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Results 201 - 250 of 2474
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Jund R R Puchheim, - - 2012
A herbal drug combination (Dry Extract BNO 1016) has been assessed for efficacy and tolerability in patients with acute viral rhinosinusitis. In this randomised, controlled trial patients with symptom duration of up to 3 days, mild to moderate facial pain and a Major Symptom Score (MSS) between 8 and 12 ...
Huang Johnny X JX Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, - - 2012
This study utilizes sensitive, modern isothermal titration calorimetric methods to characterize the microscopic thermodynamic parameters that drive the binding of basic drugs to α-1-acid glycoprotein (AGP) and thereby rationalize the thermodynamic data in relation to docking models and crystallographic structures of the drug-AGP complexes. The binding of basic compounds from ...
Nijhawan Ank E AE Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. - - 2012
Trichomonas vaginalis is the most prevalent curable sexually transmitted infection in the United States and may lead to preterm delivery, infertility, and increased HIV transmission. Incarcerated women may be at especially high risk for infection, although few studies have examined routine screening for Trichomonas infection in this population. Women older ...
Marín-Franch Iván I Indiana University School of Optometry, Bloomington, Indiana 47405, USA. - - 2012
Measurement of retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) is commonly used in the detection and management of glaucoma. The Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA) is widely used, but image acquisition is subject to artifacts, such as those caused by normal fixational eye ...
Sun Shuying S Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California, - - 2012
A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.
Rosenow F - - 2012
The term non-convulsive status epilepticus (NCSE) refers to a heterogeneous group of diseases with different etiology, prognosis and treatment. The different forms of NCSE comprise about 25-50% of all status epilepticus cases. The most frequent form encountered in clinical practice is complex-partial SE but the rarer conditions of absence status, ...
Alasker Ahmed - - 2012
An increasing number of small renal masses (SRMs) are being detected with modern cross-sectional imaging. The natural history of SRMs is mostly unknown. Initial active surveillance (AS) is a reasonable treatment option for small renal masses (SRMs) < 4 cm in the infirm patient with major comorbidities. Partial nephrectomy (PN) is the ...
Arthur Joseph G - - 2012
We derive a formula that relates the spike-triggered covariance (STC) to the phase resetting curve (PRC) of a neural oscillator. We use this to show how changes in the shape of the PRC alter the sensitivity of the neuron to different stimulus features, which are the eigenvectors of the STC. ...
Atmaca Halil - - 2012
PURPOSE: Depending on the location and extent of the meniscectomy, loading on the tibial articular cartilage alters. The main purpose of the present study was to analyze the loading on the tibial articular cartilage following medial meniscectomy performed in various location and extent, as well as in the healthy knee, ...
Ahn Eu-Ree - - 2012
The forkhead-associated (FHA) domain is involved in protein-protein interaction by recognizing a phosphothreonine epitope on target proteins. In this study, we investigated in planta functions of the Arabidopsis FHA domain 2. AtFHA2 was mainly localized in the nucleus. Arabidopsis fha2 null mutants grew normally during the vegetative stage, but had ...
Chakrabarti Mrinmay - - 2012
Neuroblastoma is an extracranial solid tumor that usually occurs in infants and children. Malignant neuroblastomas remain mostly refractory to currently available chemotherapeutic agents. So, new therapeutic agents and their molecular mechanisms for induction of cell death must be explored for successful treatment of human malignant neuroblastomas. Two polyphenolic compounds, which ...
Trabert J - - 2012
Given the number of studies that have investigated the subject of intracerebral hemorrhage, there are still many research questions unanswered, including prevention and treatment of progressive hemorrhage, indications for surgical intervention, secondary prophylaxis and also treatment of intracerebral hemorrhage in patients with new anticoagulants. This article presents an overview of ...
- - 2012
In 2007, the national prevalence of HIV in Kenya was 7.1% among persons aged 15-64 years, with provincial prevalence rates ranging from 0.8% in North Eastern Province to 14.9% in Nyanza Province. Although an estimated 85.0% of males in Kenya are circumcised, nearly half of all uncircumcised men live in ...
Seideman Casey A - - 2012
Within the last decade, the adaptation of robotic urologic surgery has had a profound impact on surgical practice, with robotic upper tract reconstruction for ureteropelvic junction obstruction gaining rapid acceptance. Recent advances in robotic reconstruction demonstrate efficacious outcomes of robotic pyeloplasty, as compared with conventional laparoscopic pyeloplasty, even in the ...
- - 2012
Background: In 2009, 6.7% of the estimated 1.1 million persons living with human immunodeficiency virus (HIV) infection in the United States were youths (defined in this report as persons aged 13-24 years); more than half of youths with HIV (59.5%) were unaware of their infection. Methods: CDC used National HIV ...
Romero-Maroto M - - 2012
INTRODUCTION: Two processes of vastly different clinical characteristics-what we know today as "Aphthous Stomatitis" and "noma"-occupied the minds of dentists and doctors from the sixteenth to eighteenth centuries. The aim of this article was to look at their knowledge-concerning the differential diagnosis and treatment of these two processes. MATERIALS AND ...
Dekker Nicky - - 2012
Referral of patients with endometrial (EC) and/or ovarian cancer (OC) for genetic counseling is based on age at diagnosis and family history. Many patients with hereditary cancers are missed by following this strategy. We determined acceptance and mutation detection rate of offering genetic counseling and testing to unselected EC and ...
Franz Maximilian B - - 2012
INTRODUCTION: The corpus luteum (CL), develops from the ruptured follicle after gonadotropin stimulation. Based on intracellular reorganization of the cytoskeleton an human chorionic gonadotropin (hCG) dependent sprouting and migration of luteinizing granulosa cells (LGCs) and endothelial cells is observed. Rho-GTPases are shown to be key regulators of cytoskeletal restructuring. In ...
Saar Indrek - - 2012
Neuropeptide galanin and its three receptors, galanin receptor type 1-galanin receptor type 3, are known to be involved in the regulation of numerous psychological processes, including depression. Studies have suggested that stimulation of galanin receptor type 2 (GalR2) leads to attenuation of the depression-like behavior in animals. However, due to ...
Wang Zhifu - - 2012
Sepsis represents a systemic inflammatory response to infection and its sequelae include severe sepsis, septic shock, multiple organ dysfunction syndrome (MODS) and death. Studies in mice and humans indicate that the inducible nitric oxide synthase (iNOS, NOS2) plays an important role in the development of sepsis and its sequelae. It ...
- - 2012
The recycling of lead has increased during the past 20 years, with more workers and their families potentially being exposed to lead from recycling facilities, including facilities that recycle lead-acid batteries. During November 2010-May 2011, four voluntary blood lead screening clinics for children of employees of a battery recycling facility ...
Schwarz Frank - - 2012
PURPOSE: This case illustrates a pulp tissue-induced dentointegration of a titanium implant. MATERIALS AND METHODS: One commercially available titanium implant with a sand-blasted and acid-etched surface was placed in the maxilla of a foxhound where the palatinal root of the previously (i.e., 8 weeks) removed first molar was unintentionally retained. After ...
- - 2012
Human immunodeficiency virus (HIV) infections attributed to male-to-male sexual contact comprised 64% of the estimated new HIV infections in the United States in 2009. Assessing the geographic distribution of HIV infection by transmission category can help public health programs target prevention resources to men who have sex with men (MSM) ...
Dekate Parag - - 2012
Acute diarrhea is the second leading cause of under-five mortality in India. It is defined as the passage of frequent watery stools (>3/24 h). Recent change in consistency of stools is more important than frequency. Acute diarrhea is caused by variety of viral, bacterial and parasitic agents. The common ones are: ...
Mazza Alberto - - 2012
The role of arterial hypertension (HT) as risk factor for Parkinson's disease (PD) is still debated. Case-control and retrospective studies do not support an association between HT and PD and the risk of PD seems to be lower in hypertensive than in normotensive subjects. In addition, the use of calcium-channel ...
Humbert Ianessa A IA Department of Physical Medicine and Rehabilitation, Johns Hopkins University, School of Medicine, 98 North Broadway, Suite 409, Baltimore, MD 21231, - - 2013
Oropharyngeal swallowing is a complex sensorimotor phenomenon that has had decades of research dedicated to understanding it more thoroughly. However, the underlying neural mechanisms responsible for normal and disordered swallowing remain very vague. We consider this gap in knowledge the result of swallowing research that has been broad (identifying phenomena) ...
Pastor Verónica V Department of Physiology and Institute of Cell Biology, School of Medicine, University of Buenos Aires, Paraguay 2155 7th floor, C1121A6B, Buenos Aires, - - 2013
Prior exposure to drugs of abuse may increase or decrease the reinforcing effects of the drug in later consumptions. Based on the initial locomotor activity (LA) response to an acute drug administration or to novelty in an open-field arena, animals can be classified as low or high LA responders (LR ...
Mulvihill John J - - 2012
Computational models of diseased arteries are advancing rapidly, and a need exists to develop more accurate material models of human atherosclerotic plaques. However, intact samples for in vitro mechanical testing are not readily available. Most plaque samples are harvested from carotid endarterectomies where the geometries are not suitable for the ...
Qiu Qian-Hui - - 2012
Abstract Conclusion: Nasal polyposis (NP) is frequently found to run in families. Earlier onset of the condition strongly suggested the genetic basis for the development of NP and implied that it might be a genetic disease involving multiple genes. Objective: The etiology and pathogenesis of NP remain largely unknown, although ...
Pinto Alvaro - - 2012
In the last few years, the treatment of castration-resistant prostate carcinoma (CRPC) has changed completely. The approval of docetaxel and subsequent investigation in this field have led to development of new agents that have demonstrated an improvement in overall survival in the post-docetaxel setting, such as cabazitaxel and abiraterone. Radium-223 ...
Jin Sung-Chul - - 2012
INTRODUCTION: We evaluated the outcomes of middle cerebral artery bifurcation (MCAB) aneurysms treated with simple coiling using single or multiple catheters without stents or balloons. METHODS: This study included 100 patients with 103 MCAB aneurysms who underwent a simple coiling procedure without the adjuvant use of stents or balloons. The ...
Tormey W P - - 2012
BACKGROUND: Biochemical toxicology in suicides provides a template to improve preventive interventions in cases of suicide. The menu for biochemical toxicological analysis in coroners' cases is not prescriptive in Ireland or in the United Kingdom. The aim of the study was to confirm that reliance on the results of an ...
Baluom Muhammad - - 2012
AIMS: Fostamatinib (R788) is an orally-dosed prodrug designed to deliver the active metabolite R940406 (R406), a spleen tyrosine kinase (SYK) inhibitor, for the treatment of rheumatoid arthritis. The objectives were to evaluate the human pharmacokinetic properties of fostamatinib and R406. METHODS: Three clinical studies were conducted in healthy subjects: (A) ...
Gordon Jason - - 2012
The aim of this study was to assess trends in hip fracture rates and outcomes following hospitalisation for hip fracture. Hip fracture admissions increased over the study period. Men fared worst in terms of higher absolute mortality. Refracture rates and male health outcomes require further attention. PURPOSE: The aim of ...
Takeuchi Masato - - 2012
Intravenous immunoglobulin (IVIG) is currently the standard treatment for Kawasaki disease (KD). Although IVIG therapy is generally well tolerated, several minor adverse reactions have been reported. We report a patient with KD treated with IVIG, who developed a cutaneous reaction in the convalescent phase (approximately 10 days after therapy). We identified ...
Pereira Rosangela A - - 2012
OBJECTIVE: To examine the patterns of consumption of foods high in solid fats and added sugars (SoFAS) in Brazil. DESIGN: Cross-sectional study; individual dietary intake survey. Food intake was assessed by means of two non-consecutive food records. Foods providing >9·1 % of energy from saturated fat, or >1·3 % of ...
Fiorito Elisa - - 2012
Estrogen receptor (ER) is a hormone-regulated transcription factor that controls cell division and differentiation in the ovary, breast, and uterus. The expression of ER is a common feature of the majority of breast cancers, which is used as a therapeutic target. Recent genetic studies have shown that ER binding occurs ...
Ford A C - - 2012
BACKGROUND: Gastro-oesophageal reflux symptoms (GERS) are common in the community. However, few studies have examined their long-term natural history, or impact on survival. AIM: To examine these issues in individuals recruited into a community-based screening programme for Helicobacter pylori in 1994. METHODS: Data on mortality and cause of death at ...
Saul-Tcherkas Vered - - 2012
Water and nutrient availability are the major limiting factors of biological activity in arid and semiarid ecosystems. Therefore, perennial plants have developed different ecophysiological adaptations to cope with harsh conditions. The chemical profile of the root exudates varies among plant species and this can induce variability in associated microbial populations. ...
Fırat Cemal - - 2012
Abstract The extravasation of many agents during administration by way of the peripheral veins can produce severe necrosis of the skin and subcutaneous tissue. The incidence of an extravasation injury is elevated in the populations prone to complications, including the younger age groups. The severity of the necrosis depends on ...
Patil Seema - - 2012
PURPOSE: The aim of the study was to assess the distribution of accessory foramina in the mandibular body with computed tomography (CT). MATERIALS AND METHODS: The CT images of the mandibular body in 300 subjects (183 females and 117 males aged between 12 and 85 years) were retrospectively analysed for ...
Mayes Rick - - 2012
Globally, chronic disease and conditions such as diabetes, cardiovascular disease, depression and cancer are the leading causes of morbidity and mortality. Why, then, are public health efforts and programs aimed at preventing chronic disease so difficult to implement and maintain? Also, why is primary care-the key medical specialty for helping ...
Fan Peng-Fei - - 2012
Most gibbons dwell in the tropical forests of Southeastern Asia, but eastern hoolock gibbons (Hoolock leuconedys) survive in high montane forest ranging from 1,600 to 2,700 m a.s.l. in Gaoligongshan (>24°30'N), Yunnan, China. To assess the behavioral adaptations of hoolock gibbons to the montane forest, we related temperature and food availability ...
Christopher-Stine Lisa - - 2012
A 21-year-old man presented with fever, arthralgias, dyspnea, and periorbital swelling. Examination revealed periorbital edema and erythema. Chest CT revealed bilateral subpleural reticular and ground-glass opacities. Diagnostic tests and a diagnostic procedure were performed.
Wu Yongzhen - - 2012
The high performance and low cost of dye-sensitized solar cells (DSSCs) have drawn great interest from both academic and industrial circles. The research on exploring novel efficient sensitizers, especially on inexpensive metal-free pure organic dyes, has never been suspended. The donor-π bridge-acceptor (D-π-A) configuration is mainstream in the design of ...
Hassanein Sahar M A - - 2012
Abstract Objectives: To study the impact of interrupted loud noise in Neonatal Intensive Care Unit (NICU) on neonatal physiologic parameters, and apply methods to alleviate noise sources through teaching NICU's staff. Methods: Noise level measured at different day times and during different noisy events in the NICU. Changes in the ...
Bardou Patrick - - 2012
PURPOSE: The objective of this study was to assess if an increase in electrical impedance was associated with intraneural (sub-epineural) needle tip placement. METHODS: Two electrical impedance measurements were carried out in each of 140 peripheral nerve blocks. The first measurement was performed at a distance of 0.5-1 cm from the ...
Grana Tomas R - - 2012
The mechanisms by which nerve growth factor (NGF) increases the level of low density lipoprotein receptor-related protein (LRP1) are not known. Administration of nitric oxide synthase (NOS) inhibitors modulates several of the neurotrophic actions of NGF, including TrkA signalling pathway activation, increases in gene expression and neurite outgrowth. The present ...
Alvarez Gm - - 2012
Glycolytic and pentose phosphate pathway (PPP) activities were modulated in porcine cumulus-oocyte complexes (COCs) during in vitro maturation (IVM) by the addition of inhibitors or stimulators of key enzymes of the pathways to elucidate their relative participation in oocyte maturation. The activities of glycolysis and PPP were evaluated by lactate ...
Kristiansen Anne Lene - - 2012
Infant and childhood nutrition influences short- and long-term health. The objective of the present paper has been to explore dietary patterns and their associations with child and parent characteristics at two time points. Parents of Norwegian 2-year-olds were, in 1999 (n 3000) and in 2007 (n 2984), invited to participate ...
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