
Rogers Geraint B GB Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King's College London, London, - - 2013
High-throughput pyrosequencing and quantitative PCR (Q-PCR) analysis offer greatly improved accuracy and depth of characterisation of lower respiratory infections. However, such approaches suffer from an inability to distinguish between DNA derived from viable and non-viable bacteria. This discrimination represents an important step in characterising microbial communities, particularly in contexts with ...
Gagne-Bourgue Francois - - 2012
AIMS: To isolate and characterize indigenous bacterial endophytes from cultivars of switchgrass and study their antimicrobial and growth promoting potential. METHODS AND RESULTS: The diversity, molecular and biochemical characterizations of indigenous and culturable bacterial endophytes residing in leaves of switchgrass have not been studied previoulsy. This paper describes the characterization ...
Zhang Yu - - 2012
BACKGROUND: Because of complicating anatomic factors, endoscopic submucosal dissection is seldom performed in subepithelial tumors of the esophagogastric junction originating from the muscularis propria layer. AIM: This study was designed to evaluate the feasibility of endoscopic muscularis excavation for treating subepithelial tumors of the esophagogastric junction originating from the muscularis ...
Riveros Fabián - - 2012
Biomechanical studies on abdominal aortic aneurysms (AAA) seek to provide for better decision criteria to undergo surgical intervention for AAA repair. More accurate results can be obtained by using appropriate material models for the tissues along with accurate geometric models and more realistic boundary conditions for the lesion. However, patient-specific ...
Li Chao - - 2012
Conventional reverse genetics for classical swine fever virus (CSFV) is based on the transfection of permissive cells with either in vitro or intracellularly synthesized RNA transcripts from a viral genomic cDNA clone. These strategies are complicated, inefficient and time-consuming. This study is aimed to develop an improved reverse genetics method ...
Lemnitzer Frederic - - 2012
The herpesvirus replication cycle comprises maturation processes in the nucleus and cytoplasm of the infected cells. After their nuclear assembly viral capsids translocate via primary envelopment towards the cytoplasm. This event is mediated by the nuclear envelopment complex, which is composed by two conserved viral proteins belonging to the UL34 ...
- - 2012
To the Editor: Olesen et al. (Aug. 16 issue)(1) report that in their study, warfarin treatment was associated with a decreased risk of thromboembolic events among patients requiring renal-replacement therapy. In contrast, three large registry studies concluded that in patients with atrial fibrillation who were undergoing hemodialysis, warfarin was associated ...
Tighe B - - 2012
BACKGROUND: Dietetic students are exposed to bioethical dilemmas on clinical placements; however, the nature of these situations has not been investigated. The present study aimed to analyse students' reports of incidents and their associated personal development plans (PDP) to assess the type of ethical incidents faced and how they cope ...
Nelson Amanda M - - 2013
Prostaglandins (PGs) are key inflammatory mediators involved in wound healing and regulating hair growth; however, their role in skin regeneration after injury is unknown. Using wound-induced hair follicle neogenesis (WIHN) as a marker of skin regeneration, we hypothesized that PGD2 decreases follicle neogenesis. PGE2 and PGD2 were elevated early and ...
Bordes Jacques - - 2012
Modern wheat (Triticum aestivum L.) varieties in Western Europe have mainly been bred, and selected in conditions where high levels of nitrogen-rich fertilizer are applied. However, high input crop management has greatly increased the risk of nitrates leaching into groundwater with negative impacts on the environment. To investigate wheat nitrogen ...
Shigemitsu Takanari - - 2012
KEY MESSAGE : We showed that rice prolamin polypeptides formed ER-derived PBs in transgenic rice calli, and that this heterologous transgene expression system is suitable for studying the mechanism of rice PB-I formation. Rice prolamins, alcohol-soluble seed storage proteins, accumulate directly within the rough endoplasmic reticulum (ER) lumen, leading to ...
Tota Santoshkumar - - 2012
RATIONAL: Studies have shown the involvement of angiotensin II (Ang II) in neurobehavioral aspects, but the exact role of Ang II in memory is still ambiguous. OBJECTIVE: This study explored the effect of central Ang II on spatial memory along with cholinergic neurotransmission, brain energy metabolism, cerebral blood flow (CBF), ...
Yassin Mohamed F - - 2012
Due to heavy traffic emissions within an urban environment, air quality during the last decade becomes worse year by year and hazard to public health. In the present work, numerical modeling of flow and dispersion of gaseous emissions from vehicle exhaust in a street canyon were investigated under changes of ...
Achan Jane - - 2012
Human immunodeficiency virus (HIV) protease inhibitors show activity against Plasmodium falciparum in vitro. We hypothesized that the incidence of malaria in HIV-infected children would be lower among children receiving lopinavir-ritonavir-based antiretroviral therapy (ART) than among those receiving nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based ART. We conducted an open-label trial in which HIV-infected ...
- - 2012
To the Editor: With regard to the article by Kelly et al. (Sept. 6 issue)(1): in principle, the children could become shorter adults because of therapy, as the authors conclude, or they could become taller because of continued wheezing. Height depends on shape as well as bone length. At rest, ...
Zhou Xue - - 2012
The hypothesis for the etiology of schizophrenia involves various neurotransmitters, including 5-HT. Metabolic disorder of 5-HT is an important underlying neurobiochemical cause leading to the development of mental illness. Abnormality in the receptors involved in 5-HT synthesis and metabolism may affect the functioning of 5-HT in the central nervous system. ...
Magdy Emad A - - 2012
First branchial cleft (FBC) anomalies are uncommon. The aim of this retrospective clinical study is to describe our experience in dealing with these sporadically reported lesions. Eighteen cases presenting with various FBC anomalies managed surgically during an 8-year period at a tertiary referral medical institution were included. Ten were males ...
Al-Khedery Basima - - 2012
ABSTRACT: BACKGROUND: Anaplasma phagocytophilum is an intracellular organism in the Order Rickettsiales that infects diverse animal species and is causing an emerging disease in humans, dogs and horses. Different strains have very different cell tropisms and virulence. For example, in the U.S., strains have been described that infect ruminants but ...
Leung Ka-Ho - - 2012
A G-quadruplex-selective luminescent iridium(iii) switch-on probe has been developed for the detection of cysteine (Cys) in aqueous solution. The system is highly sensitive and selective towards Cys with a tunable range of detection. The detection of glutathione (GSH) is also examined.
Soto Paul L - - 2012
RATIONALE: Studies investigating dopamine D(2) receptor antagonism of cocaine's discriminative stimulus effects have resulted in varied effects possibly due to the use of different antagonists, species, and procedures. OBJECTIVES: The present study sought to further investigate D(2) antagonism of cocaine's discriminative stimulus effects using a variety of D(2) antagonists and ...
Dupuy Célie - - 2012
A multibiomarker approach was developed on juvenile Atlantic tomcod (Microgadus tomcod) to evaluate the pertinence of this approach for low-cost screening assessment of the environmental quality of various coastal sites within estuaries. Several biometric indices and biomarkers (ethoxyresorufin-O-deethylase (EROD) activity, metallothionein concentration, and immune responses) were investigated on immature and ...
Lombard Jay - - 2012
Psychiatric disorders are a leading cause of disability worldwide and despite significant pharmacologic advances, often remain difficult to diagnose correctly and treat fully. Factors which contribute to these difficulties include imprecise understanding of etiology, syndromal nature of many disorders and overlap in diagnostic criteria between conditions, medical and psychiatric comorbidity ...
Hughes-Davies Tom - - 2012
To the Editor: With regard to the article by Kelly et al. (Sept. 6 issue)(1): in principle, the children could become shorter adults because of therapy, as the authors conclude, or they could become taller because of continued wheezing. Height depends on shape as well as bone length. At rest, ...
Zong Wei - - 2012
Histone modifications affect gene expression level. Several studies have shown that they may play key roles in regulating gene expression in plants under abiotic stress, but genome-wide surveys of such stress-related modifications are very limited, especially for crops. By using ChIP-Seq and RNA-Seq, we investigated the genome-wide distribution pattern of ...
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